Mair Churchill, PhD
Professor, Pharmacology

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Department: Pharmacology

Publications

  • Dostal V, Churchill MEA. Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription. Biochim Biophys Acta Gene Regul Mech. 2019 May;1862(5):598-607. PubMed PMID: 30807854
  • Duex JE, Swain KE, Dancik GM, Paucek RD, Owens C, Churchill MEA, Theodorescu D. Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. Mol Cancer Res. 2018 Jan;16(1):69-77. PubMed PMID: 28970362
  • Sauer PV, Gu Y, Liu WH, Mattiroli F, Panne D, Luger K, Churchill ME. Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1. Nucleic Acids Res. 2018 Nov 2;46(19):9907-9917. PubMed PMID: 30239791
  • Wysoczynski-Horita CL, Boursier ME, Hill R, Hansen K, Blackwell HE, Churchill MEA. Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands. Mol Microbiol. 2018 May;108(3):240-257. PubMed PMID: 29437248
  • Duex JE, Swain KE, Dancik GM, Paucek RD, Owens C, Churchill MEA, Theodorescu D. Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. Mol Cancer Res. 2018 Jan;16(1):69-77. PubMed PMID: 28970362
  • Sleven H, Welsh SJ, Yu J, Churchill ME, Wright CF, Henderson A, Horvath R, Rankin J, Vogt J, Magee A, McConnell V, Green A, King MD, Cox H, Armstrong L, Lehman A, Nelson TN, Williams J, Clouston P, Hagman J, Németh AH. De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome. Am J Hum Genet. 2017 Jan 5;100(1):138-150. PubMed PMID: 28017370
  • Sleven H, Welsh SJ, Yu J, Churchill MEA, Wright CF, Henderson A, Horvath R, Rankin J, Vogt J, Magee A, McConnell V, Green A, King MD, Cox H, Armstrong L, Lehman A, Nelson TN, Williams J, Clouston P, Hagman J, Németh AH. De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome. Am J Hum Genet. 2017 Jan 5;100(1):138-150. PubMed PMID: 28017370
  • Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 4;7:10830. PubMed PMID: 26940659
  • Malarkey CS, Lionetti C, Deceglie S, Roberti M, Churchill ME, Cantatore P, Loguercio Polosa P. The sea urchin mitochondrial transcription factor A binds and bends DNA efficiently despite its unusually short C-terminal tail. Mitochondrion. 2016 Jul;29:1-6. PubMed PMID: 27101895
  • Malarkey CS, Gustafson CE, Saifee JF, Torres RM, Churchill ME, Janoff EN. Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production. PLoS One. 2016 Jun 9;11(6):e0157157. PubMed PMID: 27280778
  • Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME. The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife. 2016 Sep 30;5. PubMed PMID: 27690308
  • Miknis GF, Stevens SJ, Smith LE, Ostrov DA, Churchill ME. Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett. 2015 Feb 15;25(4):963-8. PubMed PMID: 25582598
  • Zan J, Choi O, Meharena H, Uhlson CL, Churchill ME, Hill RT, Fuqua C. A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11. Microbiology. 2015 Jan;161(Pt 1):50-6. PubMed PMID: 25355937
  • Sánchez-Giraldo R, Acosta-Reyes FJ, Malarkey CS, Saperas N, Churchill ME, Campos JL. Two high-mobility group box domains act together to underwind and kink DNA. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1423-32. PubMed PMID: 26143914
  • Miknis GF, Stevens SJ, Smith LE, Ostrov DA, Churchill ME. Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett. 2015 Feb 15;25(4):963-8. PubMed PMID: 25582598
  • Zan J, Choi O, Meharena H, Uhlson CL, Churchill ME, Hill RT, Fuqua C. A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11. Microbiology. 2015 Jan;161(Pt 1):50-6. PubMed PMID: 25355937
  • Blakeslee WW, Wysoczynski CL, Fritz KS, Nyborg JK, Churchill ME, McKinsey TA. Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal. 2014 Dec;26(12):2912-20. PubMed PMID: 25220405
  • Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK. Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1072-81. PubMed PMID: 24616510
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General Information

Department: Pharmacology
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