Mark Abzug, MD
Professor, Pediatrics-Infectious Diseases

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Medical School:
  • MD, Boston University School of Medicine (1982)
Internship:
  • Strong Memorial Hospital of the University of Rochester Program (1983)
Residency:
  • Strong Memorial Hospital of the University of Rochester Program, Pediatrics (1985)
Fellowships:
  • University of Colorado (University Hospital) Program, Pediatric Infectious Diseases (1988)
Languages: English
Department: Pediatrics-Infectious Diseases

Research Interests

Dr. Abzug directs clinical research on patients with viral infections, infections in immunocompromised patients, and pediatric HIV infection. He is involved in national collaborative clinical trials of antiviral therapies, including studies of the National Institutes of Health Collaborative Antiviral Study Group and the National Institutes of Health International Maternal Pediatric Adolescent AIDS Clinical Trials Network.

Publications

  • Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30413631
  • Slogrove AL, Schomaker M, Davies MA, Williams P, Balkan S, Ben-Farhat J, Calles N, Chokephaibulkit K, Duff C, Eboua TF, Kekitiinwa-Rukyalekere A, Maxwell N, Pinto J, Seage G 3rd, Teasdale CA, Wanless S, Warszawski J, Wools-Kaloustian K, Yotebieng M, Timmerman V, Collins IJ, Goodall R, Smith C, Patel K, Paul M, Gibb D, Vreeman R, Abrams EJ, Hazra R, Van Dyke R, Bekker LG, Mofenson L, Vicari M, Essajee S, Penazzato M, Anabwani G, Q Mohapi E, N Kazembe P, Hlatshwayo M, Lumumba M, Goetghebuer T, Thorne C, Galli L, van Rossum A, Giaquinto C, Marczynska M, Marques L, Prata F, Ene L, Okhonskaia L, Rojo P, Fortuny C, Naver L, Rudin C, Le Coeur S, Volokha A, Rouzier V, Succi R, Sohn A, Kariminia A, Edmonds A, Lelo P, Ayaya S, Ongwen P, Jefferys LF, Phiri S, Mubiana-Mbewe M, Sawry S, Renner L, Sylla M, Abzug MJ, Levin M, Oleske J, Chernoff M, Traite S, Purswani M, Chadwick EG, Judd A, Leroy V. The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. PLoS Med. 2018 Mar;15(3):e1002514. PubMed PMID: 29494593
  • Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
  • Strommen A, Hurst AL, Curtis D, Abzug MJ. Use of Intravenous Posaconazole in Hematopoietic Stem Cell Transplant Patients. J Pediatr Hematol Oncol. 2018 May;40(4):e203-e206. PubMed PMID: 29309375
  • Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
  • Bellavia A, Williams PL, DiMeglio LA, Hazra R, Abzug MJ, Patel K, Jacobson DL, Van Dyke RB, Geffner ME. Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth. AIDS. 2017 Jun 1;31(9):1333-1341. PubMed PMID: 28358737
  • Neilan AM, Karalius B, Patel K, Van Dyke RB, Abzug MJ, Agwu AL, Williams PL, Purswani M, Kacanek D, Oleske JM, Burchett SK, Wiznia A, Chernoff M, Seage GR 3rd, Ciaranello AL. Association of Risk of Viremia, Immunosuppression, Serious Clinical Events, and Mortality With Increasing Age in Perinatally Human Immunodeficiency Virus-Infected Youth. JAMA Pediatr. 2017 May 1;171(5):450-460. PubMed PMID: 28346597
  • Melvin AJ, Montepiedra G, Aaron L, Meyer WA 3rd, Spiegel HM, Borkowsky W, Abzug MJ, Best BM, Crain MJ, Borum PR, Graham B, Anthony P, Shin K, Siberry GK. Safety and Efficacy of Atorvastatin in Human Immunodeficiency Virus-Infected Children, Adolescents and Young Adults with Hyperlipidemia. Pediatr Infect Dis J. 2016 Oct 3. [Epub ahead of print] PubMed PMID: 27749649
  • Larochelle MB, Phan R, Craddock J, Abzug MJ, Curtis D, Robinson CC, Giller RH, Cosgrove S, Siringo F, McCourt E, Palestine AG. Cytomegalovirus retinitis in pediatric stem cell transplants: report of a recent cluster and the development of a screening protocol. Am J Ophthalmol. 2016 Oct 13. [Epub ahead of print] PubMed PMID: 27746296
  • Melvin AJ, Montepiedra G, Aaron L, Meyer WA 3rd, Spiegel HM, Borkowsky W, Abzug MJ, Best BM, Crain MJ, Borum PR, Graham B, Anthony P, Shin K, Siberry GK. Safety and Efficacy of Atorvastatin in Human Immunodeficiency Virus-Infected Children, Adolescents and Young Adults with Hyperlipidemia. Pediatr Infect Dis J. 2016 Oct 3. [Epub ahead of print] PubMed PMID: 27749649
  • Larochelle MB, Phan R, Craddock J, Abzug MJ, Curtis D, Robinson CC, Giller RH, Cosgrove S, Siringo F, McCourt E, Palestine AG. Cytomegalovirus retinitis in pediatric stem cell transplants: report of a recent cluster and the development of a screening protocol. Am J Ophthalmol. 2016 Oct 13. [Epub ahead of print] PubMed PMID: 27746296
  • Camacho-Gonzalez AF, Chernoff MC, Williams PL, Chahroudi A, Oleske JM, Traite S, Chakraborty R, Purswani MU, Abzug MJ. Sexually Transmitted Infections in Youth With Controlled and Uncontrolled Human Immunodeficiency Virus Infection. J Pediatric Infect Dis Soc. 2016 Jul 20. [Epub ahead of print] PubMed PMID: 27440505
  • Messacar K, Abzug MJ, Dominguez SR. The Emergence of Enterovirus-D68. Microbiol Spectr. 2016 Jun;4(3). PubMed PMID: 27337448
  • Wolf ER, Beste S, Barr E, Wallace J, McFarland EJ, Abzug MJ, Darrow J, Melvin A. Health Outcomes of International HIV-Infected Adoptees in the U.S. Pediatr Infect Dis J. 2015 Nov 30. [Epub ahead of print] PubMed PMID: 26629872
  • Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26489019
  • Fisher BT, Ross RK, Roilides E, Palazzi DL, Abzug MJ, Hoffman JA, Berman DM, Prasad PA, Localio AR, Steinbach WJ, Vogiatzi L, Dutta A, Zaoutis TE. Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia. J Pediatric Infect Dis Soc. 2015 Apr 29. [Epub ahead of print] PubMed PMID: 26407259
  • Abzug MJ, Michaels MG, Wald E, Jacobs RF, Romero JR, Sánchez PJ, Wilson G, Krogstad P, Storch GA, Lawrence R, Shelton M, Palmer A, Robinson J, Dennehy P, Sood SK, Cloud G, Jester P, Acosta EP, Whitley R, Kimberlin D. A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. J Pediatric Infect Dis Soc. 2015 Apr 16. [Epub ahead of print] PubMed PMID: 26407253
  • Wolf ER, Beste S, Barr E, Wallace J, McFarland EJ, Abzug MJ, Darrow J, Melvin A. Health Outcomes of International HIV-Infected Adoptees in the U.S. Pediatr Infect Dis J. 2015 Nov 30. [Epub ahead of print] PubMed PMID: 26629872
  • Wattier RL, Dvorak CC, Hoffman JA, Brozovich AA, Bin-Hussain I, Groll AH, Castagnola E, Knapp KM, Zaoutis TE, Gustafsson B, Sung L, Berman D, Halasa NB, Abzug MJ, Velegraki A, Sharma TS, Fisher BT, Steinbach WJ. A Prospective, International Cohort Study of Invasive Mold Infections in Children. J Pediatric Infect Dis Soc. 2015 Dec;4(4):313-22. PubMed PMID: 26582870
  • Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26489019
  • Olson D, Moen A, Barr E, Mirsky D, Schreiner T, Abzug MJ. An 8-Year-Old Boy With Ascending Paralysis. J Pediatric Infect Dis Soc. 2015 May 21. [Epub ahead of print] PubMed PMID: 26407267
  • Fisher BT, Ross RK, Roilides E, Palazzi DL, Abzug MJ, Hoffman JA, Berman DM, Prasad PA, Localio AR, Steinbach WJ, Vogiatzi L, Dutta A, Zaoutis TE. Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia. J Pediatric Infect Dis Soc. 2015 Apr 29. [Epub ahead of print] PubMed PMID: 26407259
  • Abzug MJ, Michaels MG, Wald E, Jacobs RF, Romero JR, Sánchez PJ, Wilson G, Krogstad P, Storch GA, Lawrence R, Shelton M, Palmer A, Robinson J, Dennehy P, Sood SK, Cloud G, Jester P, Acosta EP, Whitley R, Kimberlin D. A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. J Pediatric Infect Dis Soc. 2015 Apr 16. [Epub ahead of print] PubMed PMID: 26407253
  • Weinberg A, Muresan P, Richardson K, Fenton T, Dominguez T, Bloom A, Watts DH, Abzug MJ, Nachman SA, Levin MJ. Heterogeneity of T Cell Responses to Pandemic pH1N1 Monovalent Vaccine in HIV-Infected Pregnant Women. AIDS Res Hum Retroviruses. 2015 Nov;31(11):1170-7. PubMed PMID: 26322930
  • Mirani G, Williams PL, Chernoff M, Abzug MJ, Levin MJ, Seage GR 3rd, Oleske JM, Purswani MU, Hazra R, Traite S, Zimmer B, Van Dyke RB. Changing Trends in Complications and Mortality Rates Among US Youth and Young Adults With HIV Infection in the Era of Combination Antiretroviral Therapy. Clin Infect Dis. 2015 Dec 15;61(12):1850-61. PubMed PMID: 26270680
  • Weinberg A, Muresan P, Richardson KM, Fenton T, Dominguez T, Bloom A, Watts DH, Abzug MJ, Nachman SA, Levin MJ. Determinants of vaccine immunogenicity in HIV-infected pregnant women: analysis of B and T cell responses to pandemic H1N1 monovalent vaccine. PLoS One. 2015;10(4):e0122431. PubMed PMID: 25874544
  • Krogstad P, Patel K, Karalius B, Hazra R, Abzug MJ, Oleske J, Seage GR 3rd, Williams PL, Borkowsky W, Wiznia A, Pinto J, Van Dyke RB. Incomplete immune reconstitution despite virologic suppression in HIV-1 infected children and adolescents. AIDS. 2015 Mar 27;29(6):683-93. PubMed PMID: 25849832
  • Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, Arav-Boger R, Michaels MG, Ashouri N, Englund JA, Estrada B, Jacobs RF, Romero JR, Sood SK, Whitworth MS, Abzug MJ, Caserta MT, Fowler S, Lujan-Zilbermann J, Storch GA, DeBiasi RL, Han JY, Palmer A, Weiner LB, Bocchini JA, Dennehy PH, Finn A, Griffiths PD, Luck S, Gutierrez K, Halasa N, Homans J, Shane AL, Sharland M, Simonsen K, Vanchiere JA, Woods CR, Sabo DL, Aban I, Kuo H, James SH, Prichard MN, Griffin J, Giles D, Acosta EP, Whitley RJ. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med. 2015 Mar 5;372(10):933-43. PubMed PMID: 25738669
  • Rao S, Abzug MJ, Carosone-Link P, Peterson T, Child J, Siparksy G, Soranno D, Cadnapaphornchai MA, Simões EA. Intravenous acyclovir and renal dysfunction in children: a matched case control study. J Pediatr. 2015 Jun;166(6):1462-8.e1-4. PubMed PMID: 25708691
  • Messacar K, Schreiner TL, Maloney JA, Wallace A, Ludke J, Oberste MS, Nix WA, Robinson CC, Glodé MP, Abzug MJ, Dominguez SR. A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet. 2015 Apr 25;385(9978):1662-71. PubMed PMID: 25638662
  • Abzug MJ. The enteroviruses: Problems in need of treatments. J Infect. 2014 Jan;68 Suppl 1:S108-14. PubMed PMID: 24119825
  • Halgrimson WR, Chan KH, Abzug MJ, Perkins JN, Carosone-Link P, Simões EA. Incidence of acute mastoiditis in Colorado children in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2014 May;33(5):453-7. PubMed PMID: 24732389
  • Abzug MJ. Acute sinusitis in children: Do antibiotics have any role?. J Infect. 2014 Jan;68 Suppl 1:S33-7. PubMed PMID: 24119829
  • Abzug MJ. The enteroviruses: Problems in need of treatments. J Infect. 2014 Jan;68 Suppl 1:S108-14. PubMed PMID: 24119825
  • Halgrimson WR, Chan KH, Abzug MJ, Perkins JN, Carosone-Link P, Simões EA. Incidence of Acute Mastoiditis in Colorado Children in the Pneumococcal Conjugate Vaccine Era. Pediatr Infect Dis J. 2013 Oct 22. [Epub ahead of print] PubMed PMID: 24153007
  • Williams PL, Abzug MJ, Jacobson DL, Wang J, Van Dyke RB, Hazra R, Patel K, Dimeglio LA, McFarland EJ, Silio M, Borkowsky W, Seage GR 3rd, Oleske JM, Geffner ME, International Maternal Pediatric and Adolescent AIDS Clinical Trials P219219C Study and the Pediatric HIVAIDS Cohort Study. Pubertal onset in children with perinatal HIV infection in the era of combination antiretroviral treatment. AIDS. 2013 Jul 31;27(12):1959-70. PubMed PMID: 24145244
  • Abzug MJ, Song LY, Levin MJ, Nachman SA, Borkowsky W, Pelton SI, International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams. Antibody persistence and immunologic memory after sequential pneumococcal conjugate and polysaccharide vaccination in HIV-infected children on highly active antiretroviral therapy. Vaccine. 2013 Oct 1;31(42):4782-90. PubMed PMID: 23954381
  • Abzug MJ, Nachman SA, Muresan P, Handelsman E, Watts DH, Fenton T, Heckman B, Petzold E, Weinberg A, Levin MJ, International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1086 Protocol Team. Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women. Clin Infect Dis. 2013 May;56(10):1488-97. PubMed PMID: 23378284
  • Kimberlin DW, Acosta EP, Prichard MN, Sánchez PJ, Ampofo K, Lang D, Ashouri N, Vanchiere JA, Abzug MJ, Abughali N, Caserta MT, Englund JA, Sood SK, Spigarelli MG, Bradley JS, Lew J, Michaels MG, Wan W, Cloud G, Jester P, Lakeman FD, Whitley RJ, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza. J Infect Dis. 2013 Mar 1;207(5):709-20. PubMed PMID: 23230059
  • Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, Palazzi DL, Castagnola E, Halasa N, Velegraki A, Dvorak CC, Charkabarti A, Sung L, Danziger-Isakov L, Lachenauer C, Arrieta A, Knapp K, Abzug MJ, Ziebold C, Lehrnbecher T, Klingspor L, Warris A, Leckerman K, Martling T, Walsh TJ, Benjamin DK Jr, Zaoutis TE, International Pediatric Fungal Network. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J. 2012 Dec;31(12):1252-7. PubMed PMID: 22982980
  • Abzug MJ, Qin M, Levin MJ, Fenton T, Beeler JA, Bellini WJ, Audet S, Sowers SB, Borkowsky W, Nachman SA, Pelton SI, Rosenblatt HM, International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams. Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy. J Infect Dis. 2012 Aug 15;206(4):512-22. PubMed PMID: 22693229
  • Lujan-Zilbermann J, Warshaw MG, Williams PL, Spector SA, Decker MD, Abzug MJ, Heckman B, Manzella A, Kabat B, Jean-Philippe P, Nachman S, Siberry GK, International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1065 Protocol Team. Immunogenicity and safety of 1 vs 2 doses of quadrivalent meningococcal conjugate vaccine in youth infected with human immunodeficiency virus. J Pediatr. 2012 Oct;161(4):676-81.e2. PubMed PMID: 22622049
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Professional Memberships

  • American Academy of Pediatrics (AAP), Member
  • Pediatric Infectious Disease Society, Member
  • Society For Pediatric Research (SPR), Member
  • American Board of Pediatrics Subboard of Pediatric Infectious Diseases Self-Assessment Team, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pediatric Infectious Diseases, Board Certification (1994)
  • Pediatrics, Board Certification (1986)
Conditions & Treatments
  • Infections - Viral Infections
  • Immune System - AIDS
  • Immune System - AIDS / HIV Disease
  • Immune System - AIDS Immunization
  • Immune System
  • Infections
Clinical Interests
I am interested in Perinatal Infection, Enterovirus Infections and Infections in Immunocompromised Patients.

General Information

Medical Schools:
  • MD, Boston University School of Medicine (1982)
Internships:
  • Strong Memorial Hospital of the University of Rochester Program (1983)
Residency Programs:
  • Strong Memorial Hospital of the University of Rochester Program, Pediatrics (1985)
Fellowships:
  • University of Colorado (University Hospital) Program, Pediatric Infectious Diseases (1988)
Languages: English
Department: Pediatrics-Infectious Diseases
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