Yiqun Shellman, PhD
Associate Professor, Dermatology
My research interests are cancer and aging of pigment-producing cell (melanocyte), with the aim of bench-to-bedside. With a deep understanding of molecular and biochemical pathways, we aim to develop treatments to thwart melanomas’ anti-apoptotic defenses. We also study proliferation, differentiation, stem cell fate, maintenance and development of melanocyte, as well as the host factors in antitumor immunity. We use in vitro and in vivo models, including human patient-derived iPSCs, transgenic mice, and mouse xenograft studies with melanomas from relapsed patients. We aim to decipher the mechanisms of melanocyte lineage regulation in health and disease, and have pointed to potential treatments for difficult-to-treat melanomas. A new R01 and a recently renewed VA merit award fund these projects.
Shellman MH, Shellman YG. Human against Machine? Machine Learning Identifies MicroRNA Ratios as Biomarkers for Melanoma. J Invest Dermatol. 2020 Jan;140(1):18-20. PubMed PMID: 31864430
Mukherjee N, Skees J, Todd KJ, West DA, Lambert KA, Robinson WA, Amato CM, Couts KL, Van Gulick R, MacBeth M, Nassar K, Tan AC, Zhai Z, Fujita M, Bagby SM, Dart CR, Lambert JR, Norris DA, Shellman YG. MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443. PubMed PMID: 32513939
Mukherjee N, Amato CM, Skees J, Todd KJ, Lambert KA, Robinson WA, Van Gulick R, Weight RM, Dart CR, Tobin RP, McCarter MD, Fujita M, Norris DA, Shellman YG. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel). 2020 Aug 5;12(8). PubMed PMID: 32764384
Iwanaga R, Truong BT, Hsu JY, Lambert KA, Vyas R, Orlicky D, Shellman YG, Tan AC, Ceol C, Artinger KB. Loss of prdm1a accelerates melanoma onset and progression. Mol Carcinog. 2020 Sep;59(9):1052-1063. PubMed PMID: 32562448
Goldstein NB, Steel A, Barbulescu CC, Koster MI, Wright MJ, Jones KL, Gao B, Ward B, Woessner B, Trottier Z, Pakieser J, Hu J, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, Birlea SA. Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling. J Invest Dermatol. 2020 Aug 13. [Epub ahead of print] PubMed PMID: 32800877