Research in the Tennis Lab is focused on investigating signaling pathways in premalignant lung lesions and lung cancer chemoprevention. Projects include response prediction and monitoring biomarkers for targeted lung cancer chemoprevention, characterizing in vivo and ex vivo mouse models of early lung cancer progression, and the role of Frizzled 9 in early lung lesions and chemoprevention. Our publications include work on the role of Sprouty4 in tumor suppressive Wnt signaling, methylation of Wn7a, the importance of Frizzled 9 for activity of the lung cancer chemoprevention drug iloprost, primary tumor vs breast metastasis determination, and lung tumor associated macrophages. Translational research projects allow us to pursue prevention research that includes strong collaborations with clinicians at the University of Colorado Anschutz Medical Campus and the Rocky Mountain Regional VA Medical Center. The Tennis Lab is also committed to mentoring young scientists from all backgrounds who are interested in cancer research and we promote STEM outreach and education through involvement with CU Science Discovery and other community programs.