Michael Narkewicz, MD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

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Medical School:
  • MD, University of Vermont College of Medicine (1983)
Undergraduate School:
  • AB, Dartmouth College (NH) (1979)
Residency:
  • University of Colorado, Pediatrics (1986)
Fellowships:
  • University of Colorado, Pediatric Gastroenterology (1989)
Languages: English, French
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition

Professional Titles

  • Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition
  • Professor of Pediatrics

Recognition & Awards

  • Top Doctor in Denver, Pediatric Transplant Hepatology, 5280 Magazine, (2017)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
  • Top Doctor in Denver: Pediatric Transplant Hepatology, 5280 Magazine, (2016)
  • Top Doctor in Denver: Pediatric Transplant Hepatology, 5280 Magazine, (2015)
  • 5280 Top Doctors of Denver: Pediatric Gastroenterology and Pediatric Transplant Hepatology, 5280 Magazine, (2014)
  • 5280 Top Doctors of Denver: Pediatric Gastroenterology and Pediatric Transplant Hepatology, 5280 Magazine, (2013)
Research interests for Patients:
My research focuses on new therapies for children with hepatitis B and C. I lead a large study that is trying to develop tests that will predict which patients with cystic fibrosis are at risk for the development of advanced liver disease

Publications

  • Murray KF, Balistreri WF, Bansal S, Whitworth S, Evans HM, Gonzalez-Peralta RP, Wen J, Massetto B, Kersey K, Shao J, Garrison KL, Parhy B, Brainard DM, Arnon R, Gillis LA, Jonas MM, Chuan-Hao L, Narkewicz MR, Schwarz K, Rosenthal P. Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11. Hepatology. 2018 Aug 2. [Epub ahead of print] PubMed PMID: 30070726
  • Anderson BT, Feinstein JA, Kramer RE, Narkewicz MR, Bruckner AL, Brumbaugh DE. The approach and safety of esophageal dilation for treatment of strictures in children with epidermolysis bullosa. J Pediatr Gastroenterol Nutr. 2018 Jul 26. [Epub ahead of print] PubMed PMID: 30052567
  • Liptzin DR, Di Maria MV, Younoszai A, Narkewicz MR, Kelly SL, Wolfe KR, Veress LA. Pulmonary Screening in Subjects after the Fontan Procedure. J Pediatr. 2018 Aug;199:140-143. PubMed PMID: 29747936
  • Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ. Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr. 2018 May;196:139-147.e3. PubMed PMID: 29519540
  • Leung DH, Narkewicz MR. Cystic Fibrosis-related cirrhosis. J Cyst Fibros. 2017 Sep 16. [Epub ahead of print] PubMed PMID: 28986027
  • Ye W, Narkewicz MR, Leung DH, Karnsakul W, Murray KF, Alonso EM, Magee JC, Schwarzenberg SJ, Weymann A, Molleston JP. Variceal Hemorrhage and Adverse Liver Outcomes in Patients With Cystic Fibrosis Cirrhosis. J Pediatr Gastroenterol Nutr. 2017 Sep 12. [Epub ahead of print] PubMed PMID: 28906321
  • Debray D, Narkewicz MR, Bodewes FAJA, Colombo C, Housset C, de Jonge HR, Jonker JW, Kelly DA, Ling SC, Poynard T, Sogni P, Trauner M, Witters P, Baumann U, Wilschanski M, Verkade HJ. Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives. J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):443-448. PubMed PMID: 28753176
  • Feldman AG, Sokol RJ, Hardison RM, Alonso EM, Squires RH, Narkewicz MR. Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure. J Pediatr. 2017 Jan 12. [Epub ahead of print] PubMed PMID: 28088395
  • Woodruff SA, Sontag MK, Accurso FJ, Sokol RJ, Narkewicz MR. Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen. J Cyst Fibros. 2016 Aug 20. [Epub ahead of print] PubMed PMID: 27555301
  • Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH. Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2016 Aug 4. [Epub ahead of print] PubMed PMID: 27496798
  • Rogers GB, Narkewicz MR, Hoffman LR. The CF gastrointestinal microbiome: Structure and clinical impact. Pediatr Pulmonol. 2016 Oct;51(S44):S35-S44. PubMed PMID: 27662102
  • Li R, Belle SH, Horslen S, Chen LW, Zhang S, Squires RH. Clinical Course among Cases of Acute Liver Failure of Indeterminate Diagnosis. J Pediatr. 2016 Apr;171:163-70.e1-3. PubMed PMID: 26831743
  • Woodruff SA, Sontag MK, Accurso FJ, Sokol RJ, Narkewicz MR. Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen. J Cyst Fibros. 2016 Aug 20. [Epub ahead of print] PubMed PMID: 27555301
  • Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH. Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2016 Aug 4. [Epub ahead of print] PubMed PMID: 27496798
  • Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. CD4( ) and CD8( ) T Cell Activation in Children with Hepatitis C. J Pediatr. 2015 Dec 30. [Epub ahead of print] PubMed PMID: 26743497
  • Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2015 Dec 24. [Epub ahead of print] PubMed PMID: 26725209
  • Vue PM, McFann K, Narkewicz MR. Genetic Mutations in Pediatric Pancreatitis. Pancreas. 2016 Aug;45(7):992-6. PubMed PMID: 26692446
  • Narkewicz MR. Cystic Fibrosis Liver Disease and Ursodeoxycholic Acid: One Small Step Forward, Miles to Go. J Pediatr. 2016 Oct;177:17-8. PubMed PMID: 27423176
  • Kramer RE, Narkewicz MR. Adverse Events Following Gastrointestinal Endoscopy in Children: Classifications, Characterizations and Implications. J Pediatr Gastroenterol Nutr. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26594830
  • Mayer-Hamblett N, Kloster M, Ramsey BW, Narkewicz MR, Saiman L, Goss CH. Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials. Contemp Clin Trials. 2012 Nov 29;34(2):232-238. [Epub ahead of print] PubMed PMID: 23200843
  • Acker SN, Bruny JL, Narkewicz MR, Roach JP, Rogers A, Karrer FM. Preoperative imaging does not predict intrahepatic involvement in choledochal cysts. J Pediatr Surg. 2013 Dec;48(12):2378-82. PubMed PMID: 24314174
  • Mohan P, Barton BA, Narkewicz MR, Molleston JP, Gonzalez-Peralta RP, Rosenthal P, Murray KF, Haber B, Schwarz KB, Goodman ZD. Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: A retrospective study. Hepatology. 2013 May 23. [Epub ahead of print] PubMed PMID: 23703847
  • Narkewicz MR, Green M, Dunn S, Millis M, McDiarmid S, Mazariegos G, Anand R, Yin W, Studies of Pediatric Liver Transplantation Research Group. Decreasing incidence of symptomatic Epstein-Barr virus disease and posttransplant lymphoproliferative disorder in pediatric liver transplant recipients: report of the studies of pediatric liver transplantation experience. Liver Transpl. 2013 Jul;19(7):730-40. PubMed PMID: 23696264
  • Molleston JP, Mellman W, Narkewicz MR, Balistreri WF, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Mohan P, Murray KF, Njoku D, Rosenthal P, Barton BA, Talor MV, Cheng I, Schwarz KB, Haber BA, PEDS-C Clinical Research Network. Autoantibodies and autoimmune disease during treatment of children with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):304-10. PubMed PMID: 23439301
  • Leichtner AM, Gillis LA, Gupta S, Heubi J, Kay M, Narkewicz MR, Rider EA, Rufo PA, Sferra TJ, Teitelbaum J, NASPGHAN Training Committee, North American Society for Pediatric Gastroenterology. NASPGHAN guidelines for training in pediatric gastroenterology. J Pediatr Gastroenterol Nutr. 2013 Jan;56 Suppl 1:S1-8. PubMed PMID: 23263531
  • Lu BR, Zhang S, Narkewicz MR, Belle SH, Squires RH, Sokol RJ, Pediatric Acute Liver Failure (PALF) Study Group. Evaluation of the Liver Injury Unit Scoring System to Predict Survival in a Multinational Study of Pediatric Acute Liver Failure. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260095
  • Mayer-Hamblett N, Kloster M, Ramsey BW, Narkewicz MR, Saiman L, Goss CH. Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials. Contemp Clin Trials. 2012 Nov 29;34(2):232-238. [Epub ahead of print] PubMed PMID: 23200843
  • Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2012 Oct 29. [Epub ahead of print] PubMed PMID: 23111765
  • Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, James Lopez M, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial. Hepatology. 2012 Aug 10. [Epub ahead of print] PubMed PMID: 22886633
  • Narkewicz MR. Heavy Breathing: A Step to Non-Invasive Assessment of Hepatic Fibrosis and Function in Infants and Children. J Pediatr Gastroenterol Nutr. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22847465
  • Flass T, Narkewicz MR. Cirrhosis and other liver disease in cystic fibrosis. J Cyst Fibros. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23266093
  • Lu BR, Zhang S, Narkewicz MR, Belle SH, Squires RH, Sokol RJ, Pediatric Acute Liver Failure (PALF) Study Group. Evaluation of the Liver Injury Unit Scoring System to Predict Survival in a Multinational Study of Pediatric Acute Liver Failure. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260095
  • Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2012 Oct 29. [Epub ahead of print] PubMed PMID: 23111765
  • Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, James Lopez M, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial. Hepatology. 2012 Aug 10. [Epub ahead of print] PubMed PMID: 22886633
  • Narkewicz MR. Heavy Breathing: A Step to Non-Invasive Assessment of Hepatic Fibrosis and Function in Infants and Children. J Pediatr Gastroenterol Nutr. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22847465
  • Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. PubMed PMID: 22487950
  • Kelly DA, Haber B, González-Peralta RP, Murray KF, Jonas MM, Molleston JP, Narkewicz MR, Sinatra FR, Lang T, Lachaux A, Wirth S, Shelton M, Te HS, Pollack H, Deng W, Noviello S, Albrecht JK. Durability of sustained response shown in paediatric patients with chronic hepatitis C who were treated with interferon alfa-2b plus ribavirin. J Viral Hepat. 2012 Apr;19(4):263-70. PubMed PMID: 22404724
  • Jonas MM, Balistreri W, Gonzalez-Peralta RP, Haber B, Lobritto S, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Schwarz KB, Barton BA, Shepherd JA, Mitchell PD, Duggan C. Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial. Hepatology. 2012 Aug;56(2):523-31. PubMed PMID: 22383118
  • Miller MR, Sokol RJ, Narkewicz MR, Sontag MK. Pulmonary function in individuals who underwent liver transplantation: from the US cystic fibrosis foundation registry. Liver Transpl. 2012 May;18(5):585-93. PubMed PMID: 22271602
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Professional Memberships

  • North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), Member
  • American Association for the Study of Liver Disease (AASLD), Fellow Member
  • American Academy of Pediatrics (AAP), Fellow AAP
  • American Pediatric Society, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pediatric Transplant Hepatology, Board Certification (2007, 2017)
  • Pediatric Gastroenterology, Board Certification (1990, 2016)
  • Pediatrics, Board Certification (1988)
Conditions & Treatments
  • Digestive System - Hepatology (Liver Disorders)
  • Surgery - Liver Transplant Surgery
  • Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
  • Digestive System
  • Surgery
Clinical Interest for Patients
I am nationally recognized for my expertise in pediatric hepatology and liver transplantation and cystic fibrosis liver disease. I have additional interests in chronic viral hepatitis, pediatric acute liver failure and chronic pancreatitis. I work closely with patients and families to find the best approaches to care to meet their needs.

Volunteer Activities
Round Up River Ranch volunteer physician. Medical Advisory Committee: Round Up River Ranch Chair, Medical Advisory Committee: American Liver Foundation

General Information

Medical Schools:
  • MD, University of Vermont College of Medicine (1983)
Undergraduate Schools:
  • AB, Dartmouth College (NH) (1979)
Residency Programs:
  • University of Colorado, Pediatrics (1986)
Fellowships:
  • University of Colorado, Pediatric Gastroenterology (1989)
Languages: English, French
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
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