Eric Simoes, MD
Professor, Pediatrics-Infectious Diseases

Photo
Medical School:
  • MD, Christian Medical College - Vellore, India (1980)
Residency:
  • Christian Medical College - Vellore, India, Pediatrics (1984)
Languages: English
Department: Pediatrics-Infectious Diseases

Professional Titles

  • Professor, Pediatrics-Infectious Diseases
  • Instructor, MSPH Program, Deptartment of Epidemiology, UC Denver School of Medicine
  • Instructor, Child Health Associates Program
  • Co-Director, Maternal and Child Health Initiative, Center for Global Health
Research interests for Patients:
Dr. Simoes is working with the World Health Organization for the management of common pediatric conditions in developing countries (Integrated Management of Childhood Illness) and studies the epidemiology, pathogenesis, and prevention of the short- and long-term effects of respiratory syncytial virus infection in children. Dr. Simoes has played a significant role in the World Health Organization's initiative to reduce childhood and infant mortality throughout the world with the development of a strategy called "Integrated Management of Childhood Illness." He has worked on this initiative since 1989, including testing and implementing its guidelines in many countries throughout Africa, Asia, and Europe.

Publications

  • Vadivel K, Mageshbabu R, Sankar S, Jain A, Perumal V, Srikanth P, Ranjan GA, Nair A, Simoes EAF, Nandagopal B, Sridharan G. Detection of parvovirus B19 in selected high-risk patient groups & their phylogenetic & selection analysis. Indian J Med Res. 2018 Apr;147(4):391-399. PubMed PMID: 29998875
  • Simões EAF, Liu AH. RSV prevention in infancy and asthma in later life. Lancet Respir Med. 2018 Jul;6(7):e30. PubMed PMID: 29976446
  • Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJ. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates. Lancet Infect Dis. 2018 Oct;18(10):e295-e311. PubMed PMID: 29914800
  • Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia after Infant Cardiothoracic Surgery. Shock. 2018 Apr 16. [Epub ahead of print] PubMed PMID: 29664834
  • Simões EAF, Bont L, Manzoni P, Fauroux B, Paes B, Figueras-Aloy J, Checchia PA, Carbonell-Estrany X. Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children. Infect Dis Ther. 2018 Mar;7(1):87-120. PubMed PMID: 29470837
  • Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Feb 9. [Epub ahead of print] PubMed PMID: 29438532
  • Kulkarni PS, Hurwitz JL, Simões EAF, Piedra PA. Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field. Viral Immunol. 2018 Mar;31(2):195-203. PubMed PMID: 29336703
  • Russell CJ, Simões EAF, Hurwitz JL. Vaccines for the Paramyxoviruses and Pneumoviruses: Successes, Candidates, and Hurdles. Viral Immunol. 2018 Mar;31(2):133-141. PubMed PMID: 29323621
  • Madhi SA, Cutland CL, Downs S, Jones S, van Niekerk N, Simoes EAF, Nunes MC. Burden of Respiratory Syncytial Virus Infection in South African Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Pregnant and Postpartum Women: A Longitudinal Cohort Study. Clin Infect Dis. 2018 May 17;66(11):1658-1665. PubMed PMID: 29253090
  • Simões EAF, Mochizuki H. Reply to Farber, Chabra, and Kovesi. Am J Respir Crit Care Med. 2017 Oct 11. [Epub ahead of print] PubMed PMID: 29019699
  • Davidson JA, Urban TT, Baird C, Tong S, Woodruff A, Twite M, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. J Pediatr. 2017 Nov;190:49-55.e2. PubMed PMID: 29144270
  • Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sánchez JF, O'Brien KL, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Pires MR, Spaeder MC, Paes BA, Simões EAF, Leung TF, da Costa Oliveira MT, de Freitas Lázaro Emediato CC, Bassat Q, Butt W, Chi H, Aamir UB, Ali A, Lucero MG, Fasce RA, Lopez O, Rath BA, Polack FP, Papenburg J, Roglic S, Ito H, Goka EA, Grobbee DE, Nair H, Bont LJ. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series. Lancet Glob Health. 2017 Oct;5(10):e984-e991. PubMed PMID: 28911764
  • Kim L, Rha B, Abramson JS, Anderson LJ, Byington CL, Chen GL, DeVincenzo J, Edwards KM, Englund JA, Falsey AR, Griffin MR, Karron RA, Martin KG, Meissner HC, Munoz FM, Pavia AT, Piedra PA, Schaffner W, Simões EAF, Singleton R, Talbot HK, Walsh EE, Zucker JR, Gerber SI. Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines. Clin Infect Dis. 2017 Sep 15;65(6):1020-1025. PubMed PMID: 28903503
  • Shi T, McAllister DA, O'Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azziz-Baumgartner E, Baggett HC, Baillie VL, Balmaseda A, Barahona A, Basnet S, Bassat Q, Basualdo W, Bigogo G, Bont L, Breiman RF, Brooks WA, Broor S, Bruce N, Bruden D, Buchy P, Campbell S, Carosone-Link P, Chadha M, Chipeta J, Chou M, Clara W, Cohen C, de Cuellar E, Dang DA, Dash-Yandag B, Deloria-Knoll M, Dherani M, Eap T, Ebruke BE, Echavarria M, de Freitas Lázaro Emediato CC, Fasce RA, Feikin DR, Feng L, Gentile A, Gordon A, Goswami D, Goyet S, Groome M, Halasa N, Hirve S, Homaira N, Howie SRC, Jara J, Jroundi I, Kartasasmita CB, Khuri-Bulos N, Kotloff KL, Krishnan A, Libster R, Lopez O, Lucero MG, Lucion F, Lupisan SP, Marcone DN, McCracken JP, Mejia M, Moisi JC, Montgomery JM, Moore DP, Moraleda C, Moyes J, Munywoki P, Mutyara K, Nicol MP, Nokes DJ, Nymadawa P, da Costa Oliveira MT, Oshitani H, Pandey N, Paranhos-Baccalà G, Phillips LN, Picot VS, Rahman M, Rakoto-Andrianarivelo M, Rasmussen ZA, Rath BA, Robinson A, Romero C, Russomando G, Salimi V, Sawatwong P, Scheltema N, Schweiger B, Scott JAG, Seidenberg P, Shen K, Singleton R, Sotomayor V, Strand TA, Sutanto A, Sylla M, Tapia MD, Thamthitiwat S, Thomas ED, Tokarz R, Turner C, Venter M, Waicharoen S, Wang J, Watthanaworawit W, Yoshida LM, Yu H, Zar HJ, Campbell H, Nair H. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017 Sep 2;390(10098):946-958. PubMed PMID: 28689664
  • Manzoni P, Figueras-Aloy J, Simões EAF, Checchia PA, Fauroux B, Bont L, Paes B, Carbonell-Estrany X. Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases. Infect Dis Ther. 2017 Sep;6(3):383-411. PubMed PMID: 28653300
  • Nunes MC, Cutland CL, Jones S, Downs S, Weinberg A, Ortiz JR, Neuzil KM, Simões EAF, Klugman KP, Madhi SA. Efficacy of maternal influenza vaccination against all-cause lower respiratory tract infection hospitalizations in young infants: Results from a randomized controlled trial. Clin Infect Dis. 2017 May 29. [Epub ahead of print] PubMed PMID: 28575286
  • Katz MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, Crane J, Doroshenko A, Ebruke BE, Edwards KM, Fortuna L, Jagelaviciene A, Joshi J, Kemp J, Kovacs S, Lambach P, Lewis KDC, Ortiz JR, Simões EAF, Turner P, Tagbo BN, Vaishnavi V, Bonhoeffer J. Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2017 May 5. [Epub ahead of print] PubMed PMID: 28483201
  • Madhi SA, Nunes MC, Weinberg A, Kuwanda L, Hugo A, Jones S, van Niekerk N, Ortiz JR, Neuzil KM, Klugman KP, Simões EAF, Cutland CL. Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials. Clin Infect Dis. 2017 Jun 15;64(12):1773-1779. PubMed PMID: 28369198
  • Fauroux B, Simões EAF, Checchia PA, Paes B, Figueras-Aloy J, Manzoni P, Bont L, Carbonell-Estrany X. The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood. Infect Dis Ther. 2017 Jun;6(2):173-197. PubMed PMID: 28357706
  • Thompson MG, Hunt DR, Arbaji AK, Simaku A, Tallo VL, Biggs HM, Kulb C, Gordon A, Khader IA, Bino S, Lucero MG, Azziz-Baumgartner E, Shifflett P, Sanchez F, Marar BI, Bakalli I, Simões EA, Levine MZ, Meece JK, Balmaseda A, Al-Sanouri TM, Dhimolea M, de Jesus JN, Thornburg NJ, Gerber SI, Gresh L. Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods. BMC Infect Dis. 2017 Mar 22;17(1):222. PubMed PMID: 28330443
  • Checchia PA, Paes B, Bont L, Manzoni P, Simões EA, Fauroux B, Figueras-Aloy J, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease. Infect Dis Ther. 2017 Mar;6(1):37-56. PubMed PMID: 28070870
  • Anderson EJ, Krilov LR, DeVincenzo JP, Checchia PA, Halasa N, Simões EA, Domachowske JB, Forbes ML, Pannaraj PS, McBride SJ, McLaurin KK, Kumar VR, Ambrose CS. SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. Am J Perinatol. 2017 Jan;34(1):51-61. PubMed PMID: 27233106
  • Davidson JA, Urban TT, Baird C, Tong S, Woodruff A, Twite M, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. J Pediatr. 2017 Nov;190:49-55.e2. PubMed PMID: 29144270
  • Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sánchez JF, O'Brien KL, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Pires MR, Spaeder MC, Paes BA, Simões EAF, Leung TF, da Costa Oliveira MT, de Freitas Lázaro Emediato CC, Bassat Q, Butt W, Chi H, Aamir UB, Ali A, Lucero MG, Fasce RA, Lopez O, Rath BA, Polack FP, Papenburg J, Roglic S, Ito H, Goka EA, Grobbee DE, Nair H, Bont LJ. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series. Lancet Glob Health. 2017 Oct;5(10):e984-e991. PubMed PMID: 28911764
  • Kim L, Rha B, Abramson JS, Anderson LJ, Byington CL, Chen GL, DeVincenzo J, Edwards KM, Englund JA, Falsey AR, Griffin MR, Karron RA, Martin KG, Meissner HC, Munoz FM, Pavia AT, Piedra PA, Schaffner W, Simões EAF, Singleton R, Talbot HK, Walsh EE, Zucker JR, Gerber SI. Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines. Clin Infect Dis. 2017 Sep 15;65(6):1020-1025. PubMed PMID: 28903503
  • Anderson EJ, Krilov LR, DeVincenzo JP, Checchia PA, Halasa N, Simões EA, Domachowske JB, Forbes ML, Pannaraj PS, McBride SJ, McLaurin KK, Kumar VR, Ambrose CS. SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. Am J Perinatol. 2017 Jan;34(1):51-61. PubMed PMID: 27233106
  • Root ED, Agustian D, Kartasasmita C, Uyeki TM, Simões EAF. Demographic and ecological risk factors for human influenza A virus infections in rural Indonesia. Influenza Other Respir Viruses. 2017 Sep;11(5):425-433. PubMed PMID: 28715152
  • Anderson EJ, Carosone-Link P, Yogev R, Yi J, Simões EAF. Effectiveness of Palivizumab in High-risk Infants and Children: A Propensity Score Weighted Regression Analysis. Pediatr Infect Dis J. 2017 Aug;36(8):699-704. PubMed PMID: 28709160
  • Shi T, McAllister DA, O'Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azziz-Baumgartner E, Baggett HC, Baillie VL, Balmaseda A, Barahona A, Basnet S, Bassat Q, Basualdo W, Bigogo G, Bont L, Breiman RF, Brooks WA, Broor S, Bruce N, Bruden D, Buchy P, Campbell S, Carosone-Link P, Chadha M, Chipeta J, Chou M, Clara W, Cohen C, de Cuellar E, Dang DA, Dash-Yandag B, Deloria-Knoll M, Dherani M, Eap T, Ebruke BE, Echavarria M, de Freitas Lázaro Emediato CC, Fasce RA, Feikin DR, Feng L, Gentile A, Gordon A, Goswami D, Goyet S, Groome M, Halasa N, Hirve S, Homaira N, Howie SRC, Jara J, Jroundi I, Kartasasmita CB, Khuri-Bulos N, Kotloff KL, Krishnan A, Libster R, Lopez O, Lucero MG, Lucion F, Lupisan SP, Marcone DN, McCracken JP, Mejia M, Moisi JC, Montgomery JM, Moore DP, Moraleda C, Moyes J, Munywoki P, Mutyara K, Nicol MP, Nokes DJ, Nymadawa P, da Costa Oliveira MT, Oshitani H, Pandey N, Paranhos-Baccalà G, Phillips LN, Picot VS, Rahman M, Rakoto-Andrianarivelo M, Rasmussen ZA, Rath BA, Robinson A, Romero C, Russomando G, Salimi V, Sawatwong P, Scheltema N, Schweiger B, Scott JAG, Seidenberg P, Shen K, Singleton R, Sotomayor V, Strand TA, Sutanto A, Sylla M, Tapia MD, Thamthitiwat S, Thomas ED, Tokarz R, Turner C, Venter M, Waicharoen S, Wang J, Watthanaworawit W, Yoshida LM, Yu H, Zar HJ, Campbell H, Nair H. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017 Sep 2;390(10098):946-958. PubMed PMID: 28689664
  • Manzoni P, Figueras-Aloy J, Simões EAF, Checchia PA, Fauroux B, Bont L, Paes B, Carbonell-Estrany X. Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases. Infect Dis Ther. 2017 Sep;6(3):383-411. PubMed PMID: 28653300
  • Nunes MC, Cutland CL, Jones S, Downs S, Weinberg A, Ortiz JR, Neuzil KM, Simões EAF, Klugman KP, Madhi SA. Efficacy of maternal influenza vaccination against all-cause lower respiratory tract infection hospitalizations in young infants: Results from a randomized controlled trial. Clin Infect Dis. 2017 May 29. [Epub ahead of print] PubMed PMID: 28575286
  • Katz MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, Crane J, Doroshenko A, Ebruke BE, Edwards KM, Fortuna L, Jagelaviciene A, Joshi J, Kemp J, Kovacs S, Lambach P, Lewis KDC, Ortiz JR, Simões EAF, Turner P, Tagbo BN, Vaishnavi V, Bonhoeffer J. Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2017 May 5. [Epub ahead of print] PubMed PMID: 28483201
  • Mochizuki H, Simões EAF. Reply: Preventing Respiratory Syncytial Virus Infection to Prevent Asthma: The Missing Link. Am J Respir Crit Care Med. 2017 Jul 1;196(1):117. PubMed PMID: 28379713
  • Madhi SA, Nunes MC, Weinberg A, Kuwanda L, Hugo A, Jones S, van Niekerk N, Ortiz JR, Neuzil KM, Klugman KP, Simões EAF, Cutland CL. Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials. Clin Infect Dis. 2017 Jun 15;64(12):1773-1779. PubMed PMID: 28369198
  • Fauroux B, Simões EAF, Checchia PA, Paes B, Figueras-Aloy J, Manzoni P, Bont L, Carbonell-Estrany X. The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood. Infect Dis Ther. 2017 Jun;6(2):173-197. PubMed PMID: 28357706
  • Thompson MG, Hunt DR, Arbaji AK, Simaku A, Tallo VL, Biggs HM, Kulb C, Gordon A, Khader IA, Bino S, Lucero MG, Azziz-Baumgartner E, Shifflett P, Sanchez F, Marar BI, Bakalli I, Simões EA, Levine MZ, Meece JK, Balmaseda A, Al-Sanouri TM, Dhimolea M, de Jesus JN, Thornburg NJ, Gerber SI, Gresh L. Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods. BMC Infect Dis. 2017 Mar 22;17(1):222. PubMed PMID: 28330443
  • Mochizuki H, Kusuda S, Okada K, Yoshihara S, Furuya H, Simões EAF. Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing. Six-Year Follow-up Study. Am J Respir Crit Care Med. 2017 Jul 1;196(1):29-38. PubMed PMID: 28152315
  • Checchia PA, Paes B, Bont L, Manzoni P, Simões EA, Fauroux B, Figueras-Aloy J, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease. Infect Dis Ther. 2017 Mar;6(1):37-56. PubMed PMID: 28070870
  • Simões EA. The Outpatient Burden of Respiratory Syncytial Virus Infections in Older Children. J Infect Dis. 2016 Oct 12. [Epub ahead of print] PubMed PMID: 27738053
  • Root ED, Lucero M, Nohynek H, Stubbs R, Tallo V, Lupisan SP, Sanvictores DM, Nillos LT, Simões EA. Distance to health services modifies the effect of an 11-valent pneumococcal vaccine on pneumonia risk among children less than 2 years of age in Bohol, Philippines. Int J Epidemiol. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27605588
  • Anderson EJ, Krilov LR, DeVincenzo JP, Checchia PA, Halasa N, Simões EA, Domachowske JB, Forbes ML, Pannaraj PS, McBride SJ, McLaurin KK, Kumar VR, Ambrose CS. SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. Am J Perinatol. 2017 Jan;34(1):51-61. PubMed PMID: 27233106
  • Simões EA, Anderson EJ, Wu X, Ambrose CS. Correction: Effects of Chronologic Age and Young Child Exposure on Respiratory Syncytial Virus Disease among US Preterm Infants Born at 32 to 35 Weeks Gestation. PLoS One. 2016 Dec 13;11(12):e0168882. PubMed PMID: 27959962
  • Skuby SO, Rhee E, Thilo EH, Simões EA. Tetanus and Occam's Razor: Almost Forgotten but Not Gone: A Case Report. Pediatrics. 2016 Nov;138(5). PubMed PMID: 27940761
  • Simões EA, Anderson EJ, Wu X, Ambrose CS. Effects of Chronologic Age and Young Child Exposure on Respiratory Syncytial Virus Disease among US Preterm Infants Born at 32 to 35 Weeks Gestation. PLoS One. 2016 Nov 29;11(11):e0166226. PubMed PMID: 27898687
  • Paes B, Fauroux B, Figueras-Aloy J, Bont L, Checchia PA, Simões EA, Manzoni P, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Chronic Lung Disease. Infect Dis Ther. 2016 Dec;5(4):453-471. PubMed PMID: 27864751
  • Simões EA. The Outpatient Burden of Respiratory Syncytial Virus Infections in Older Children. J Infect Dis. 2016 Oct 12. [Epub ahead of print] PubMed PMID: 27738053
  • Franklin JA, Anderson EJ, Wu X, Ambrose CS, Simões EA. Insurance Status and the Risk of Severe Respiratory Syncytial Virus Disease in United States Preterm Infants Born at 32-35 Weeks Gestational Age. Open Forum Infect Dis. 2016 Jul 29;3(3):ofw163. PubMed PMID: 27704018
  • Figueras-Aloy J, Manzoni P, Paes B, Simões EA, Bont L, Checchia PA, Fauroux B, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease. Infect Dis Ther. 2016 Dec;5(4):417-452. PubMed PMID: 27628014
  • Root ED, Lucero M, Nohynek H, Stubbs R, Tallo V, Lupisan SP, Sanvictores DM, Nillos LT, Simões EA. Distance to health services modifies the effect of an 11-valent pneumococcal vaccine on pneumonia risk among children less than 2 years of age in Bohol, Philippines. Int J Epidemiol. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27605588
  • Bont L, Checchia PA, Fauroux B, Figueras-Aloy J, Manzoni P, Paes B, Simões EA, Carbonell-Estrany X. Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries. Infect Dis Ther. 2016 Sep;5(3):271-98. PubMed PMID: 27480325
  • Rao S, Lucero MG, Nohynek H, Tallo V, Lupisan SP, Garcea RL, Simões EA. WU and KI polyomavirus infections in Filipino children with lower respiratory tract disease. J Clin Virol. 2016 Sep;82:112-8. PubMed PMID: 27479174
  • Nunes MC, Cutland CL, Jones S, Hugo A, Madimabe R, Simões EA, Weinberg A, Madhi SA. Duration of Infant Protection Against Influenza Illness Conferred by Maternal Immunization: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr. 2016 Sep 1;170(9):840-7. PubMed PMID: 27380464
  • Caballero MT, Jones MH, Karron RA, Hartert TV, Simões EA, Stein RT, Wairagkar N, Polack FP. The Impact of Respiratory Syncytial Virus Disease Prevention on Pediatric Asthma. Pediatr Infect Dis J. 2016 Jul;35(7):820-2. PubMed PMID: 27351360
  • Paes B, Fauroux B, Figueras-Aloy J, Bont L, Checchia PA, Simões EA, Manzoni P, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Chronic Lung Disease. Infect Dis Ther. 2016 Dec;5(4):453-471. PubMed PMID: 27864751
  • Figueras-Aloy J, Manzoni P, Paes B, Simões EA, Bont L, Checchia PA, Fauroux B, Carbonell-Estrany X. Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease. Infect Dis Ther. 2016 Dec;5(4):417-452. PubMed PMID: 27628014
  • Bont L, Checchia PA, Fauroux B, Figueras-Aloy J, Manzoni P, Paes B, Simões EA, Carbonell-Estrany X. Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries. Infect Dis Ther. 2016 Sep;5(3):271-98. PubMed PMID: 27480325
  • Nunes MC, Cutland CL, Jones S, Hugo A, Madimabe R, Simões EA, Weinberg A, Madhi SA. Duration of Infant Protection Against Influenza Illness Conferred by Maternal Immunization: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr. 2016 Sep 1;170(9):840-7. PubMed PMID: 27380464
  • Caballero MT, Jones MH, Karron RA, Hartert TV, Simões EA, Stein RT, Wairagkar N, Polack FP. The Impact of Respiratory Syncytial Virus Disease Prevention on Pediatric Asthma. Pediatr Infect Dis J. 2016 Jul;35(7):820-2. PubMed PMID: 27351360
  • Zanone SM, Krause LK, Madhi SA, Bassat Q, Jha P, Simões EA, Wairagkar N, Polack FP. Challenges in estimating RSV-associated mortality rates. Lancet Respir Med. 2016 May;4(5):345-7. PubMed PMID: 27304556
  • Zhang S, Sammon PM, King I, Andrade AL, Toscano CM, Araujo SN, Sinha A, Madhi SA, Khandaker G, Yin JK, Booy R, Huda TM, Rahman QS, El Arifeen S, Gentile A, Giglio N, Bhuiyan MU, Sturm-Ramirez K, Gessner BD, Nadjib M, Carosone-Link PJ, Simões EA, Child JA, Ahmed I, Bhutta ZA, Soofi SB, Khan RJ, Campbell H, Nair H. Cost of management of severe pneumonia in young children: systematic analysis. J Glob Health. 2016 Jun;6(1):010408. PubMed PMID: 27231544
  • Zanone SM, Krause LK, Madhi SA, Bassat Q, Jha P, Simões EA, Wairagkar N, Polack FP. Challenges in estimating RSV-associated mortality rates. Lancet Respir Med. 2016 May;4(5):345-7. PubMed PMID: 27304556
  • Simões EA. Motavizumab, RSV, and subsequent wheezing. Lancet Infect Dis. 2016 Jun;16(6):639-40. PubMed PMID: 27301921
  • Zhang S, Sammon PM, King I, Andrade AL, Toscano CM, Araujo SN, Sinha A, Madhi SA, Khandaker G, Yin JK, Booy R, Huda TM, Rahman QS, El Arifeen S, Gentile A, Giglio N, Bhuiyan MU, Sturm-Ramirez K, Gessner BD, Nadjib M, Carosone-Link PJ, Simões EA, Child JA, Ahmed I, Bhutta ZA, Soofi SB, Khan RJ, Campbell H, Nair H. Cost of management of severe pneumonia in young children: systematic analysis. J Glob Health. 2016 Jun;6(1):010408. PubMed PMID: 27231544
  • Maurer-Stroh S, Lee CW, Patel C, Lucero M, Nohynek H, Sung WK, Murad C, Ma J, Hibberd ML, Wong CW, Simões EA. Comparison of microarray-predicted closest genomes to sequencing for poliovirus vaccine strain similarity and influenza A phylogeny. Diagn Microbiol Infect Dis. 2015 Nov 6. [Epub ahead of print] PubMed PMID: 26658310
  • Simões EA, Kiio F, Carosone-Link PJ, Ndegwa SN, Ayugi J, Macharia IM. Otitis Media and Its Sequelae in Kenyan Schoolchildren. J Pediatric Infect Dis Soc. 2015 Jul 9. [Epub ahead of print] PubMed PMID: 26407271
  • Maurer-Stroh S, Lee CW, Patel C, Lucero M, Nohynek H, Sung WK, Murad C, Ma J, Hibberd ML, Wong CW, Simões EA. Comparison of microarray-predicted closest genomes to sequencing for poliovirus vaccine strain similarity and influenza A phylogeny. Diagn Microbiol Infect Dis. 2015 Nov 6. [Epub ahead of print] PubMed PMID: 26658310
  • Simões EA, Kiio F, Carosone-Link PJ, Ndegwa SN, Ayugi J, Macharia IM. Otitis Media and Its Sequelae in Kenyan Schoolchildren. J Pediatric Infect Dis Soc. 2015 Jul 9. [Epub ahead of print] PubMed PMID: 26407271
  • Simões EA, Carbonell-Estrany X, Guilbert T, Mansbach JM, Piedra PA, Ramilo O, Welliver R Sr. Clinical Endpoints for Respiratory Syncytial Virus Prophylaxis Trials in Infants and Children in High-income and Middle-income Countries. Pediatr Infect Dis J. 2015 Oct;34(10):1086-92. PubMed PMID: 26121204
  • Thomas DS, Anthamatten P, Root ED, Lucero M, Nohynek H, Tallo V, Williams GM, Simões EA. Disease mapping for informing targeted health interventions: childhood pneumonia in Bohol, Philippines. Trop Med Int Health. 2015 Nov;20(11):1525-1533. PubMed PMID: 26104587
  • Farzin A, Saha SK, Baqui AH, Choi Y, Ahmed NU, Simoes EA, El Arifeen S, Al-Emran HM, Bari S, Rahman SM, Mannan I, Crook D, Seraji HR, Begum N, Black RE, Santosham M, Darmstadt GL. Population-based Incidence and Etiology of Community-acquired Neonatal Viral Infections in Bangladesh: A Community-based and Hospital-based Surveillance Study. Pediatr Infect Dis J. 2015 Jul;34(7):706-11. PubMed PMID: 25961894
  • Bandell AR, Simões EA. Live attenuated influenza vaccine tetravalent: a clinical review. Expert Rev Vaccines. 2015 Jul;14(7):963-73. PubMed PMID: 25864428
  • Simões EA, Ambrose CS, Wu X, Anderson EJ. Intensive care unit admission rates for respiratory syncytial virus infection as a function of age in preterm infants born at 32-35-week gestation and not receiving immunoprophylaxis. Pediatr Infect Dis J. 2015 Mar;34(3):331. PubMed PMID: 25742086
  • Simões EA, DeVincenzo JP, Boeckh M, Bont L, Crowe JE Jr, Griffiths P, Hayden FG, Hodinka RL, Smyth RL, Spencer K, Thirstrup S, Walsh EE, Whitley RJ. Challenges and opportunities in developing respiratory syncytial virus therapeutics. J Infect Dis. 2015 Mar 15;211 Suppl 1:S1-S20. PubMed PMID: 25713060
  • Rao S, Abzug MJ, Carosone-Link P, Peterson T, Child J, Siparksy G, Soranno D, Cadnapaphornchai MA, Simões EA. Intravenous acyclovir and renal dysfunction in children: a matched case control study. J Pediatr. 2015 Jun;166(6):1462-8.e1-4. PubMed PMID: 25708691
  • Kristensen K, Fisker N, Haerskjold A, Ravn H, Simões EA, Stensballe L. Caesarean Section and Hospitalization for Respiratory Syncytial Virus Infection: A Population Based Study. Pediatr Infect Dis J. 2014 Sep 17. [Epub ahead of print] PubMed PMID: 25232778
  • Nunes MC, Cutland CL, Dighero B, Bate J, Jones S, Hugo A, van Niekerk N, Kuwanda L, Izu A, Weinberg A, Madhi SA. Kinetics of Hemagglutination-Inhibiting Antibodies Following Maternal Influenza Vaccination Among Mothers With and Those Without HIV Infection and Their Infants. J Infect Dis. 2015 Jun 16. [Epub ahead of print] PubMed PMID: 26080370
  • Omer SB, Richards JL, Madhi SA, Tapia MD, Steinhoff MC, Aqil AR, Wairagkar N. Three randomized trials of maternal influenza immunization in Mali, Nepal, and South Africa: Methods and expectations. Vaccine. 2015 Jul 31;33(32):3801-12. PubMed PMID: 26095508
  • Kristensen K, Fisker N, Haerskjold A, Ravn H, Simões EA, Stensballe L. Caesarean Section and Hospitalization for Respiratory Syncytial Virus Infection: A Population Based Study. Pediatr Infect Dis J. 2014 Sep 17. [Epub ahead of print] PubMed PMID: 25232778
  • Madhi SA, Cutland CL, Kuwanda L, Weinberg A, Hugo A, Jones S, Adrian PV, van Niekerk N, Treurnicht F, Ortiz JR, Venter M, Violari A, Neuzil KM, Simões EA, Klugman KP, Nunes MC, Maternal Flu Trial (Matflu) Team. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med. 2014 Sep 4;371(10):918-31. PubMed PMID: 25184864
  • Ambrose CS, Anderson EJ, Simões EA, Wu X, Elhefni H, Park CL, Sifakis F, Groothuis JR. Respiratory syncytial virus disease in preterm infants in the U.S. born at 32-35 weeks gestation not receiving immunoprophylaxis. Pediatr Infect Dis J. 2014 Jun;33(6):576-82. PubMed PMID: 24622396
  • Paynter S, Yakob L, Simões EA, Lucero MG, Tallo V, Nohynek H, Ware RS, Weinstein P, Williams G, Sly PD. Using mathematical transmission modelling to investigate drivers of respiratory syncytial virus seasonality in children in the Philippines. PLoS One. 2014;9(2):e90094. PubMed PMID: 24587222
  • Seale AC, Blencowe H, Manu AA, Nair H, Bahl R, Qazi SA, Zaidi AK, Berkley JA, Cousens SN, Lawn JE, pSBI Investigator Group. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis. 2014 Aug;14(8):731-41. PubMed PMID: 24974250
  • Hall CB, Simoes EA, Anderson LJ. Clinical and epidemiologic features of respiratory syncytial virus. Curr Top Microbiol Immunol. 2013;372:39-57. PubMed PMID: 24362683
  • Paynter S, Ware RS, Lucero MG, Tallo V, Nohynek H, Simões EA, Weinstein P, Sly PD, Williams G, ARIVAC Consortium. Poor growth and pneumonia seasonality in infants in the Philippines: cohort and time series studies. PLoS One. 2013;8(6):e67528. PubMed PMID: 23840731
  • Narayanan H, Sankar S, Simoes EA, Nandagopal B, Sridharan G. Analysis of sequence diversity of human metapneumovirus collected from young children with acute respiratory tract infections in South India. Mol Diagn Ther. 2013 Aug;17(4):247-55. PubMed PMID: 23559039
  • Narayanan H, Sankar S, Simoes EA, Nandagopal B, Sridharan G. Molecular detection of human metapneumovirus and human bocavirus on oropharyngeal swabs collected from young children with acute respiratory tract infections from rural and peri-urban communities in South India. Mol Diagn Ther. 2013 Apr;17(2):107-15. PubMed PMID: 23559038
  • Nair H, Simões EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JS, Feikin DR, Mackenzie GA, Moïsi JC, Roca A, Baggett HC, Zaman SM, Singleton RJ, Lucero MG, Chandran A, Gentile A, Cohen C, Krishnan A, Bhutta ZA, Arguedas A, Clara AW, Andrade AL, Ope M, Ruvinsky RO, Hortal M, McCracken JP, Madhi SA, Bruce N, Qazi SA, Morris SS, El Arifeen S, Weber MW, Scott JA, Brooks WA, Breiman RF, Campbell H, Severe Acute Lower Respiratory Infections Working Group. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013 Apr 20;381(9875):1380-90. PubMed PMID: 23369797
  • Paynter S, Weinstein P, Ware RS, Lucero MG, Tallo V, Nohynek H, Barnett AG, Skelly C, Simões EA, Sly PD, Williams G, the ARIVAC Consortium. Sunshine, rainfall, humidity and child pneumonia in the tropics: time-series analyses. Epidemiol Infect. 2012 Aug 13;:1-9. [Epub ahead of print] PubMed PMID: 22884022
  • Paynter S, Weinstein P, Ware RS, Lucero MG, Tallo V, Nohynek H, Barnett AG, Skelly C, Simões EA, Sly PD, Williams G, the ARIVAC Consortium. Sunshine, rainfall, humidity and child pneumonia in the tropics: time-series analyses. Epidemiol Infect. 2012 Aug 13;:1-9. [Epub ahead of print] PubMed PMID: 22884022
  • Simões EA. Community case management of severe pneumonia. Lancet. 2012 May 5;379(9827):1703; author reply 1703-4. PubMed PMID: 22559896
  • Geevarghese B, Simões EA. Antibodies for prevention and treatment of respiratory syncytial virus infections in children. Antivir Ther. 2012;17(1 Pt B):201-11. PubMed PMID: 22311607
  • Tanskanen A, Nillos LT, Lehtinen A, Nohynek H, Sanvictores DH, Simões EA, Tallo VL, Lucero MG, ARIVAC Consortium. Geographic Information System and tools of spatial analysis in a pneumococcal vaccine trial. BMC Res Notes. 2012 Jan 20;5:51. PubMed PMID: 22264271
  • Kristensen K, Hjuler T, Ravn H, Simões EA, Stensballe LG. Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study. Clin Infect Dis. 2012 Mar;54(6):810-7. PubMed PMID: 22247121
  • Zachariah P, Ruttenber M, Simões EA. Down syndrome and hospitalizations due to respiratory syncytial virus: a population-based study. J Pediatr. 2012 May;160(5):827-31.e1. PubMed PMID: 22177993
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Professional Memberships

  • American Society of Microbiology, Member
  • Western Society of Pediatric Research, Member
  • Infectious Diseases Society of America, Member
  • Pediatric Infectious Diseases Society, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pediatric Infectious Diseases
Conditions & Treatments
  • Child and Teen Health - Pediatric Diseases and Conditions
  • Infections - Viral Infections
  • Lungs and Breathing - Pulmonary Disorders
  • Child and Teen Health
  • Infections
  • Lungs and Breathing
Clinical Interest for Patients
I am interested in Pediatric Acute Respiratory Infections, Respiratory Syncytial Virus Prevention and International Health.

General Information

Medical Schools:
  • MD, Christian Medical College - Vellore, India (1980)
Residency Programs:
  • Christian Medical College - Vellore, India, Pediatrics (1984)
Languages: English
Department: Pediatrics-Infectious Diseases
;