Kelly Maloney, MD
Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

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Medical School:
  • MD, University of Colorado Denver Health Sciences Center (1990)
Undergraduate School:
  • BS, University of California–Davis (CA) (1986)
Internship:
  • University of Colorado (Children's Hospital Colorado) Program (1993)
Residency:
  • University of Colorado (Children's Hospital Colorado) Program, Chief Resident, Pediatrics (1997)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Hematology / Oncology (1998)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Recognition & Awards

  • Golden Apple Teaching Award, University of Colorado Health Sciences Center, (1992)
  • Appleton and Lange Pediatric Award, University of Colorado Health Sciences Center, (1990)
  • Alpha Omega Alpha, University of Colorado Health Sciences Center, (1989)
  • Phi Beta Kappa, University of California, Davis, (1986)
Research interests for Patients:
Clinical trials for childhood acute lymphoblastic leukemia.

Teaching

  • Associate Professor (2008)
    School of Medicine, Pediatrics
    Hematology/Oncology
  • Pricipal Investigator (2005)
    School of Medicine, Pediatrics
    Children’s Oncology Group

Publications

  • Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Jan 14. [Epub ahead of print] PubMed PMID: 30643249
  • Ross S, Eisenman K, Maloney KW. Successful Use of EPOCH-R in 2 Young Adult Patients With Burkitt Lymphoma and Acute Kidney Injury: A Case Report. J Pediatr Hematol Oncol. 2018 Aug 8. [Epub ahead of print] PubMed PMID: 30095692
  • Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23;132(8):815-824. PubMed PMID: 29997224
  • Gupta S, Devidas M, Loh ML, Raetz EA, Chen S, Wang C, Brown P, Carroll AJ, Heerema NA, Gastier-Foster JM, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Winick NJ, Carroll WL, Hunger SP, Borowitz MJ, Wood BL. Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group (COG). Leukemia. 2018 Jun;32(6):1370-1379. PubMed PMID: 29472723
  • Wood B, Wu D, Crossley B, Dai Y, Williamson D, Gawad C, Borowitz MJ, Devidas M, Maloney KW, Larsen E, Winick N, Raetz E, Carroll WL, Hunger SP, Loh M, Robins H, Kirsch I. Measurable residual disease detection by high throughput sequencing improves risk stratification for pediatric B-ALL. Blood. 2017 Dec 28. [Epub ahead of print] PubMed PMID: 29284596
  • Esbenshade AJ, Pierson CR, Thompson AL, Reed D, Gupta A, Levy A, Kahalley LS, Harker-Murray P, Schore R, Muscal JA, Embry L, Maloney K, Horton T, Zweidler-Mckay P, Dhall G. Long-term evidence that a pediatric oncology mentorship program for young investigators is feasible and beneficial in the cooperative group setting: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2017 Nov 28. [Epub ahead of print] PubMed PMID: 29193588
  • Maloney KW, Gore L. Agents in Development for Childhood Acute Lymphoblastic Leukemia. Paediatr Drugs. 2017 Nov 15. [Epub ahead of print] PubMed PMID: 29143289
  • Burke MJ, Devidas M, Maloney K, Angiolillo A, Schore R, Dunsmore K, Larsen E, Mattano LA Jr, Salzer W, Winter SS, Carroll W, Winick NJ, Loh ML, Raetz E, Hunger SP, Bleyer A. Severe pegaspargase hypersensitivity reaction rates (grade =3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children's oncology group (COG) clinical trials. Leuk Lymphoma. 2017 Nov 8;:1-10. [Epub ahead of print] PubMed PMID: 29115886
  • Wood B, Wu D, Crossley B, Dai Y, Williamson D, Gawad C, Borowitz MJ, Devidas M, Maloney KW, Larsen E, Winick N, Raetz E, Carroll WL, Hunger SP, Loh M, Robins H, Kirsch I. Measurable residual disease detection by high throughput sequencing improves risk stratification for pediatric B-ALL. Blood. 2017 Dec 28. [Epub ahead of print] PubMed PMID: 29284596
  • Esbenshade AJ, Pierson CR, Thompson AL, Reed D, Gupta A, Levy A, Kahalley LS, Harker-Murray P, Schore R, Muscal JA, Embry L, Maloney K, Horton T, Zweidler-Mckay P, Dhall G. Long-term evidence that a pediatric oncology mentorship program for young investigators is feasible and beneficial in the cooperative group setting: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2017 Nov 28. [Epub ahead of print] PubMed PMID: 29193588
  • Maloney KW, Gore L. Agents in Development for Childhood Acute Lymphoblastic Leukemia. Paediatr Drugs. 2017 Nov 15. [Epub ahead of print] PubMed PMID: 29143289
  • Burke MJ, Devidas M, Maloney K, Angiolillo A, Schore R, Dunsmore K, Larsen E, Mattano LA Jr, Salzer W, Winter SS, Carroll W, Winick NJ, Loh ML, Raetz E, Hunger SP, Bleyer A. Severe pegaspargase hypersensitivity reaction rates (grade =3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children's oncology group (COG) clinical trials. Leuk Lymphoma. 2017 Nov 8;:1-10. [Epub ahead of print] PubMed PMID: 29115886
  • Winick N, Devidas M, Chen S, Maloney K, Larsen E, Mattano L, Borowitz MJ, Carroll A, Gastier-Foster JM, Heerema NA, Willman C, Wood B, Loh ML, Raetz E, Hunger SP, Carroll WL. Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2017 Aug 1;35(22):2527-2534. PubMed PMID: 28535084
  • Landier W, Hageman L, Chen Y, Kornegay N, Evans WE, Bostrom BC, Casillas J, Dickens DS, Angiolillo AL, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1. J Clin Oncol. 2017 May 20;35(15):1730-1736. PubMed PMID: 28339328
  • Maloney JP, Branchford BR, Brodsky GL, Cosmic MS, Calabrese DW, Aquilante CL, Maloney KW, Gonzalez JR, Zhang W, Moreau KL, Wiggins KL, Smith NL, Broeckel U, Di Paola J. The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk. FASEB J. 2017 Jul;31(7):2771-2784. PubMed PMID: 28302652
  • Landier W, Chen Y, Hageman L, Kim H, Bostrom BC, Casillas JN, Dickens DS, Evans WE, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Comparison of self-report and electronic monitoring of 6MP intake in childhood ALL: a Children's Oncology Group study. Blood. 2017 Apr 6;129(14):1919-1926. PubMed PMID: 28153823
  • Rogers AE, Eisenman KM, Dolan SA, Belderson KM, Zauche JR, Tong S, Gralla J, Hilden JM, Wang M, Maloney KW, Dominguez SR. Risk factors for bacteremia and central line-associated blood stream infections in children with acute myelogenous leukemia: A single-institution report. Pediatr Blood Cancer. 2016 Sep 12. [Epub ahead of print] PubMed PMID: 27616655
  • Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, L Loh M, P Hunger S, Mullighan CG. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun. 2016 Nov 8;7:13331. PubMed PMID: 27824051
  • Rogers AE, Eisenman KM, Dolan SA, Belderson KM, Zauche JR, Tong S, Gralla J, Hilden JM, Wang M, Maloney KW, Dominguez SR. Risk factors for bacteremia and central line-associated blood stream infections in children with acute myelogenous leukemia: A single-institution report. Pediatr Blood Cancer. 2016 Sep 12. [Epub ahead of print] PubMed PMID: 27616655
  • Kolenova A, Maloney KW, Hunger SP. Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia or Chronic Myeloid Leukemia in Lymphoid Blast Crisis. J Pediatr Hematol Oncol. 2016 Aug;38(6):e193-5. PubMed PMID: 27164534
  • Liu C, Yang W, Devidas M, Cheng C, Pei D, Smith C, Carroll WL, Raetz EA, Bowman WP, Larsen EC, Maloney KW, Martin PL, Mattano LA Jr, Winick NJ, Mardis ER, Fulton RS, Bhojwani D, Howard SC, Jeha S, Pui CH, Hunger SP, Evans WE, Loh ML, Relling MV. Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia. J Clin Oncol. 2016 Jun 20;34(18):2133-40. PubMed PMID: 27114598
  • Kunin-Batson AS, Lu X, Balsamo L, Graber K, Devidas M, Hunger SP, Carroll WL, Winick NJ, Mattano LA Jr, Maloney KW, Kadan-Lottick NS. Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer. 2016 May 15;122(10):1608-17. PubMed PMID: 27028090
  • Dupuis LL, Lu X, Mitchell HR, Sung L, Devidas M, Mattano LA Jr, Carroll WL, Winick N, Hunger SP, Maloney KW, Kadan-Lottick NS. Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group. Cancer. 2016 Apr 1;122(7):1116-25. PubMed PMID: 26773735
  • Karol SE, Mattano LA Jr, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood. 2015 Nov 20. [Epub ahead of print] PubMed PMID: 26590194
  • Vrooman LM, Kirov II, Dreyer ZE, Kelly M, Hijiya N, Brown P, Drachtman RA, Messinger YH, Ritchey AK, Hale GA, Maloney K, Lu Y, Plourde PV, Silverman LB. Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2015 Sep 16. [Epub ahead of print] PubMed PMID: 26376459
  • Mitchell HR, Lu X, Myers RM, Sung L, Balsamo LM, Carroll WL, Raetz E, Loh ML, Mattano LA Jr, Winick NJ, Devidas M, Hunger SP, Maloney K, Kadan-Lottick NS. Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331. Int J Cancer. 2015 Aug 1. [Epub ahead of print] PubMed PMID: 26235006
  • Karol SE, Mattano LA Jr, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood. 2015 Nov 20. [Epub ahead of print] PubMed PMID: 26590194
  • Vrooman LM, Kirov II, Dreyer ZE, Kelly M, Hijiya N, Brown P, Drachtman RA, Messinger YH, Ritchey AK, Hale GA, Maloney K, Lu Y, Plourde PV, Silverman LB. Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2015 Sep 16. [Epub ahead of print] PubMed PMID: 26376459
  • Mitchell HR, Lu X, Myers RM, Sung L, Balsamo LM, Carroll WL, Raetz E, Loh ML, Mattano LA Jr, Winick NJ, Devidas M, Hunger SP, Maloney K, Kadan-Lottick NS. Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331. Int J Cancer. 2015 Aug 1. [Epub ahead of print] PubMed PMID: 26235006
  • Bhatia S, Landier W, Hageman L, Chen Y, Kim H, Sun CL, Kornegay N, Evans WE, Angiolillo AL, Bostrom B, Casillas J, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Wong FL, Relling MV. Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. JAMA Oncol. 2015 Jun;1(3):287-95. PubMed PMID: 26181173
  • Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan-Lottick NS. A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group. Cancer. 2014 Jan 28. [Epub ahead of print] PubMed PMID: 24473774
  • Lau S, Lu X, Balsamo L, Devidas M, Winick N, Hunger SP, Carroll W, Stork L, Maloney K, Kadan-Lottick N. Family life events in the first year of acute lymphoblastic leukemia therapy: a children's oncology group report. Pediatr Blood Cancer. 2014 Dec;61(12):2277-84. PubMed PMID: 25175168
  • Bhatia S, Landier W, Hageman L, Kim H, Chen Y, Crews KR, Evans WE, Bostrom B, Casillas J, Dickens DS, Maloney KW, Neglia JP, Ravindranath Y, Ritchey AK, Wong FL, Relling MV. 6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study. Blood. 2014 Oct 9;124(15):2345-53. PubMed PMID: 24829202
  • Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan-Lottick NS. A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group. Cancer. 2014 Jan 28. [Epub ahead of print] PubMed PMID: 24473774
  • Hoffman LM, Gore L, Maloney KW. Pulmonary Presentation of Relapsed Acute Myeloid Leukemia. J Pediatr Hematol Oncol. 2013 Apr 24. [Epub ahead of print] PubMed PMID: 23619108
  • Heerema NA, Carroll AJ, Devidas M, Loh ML, Borowitz MJ, Gastier-Foster JM, Larsen EC, Mattano LA Jr, Maloney KW, Willman CL, Wood BL, Winick NJ, Carroll WL, Hunger SP, Raetz EA. Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group. J Clin Oncol. 2013 Sep 20;31(27):3397-402. PubMed PMID: 23940221
  • Levy AS, Pyke-Grimm KA, Lee DA, Palla SL, Naranjo A, Saulnier Sholler G, Gratias E, Maloney K, Parshankar F, Lee-Scott M, Beierle EA, Gow K, Kim GE, Hunger S, Smith FO, Horton TM. Mentoring in pediatric oncology: a report from the Children's Oncology Group Young Investigator Committee. J Pediatr Hematol Oncol. 2013 Aug;35(6):456-61. PubMed PMID: 23892351
  • Hoffman LM, Gore L, Maloney KW. Pulmonary Presentation of Relapsed Acute Myeloid Leukemia. J Pediatr Hematol Oncol. 2013 Apr 24. [Epub ahead of print] PubMed PMID: 23619108
  • Seewald L, Taub JW, Maloney KW, McCabe ER. Acute leukemias in children with Down syndrome. Mol Genet Metab. 2012 Sep;107(1-2):25-30. PubMed PMID: 22867885
  • Maloney KW, Giller R, Hunger SP. Recent advances in the understanding and treatment of pediatric leukemias. Adv Pediatr. 2012;59(1):329-58. PubMed PMID: 22789585
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Professional Memberships

  • American Society of Hematology, Member
  • Alpha Omega Alpha Medical Honor Society, Member
  • Children’s Oncology Group, Co-Chair, Standard Risk ALL
  • American Society of Pediatric Hematology/Oncology, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado Center for Cancer and Blood Disorders
7720 South Broadway
Suite 110
Littleton, CO 80122
720-777-9840

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Hematology / Oncology, Board Certification (2005)
Conditions & Treatments
  • Blood / Lymphatic System - Blood Disorders
  • Cancers - Leukemia (Childhood)
  • Blood / Lymphatic System
  • Cancers
Clinical Interest for Patients
I mainly see children, adolescents and young adults with acute leukemias and non Hodgkin's lymphoma. I also specialized in children with Down Syndrome and blood cancers or blood abnormalities.

Care Philosophy
The diagnosis I treat are complex and frightening at times. I believe cancer affects the whole family, thus my focus is on all members-patient, siblings and parents, other family members as well as friends. One of my main goals is to find fun when we can and normalize the child's life as best as we can. I find it a privilege to be a part of the person's journey through cancer.

Personal Interests
I am the proud mother of two children. I love to be outdoors and enjoying all the beauty Colorado has to offer.

Volunteer Activities
I am on the board of Make a Wish Colorado. As well, I volunteer at our camps for our patients-Wapiyapi and Round Up River Ranch.

General Information

Medical Schools:
  • MD, University of Colorado Denver Health Sciences Center (1990)
Undergraduate Schools:
  • BS, University of California–Davis (CA) (1986)
Internships:
  • University of Colorado (Children's Hospital Colorado) Program (1993)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Chief Resident, Pediatrics (1997)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Hematology / Oncology (1998)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
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