Linda Barbour, MD
Professor, Medicine-Endocrinology/Metabolism/Diabetes

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Medical School:
  • MD, University of Colorado Denver School of Medicine (1984)
Fellowships:
  • University of Colorado, Endocrinology, Diabetes and Metabolism (2002)
  • University of Colorado (University Hospital) Program, Preventive Medicine (1992)
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes

Research Interests

My research interests include endocrine disorders in pregnancy, obesity and diabetes and pregnancy, and fetal programming of obesity.

Publications

  • Soderborg TK, Carpenter CM, Janssen RC, Weir TL, Robertson CE, Ir D, Young BE, Krebs NF, Hernandez TL, Barbour LA, Frank DN, Kroehl M, Friedman JE. Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota. Front Endocrinol (Lausanne). 2020;11:603021. PubMed PMID: 33329403
  • Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 Nov 20. [Epub ahead of print] PubMed PMID: 33216249
  • Farabi SS, Barbour LA, Hernandez TL. Sleep-disordered breathing in pregnancy: a developmental origin of offspring obesity?. J Dev Orig Health Dis. 2020 May 19;:1-13. [Epub ahead of print] PubMed PMID: 32425147
  • Nicklas JM, Leiferman JA, Lockhart S, Daly KM, Bull SS, Barbour LA. Development and Modification of a Mobile Health Program to Promote Postpartum Weight Loss in Women at Elevated Risk for Cardiometabolic Disease: Single-Arm Pilot Study. JMIR Form Res. 2020 Apr 9;4(4):e16151. PubMed PMID: 32271149
  • Shomaker LB, Gulley LD, Clark ELM, Hilkin AM, Pivarunas B, Tanofsky-Kraff M, Nadeau KJ, Barbour LA, Scott SM, Sheeder JL. Protocol for a pilot randomized controlled feasibility study of brief interpersonal psychotherapy for addressing social-emotional needs and preventing excess gestational weight gain in adolescents. Pilot Feasibility Stud. 2020;6:39. PubMed PMID: 32206334
  • Valent, A, BARBOUR LA. Diabetes in Pregnancy. In: McDermott, M.T., editor. Endocrine Secrets, 7th Edition. Pennsylvania: Elsevier Saunders; 2020, 67-86.
  • Donnelly, M, BARBOUR LA. Thyroid Disease in Pregnancy. In McDermott MT (ed). Endocrine Secrets, 7th Edition. Pennsylvania: Elsevier Saunders; 2020, 345-358.
  • Farabi SS, Barbour LA, Heiss K, Hirsch NM, Dunn E, Hernandez TL. Obstructive Sleep Apnea is Associated with Altered Glycemic Patterns in Pregnant Women with Obesity. J Clin Endocrinol Metab. 2019 Feb 22. [Epub ahead of print] PubMed PMID: 30794722
  • Barbour LA, Feig DS. Metformin for Gestational Diabetes Mellitus: Progeny, Perspective, and a Personalized Approach. Diabetes Care. 2019 Mar;42(3):396-399. PubMed PMID: 30787061
  • Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462. PubMed PMID: 30367045
  • Barbour LA, Hernandez TL. Maternal Lipids and Fetal Overgrowth: Making Fat from Fat. Clin Ther. 2018 Oct;40(10):1638-1647. PubMed PMID: 30236792
  • Wexler DJ, Powe CE, Barbour LA, Buchanan T, Coustan DR, Corcoy R, Damm P, Dunne F, Feig DS, Ferrara A, Harper LM, Landon MB, Meltzer SJ, Metzger BE, Roeder H, Rowan JA, Sacks DA, Simmons D, Umans JG, Catalano PM. Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Obstet Gynecol. 2018 Aug;132(2):496-505. PubMed PMID: 29995731
  • Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR. A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. Am J Obstet Gynecol. 2018 Oct;219(4):367.e1-367.e7. PubMed PMID: 29959933
  • Barbour LA, Farabi SS, Friedman JE, Hirsch NM, Reece MS, Van Pelt RE, Hernandez TL. Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy. Obesity (Silver Spring). 2018 Aug;26(8):1347-1356. PubMed PMID: 29931812
  • Barbour LA, Hernandez TL. Maternal Non-glycemic Contributors to Fetal Growth in Obesity and Gestational Diabetes: Spotlight on Lipids. Curr Diab Rep. 2018 May 9;18(6):37. PubMed PMID: 29744612
  • Hernandez TL, Mande A, Barbour LA. Nutrition therapy within and beyond gestational diabetes. Diabetes Res Clin Pract. 2018 Nov;145:39-50. PubMed PMID: 29679625
  • Riveros-Perez E, Hermesch AC, Barbour LA, Hawkins JL. Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations. Int J Womens Health. 2018;10:117-125. PubMed PMID: 29535558
  • Dutton H, Borengasser SJ, Gaudet LM, Barbour LA, Keely EJ. Obesity in Pregnancy: Optimizing Outcomes for Mom and Baby. Med Clin North Am. 2018 Jan;102(1):87-106. PubMed PMID: 29156189
  • Riveros-Perez E, Hermesch A, Barbour L, Hawkins J. Aplastic anemia in two consecutive pregnancies: obstetric and anesthetic management. Int J Obstet Anesth. 2018 Feb;33:71-75. PubMed PMID: 29108725
  • Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan;105(1):234-236. PubMed PMID: 28049665
  • Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan;39(1):122-9. PubMed PMID: 26628417
  • McIntyre HD, Sacks DA, Barbour LA, Feig DS, Catalano PM, Damm P, McElduff A. Issues With the Diagnosis and Classification of Hyperglycemia in Early Pregnancy. Diabetes Care. 2016 Jan;39(1):53-4. PubMed PMID: 26519336
  • Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240
  • Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27876761
  • Moore GS, Allshouse AA, Fisher BM, Kahn BF, Hernandez TL, Reece MS, Reynolds RM, Lee W, Barbour LA, Galan HL. Can Fetal Limb Soft Tissue Measurements in the Third Trimester Predict Neonatal Adiposity?. J Ultrasound Med. 2016 Sep;35(9):1915-24. PubMed PMID: 27417735
  • Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016 Jul 14;11(7):e0159575. PubMed PMID: 27414406
  • Lemas DJ, Young BE, Baker PR 2nd, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May;103(5):1291-300. PubMed PMID: 27140533
  • Shapiro AL, Kaar JL, Crume TL, Starling AP, Siega-Riz AM, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study. Int J Obes (Lond). 2016 Jul;40(7):1056-62. PubMed PMID: 27133623
  • Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia. 2016 May;59(5):895-906. PubMed PMID: 26843076
  • Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan;39(1):122-9. PubMed PMID: 26628417
  • McIntyre HD, Sacks DA, Barbour LA, Feig DS, Catalano PM, Damm P, McElduff A. Issues With the Diagnosis and Classification of Hyperglycemia in Early Pregnancy. Diabetes Care. 2016 Jan;39(1):53-4. PubMed PMID: 26519336
  • Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240
  • Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2016 Aug;11(4):264-71. PubMed PMID: 26198967
  • Nicklas JM, Barbour LA. Optimizing Weight for Maternal and Infant Health - Tenable, or Too Late?. Expert Rev Endocrinol Metab. 2015;10(2):227-242. PubMed PMID: 26442123
  • Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2015 Jul 22. [Epub ahead of print] PubMed PMID: 26198967
  • Donnelly MA, Wood C, Casey B, Hobbins J, Barbour LA. Early severe fetal Graves disease in a mother after thyroid ablation and thyroidectomy. Obstet Gynecol. 2015 May;125(5):1059-62. PubMed PMID: 25710616
  • Buschur E, Stetson B, Barbour LA. Diabetes In Pregnancy. . 2000. PubMed PMID: 25905241
  • Abushamat L, BARBOUR LA. Management of Diabetes in Pregnancy. In: McDermott, M.T. editor. Diabetes Secrets. Pennsylvania: Elsevier Saunders; 2020, in press.
  • Valent A, BARBOUR LA. Polycystic Ovarian Disease in Pregnancy. In Endocrinology and Metabolism Clinics of North America, Androgens in Women: Too Much, Too Little, Just Right, March 2021, in press.
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Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Women's Care Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 3rd Fl
Aurora, CO 80045
720-848-1060

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1987)
  • Endocrinology, Diabetes and Metabolism, Board Certification
Conditions & Treatments
  • Endocrine System (Hormones)
  • Endocrine System (Hormones) - Adult Type 1 Diabetes
  • Endocrine System (Hormones) - Adult Type 2 Diabetes
  • Endocrine System (Hormones) - Thyroid Disease
  • Endocrine System (Hormones) - Adrenal Diseases
Clinical Interests
Endocrine Disorders During Pregnancy, Diabetes in Pregnancy, Thyroid Disease in Pregnancy, Obesity in Pregnancy, Fetal Overgrowth

General Information

Medical Schools:
  • MD, University of Colorado Denver School of Medicine (1984)
Fellowships:
  • University of Colorado, Endocrinology, Diabetes and Metabolism (2002)
  • University of Colorado (University Hospital) Program, Preventive Medicine (1992)
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes
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