Kathryn Haskins, PhD
Professor, Immunology and Microbiology

Publications

• Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes. Wenzlau JM, Gu Y, Michels A, Rewers M, Haskins K, Yu L. Diagnostics (Basel). 2023 Sep 4;13(17):2859. doi: 10.3390/diagnostics13172859. PMID: 37685398
• Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate. Crawford SA, Groegler J, Dang M, Michel C, Powell RL, Hohenstein AC, Reyes K, Haskins K, Wiles TA, Delong T. J Biol Chem. 2023 Nov;299(11):105264. doi: 10.1016/j.jbc.2023.105264. Epub 2023 Sep 19. PMID: 37734557
• Jamison, B.L., DiLisio, J.E., Beard, K.S., Neef, T., Bradley, B., Goodman, J., Gill, R.G., Miller, S.D., Baker, R.L. and Haskins, K. 2022. Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the Non-Obese Diabetic (NOD) Mouse. Diabetes 71: 483-96.
• Wenzlau, J.M., Dilisio J.E., Barbour, G., Dang, M., Hohenstein, A.C., Nakayama, M., Delong, T., Baker, R.L. and Haskins, K. 2022. Insulin B-chain hybrid peptides are agonists for InsB:9-23-reactive T cells in autoimmune diabetes. Front. Immunol. 13: 926650.
• Crawford, S.A., Wiles, T.A., Wenzlau, J.M., Powell, R.L., Barbour, G., Dang, M., Groegler, J., Barra, J.M., Burnette, K.S., Hohenstein, A.C., Baker, R.L., Tse, H.M., Haskins, K. and Delong, T. 2022. Cathepsin D drives the formation of Hybrid Insulin Peptides relevant to the pathogenesis of Type 1 Diabetes. Diabetes 71: 2793-2803.
• Dilisio, J.E. and Haskins, K. 2021. Induction of Antigen-Specific Tolerance in Autoimmune Diabetes with Nanoparticles containing Hybrid Insulin Peptides. Biomedicines 9:240.
• Wiles, T.A., Hohenstein, A., Landry, L.G., Dang, M., Powell, R., Guyer, P., James, E.A., Nakayama, M., Haskins, K., Delong, T. and Baker, R.L. 2021. Characterization of human CD4 T cells specific for a C-peptide/C-peptide hybrid insulin peptide. Frontiers in Immunology 12.
• Srivastava, N., Hu, H., Vomund, A.N., Peterson, O.J., Baker, R.L., Haskins, K., Teyton, L., Wan, X. and Emil R. Unanue, E.R. 2021. Chromogranin A deficiency confers protection from autoimmune diabetes via multiple mechanisms. Diabetes: 70:2860-70.
• Arribas-Layton, D., Guyer, P., Delong, T., Dang, M., Chow, I.-T., Speake, C., Greenbaum, C., Kwok, W.W., Baker, R.L., Haskins, K. and James, E.A. 2020. Hybrid Insulin Peptides are recognized by Human T cells in the context of DRB1*04:01. Diabetes 69: 1492-1502.
• Dai, Y.D., Dias, P., Margosiak, A., Marquardt, K., Bashratyan, R., Hu, W.-Y., Haskins, K. and Evans, L.H. 2020. Endogenous retrovirus Gag antigen and its gene variants are unique autoantigens expressed in the pancreatic islets of non-obese diabetic mice. Immunol Lett. 223: 62-70.
• Haskins, K. and Wenzlau, J. 2020. CD4 T Cells and Neo-Antigens in Autoimmune Diabetes. Critical Reviews in Immunology.
• Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 Aug 4;23(8):1004. PubMed PMID: 28777787
• Wiles TA, Delong T, Baker RL, Bradley B, Barbour G, Powell RL, Reisdorph N, Haskins K. An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. J Autoimmun. 2017 Mar;78:11-18. PubMed PMID: 27802879
• Jamison, B.L., DiLisio, J.E., Beard, K.S., Neef, T., Bradley, B., Goodman, J., Gill, R.G., Miller, S.D., Baker, R.L. and Haskins, K. 2021. Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the Non-Obese Diabetic (NOD) Mouse. Diabetes. (In press)
• An Insulin-Chromogranin A hybrid peptide activates DR11 restricted T cells in human type 1 diabetes. Callebaut, A., Guyer, P., Baker, R.L., Hohenstein, A., Gottlieb, P.A., Mathieu, C., Overbergh, L., Haskins, K. and Eddie A. James, E.A. 2024. Diabetes. In Press.