Jason Tregellas, PhD
Professor, Psychiatry-Psychopharmacology

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Graduate School :
  • PhD, University of Colorado Denver (2003)
Undergraduate School:
  • BA, University of Colorado - Boulder (CO) (1994)
Fellowships:
  • University of Colorado, Psychiatry (2005)
Languages: English
Department: Psychiatry-Psychopharmacology

Publications

  • Tanabe J, Tregellas JR. Beyond the AJR: Should Patients With First-Episode Psychosis Undergo Brain MRI?. AJR Am J Roentgenol. 2023 Oct 11. [Epub ahead of print] PubMed PMID: 37818960
  • Hranilovich JA, Legget KT, Dodd KC, Wylie KP, Tregellas JR. Functional magnetic resonance imaging of headache: Issues, best-practices, and new directions, a narrative review. Headache. 2023 Mar;63(3):309-321. PubMed PMID: 36942411
  • Legget KT, Cornier MA, Sarabia L, Delao EM, Mikulich-Gilbertson SK, Natvig C, Erpelding C, Mitchell T, Hild A, Kronberg E, Tregellas JR. Sex Differences in Effects of Mood, Eating-Related Behaviors, and BMI on Food Appeal and Desire to Eat: A Cross-Sectional Survey Study. Nutrients. 2023 Feb 2;15(3). PubMed PMID: 36771467
  • Wylie KP, Kluger BM, Medina LD, Holden SK, Kronberg E, Tregellas JR, Buard I. Hippocampal, basal ganglia and olfactory connectivity contribute to cognitive impairments in Parkinson's disease. Eur J Neurosci. 2023 Feb;57(3):511-526. PubMed PMID: 36516060
  • Bear JJ, Sargent JL, O'Neill BR, Chapman KE, Ghosh D, Kirsch HE, Tregellas JR. Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy. J Clin Neurophysiol. 2023 Feb 1;40(2):123-129. PubMed PMID: 34817446
  • Legget KT, Cornier MA, Erpelding C, Lawful BP, Bear JJ, Kronberg E, Tregellas JR. An implicit priming intervention alters brain and behavioral responses to high-calorie foods: a randomized controlled study. Am J Clin Nutr. 2022 Jan 14. [Epub ahead of print] PubMed PMID: 35030242
  • Wylie KP, Kluger BM, Medina LD, Holden SK, Kronberg E, Tregellas JR, Buard I. Hippocampal, basal ganglia and olfactory connectivity contribute to cognitive impairments in Parkinson's disease. Eur J Neurosci. 2022 Dec 14. [Epub ahead of print] PubMed PMID: 36516060
  • Purcell SA, Legget KT, Halliday TM, Pan Z, Creasy SA, Blankenship JM, Hild A, Tregellas JR, Melanson EL, Cornier MA. Appetitive and Metabolic Responses to an Exercise versus Dietary Intervention in Adults with Obesity. Transl J Am Coll Sports Med. 2022 Fall;7(4). PubMed PMID: 36337848
  • Legget KT, Cornier MA, Erpelding C, Lawful BP, Bear JJ, Kronberg E, Tregellas JR. An implicit priming intervention alters brain and behavioral responses to high-calorie foods: a randomized controlled study. Am J Clin Nutr. 2022 Apr 1;115(4):1194-1204. PubMed PMID: 35030242
  • Legget KT, Wylie KP, Cornier MA, Berman BD, Tregellas JR. Altered between-network connectivity in individuals prone to obesity. Physiol Behav. 2021 Feb 1;229:113242. PubMed PMID: 33157075
  • Bear JJ, Sargent JL, O'Neill BR, Chapman KE, Ghosh D, Kirsch HE, Tregellas JR. Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy. J Clin Neurophysiol. 2021 Nov 23. [Epub ahead of print] PubMed PMID: 34817446
  • Wylie KP, Kronberg E, Legget KT, Sutton B, Tregellas JR. Stable Meta-Networks, Noise, and Artifacts in the Human Connectome: Low- to High-Dimensional Independent Components Analysis as a Hierarchy of Intrinsic Connectivity Networks. Front Neurosci. 2021;15:625737. PubMed PMID: 34025337
  • Legget KT, Wylie KP, Cornier MA, Berman BD, Tregellas JR. Altered between-network connectivity in individuals prone to obesity. Physiol Behav. 2021 Feb 1;229:113242. PubMed PMID: 33157075
  • Tregellas JR, Legget KT. Rapid Early Brain Development Highlights a Critical Period and Possible Intervention Window. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Oct;5(10):937-938. PubMed PMID: 33032731
  • Shapiro ALB, Moore BF, Sutton B, Wilkening G, Stence N, Dabelea D, Tregellas JR. In Utero Exposure to Maternal Overweight or Obesity is Associated with Altered Offspring Brain Function in Middle Childhood. Obesity (Silver Spring). 2020 Sep;28(9):1718-1725. PubMed PMID: 32772475
  • Bear JJ, Kirsch HE, Berman BD, Chapman KE, Tregellas JR. Spike-associated networks and intracranial electrographic findings. Epileptic Disord. 2020 Jun 1;22(3):291-299. PubMed PMID: 32554357
  • Wylie KP, Tregellas JR, Bear JJ, Legget KT. Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing. J Autism Dev Disord. 2020 Aug;50(8):2765-2778. PubMed PMID: 32006272
  • Berman BD, Groth CL, Shelton E, Sillau SH, Sutton B, Legget KT, Tregellas JR. Hemodynamic responses are abnormal in isolated cervical dystonia. J Neurosci Res. 2020 Apr;98(4):692-703. PubMed PMID: 31692015
  • Berman BD, Groth CL, Shelton E, Sillau SH, Sutton B, Legget KT, Tregellas JR. Hemodynamic responses are abnormal in isolated cervical dystonia. J Neurosci Res. 2019 Nov 6. [Epub ahead of print] PubMed PMID: 31692015
  • Bear JJ, Chapman KE, Tregellas JR. The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies. Epilepsia. 2019 Aug;60(8):1491-1507. PubMed PMID: 31247129
  • Regner MF, Tregellas J, Kluger B, Wylie K, Gowin JL, Tanabe J. The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation. Neurosci Biobehav Rev. 2019 Aug;103:414-424. PubMed PMID: 31207255
  • Wylie KP, Harris JG, Ghosh D, Olincy A, Tregellas JR. Association of Working Memory With Distributed Executive Control Networks in Schizophrenia. J Neuropsychiatry Clin Neurosci. 2019 Fall;31(4):368-377. PubMed PMID: 31117908
  • Shapiro ALB, Wilkening G, Aalborg J, Ringham BM, Glueck DH, Tregellas JR, Dabelea D. Childhood Metabolic Biomarkers Are Associated with Performance on Cognitive Tasks in Young Children. J Pediatr. 2019 Aug;211:92-97. PubMed PMID: 31060808
  • Halliday TM, Polsky S, Schoen JA, Legget KT, Tregellas JR, Williamson KM, Cornier MA. Comparison of surgical versus diet-induced weight loss on appetite regulation and metabolic health outcomes. Physiol Rep. 2019 Apr;7(7):e14048. PubMed PMID: 30927343
  • Jensen AM, Tregellas JR, Sutton B, Xing F, Ghosh D. Kernel machine tests of association between brain networks and phenotypes. PLoS One. 2019;14(3):e0199340. PubMed PMID: 30897094
  • Shapiro ALB, Johnson SL, Sutton B, Legget KT, Dabelea D, Tregellas JR. Eating in the absence of hunger in young children is related to brain reward network hyperactivity and reduced functional connectivity in executive control networks. Pediatr Obes. 2019 Jun;14(6):e12502. PubMed PMID: 30659756
  • Tregellas JR, Wylie KP. Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia. Nicotine Tob Res. 2019 Feb 18;21(3):349-356. PubMed PMID: 30137618
  • Legget KT, Cornier MA, Bessesen DH, Mohl B, Thomas EA, Tregellas JR. Greater Reward-Related Neuronal Response to Hedonic Foods in Women Compared with Men. Obesity (Silver Spring). 2018 Feb;26(2):362-367. PubMed PMID: 29239138
  • Shapiro ALB, Sauder KA, Tregellas JR, Legget KT, Gravitz SL, Ringham BM, Glueck DH, Johnson SL, Dabelea D. Exposure to maternal diabetes in utero and offspring eating behavior: The EPOCH study. Appetite. 2017 Sep 1;116:610-615. PubMed PMID: 28478063
  • Smucny J, Tregellas JR. Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging. J Psychopharmacol. 2017 Jul;31(7):801-811. PubMed PMID: 28441884
  • Smucny J, Wylie KP, Kronberg E, Legget KT, Tregellas JR. Nicotinic modulation of salience network connectivity and centrality in schizophrenia. J Psychiatr Res. 2017 Jun;89:85-96. PubMed PMID: 28193583
  • Wylie KP, Smucny J, Legget KT, Tregellas JR. Targeting Functional Biomarkers in Schizophrenia with Neuroimaging. Curr Pharm Des. 2016 Jan 26. [Epub ahead of print] PubMed PMID: 26818860
  • Sayer RD, Amankwaah AF, Tamer GG, Chen N, Wright AJ, Tregellas JR, Cornier MA, Kareken DA, Talavage TM, McCrory MA, Campbell WW. Effects of Dietary Protein and Fiber at Breakfast on Appetite, ad Libitum Energy Intake at Lunch, and Neural Responses to Visual Food Stimuli in Overweight Adults. Nutrients. 2016 Jan 5;8(1). PubMed PMID: 26742068
  • Smucny J, Olincy A, Rojas DC, Tregellas JR. Neuronal effects of nicotine during auditory selective attention in schizophrenia. Hum Brain Mapp. 2016 Jan;37(1):410-21. PubMed PMID: 26518728
  • Regner MF, Saenz N, Maharajh K, Yamamoto DJ, Mohl B, Wylie K, Tregellas J, Tanabe J. Top-Down Network Effective Connectivity in Abstinent Substance Dependent Individuals. PLoS One. 2016 Oct 24;11(10):e0164818. PubMed PMID: 27776135
  • Drew Sayer R, Tamer GG Jr, Chen N, Tregellas JR, Cornier MA, Kareken DA, Talavage TM, McCrory MA, Campbell WW. Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity. Obesity (Silver Spring). 2016 Oct;24(10):2057-63. PubMed PMID: 27542906
  • Berman BD, Smucny J, Wylie KP, Shelton E, Kronberg E, Leehey M, Tregellas JR. Levodopa modulates small-world architecture of functional brain networks in Parkinson's disease. Mov Disord. 2016 Nov;31(11):1676-1684. PubMed PMID: 27461405
  • Smucny J, Olincy A, Tregellas JR. Nicotine restores functional connectivity of the ventral attention network in schizophrenia. Neuropharmacology. 2016 Sep;108:144-51. PubMed PMID: 27085606
  • Legget KT, Wylie KP, Cornier MA, Melanson EL, Paschall CJ, Tregellas JR. Exercise-related changes in between-network connectivity in overweight/obese adults. Physiol Behav. 2016 May 1;158:60-7. PubMed PMID: 26921099
  • Wylie KP, Smucny J, Legget KT, Tregellas JR. Targeting Functional Biomarkers in Schizophrenia with Neuroimaging. Curr Pharm Des. 2016;22(14):2117-23. PubMed PMID: 26818860
  • Sayer RD, Amankwaah AF, Tamer GG Jr, Chen N, Wright AJ, Tregellas JR, Cornier MA, Kareken DA, Talavage TM, McCrory MA, Campbell WW. Effects of Dietary Protein and Fiber at Breakfast on Appetite, ad Libitum Energy Intake at Lunch, and Neural Responses to Visual Food Stimuli in Overweight Adults. Nutrients. 2016 Jan 5;8(1). PubMed PMID: 26742068
  • Smucny J, Olincy A, Rojas DC, Tregellas JR. Neuronal effects of nicotine during auditory selective attention in schizophrenia. Hum Brain Mapp. 2016 Jan;37(1):410-21. PubMed PMID: 26518728
  • Tregellas JR, Smucny J, Legget KT, Stevens KE. Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study. Schizophr Res. 2015 Dec;169(1-3):351-4. PubMed PMID: 26453015
  • Smucny J, Stevens KE, Tregellas JR. The antiepileptic drug levetiracetam improves auditory gating in DBA/2 mice. NPJ Schizophr. 2015;1. PubMed PMID: 26317115
  • Legget KT, Cornier MA, Rojas DC, Lawful B, Tregellas JR. Harnessing the power of disgust: a randomized trial to reduce high-calorie food appeal through implicit priming. Am J Clin Nutr. 2015 Aug;102(2):249-55. PubMed PMID: 26109580
  • Smucny J, Stevens KE, Olincy A, Tregellas JR. Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation. Transl Psychiatry. 2015 Jun 23;5:e587. PubMed PMID: 26101850
  • Wylie KP, Kronberg E, Maharajh K, Smucny J, Cornier MA, Tregellas JR. Between-network connectivity occurs in brain regions lacking layer IV input. Neuroimage. 2015 Aug 1;116:50-8. PubMed PMID: 25979667
  • Smucny J, Visani A, Tregellas JR. Could vagus nerve stimulation target hippocampal hyperactivity to improve cognition in schizophrenia?. Front Psychiatry. 2015;6:43. PubMed PMID: 25852579
  • Smucny J, Olincy A, Eichman LS, Tregellas JR. Neuronal effects of nicotine during auditory selective attention. Psychopharmacology (Berl). 2015 Jun;232(11):2017-28. PubMed PMID: 25491929
  • Cornier MA, Shott ME, Thomas EA, Bechtell JL, Bessesen DH, Tregellas JR, Frank GK. The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste. Behav Brain Res. 2015 Feb 1;278:446-52. PubMed PMID: 25447301
  • Cornier MA, McFadden KL, Thomas EA, Bechtell JL, Bessesen DH, Tregellas JR. Propensity to obesity impacts the neuronal response to energy imbalance. Front Behav Neurosci. 2015;9:52. PubMed PMID: 25767441
  • Cornier MA, McFadden KL, Thomas EA, Bechtell JL, Bessesen DH, Tregellas JR. Propensity to obesity impacts the neuronal response to energy imbalance. Front Behav Neurosci. 2015;9:52. PubMed PMID: 25767441
  • Tregellas JR, Smucny J, Harris JG, Olincy A, Maharajh K, Kronberg E, Eichman LC, Lyons E, Freedman R. Intrinsic Hippocampal Activity as a Biomarker for Cognition and Symptoms in Schizophrenia. Am J Psychiatry. 2014 Jan 17. [Epub ahead of print] PubMed PMID: 24435071
  • Smucny J, Stevens KE, Tregellas JR. Acute administration of ?(9) tetrahydrocannabinol does not prevent enhancement of sensory gating by clozapine in DBA/2 mice. Pharmacol Biochem Behav. 2014 Mar;118:22-9. PubMed PMID: 24418217
  • Dalwani MS, Tregellas JR, Andrews-Hanna JR, Mikulich-Gilbertson SK, Raymond KM, Banich MT, Crowley TJ, Sakai JT. Default mode network activity in male adolescents with conduct and substance use disorder. Drug Alcohol Depend. 2014 Jan 1;134:242-50. PubMed PMID: 24210423
  • Tregellas JR. Neuroimaging biomarkers for early drug development in schizophrenia. Biol Psychiatry. 2014 Jul 15;76(2):111-9. PubMed PMID: 24094513
  • Dalwani MS, Tregellas JR, Andrews-Hanna JR, Mikulich-Gilbertson SK, Raymond KM, Banich MT, Crowley TJ, Sakai JT. Default mode network activity in male adolescents with conduct and substance use disorder. Drug Alcohol Depend. 2014 Jan 1;134:242-50. PubMed PMID: 24210423
  • McFadden KL, Tregellas JR, Shott ME, Frank GK. Reduced salience and default mode network activity in women with anorexia nervosa. J Psychiatry Neurosci. 2014 May;39(3):178-88. PubMed PMID: 24280181
  • Smucny J, Stevens KE, Tregellas JR. Acute administration of ?? tetrahydrocannabinol does not prevent enhancement of sensory gating by clozapine in DBA/2 mice. Pharmacol Biochem Behav. 2014 Mar;118:22-9. PubMed PMID: 24418217
  • Tregellas JR, Smucny J, Harris JG, Olincy A, Maharajh K, Kronberg E, Eichman LC, Lyons E, Freedman R. Intrinsic hippocampal activity as a biomarker for cognition and symptoms in schizophrenia. Am J Psychiatry. 2014 May;171(5):549-56. PubMed PMID: 24435071
  • Du YP, Chu R, Tregellas JR. Enhancing the detection of BOLD signal in fMRI by reducing the partial volume effect. Comput Math Methods Med. 2014;2014:973972. PubMed PMID: 24734119
  • Smucny J, Wylie KP, Tregellas JR. Functional magnetic resonance imaging of intrinsic brain networks for translational drug discovery. Trends Pharmacol Sci. 2014 Aug;35(8):397-403. PubMed PMID: 24906509
  • McFadden KL, Cornier MA, Tregellas JR. The role of alpha-7 nicotinic receptors in food intake behaviors. Front Psychol. 2014;5:553. PubMed PMID: 24936193
  • Wylie KP, Rojas DC, Ross RG, Hunter SK, Maharajh K, Cornier MA, Tregellas JR. Reduced brain resting-state network specificity in infants compared with adults. Neuropsychiatr Dis Treat. 2014;10:1349-59. PubMed PMID: 25092980
  • Tregellas JR. Response to Mattes. Am J Psychiatry. 2014 Sep;171(9):1001. PubMed PMID: 25178756
  • Cornier MA, Shott ME, Thomas EA, Bechtell JL, Bessesen DH, Tregellas JR, Frank GK. The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste. Behav Brain Res. 2014 Oct 30;278C:446-452. [Epub ahead of print] PubMed PMID: 25447301
  • Smucny J, Olincy A, Eichman LS, Tregellas JR. Neuronal effects of nicotine during auditory selective attention. Psychopharmacology (Berl). 2014 Dec 10. [Epub ahead of print] PubMed PMID: 25491929
  • Wylie KP, Tanabe J, Martin LF, Wongngamnit N, Tregellas JR. Nicotine increases cerebellar activity during finger tapping. PLoS One. 2013;8(12):e84581. PubMed PMID: 24358367
  • McFadden KL, Tregellas JR, Shott ME, Frank GK. Reduced salience and default mode network activity in women with anorexia nervosa. J Psychiatry Neurosci. 2013 Nov 26;38(6):130046. [Epub ahead of print] PubMed PMID: 24280181
  • Tregellas JR. Neuroimaging Biomarkers for Early Drug Development in Schizophrenia. Biol Psychiatry. 2013 Oct 3. [Epub ahead of print] PubMed PMID: 24094513
  • McFadden KL, Cornier MA, Melanson EL, Bechtell JL, Tregellas JR. Effects of exercise on resting-state default mode and salience network activity in overweight/obese adults. Neuroreport. 2013 Oct 23;24(15):866-71. PubMed PMID: 24022176
  • Smucny J, Wylie K, Rojas D, Stevens K, Olincy A, Kronberg E, Zheng L, Tregellas J. Evidence for gamma and beta sensory gating deficits as translational endophenotypes for schizophrenia. Psychiatry Res. 2013 Nov 30;214(2):169-74. PubMed PMID: 23972946
  • Smucny J, Tregellas J. Nicotinic modulation of intrinsic brain networks in schizophrenia. Biochem Pharmacol. 2013 Oct 15;86(8):1163-72. PubMed PMID: 23796751
  • Gadgil M, Peterson E, Tregellas J, Hepburn S, Rojas DC. Differences in global and local level information processing in autism: an fMRI investigation. Psychiatry Res. 2013 Aug 30;213(2):115-21. PubMed PMID: 23768913
  • Smucny J, Olincy A, Eichman LC, Lyons E, Tregellas JR. Early sensory processing deficits predict sensitivity to distraction in schizophrenia. Schizophr Res. 2013 Jun;147(1):196-200. PubMed PMID: 23590872
  • Krmpotich TD, Tregellas JR, Thompson LL, Banich MT, Klenk AM, Tanabe JL. Resting-state activity in the left executive control network is associated with behavioral approach and is increased in substance dependence. Drug Alcohol Depend. 2013 Apr 1;129(1-2):1-7. PubMed PMID: 23428318
  • Smucny J, Rojas DC, Eichman LC, Tregellas JR. Neural effects of auditory distraction on visual attention in schizophrenia. PLoS One. 2013;8(4):e60606. PubMed PMID: 23560100
  • Thomas EA, Bechtell JL, Vestal BE, Johnson SL, Bessesen DH, Tregellas JR, Cornier MA. Eating-related behaviors and appetite during energy imbalance in obese-prone and obese-resistant individuals. Appetite. 2013 Jun;65:96-102. PubMed PMID: 23402714
  • Wilson LB, Rojas DC, Shatti S, Tregellas JR. Greater neuronal responses during automatic semantic processing in schizophrenia. Neuroreport. 2013 Mar 27;24(5):212-6. PubMed PMID: 23399997
  • Smucny J, Rojas DC, Eichman LC, Tregellas JR. Neuronal effects of auditory distraction on visual attention. Brain Cogn. 2013 Mar;81(2):263-70. PubMed PMID: 23291265
  • Wilson LB, Tregellas JR, Slason E, Pasko BE, Hepburn S, Rojas DC. Phonological processing in first-degree relatives of individuals with autism: an fMRI study. Hum Brain Mapp. 2013 Jun;34(6):1447-63. PubMed PMID: 22419478
  • Armstrong J, Lakin A, Blumberg-Romero L, Campbell T, Heldens J, Lieu C, Neiman J, Sandene E, Steinbeiss M, Thompson D, Tregellas J, Flaig T, Higgins J. Clinical research reactivation during the COVID-19 pandemic: An academic center process and lessons for the future. J Translational Sci (In Press)
  • Hranilovich JA, Legget KT, Dodd KC, Wylie KP, Tregellas JR. Understanding functional magnetic resonance imaging for headache. Headache (In Press).
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Department of Psychiatry - Faculty and Staff Mental Health
1890 N Revere Ct
Anschutz Health Sciences Bldg, Suite 5242
Aurora, CO 80045
303-724-4987

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Clinical Pharmacology

General Information

Graduate Schools:
  • PhD, University of Colorado Denver (2003)
Undergraduate Schools:
  • BA, University of Colorado - Boulder (CO) (1994)
Fellowships:
  • University of Colorado, Psychiatry (2005)
Languages: English
Department: Psychiatry-Psychopharmacology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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