Graduate School :
Department: Pediatrics-Critical Care Medicine
- PhD, Rice University (1979)
- AB, Rice University (TX) (1973)
- University of California (San Diego) Program, Pharmacology (1984)
Department: Pediatrics-Critical Care Medicine
Publications
- Applegate TJ, Krafsur GM, Boon JA, Zhang H, Li M, Holt TN, Ambler SK, Abrams BA, Gustafson DL, Bartels K, Garry FB, Stenmark KR, Brown RD. Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension. Front Physiol. 2021;12:712583. PubMed PMID: 34552503
- Kumar S, Frid MG, Zhang H, Li M, Riddle S, Brown RD, Yadav SC, Roy MK, Dzieciatkowska ME, D'Alessandro A, Hansen KC, Stenmark KR. Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages. JCI Insight. 2021 Nov 8;6(21). PubMed PMID: 34499621
- Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021;12:640718. PubMed PMID: 33868271
- Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17ß-Estradiol and estrogen receptor a protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. J Clin Invest. 2021 Mar 15;131(6). PubMed PMID: 33497359
- Zhang H, Brown RD, Williams J, Delaney C, Stenmark KR. Hypoxic remodeling of neonatal pulmonary artery and myocardium. Chapter 20, pp. 111-118. doi: 10.1201/9780367494018-20. IN: Hypoxic Respiratory Failure in the Newborn: From Origins to Clinical Management. Ed, Dakshinamurti S. CRC Press, 2021. ISBN 9780367493998
- Petrou CL, D'Ovidio TJ, Bölükbas DA, Tas S, Brown RD, Allawzi A, Lindstedt S, Nozik-Grayck E, Stenmark KR, Wagner DE, Magin CM. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro. J Mater Chem B. 2020 Aug 21;8(31):6814-6826. PubMed PMID: 32343292
- Brown RD, Fini MA, Stenmark KR. Band on the run: insights into right ventricular reverse remodelling. Cardiovasc Res. 2020 Aug 1;116(10):1651-1653. PubMed PMID: 32289148
- Zhang H, Brown RD, Stenmark KR, Hu CJ. RNA-Binding Proteins in Pulmonary Hypertension. Int J Mol Sci. 2020 May 26;21(11). PubMed PMID: 32466553
- Brown RD, Allawzi A, Petrou C, Magin CM, GrayckEN, Stenmark KR. Activation of Pulmonary and Cardiac Cell Populations in Response to Environmental Hypoxia or Lung Injury Using Transgenic Mouse Strains Expressing Phenotype-Sensitive Fluorescent Reporter Proteins. Am J Respir Crit Care Med 201:A3870, 2020
- Brown RD, Applegate TJ, Krafsur GM, Boon JA, Zhang H, Holt TN, Abrams BA, Gustafson DL, Bartels K, Garry FA, Stenmark KR. Therapeutic Actions of the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Hypoxia-Induced Pulmonary Hypertension. Am J Respir Crit Care Med 201:A3873, 2020
- Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
- Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
- Bruns DR, Tatman PD, Kalkur RS, Brown RD, Stenmark KR, Buttrick PM, Walker LA. The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation. PLoS One. 2019;14(8):e0220573. PubMed PMID: 31374110
- Jennings KJ, Krafsur GM, Brown RD, Holt TN, Coleman SJ, Speidel SE, Enns RM, Stenmark KR, Thomas MG. Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle. Transl Anim Sci. 2019 Dec;3(Suppl 1):1669-1672. PubMed PMID: 32704934
- Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. PubMed PMID: 28555642
- Neary JM, Brown RD, Holt TN, Stenmark KR, Enns RM, Thomas MG, Garry FB. Static and dynamic components of right ventricular afterload are negatively associated with calf survival at high altitude. J Anim Sci. 2016 Oct;94(10):4172-4178. PubMed PMID: 27898844
- Bartels K, Brown RD, Fox DL, Bull TM, Neary JM, Dorosz JL, Fonseca BM, Stenmark KR. Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension. Anesth Analg. 2016 May;122(5):1280-6. PubMed PMID: 26974020
- Schäfer M, Myers C, Brown RD, Frid MG, Tan W, Hunter K, Stenmark KR. Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment. Curr Hypertens Rep. 2016 Jan;18(1):4. PubMed PMID: 26733189
- Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
- Neary JM, Garry FB, Holt TN, Brown RD, Stenmark KR, Enns RM, Thomas MG. The altitude at which a calf is born and raised influences the rate at which mean pulmonary arterial pressure increases with age. J Anim Sci. 2015 Oct;93(10):4714-20. PubMed PMID: 26523564
- Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
- Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA 3rd, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015 Apr 15;6:6863. PubMed PMID: 25873470
- Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT Jr, Long CS, Garrington TP, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan;304(2):H269-81. PubMed PMID: 23125215
- Zhang H, Brown RD, Williams J, Delaney C, Stenmark KR. Hypoxic remodeling of neonatal pulmonary artery and myocardium. IN: Hypoxic respiratory failure in the newborn - From origins to clinical management. eds, S Dakshinamurti, S Abman, P-Y Cheung, S Lakshminrusimha, P McNamara, W Milson, CRC Press (Taylor & Frances Publishers, Boca Raton, FL). In press, 2020
Practice Locations
Hospital Affiliation
- University of Colorado Hospital
Specialty Information
Conditions & Treatments
- Critical Care
General Information
Graduate Schools:
- PhD, Rice University (1979)
Undergraduate Schools:
- AB, Rice University (TX) (1973)
Fellowships:
- University of California (San Diego) Program, Pharmacology (1984)
Department: Pediatrics-Critical Care Medicine