Benzi Kluger, MD
Professor Adjoint, Neurology

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Medical School:
  • MD, University of Colorado Denver School of Medicine (2001)
Graduate School :
  • MS, University of Florida (2008)
Undergraduate School:
  • BA, University of Colorado - Boulder (CO) (1997)
Internship:
  • University of Colorado (University Hospital) Program (2002)
Residency:
  • University of Colorado (University Hospital) Program, Neurology (2005)
Fellowships:
  • University of Florida Program, Movement Disorders and Behavioral Neurology (2005)
Languages: English, Spanish
Department: Neurology

Professional Titles

  • Chief and Founder Palliative Care Section
  • Neuropalliative Care Specialist
  • Associate Professor

Recognition & Awards

  • Elected as Fellow Member of the American Academy of Neurology, American Academy of Neurology (2016)

Research Interests

My primary research interest is in applying palliative care approaches to reduce the suffering and improve the lives of patients and families affected by neurologic illnesses. This includes improving our understanding and ability to manage fatigue, problems with thinking and memory, and other difficult symptoms. We are using brain imaging to study these problems and we are trying both medications and non-medical means like acupuncture to treat them.

Teaching

  • Associate Professor (2013)
    School of Medicine, Neurology
    Behavioral Neurology, Movement Disorders, neuropsychology, neurophysiology, transcranial magnetic stimulation

Publications

  • Holden SK, Medina LD, Hoyt B, Sillau SH, Berman BD, Goldman JG, Weintraub D, Kluger BM. Validation of a performance-based assessment of cognitive functional ability in Parkinson's disease. Mov Disord. 2018 Oct 10. [Epub ahead of print] PubMed PMID: 30306618
  • Katz M, Goto Y, Kluger BM, Galifianakis NB, Miyasaki JM, Kutner JS, Jones CA, Pantilat SZ. Top Ten Tips Palliative Care Clinicians Should Know About Parkinson's Disease and Related Disorders. J Palliat Med. 2018 Oct;21(10):1507-1517. PubMed PMID: 30204543
  • Sebring K, Shattuck J, Berk J, Boersma I, Sillau S, Kluger BM. Assessing the validity of proxy caregiver reporting for potential palliative care outcome measures in Parkinson's disease. Palliat Med. 2018 Oct;32(9):1522-1528. PubMed PMID: 30015552
  • Berliner JM, Kluger BM, Corcos DM, Pelak VS, Gisbert R, McRae C, Atkinson CC, Schenkman M. Patient perceptions of visual, vestibular, and oculomotor deficits in people with Parkinson's disease. Physiother Theory Pract. 2018 Jul 6;:1-8. [Epub ahead of print] PubMed PMID: 29979909
  • Creutzfeldt CJ, Kluger B, Kelly AG, Lemmon M, Hwang DY, Galifianakis NB, Carver A, Katz M, Curtis JR, Holloway RG. Neuropalliative care: Priorities to move the field forward. Neurology. 2018 Jul 31;91(5):217-226. PubMed PMID: 29950434
  • Jones W, Silkworth W, Dusto N, Pelak VS, Berliner J, Buard I, Kluger B. Central Visual Oscillopsia: Case Report and Review of the Literature. Cogn Behav Neurol. 2018 Jun;31(2):86-95. PubMed PMID: 29927799
  • Hall DA, Ramos AR, Gelfand JM, Videnovic A, Benatar M, Cahill C, Kluger BM, Goldman M. The state of clinical research in neurology. Neurology. 2018 Apr 10;90(15):e1347-e1354. PubMed PMID: 29549220
  • Buard I, Berliner JM, Kluger BM. Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes. Brain Stimul. 2018 May - Jun;11(3):653-655. PubMed PMID: 29500042
  • Vaughan CL, Kluger BM. Palliative Care for Movement Disorders. Curr Treat Options Neurol. 2018 Feb 21;20(1):2. PubMed PMID: 29464435
  • Park HK, Ilango S, Charriez CM, Checkoway H, Riley D, Standaert DG, Bordelon Y, Shprecher DR, Reich SG, Hall D, Kluger B, Marras C, Jankovic J, Dubinsky R, Litvan I. Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study. Mov Disord. 2018 Mar;33(3):468-472. PubMed PMID: 29460982
  • Marras C, Cunningham CR, Hou J, Proudfoot J, Standaert DG, Juncos J, Riley D, Reich SG, Hall D, Kluger B, Bordelon Y, Shprecher DR, Litvan I. Anti-inflammatory drug use and progressive supranuclear palsy. Parkinsonism Relat Disord. 2018 Mar;48:89-92. PubMed PMID: 29307562
  • Kluger BM, Persenaire MJ, Holden SK, Palmer LT, Redwine H, Berk J, Anderson CA, Filley CM, Kutner J, Miyasaki J, Carter J. Implementation issues relevant to outpatient neurology palliative care. Ann Palliat Med. 2018 Jul;7(3):339-348. PubMed PMID: 29307208
  • Schenkman M, Moore CG, Kohrt WM, Hall DA, Delitto A, Comella CL, Josbeno DA, Christiansen CL, Berman BD, Kluger BM, Melanson EL, Jain S, Robichaud JA, Poon C, Corcos DM. Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2018 Feb 1;75(2):219-226. PubMed PMID: 29228079
  • Buard I, Sciacca DM, Martin CS, Rogers S, Sillau SH, Greher MR, Chen R, Kluger BM. Transcranial magnetic stimulation does not improve mild cognitive impairment in Parkinson's disease. Mov Disord. 2018 Mar;33(3):489-491. PubMed PMID: 29178298
  • Liu Y, Kline D, Aerts S, Youngwerth JM, Kutner JS, Sillau S, Kluger BM. Inpatient Palliative Care for Neurological Disorders: Lessons from a Large Retrospective Series. J Palliat Med. 2017 Jan;20(1):59-64. PubMed PMID: 27898260
  • Kluger BM. Fatigue in Parkinson's Disease. Int Rev Neurobiol. 2017;133:743-768. PubMed PMID: 28802940
  • Kluger BM, Garimella S, Garvan C. Minimal clinically important difference of the Modified Fatigue Impact Scale in Parkinson's disease. Parkinsonism Relat Disord. 2017 Jul 20. [Epub ahead of print] PubMed PMID: 28751191
  • Hall K, Sumrall M, Thelen G, Kluger BM. Palliative care for Parkinson's disease: suggestions from a council of patient and carepartners. NPJ Parkinsons Dis. 2017;3:16. PubMed PMID: 28649616
  • Boersma I, Jones J, Coughlan C, Carter J, Bekelman D, Miyasaki J, Kutner J, Kluger B. Palliative Care and Parkinson's Disease: Caregiver Perspectives. J Palliat Med. 2017 Sep;20(9):930-938. PubMed PMID: 28520498
  • Christiansen C, Moore C, Schenkman M, Kluger B, Kohrt W, Delitto A, Berman B, Hall D, Josbeno D, Poon C, Robichaud J, Wellington T, Jain S, Comella C, Corcos D, Melanson E. Factors Associated With Ambulatory Activity in De Novo Parkinson Disease. J Neurol Phys Ther. 2017 Apr;41(2):93-100. PubMed PMID: 28263256
  • Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. Pediatr Neurol. 2017 Mar;68:3-17. PubMed PMID: 28216033
  • Kluger BM, Pedersen KF, Tysnes OB, Ongre SO, Øygarden B, Herlofson K. Is fatigue associated with cognitive dysfunction in early Parkinson's disease?. Parkinsonism Relat Disord. 2017 Apr;37:87-91. PubMed PMID: 28202373
  • Kluger BM, Fox S, Timmons S, Katz M, Galifianakis NB, Subramanian I, Carter JH, Johnson MJ, Richfield EW, Bekelman D, Kutner JS, Miyasaki J. Palliative care and Parkinson's disease: Meeting summary and recommendations for clinical research. Parkinsonism Relat Disord. 2017 Apr;37:19-26. PubMed PMID: 28108265
  • Herlofson K, Kluger BM. Fatigue in Parkinson's disease. J Neurol Sci. 2017 Mar 15;374:38-41. PubMed PMID: 28087059
  • Liu Y, Kline D, Aerts S, Youngwerth JM, Kutner JS, Sillau S, Kluger BM. Inpatient Palliative Care for Neurological Disorders: Lessons from a Large Retrospective Series. J Palliat Med. 2017 Jan;20(1):59-64. PubMed PMID: 27898260
  • Bluett B, Litvan I, Cheng S, Juncos J, Riley DE, Standaert DG, Reich SG, Hall DA, Kluger B, Shprecher D, Marras C, Jankovic J. Understanding falls in progressive supranuclear palsy. Parkinsonism Relat Disord. 2017 Feb;35:75-81. PubMed PMID: 28007518
  • Bluett B, Litvan I, Cheng S, Juncos J, Riley DE, Standaert DG, Reich SG, Hall DA, Kluger B, Shprecher D, Marras C, Jankovic J. Understanding falls in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016 Dec 15. [Epub ahead of print] PubMed PMID: 28007518
  • Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, Kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 Oct;15(5):623-31. PubMed PMID: 27372099
  • Boersma I, Jones J, Carter J, Bekelman D, Miyasaki J, Kutner J, Kluger B. Parkinson disease patients' perspectives on palliative care needs: What are they telling us?. Neurol Clin Pract. 2016 Jun;6(3):209-219. PubMed PMID: 27347438
  • Friedman JH, Beck JC, Chou KL, Clark G, Fagundes CP, Goetz CG, Herlofson K, Kluger B, Krupp LB, Lang AE, Lou JS, Marsh L, Newbould A, Weintraub D. Fatigue in Parkinson's disease: report from a mutidisciplinary symposium. NPJ Parkinsons Dis. 2016;2. PubMed PMID: 27239558
  • Wang C, Trongnetrpunya A, Samuel IB, Ding M, Kluger BM. Compensatory Neural Activity in Response to Cognitive Fatigue. J Neurosci. 2016 Apr 6;36(14):3919-24. PubMed PMID: 27053200
  • Kluger BM, Rakowski D, Christian M, Cedar D, Wong B, Crawford J, Uveges K, Berk J, Abaca E, Corbin L, Garvan C. Randomized, Controlled Trial of Acupuncture for Fatigue in Parkinson's Disease. Mov Disord. 2016 Jul;31(7):1027-32. PubMed PMID: 27028133
  • Holden SK, Jones WE, Baker KA, Boersma IM, Kluger BM. Outcome measures for Parkinson's disease dementia: a systematic review. Mov Disord Clin Pract. 2016 Jan-Feb;3(1):9-18. PubMed PMID: 26998505
  • Brody DM, Litvan I, Warner S, Riley DE, Hall DA, Kluger BM, Shprecher DR, Cunningham CR. Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord. 2016 May;31(5):663-7. PubMed PMID: 26890571
  • Borah S, McConnell B, Hughes R, Kluger B. Potential relationship of self-injurious behavior to right temporo-parietal lesions. Neurocase. 2016 Jun;22(3):269-72. PubMed PMID: 26882285
  • Kluger BM, Herlofson K, Chou KL, Lou JS, Goetz CG, Lang AE, Weintraub D, Friedman J. Parkinson's disease-related fatigue: A case definition and recommendations for clinical research. Mov Disord. 2016 May;31(5):625-31. PubMed PMID: 26879133
  • Litvan I, Lees PS, Cunningham CR, Rai SN, Cambon AC, Standaert DG, Marras C, Juncos J, Riley D, Reich S, Hall D, Kluger B, Bordelon Y, Shprecher DR. Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. Mov Disord. 2016 May;31(5):644-52. PubMed PMID: 26854325
  • Wagle Shukla A, Brown R, Heese K, Jones J, Rodriguez RL, Malaty IM, Okun MS, Kluger BM. High rates of fatigue and sleep disturbances in dystonia. Int J Neurosci. 2016 Oct;126(10):928-35. PubMed PMID: 26289935
  • Wagle Shukla A, Brown R, Heese K, Jones J, Rodriguez RL, Malaty IM, Okun MS, Kluger BM. High rates of fatigue and sleep disturbances in dystonia. Int J Neurosci. 2016 Oct;126(10):928-35. PubMed PMID: 26289935
  • Litvan I, Lees PS, Cunningham CR, Rai SN, Cambon AC, Standaert DG, Marras C, Juncos J, Riley D, Reich S, Hall D, Kluger B, Bordelon Y, Shprecher DR. Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. Mov Disord. 2016 May;31(5):644-52. PubMed PMID: 26854325
  • Kluger BM, Herlofson K, Chou KL, Lou JS, Goetz CG, Lang AE, Weintraub D, Friedman J. Parkinson's disease-related fatigue: A case definition and recommendations for clinical research. Mov Disord. 2016 May;31(5):625-31. PubMed PMID: 26879133
  • Borah S, McConnell B, Hughes R, Kluger B. Potential relationship of self-injurious behavior to right temporo-parietal lesions. Neurocase. 2016 Jun;22(3):269-72. PubMed PMID: 26882285
  • Brody DM, Litvan I, Warner S, Riley DE, Hall DA, Kluger BM, Shprecher DR, Cunningham CR. Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord. 2016 May;31(5):663-7. PubMed PMID: 26890571
  • Holden SK, Jones WE, Baker KA, Boersma IM, Kluger BM. Outcome measures for Parkinson's disease dementia: a systematic review. Mov Disord Clin Pract. 2016 Jan-Feb;3(1):9-18. PubMed PMID: 26998505
  • Kluger BM, Rakowski D, Christian M, Cedar D, Wong B, Crawford J, Uveges K, Berk J, Abaca E, Corbin L, Garvan C. Randomized, Controlled Trial of Acupuncture for Fatigue in Parkinson's Disease. Mov Disord. 2016 Jul;31(7):1027-32. PubMed PMID: 27028133
  • Wang C, Trongnetrpunya A, Samuel IB, Ding M, Kluger BM. Compensatory Neural Activity in Response to Cognitive Fatigue. J Neurosci. 2016 Apr 6;36(14):3919-24. PubMed PMID: 27053200
  • Friedman JH, Beck JC, Chou KL, Clark G, Fagundes CP, Goetz CG, Herlofson K, Kluger B, Krupp LB, Lang AE, Lou JS, Marsh L, Newbould A, Weintraub D. Fatigue in Parkinson's disease: report from a mutidisciplinary symposium. NPJ Parkinsons Dis. 2016;2. PubMed PMID: 27239558
  • Boersma I, Jones J, Carter J, Bekelman D, Miyasaki J, Kutner J, Kluger B. Parkinson disease patients' perspectives on palliative care needs: What are they telling us?. Neurol Clin Pract. 2016 Jun;6(3):209-219. PubMed PMID: 27347438
  • Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, Kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 Oct;15(5):623-31. PubMed PMID: 27372099
  • Corbin L, Childs R, Dilli C, Christian MK, Wong B, Dong-Cedar D, Kluger BM. Acupuncture for Symptomatic Treatment of Fatigue in Parkinson's Disease: Trial Design and Implementation. Med Acupunct. 2016 Aug 1;28(4):194-205. PubMed PMID: 27602175
  • Kluger B, Triolo P, Jones W, Jankovic J. The therapeutic potential of cannabinoids for movement disorders. Mov Disord. 2015 Feb 4. [Epub ahead of print] PubMed PMID: 25649017
  • Wagle Shukla A, Brown R, Heese K, Jones J, Rodriguez RL, Malaty IM, Okun MS, Kluger BM. High rates of fatigue and sleep disturbances in dystonia. Int J Neurosci. 2015 Oct 2;:1-8. [Epub ahead of print] PubMed PMID: 26289935
  • Wang C, Ding M, Kluger BM. Functional Roles of Neural Preparatory Processes in a Cued Stroop Task Revealed by Linking Electrophysiology with Behavioral Performance. PLoS One. 2015;10(7):e0134686. PubMed PMID: 26230662
  • Kluger BM, Miyasaki J. Author response. Neurology. 2015 Mar 17;84(11):1184. PubMed PMID: 25941728
  • Finseth TA, Hedeman JL, Brown RP 2nd, Johnson KI, Binder MS, Kluger BM. Self-reported efficacy of cannabis and other complementary medicine modalities by Parkinson's disease patients in colorado. Evid Based Complement Alternat Med. 2015;2015:874849. PubMed PMID: 25821504
  • Miyasaki JM, Kluger B. Palliative care for Parkinson's disease: has the time come?. Curr Neurol Neurosci Rep. 2015 May;15(5):26. PubMed PMID: 25795037
  • Kluger B, Triolo P, Jones W, Jankovic J. The therapeutic potential of cannabinoids for movement disorders. Mov Disord. 2015 Mar;30(3):313-27. PubMed PMID: 25649017
  • Kittelson AJ, Thomas AC, Kluger BM, Stevens-Lapsley JE. Corticospinal and intracortical excitability of the quadriceps in patients with knee osteoarthritis. Exp Brain Res. 2014 Dec;232(12):3991-9. PubMed PMID: 25183161
  • Boersma I, Miyasaki J, Kutner J, Kluger B. Palliative care and neurology: time for a paradigm shift. Neurology. 2014 Aug 5;83(6):561-7. PubMed PMID: 24991027
  • Hall DA, Bennett DA, Filley CM, Shah RC, Kluger B, Ouyang B, Berry-Kravis E. Fragile X gene expansions are not associated with dementia. Neurobiol Aging. 2014 Nov;35(11):2637-8. PubMed PMID: 24958193
  • Kluger BM, Brown RP, Aerts S, Schenkman M. Determinants of Objectively Measured Physical Functional Performance in Early to Mid-stage Parkinson Disease. PM R. 2014 Nov;6(11):992-8. PubMed PMID: 24880056
  • Ghaffari BD, Kluger B. Mechanisms for alternative treatments in Parkinson's disease: acupuncture, tai chi, and other treatments. Curr Neurol Neurosci Rep. 2014 Jun;14(6):451. PubMed PMID: 24760476
  • McConnell BV, Applegate M, Keniston A, Kluger B, Maa EH. Use of complementary and alternative medicine in an urban county hospital epilepsy clinic. Epilepsy Behav. 2014 May;34:73-6. PubMed PMID: 24726950
  • Marker RJ, Stephenson JL, Kluger BM, Curran-Everett D, Maluf KS. Modulation of intracortical inhibition in response to acute psychosocial stress is impaired among individuals with chronic neck pain. J Psychosom Res. 2014 Mar;76(3):249-56. PubMed PMID: 24529046
  • Wang C, Ding M, Kluger BM. Change in intraindividual variability over time as a key metric for defining performance-based cognitive fatigability. Brain Cogn. 2014 Mar;85:251-8. PubMed PMID: 24486386
  • Dilli CR, Childs R, Berk J, Christian MK, Nguyen N, Brown RP, Kluger BM. Does prior acupuncture exposure affect perception of blinded real or sham acupuncture?. Acupunct Med. 2014 Apr;32(2):155-9. PubMed PMID: 24287578
  • Dilli CR, Childs R, Berk J, Christian MK, Nguyen N, Brown RP, Kluger BM. Does prior acupuncture exposure affect perception of blinded real or sham acupuncture?. Acupunct Med. 2013 Nov 28. [Epub ahead of print] PubMed PMID: 24287578
  • Shipley SM, Frederick MC, Filley CM, Kluger BM. Potential for misdiagnosis in community-acquired PET scans for dementia. Neurol Clin Pract. 2013 Aug;3(4):305-312. PubMed PMID: 24195019
  • Combs S, Kluger BM, Kutner JS. Research priorities in geriatric palliative care: nonpain symptoms. J Palliat Med. 2013 Sep;16(9):1001-7. PubMed PMID: 23888305
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Professional Memberships

  • American Academy of Neurology, Member
  • American Neuropsychiatric Association, Member
  • Society for Behavioral and Cognitive Neurology, Member
  • Cognitive Neuroscience Society, Member
  • Movement Disorders Society, Member
  • Parkinson's Study Group, Member
  • Parkinson Disease Society, Member
  • Huntington's Study Group, Member
  • American Neurological Association, Member

Practice Locations

Neurosciences Center - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Neurology, Board Certification (2006)
  • Hospice and Palliative Medicine
Conditions & Treatments
  • Brain and Nervous System - Alzheimer's Disease
  • Brain and Nervous System - Movement Disorders
  • Brain and Nervous System - Parkinson's Disease
  • Brain and Nervous System
Clinical Interests
I direct the University of Colorado’s Neurology Supportive and Palliative Care clinics. These team-based clinics are open to any patient or family affected by a neurologic or neurosurgical condition. The goals of this clinic are to improve the quality of life and reduce suffering for patients and families by helping them with difficult to treat medical symptoms (e.g. pain, fatigue), psychiatric symptoms (e.g. depression), psychological issues (e.g. guilt, grief), caregiver support, spiritual wellbeing and planning for the future. My specific clinical interests include movement disorders (e.g. Parkinson's disease, tremor, dystonia, chorea) and disorders of thinking and memory. I also perform botox injections for pain, muscle spasms, dystonia, headaches and other neurologic conditions.

Care Philosophy
I treat people not diseases. Everyone has unique perspectives, priorities, strengths and weaknesses that are important to understand in working towards their health goals. Good communication is critical to this relationship, especially my ability to really hear patients and to communicate my thoughts in a way that is understandable. I am open to admitting when I don’t have the answers and enjoy working with a team of other clinicians. As the director of the neuropalliative care program I want to make sure our care is always patient and family-centered, meaning that the patient and family direct our goals and plans of care.

Personal Interests
In my spare time I enjoy reading, creative writing, music, lifting weights, meditation and professional wrestling.

Volunteer Activities
I volunteer my time working with the American Academy of Neurology, Davis Phinney Foundation, Parkinson's Association of the Rockies and Huntington's Disease Society. I give talks to support groups for Parkinson’s disease and other patient populations.

General Information

Medical Schools:
  • MD, University of Colorado Denver School of Medicine (2001)
Graduate Schools:
  • MS, University of Florida (2008)
Undergraduate Schools:
  • BA, University of Colorado - Boulder (CO) (1997)
Internships:
  • University of Colorado (University Hospital) Program (2002)
Residency Programs:
  • University of Colorado (University Hospital) Program, Neurology (2005)
Fellowships:
  • University of Florida Program, Movement Disorders and Behavioral Neurology (2005)
Download CV
Languages: English, Spanish
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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