Thomas Morrison, PhD
Professor, Immunology and Microbiology

Publications

  • Wang G, Gaikwad H, McCarthy MK, Gonzalez-Juarrero M, Li Y, Armstrong M, Reisdorph N, Morrison TE, Simberg D. Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication in vitro . Precis Nanomed. 2021 Apr 17;4(1):724-737. PubMed PMID: 34676370
  • Carpentier KS, Sheridan RM, Lucas CJ, Davenport BJ, Li FS, Lucas ED, McCarthy MK, Reynoso GV, May NA, Tamburini BAJ, Hesselberth JR, Hickman HD, Morrison TE. MARCO( ) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination. EMBO J. 2021 Nov 15;40(22):e108966. PubMed PMID: 34618370
  • Huey L, Andersen G, Merkel PA, Morrison TE, McCarthy M, DomBourian MG, Annen K, Dawson ED, Rowlen KL, Knight V. Evaluation of a multiplexed coronavirus antigen array for detection of SARS-CoV-2 specific IgG in COVID-19 convalescent plasma. J Immunol Methods. 2021 Oct;497:113104. PubMed PMID: 34303688
  • Haese NN, May NA, Taft-Benz S, Moukha-Chafiq O, Madadi N, Zhang S, Karyakarte SD, Rodzinak KJ, Nguyen TH, Denton M, Streblow AD, Towers NA, Rasmussen L, Bostwick RJ, Maddry JA, Ananthan S, Augelli-Szafran CE, Suto MJ, Sanders W, Moorman N, DeFilippis V, Heise MT, Pathak AK, Streblow DN, Morrison TE. Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0024421. PubMed PMID: 34152810
  • Stenmark KR, Frid MG, Gerasimovskaya E, Zhang H, McCarthy MK, Thurman JM, Morrison TE. Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement. Pulm Circ. 2021 Apr-Jun;11(2):20458940211015799. PubMed PMID: 34046161
  • Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 Jun 1;206(11):2503-2507. PubMed PMID: 33972373
  • Ahmed SK, Haese NN, Cowan JT, Pathak V, Moukha-Chafiq O, Smith VJ, Rodzinak KJ, Ahmad F, Zhang S, Bonin KM, Streblow AD, Streblow CE, Kreklywich CN, Morrison C, Sarkar S, Moorman N, Sander W, Allen R, DeFilippis V, Tekwani BL, Wu M, Hirsch AJ, Smith JL, Tower NA, Rasmussen L, Bostwick R, Maddry JA, Ananthan S, Gerdes JM, Augelli-Szafran CE, Suto MJ, Morrison TE, Heise MT, Streblow DN, Pathak AK. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64(8):4762-4786. PubMed PMID: 33835811
  • Schultz JS, McCarthy MK, Rester C, Sabourin KR, Annen K, DomBourian M, Eisenmesser E, Frazer-Abel A, Knight V, Jaenisch T, Morrison TE, Rochford R, Kedl RM. Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA. J Clin Microbiol. 2021 May 19;59(6). PubMed PMID: 33795412
  • Powers JM, Haese NN, Denton M, Ando T, Kreklywich C, Bonin K, Streblow CE, Kreklywich N, Smith P, Broeckel R, DeFilippis V, Morrison TE, Heise MT, Streblow DN. Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses. PLoS Negl Trop Dis. 2021 Apr;15(4):e0009308. PubMed PMID: 33793555
  • Taylor SC, Hurst B, Charlton CL, Bailey A, Kanji JN, McCarthy MK, Morrison TE, Huey L, Annen K, DomBourian MG, Knight V. A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection. J Clin Microbiol. 2021 Mar 19;59(4). PubMed PMID: 33500361
  • Annen K, Morrison TE, DomBourian MG, McCarthy MK, Huey L, Merkel PA, Andersen G, Schwartz E, Knight V. Presence and short-term persistence of SARS-CoV-2 neutralizing antibodies in COVID-19 convalescent plasma donors. Transfusion. 2021 Apr;61(4):1148-1159. PubMed PMID: 33452828
  • Haist KC, Carpentier KS, Davenport BJ, Morrison TE. Plasmacytoid Dendritic Cells Mediate Control of Ross River Virus Infection via a Type I Interferon-Dependent, MAVS-Independent Mechanism. J Virol. 2021 Feb 24;95(6). PubMed PMID: 33361425
  • Sabourin KR, Schultz J, Romero J, Lamb MM, Larremore D, Morrison TE, Frazer-Abel A, Zimmer S, Kedl RM, Jaenisch T, Rochford R. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders-The COVID-19 Arapahoe SErosurveillance Study (CASES) Project. J Occup Environ Med. 2021 Mar 1;63(3):191-198. PubMed PMID: 33298759
  • Prow NA, Liu L, McCarthy MK, Walters K, Kalkeri R, Geiger J, Koide F, Cooper TH, Eldi P, Nakayama E, Diener KR, Howley PM, Hayball JD, Morrison TE, Suhrbier A. The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates. NPJ Vaccines. 2020;5:44. PubMed PMID: 32550013
  • Powell LA, Fox JM, Kose N, Kim AS, Majedi M, Bombardi R, Carnahan RH, Slaughter JC, Morrison TE, Diamond MS, Crowe JE Jr. Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease. PLoS Pathog. 2020 May;16(5):e1008517. PubMed PMID: 32365139
  • Noll KE, Whitmore AC, West A, McCarthy MK, Morrison CR, Plante KS, Hampton BK, Kollmus H, Pilzner C, Leist SR, Gralinski LE, Menachery VD, Schäfer A, Miller D, Shaw G, Mooney M, McWeeney S, Pardo-Manuel de Villena F, Schughart K, Morrison TE, Baric RS, Ferris MT, Heise MT. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep. 2020 Apr 28;31(4):107587. PubMed PMID: 32348764
  • Kuhn KA, Morrison TE. Introduction: Evolution of inflammatory arthritis from innate to adaptive immune mechanisms. Immunol Rev. 2020 Mar;294(1):5-8. PubMed PMID: 32103544
  • Davenport BJ, Bullock C, McCarthy MK, Hawman DW, Murphy KM, Kedl RM, Diamond MS, Morrison TE. Chikungunya Virus Evades Antiviral CD8( ) T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues. J Virol. 2020 Apr 16;94(9). PubMed PMID: 32102875
  • McCarthy MK, Reynoso GV, Winkler ES, Mack M, Diamond MS, Hickman HD, Morrison TE. MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2. PLoS Pathog. 2020 Jan;16(1):e1008292. PubMed PMID: 31999809
  • Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K, McAllister N, Silva LA, Morrison TE, Dermody TS. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest. 2020 Mar 2;130(3):1466-1478. PubMed PMID: 31794434
  • Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K, McAllister N, Silva LA, Morrison TE, Dermody TS. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest. 2019 Dec 3. [Epub ahead of print] PubMed PMID: 31794434
  • Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN. Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease. Front Immunol. 2019;10:2563. PubMed PMID: 31736977
  • Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 Oct 14;11(10). PubMed PMID: 31615058
  • Carpentier KS, Davenport BJ, Haist KC, McCarthy MK, May NA, Robison A, Ruckert C, Ebel GD, Morrison TE. Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses. Elife. 2019 Oct 9;8. PubMed PMID: 31596239
  • Hong JP, McCarthy MK, Davenport BJ, Morrison TE, Diamond MS. Clearance of Chikungunya Virus Infection in Lymphoid Tissues Is Promoted by Treatment with an Agonistic Anti-CD137 Antibody. J Virol. 2019 Dec 15;93(24). PubMed PMID: 31578287
  • Nguyen TH, Haese NN, Madadi N, Sarkar S, Bonin K, Streblow CE, Taft-Benz S, Tower NA, Rasmussen L, Bostwick R, Augelli-Szafran CE, Suto MJ, Morrison TE, DeFilippis V, Heise MT, Streblow DN, Pathak AK. Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus. ACS Infect Dis. 2019 Dec 13;5(12):2014-2028. PubMed PMID: 31257853
  • Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN. Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs. Antimicrob Agents Chemother. 2019 Apr;63(4). PubMed PMID: 30917980
  • Amaral JK, Taylor PC, Teixeira MM, Morrison TET, Schoen RT. The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis. Viruses. 2019 Mar 22;11(3). PubMed PMID: 30909365
  • McCarthy MK, Davenport BJJ, Morrison TE. Chronic Chikungunya Virus Disease. Curr Top Microbiol Immunol. 2019 Jan 18. [Epub ahead of print] PubMed PMID: 30656438
  • Davenport BJ, Martin CG, Beverley SM, Orlicky DJ, Vazquez-Torres A, Morrison TE. SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006921. PubMed PMID: 30372439
  • Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS. Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. MBio. 2018 Oct 9;9(5). PubMed PMID: 30301856
  • McCarthy MK, Morrison TE. Blocking the Exit: CHIKV Neutralizing Antibodies Nip Viral Egress in the Bud. Cell Host Microbe. 2018 Sep 12;24(3):328-330. PubMed PMID: 30212644
  • Lucas ED, Finlon JM, Burchill MA, McCarthy MK, Morrison TE, Colpitts TM, Tamburini BAJ. Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response. J Immunol. 2018 Sep 15;201(6):1735-1747. PubMed PMID: 30045970
  • McCarthy MK, Davenport BJ, Reynoso GV, Lucas ED, May NA, Elmore SA, Tamburini BA, Hickman HD, Morrison TE. Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment. JCI Insight. 2018 Jul 12;3(13). [Epub ahead of print] PubMed PMID: 29997290
  • Gunn BM, Jones JE, Shabman RS, Whitmore AC, Sarkar S, Blevins LK, Morrison TE, Heise MT. Ross River virus envelope glycans contribute to disease through activation of the host complement system. Virology. 2018 Feb;515:250-260. PubMed PMID: 29324290
  • Carpentier KS, Morrison TE. Innate immune control of alphavirus infection. Curr Opin Virol. 2018 Feb;28:53-60. PubMed PMID: 29175515
  • Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018 Mar 15;92(6). PubMed PMID: 29263267
  • Haist KC, Burrack KS, Davenport BJ, Morrison TE. Inflammatory monocytes mediate control of acute alphavirus infection in mice. PLoS Pathog. 2017 Dec;13(12):e1006748. PubMed PMID: 29244871
  • Carpentier KS, Morrison TE. Innate immune control of alphavirus infection. Curr Opin Virol. 2017 Nov 22;28:53-60. [Epub ahead of print] PubMed PMID: 29175515
  • Hawman DW, Carpentier KS, Fox JM, May NA, Sanders W, Montgomery SA, Moorman NJ, Diamond MS, Morrison TE. MUTATIONS IN THE E2 GLYCOPROTEIN AND THE 3' UNTRANSLATED REGION ENHANCE CHIKUNGUNYA VIRUS VIRULENCE IN MICE. J Virol. 2017 Jul 26. [Epub ahead of print] PubMed PMID: 28747508
  • Sokoloski KJ, Nease LM, May NA, Gebhart NN, Jones CE, Morrison TE, Hardy RW. Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants. PLoS Pathog. 2017 Jun;13(6):e1006473. PubMed PMID: 28662211
  • McCarthy MK, Morrison TE. Persistent RNA virus infections: do PAMPS drive chronic disease?. Curr Opin Virol. 2017 Apr;23:8-15. PubMed PMID: 28214732
  • Morrison TE, Diamond MS. Animal Models of Zika Virus Infection, Pathogenesis, and Immunity. J Virol. 2017 Apr 15;91(8). PubMed PMID: 28148798
  • Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE, Streblow DN. Animal Models of Chikungunya Virus Infection and Disease. J Infect Dis. 2016 Dec 15;214(suppl 5):S482-S487. PubMed PMID: 27920178
  • Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 Oct 18;8(10). PubMed PMID: 27763553
  • Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KM, Torres RM, Crowe JE Jr, Dermody TS, Diamond MS, Morrison TE. Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence. Cell Rep. 2016 Aug 2;16(5):1326-38. PubMed PMID: 27452455
  • Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016 May 24;7(3). PubMed PMID: 27222471
  • McCarthy MK, Morrison TE. Chronic chikungunya virus musculoskeletal disease: what are the underlying mechanisms?. Future Microbiol. 2016;11(3):331-4. PubMed PMID: 26939523
  • Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest. 2015 Dec 1;125(12):4699-713. PubMed PMID: 26571397
  • Burrack KS, Tan JJ, McCarthy MK, Her Z, Berger JN, Ng LF, Morrison TE. Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells. PLoS Pathog. 2015 Oct;11(10):e1005191. PubMed PMID: 26436766
  • McSweegan E, Weaver SC, Lecuit M, Frieman M, Morrison TE, Hrynkow S. The Global Virus Network: Challenging chikungunya. Antiviral Res. 2015 Aug;120:147-52. PubMed PMID: 26071007
  • Sokoloski KJ, Haist KC, Morrison TE, Mukhopadhyay S, Hardy RW. Noncapped Alphavirus Genomic RNAs and Their Role during Infection. J Virol. 2015 Jun;89(11):6080-92. PubMed PMID: 25833042
  • Halemano K, Barrett BS, Heilman KJ, Morrison TE, Santiago ML. Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response. J Virol. 2015 Apr;89(7):4011-4. PubMed PMID: 25589647
  • Burrack KS, Montgomery SA, Homann D, Morrison TE. CD8 T cells control Ross River virus infection in musculoskeletal tissues of infected mice. J Immunol. 2015 Jan 15;194(2):678-89. PubMed PMID: 25488988
  • Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS. A single-amino-Acid polymorphism in chikungunya virus e2 glycoprotein influences glycosaminoglycan utilization. J Virol. 2014 Mar;88(5):2385-97. PubMed PMID: 24371059
  • Burrack KS, Morrison TE. The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases. Front Immunol. 2014;5:428. PubMed PMID: 25250029
  • Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS. Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice. J Virol. 2014 Nov;88(21):12180-92. PubMed PMID: 25142598
  • Morrison TE. Reemergence of chikungunya virus. J Virol. 2014 Oct;88(20):11644-7. PubMed PMID: 25078691
  • Banda NK, Mehta G, Kjaer TR, Takahashi M, Schaack J, Morrison TE, Thiel S, Arend WP, Holers VM. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J Immunol. 2014 Sep 1;193(5):2455-68. PubMed PMID: 25070856
  • Pal P, Fox JM, Hawman DW, Huang YJ, Messaoudi I, Kreklywich C, Denton M, Legasse AW, Smith PP, Johnson S, Axthelm MK, Vanlandingham DL, Streblow DN, Higgs S, Morrison TE, Diamond MS. Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes. J Virol. 2014 Aug;88(15):8213-26. PubMed PMID: 24829346
  • Stoermer Burrack KA, Hawman DW, Jupille HJ, Oko L, Minor M, Shives KD, Gunn BM, Long KM, Morrison TE. Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection. J Virol. 2014 Apr;88(7):3719-32. PubMed PMID: 24429363
  • Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS. A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization. J Virol. 2014 Mar;88(5):2385-97. PubMed PMID: 24371059
View All (62 Total) View Less

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties
  • Allergy and Immunology

General Information

Department: Immunology and Microbiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

Update My Profile
;