Shelley Miyamoto, MD
Associate Professor, Pediatrics-Cardiology

Photo
Medical School:
  • MD, University of Iowa Roy J. and Lucille A. Carver College of Medicine (1998)
Undergraduate School:
  • BS, University of Iowa (IA) (1993)
Residency:
  • Brown University Program, Chief Resident, Pediatrics (2002)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Cardiology (2005)
Languages: English
Department: Pediatrics-Cardiology

Professional Titles

  • Associate Professor, Pediatrics-Cardiology
  • Director, Cardiomyopathy Program
  • Jack Cooper Millisor Chair in Pediatric Heart Disease

Recognition & Awards

  • Top Doctor in Denver, 5280 Magazine, (2015)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
  • Medical Student Teaching Award, School of Medicine Class of 2013, (2010)
    Medical Student Teaching Award: Best Clinical Correlates.
  • Fern Primack Heart Who Cares Award, Heart Institute at The Children's Hospital, (2009)
    Nominated by peers and colleagues in recognition of dedication to the Heart Institute and Cardiac patient families. Awarded by the Little Hearts Committee
  • Cardiovascular Scholar Award Winner, American Federation for Medical Research, (2006)
    Awarded for abstract presentation titled, "Cell-specific Responses in an Apoptotic Model of Viral Myocarditis"

Research Interests

My research interest is to identify targeted therapy specific to children suffering from poor heart function. Currently, treatment of children with heart failure is based on what is done for adult patients. Important differences exist between children and adults with heart failure and our goal is to identify treatment options that are appropriate specifically for children.

Publications

  • Grady KL, Hof KV, Andrei AC, Shankel T, Chinnock R, Miyamoto S, Ambardekar AV, Anderson A, Addonizio L, Latif F, Lefkowitz D, Goldberg L, Hollander SA, Pham M, Weissberg-Benchell J, Cool N, Yancy C, Pahl E. Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Baseline Findings. Pediatr Cardiol. 2017 Nov 3. [Epub ahead of print] PubMed PMID: 29098353
  • Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 Dec;191:82-90.e2. PubMed PMID: 29050751
  • Boruta RJ, Miyamoto SD, Younoszai AK, Patel SS, Landeck BF 2nd. Worsening in Longitudinal Strain and Strain Rate Anticipates Development of Pediatric Transplant Coronary Artery Vasculopathy as Soon as One Year Following Transplant. Pediatr Cardiol. 2017 Sep 25. [Epub ahead of print] PubMed PMID: 28948364
  • Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545
  • Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
  • Blakeslee WW, Demos-Davies KM, Lemon DD, Lutter KM, Cavasin MA, Payne S, Nunley K, Long CS, McKinsey TA, Miyamoto SD. Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. Pediatr Res. 2017 Oct;82(4):642-649. PubMed PMID: 28549058
  • Friesen RH, Slavov D, Miyamoto SD, Ing RJ, LaRiviere WB, Taylor MRG. Lack of Association Between Adrenoreceptor Genotype and the Vasoconstriction Response to Dexmedetomidine. Semin Cardiothorac Vasc Anesth. 2017 May 1;:1089253217708621. [Epub ahead of print] PubMed PMID: 28482761
  • Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambo C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27890770
  • Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H818-H826. PubMed PMID: 28130338
  • Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2016 Jul 15. [Epub ahead of print] PubMed PMID: 27427220
  • Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2016 Nov 29. [Epub ahead of print] PubMed PMID: 27908653
  • Friesen RH, Twite MD, Nichols CS, Cardwell KA, Pan Z, Darst JR, Wilson N, Fagan TE, Miyamoto SD, Ivy DD. Hemodynamic response to ketamine in children with pulmonary hypertension. Paediatr Anaesth. 2015 Nov 13. [Epub ahead of print] PubMed PMID: 26564806
  • Zoeller BB, Miyamoto SD, Younoszai AK, Landeck BF 2nd. Longitudinal Strain and Strain Rate Abnormalities Precede Invasive Diagnosis of Transplant Coronary Artery Vasculopathy in Pediatric Cardiac Transplant Patients. Pediatr Cardiol. 2016 Apr;37(4):656-62. PubMed PMID: 26818849
  • Friesen RH, Twite MD, Nichols CS, Cardwell KA, Pan Z, Darst JR, Wilson N, Fagan TE, Miyamoto SD, Ivy DD. Hemodynamic response to ketamine in children with pulmonary hypertension. Paediatr Anaesth. 2015 Nov 13. [Epub ahead of print] PubMed PMID: 26564806
  • Schwartz LI, Miyamoto SD, Stenquist S, Twite MD. Cardiac Arrest in a Heart Transplant Patient Receiving Dexmedetomidine During Cardiac Catheterization. Semin Cardiothorac Vasc Anesth. 2015 Dec 31. [Epub ahead of print] PubMed PMID: 26721807
  • Yu HC, Coughlin CR, Geiger EA, Salvador BJ, Elias ER, Cavanaugh JL, Chatfield KC, Miyamoto SD, Shaikh TH. Discovery of a potentially deleterious variant in TMEM87B in a patient with a hemizygous 2q13 microdeletion suggests a recessive condition characterized by congenital heart disease and restrictive cardiomyopathy. Cold Spring Harb Mol Case Stud. 2016 May;2(3):a000844. PubMed PMID: 27148590
  • Cortez D, Sharma N, Cavanaugh J, Tuozo F, Derk G, Lundberg E, Weiner K, Kiciman N, Alejos J, Landeck B, Aboulhosn J, Miyamoto S, McCanta AC, Batra AS. Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy. Cardiol Young. 2016 Jun 1;:1-5. [Epub ahead of print] PubMed PMID: 27246458
  • Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 Jul;174:199-203.e5. PubMed PMID: 27181939
  • Nandi D, Miyamoto SD, Pietra BA, Shaddy RE, Rossano JW. Donation after circulatory death in pediatric patients: Current utilization in the United States. J Heart Lung Transplant. 2016 Sep;35(9):1131-2. PubMed PMID: 27363738
  • Schwartz LI, Miyamoto SD, Stenquist S, Twite MD. Cardiac Arrest in a Heart Transplant Patient Receiving Dexmedetomidine During Cardiac Catheterization. Semin Cardiothorac Vasc Anesth. 2015 Dec 31. [Epub ahead of print] PubMed PMID: 26721807
  • Cortez D, Sharma N, Cavanaugh J, Tuozo F, Derk G, Lundberg E, Schlegel TT, Weiner K, Kiciman N, Alejos J, Landeck B, Aboulhosn J, Miyamoto S, Batra A, McCanta AC. The spatial QRS-T angle outperforms the Italian and Seattle ECG-based criteria for detection of hypertrophic cardiomyopathy in pediatric patients. J Electrocardiol. 2015 Sep-Oct;48(5):826-33. PubMed PMID: 26275983
  • Auerbach SR, Kukreja M, Gilbert D, Bastardi H, Feingold B, Knecht K, Kaufman BD, Brown RN, Miyamoto SD. Maintenance steroid use at 30 days post-transplant and outcomes of pediatric heart transplantation: A propensity matched analysis of the Pediatric Heart Transplant Study database. J Heart Lung Transplant. 2015 Aug;34(8):1066-72. PubMed PMID: 25980572
  • Nakano SJ, Miyamoto SD, Movsesian M, Nelson P, Stauffer BL, Sucharov CC. Age-Related Differences in Phosphodiesterase Activity and Effects of Chronic Phosphodiesterase Inhibition in Idiopathic Dilated Cardiomyopathy. Circ Heart Fail. 2014 Oct 2. [Epub ahead of print] PubMed PMID: 25278000
  • Sucharov CC, Sucharov J, Karimpour-Fard A, Nunley K, Stauffer BL, Miyamoto SD. Micro-RNA Expression in Hypoplastic Left Heart Syndrome. J Card Fail. 2015 Jan;21(1):83-8. PubMed PMID: 25291457
  • Miyamoto SD, Karimpour-Fard A, Peterson V, Auerbach SR, Stenmark KR, Stauffer BL, Sucharov CC. Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy. J Heart Lung Transplant. 2015 May;34(5):724-33. PubMed PMID: 25840506
  • Glidewell SC, Miyamoto SD, Grossfeld PD, Clouthier DE, Coldren CD, Stearman RS, Geraci MW. Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome. Clin Transl Sci. 2015 Nov 4. [Epub ahead of print] PubMed PMID: 26534787
  • Nakano SJ, Miyamoto SD, Movsesian M, Nelson P, Stauffer BL, Sucharov CC. Age-Related Differences in Phosphodiesterase Activity and Effects of Chronic Phosphodiesterase Inhibition in Idiopathic Dilated Cardiomyopathy. Circ Heart Fail. 2014 Oct 2. [Epub ahead of print] PubMed PMID: 25278000
  • Chatfield KC, Sparagna GC, Sucharov CC, Miyamoto SD, Grudis JE, Sobus RD, Hijmans J, Stauffer BL. Dysregulation of cardiolipin biosynthesis in pediatric heart failure. J Mol Cell Cardiol. 2014 Sep;74:251-9. PubMed PMID: 24937604
  • Miyamoto SD, Stauffer BL, Polk J, Medway A, Friedrich M, Haubold K, Peterson V, Nunley K, Nelson P, Sobus R, Stenmark KR, Sucharov CC. Gene expression and ß-adrenergic signaling are altered in hypoplastic left heart syndrome. J Heart Lung Transplant. 2014 Aug;33(8):785-93. PubMed PMID: 24793904
  • Castleberry C, White-Williams C, Naftel D, Tresler MA, Pruitt E, Miyamoto SD, Murphy D, Spicer R, Bannister L, Schowengerdt K, Gilmore L, Kaufman B, Zangwill S. Hypoalbuminemia and poor growth predict worse outcomes in pediatric heart transplant recipients. Pediatr Transplant. 2014 May;18(3):280-7. PubMed PMID: 24646199
  • Boucek D, Yetman AT, Yeung E, Miyamoto SD, Stehlik J, Kfoury AG, Kaza AK, Weng C, Everitt MD. Survival based on patient selection for heart transplant in adults with congenital heart disease: A multi-institutional study. Int J Cardiol. 2014 Jan 4. [Epub ahead of print] PubMed PMID: 24433616
  • Auerbach SR, Gralla J, Campbell DN, Miyamoto SD, Pietra BA. Steroid Avoidance in Pediatric Heart Transplantation Results in Excellent Graft Survival. Transplantation. 2014 Jan 2. [Epub ahead of print] PubMed PMID: 24389908
  • Moon TJ, Miyamoto SD, Younoszai AK, Landeck BF. Left ventricular strain and strain rates are decreased in children with normal fractional shortening after exposure to anthracycline chemotherapy. Cardiol Young. 2013 Sep 18;:1-12. [Epub ahead of print] PubMed PMID: 24044518
  • Miyamoto SD, Stauffer BL, Nakano S, Sobus R, Nunley K, Nelson P, Sucharov CC. Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22843448
  • Kirk R, Dipchand AI, Rosenthal DN, Addonizio L, Burch M, Chrisant M, Dubin A, Everitt M, Gajarski R, Mertens L, Miyamoto S, Morales D, Pahl E, Shaddy R, Towbin J, Weintraub R. The International Society of Heart and Lung Transplantation Guidelines for the management of pediatric heart failure: executive summary. J Heart Lung Transplant. 2014 Sep;33(9):888-909. PubMed PMID: 25110323
  • Moon TJ, Miyamoto SD, Younoszai AK, Landeck BF. Left ventricular strain and strain rates are decreased in children with normal fractional shortening after exposure to anthracycline chemotherapy. Cardiol Young. 2013 Sep 18;:1-12. [Epub ahead of print] PubMed PMID: 24044518
  • Friesen RH, Nichols CS, Twite MD, Cardwell KA, Pan Z, Pietra B, Miyamoto SD, Auerbach SR, Darst JR, Ivy DD. The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension. Anesth Analg. 2013 Oct;117(4):953-9. PubMed PMID: 23960035
  • Conway J, Chrisant MR, West LJ, Ameduri RK, Alejos JC, Lamour JM, Das B, Gilbert D, Tresler M, Naftel DC, Miyamoto SD. Outcomes of fetal listed patients awaiting heart transplantation. Pediatr Transplant. 2013 Nov;17(7):653-60. PubMed PMID: 23919733
  • Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 1;115(7):979-87. PubMed PMID: 23887897
  • Dipchand AI, Kirk R, Mahle WT, Tresler MA, Naftel DC, Pahl E, Miyamoto SD, Blume E, Guleserian KJ, White-Williams C, Kirklin JK. Ten yr of pediatric heart transplantation: a report from the Pediatric Heart Transplant Study. Pediatr Transplant. 2013 Mar;17(2):99-111. PubMed PMID: 23442098
  • Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr;57:43-6. PubMed PMID: 23333438
  • Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260102
  • Hancock HS, Wang M, Gist KM, Gibson E, Miyamoto SD, Mourani PM, Manco-Johnson MJ, Goldenberg NA. Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study. Cardiol Young. 2012 Oct 22;:1-9. [Epub ahead of print] PubMed PMID: 23088931
  • Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260102
  • Hancock HS, Wang M, Gist KM, Gibson E, Miyamoto SD, Mourani PM, Manco-Johnson MJ, Goldenberg NA. Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study. Cardiol Young. 2012 Oct 22;:1-9. [Epub ahead of print] PubMed PMID: 23088931
  • Miyamoto SD, Stauffer BL, Nakano S, Sobus R, Nunley K, Nelson P, Sucharov CC. Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22843448
  • Auerbach SR, Smith JK, Gralla J, Mitchell MB, Campbell DN, Jaggers J, Pietra BA, Miyamoto SD. Graft survival is better without prior surgery in cardiac transplantation for functionally univentricular hearts. J Heart Lung Transplant. 2012 Sep;31(9):987-95. PubMed PMID: 22789137
  • Kailin JA, Miyamoto SD, Younoszai AK, Landeck BF. Longitudinal myocardial deformation is selectively decreased after pediatric cardiac transplantation: a comparison of children 1 year after transplantation with normal subjects using velocity vector imaging. Pediatr Cardiol. 2012 Jun;33(5):749-56. PubMed PMID: 22367550
View All (48 Total) View Less

Professional Memberships

  • International Society of Heart and Lung Transplantation, Member
  • American Heart Association (AHA), Leadership Council Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pediatric Cardiology, Board Certification (2005)
  • Pediatrics, Board Certification (2009)
Conditions & Treatments
  • Heart and Circulation - Cardiomyopathy
  • Heart and Circulation - Heart Failure
  • Heart and Circulation - Congenital Heart Disease
  • Child and Teen Health
  • Heart and Circulation
Volunteer Activities
In addition to various institutional committees, I am a member of multiple American Heart Association Committees including the Leadership Council for the Cardiovascular Disease in the Young (CVDY), Past Chair of the CVDY Early Career and Mentoring Committee and the CVDY representative to the Women in Cardiology Committee. I am a member of the Medical Advisory Board for the Children's Cardiomyopathy Foundation. I am a standing member for the NIH/NHLBI study section for Mentored Patient Oriented Research and serve as an external reviewer for the Children's Hospital of Philadelphia T32 (research training grant).. Through these activities, I participate in efforts to improve awareness of heart disease, advocate for patient rights, perform peer-review of individual research grants and research programs and have the opportunity to contribute to national guideline development for children with heart disease.

General Information

Medical Schools:
  • MD, University of Iowa Roy J. and Lucille A. Carver College of Medicine (1998)
Undergraduate Schools:
  • BS, University of Iowa (IA) (1993)
Residency Programs:
  • Brown University Program, Chief Resident, Pediatrics (2002)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Cardiology (2005)
Languages: English
Department: Pediatrics-Cardiology
;