Dwight Klemm, PhD
Professor, Medicine-Pulmonary Sciences & Critical Care

Publications

• Gavin KM, Sullivan TM, Maltzahn JK, Jackman MR, Libby AE, MacLean PS, Kohrt WM, Majka SM, Klemm DJ. Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice. Front Endocrinol (Lausanne). 2022;13:844877. PubMed PMID: 35721743
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• Gavin KM, Sullivan TM, Maltzahn JK, Rahkola JT, Acosta AS, Kohrt WM, Majka SM, Klemm DJ. Hematopoietic stem cells produce intermediate lineage adipocyte progenitors that simultaneously express both myeloid and mesenchymal lineage markers in adipose tissue. Adipocyte. 2021 Dec;10(1):394-407. PubMed PMID: 34404315
• Summers ME, Richmond BW, Menon S, Sheridan RM, Kropski JA, Majka SA, Taketo MM, Bastarache JA, West JD, De Langhe S, Geraghty P, Klemm DJ, Chu HW, Friedman RS, Tao YK, Foronjy RF, Majka SM. Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling. FASEB J. 2020 Aug;34(8):10267-10285. PubMed PMID: 32533805
• Garat CV, Majka SM, Sullivan TM, Crossno JT Jr, Reusch JEB, Klemm DJ. CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension. Pulm Circ. 2020 Apr-Jun;10(2):2045894019898374. PubMed PMID: 32313640
• Gewin LS, Summers ME, Harral JW, Gaskill CF, Khodo SN, Neelisetty S, Sullivan TM, Hopp K, Reese JJ, Klemm DJ, Kon V, Ess KC, Shi W, Majka SM. Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1201-F1210. PubMed PMID: 31461347
• Gavin KM, Kohrt WM, Klemm DJ, Melanson EL. Modulation of Energy Expenditure by Estrogens and Exercise in Women. Exerc Sport Sci Rev. 2018 Oct;46(4):232-239. PubMed PMID: 30001272
• Gavin KM, Sullivan TM, Kohrt WM, Majka SM, Klemm DJ. Ovarian Hormones Regulate the Production of Adipocytes From Bone Marrow-Derived Cells. Front Endocrinol (Lausanne). 2018;9:276. PubMed PMID: 29892267
• Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J Clin Invest. 2017 Jun 1;127(6):2262-2276. PubMed PMID: 28463231
• Gavin KM, Majka SM, Kohrt WM, Miller HL, Sullivan TM, Klemm DJ. Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin ß1 and fabricated fibrin matrices. Adipocyte. 2017 Jul 3;6(3):234-249. PubMed PMID: 28441086
• Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J Clin Invest. 2017 Jun 1;127(6):2262-2276. PubMed PMID: 28463231
• Gavin KM, Majka SM, Kohrt WM, Miller HL, Sullivan TM, Klemm DJ. Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin ß1 and fabricated fibrin matrices. Adipocyte. 2017 Jul 3;6(3):234-249. PubMed PMID: 28441086
• Gavin KM, Gutman JA, Kohrt WM, Wei Q, Shea KL, Miller HL, Sullivan TM, Erickson PF, Helm KM, Acosta AS, Childs CR, Musselwhite E, Varella-Garcia M, Kelly K, Majka SM, Klemm DJ. De novo generation of adipocytes from circulating progenitor cells in mouse and human adipose tissue. FASEB J. 2015 Nov 18. [Epub ahead of print] PubMed PMID: 26581599
• Keller AC, Knaub LA, Miller MW, Birdsey N, Klemm DJ, Reusch JE. Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat. J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. PubMed PMID: 25264749
• Majka SM, Miller HL, Helm KM, Acosta AS, Childs CR, Kong R, Klemm DJ. Analysis and isolation of adipocytes by flow cytometry. Methods Enzymol. 2014;537:281-96. PubMed PMID: 24480352
• Keller AC, Knaub LA, Miller MW, Birdsey N, Klemm DJ, Reusch JE. Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat. J Cardiovasc Pharmacol. 2014 Sep 26. [Epub ahead of print] PubMed PMID: 25264749
• Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C684-98. PubMed PMID: 25122876
• West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. PubMed PMID: 24871858
• Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr;42(2):231-8. PubMed PMID: 24646223
• Majka SM, Miller HL, Helm KM, Acosta AS, Childs CR, Kong R, Klemm DJ. Analysis and isolation of adipocytes by flow cytometry. Methods Enzymol. 2014;537:281-96. PubMed PMID: 24480352
• Garat CV, Crossno JT Jr, Sullivan TM, Reusch JE, Klemm DJ. Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells. J Cardiovasc Pharmacol. 2013 Dec;62(6):539-48. PubMed PMID: 24084215
• McCurdy CE, Klemm DJ. Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?. Adipocyte. 2013 Jul 1;2(3):135-42. PubMed PMID: 23991359
• Chow K, Fessel JP, Kaoriihida-Stansbury, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH Jr, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan;3(1):31-49. PubMed PMID: 23662173
• Libby AE, Solt M, Jackman M, Sherk R, Foright G, Johnson TT, Nguyen M, Breit N, Hulett M, Rudolph E, Wellberg P, Roberson P, Jambal R, Scalzo J, Higgins TR, Kumar M, Weirman Z, Pan K, Shankar D, Klem D, Moreau K, Kohrt W,MacLean P. 2024. Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function. Amer J Endocrinol Metab. Accepted Jam 2024.