Zhangguo Chen, MD, PhD
Associate Research Professor, Immunology and Microbiology

Publications

• Wang X, Waschke BC, Woolaver RA, Chen Z, Zhang G, Piscopio AD, Liu X, Wang JH. Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas. Cancer Immunol Res. 2019 Aug;7(8):1318-1331. PubMed PMID: 31235619
• Chen Z, Wang JH. Signaling control of antibody isotype switching. Adv Immunol. 2019;141:105-164. PubMed PMID: 30904131
• Woolaver RA, Wang X, Dollin Y, Xie P, Wang JH, Chen Z. TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-?B1 Activation. J Immunol. 2018 Dec 1;201(11):3421-3430. PubMed PMID: 30341187
• Wang X, Chen Z, Mishra AK, Silva A, Ren W, Pan Z, Wang JH. Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica. 2018 Mar;103(3):466-476. PubMed PMID: 29217775
• Wang X, Chen Z, Mishra AK, Silva A, Ren W, Pan Z, Wang JH. Chemotherapy-induced differential cell cycle arrest in B cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29217775
• Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH. Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. J Hematol Oncol. 2016 Jan 7;9(1):2. PubMed PMID: 26740101
• Mishra AK, Kadoishi T, Wang X, Driver E, Chen Z, Wang XJ, Wang JH. Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8 T Cells co-expressing PD-1 and LAG-3 inhibitory receptors. Oncotarget. 2016 Dec 6;7(49):81341-81356. PubMed PMID: 27835902
• Chen Z, Gowan K, Leach SM, Viboolsittiseri SS, Mishra AK, Kadoishi T, Diener K, Gao B, Jones K, Wang JH. Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing. BMC Genomics. 2016 Oct 21;17(1):823. PubMed PMID: 27769169
• Chen Z, Eder MD, Elos MT, Viboolsittiseri SS, Chen X, Wang JH. Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions. J Immunol. 2016 Mar 1;196(5):2335-47. PubMed PMID: 26810227
• Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH. Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. J Hematol Oncol. 2016 Jan 7;9:2. PubMed PMID: 26740101
• Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 1;195(11):5461-71. PubMed PMID: 26500350
• Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Hansen E, Wang JH. AID-initiated DNA lesions are differentially processed in distinct B cell populations. J Immunol. 2014 Dec 1;193(11):5545-56. PubMed PMID: 25339658
• Chen Z, Wang JH. Generation and repair of AID-initiated DNA lesions in B lymphocytes. Front Med. 2014 Jun;8(2):201-16. PubMed PMID: 24748462