Meredith Tennis, PhD
Associate Professor, Medicine-Pulmonary Sciences & Critical Care

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Graduate School :
  • PhD, Georgetown University (2006)
Undergraduate School:
  • BS, Gonzaga University (WA) (1997)
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Associate Professor, Medicine-Pulmonary Sciences & Critical Care
  • Anschutz Medical Campus Director, CU Science Discovery

Research Interests

Research in the Tennis Lab is focused on investigating signaling pathways in premalignant lung lesions and lung cancer chemoprevention. Projects include response prediction and monitoring biomarkers for targeted lung cancer chemoprevention, characterizing in vivo and ex vivo mouse models of early lung cancer progression, and the role of Frizzled 9 in early lung lesions and chemoprevention. Our publications include work on the role of Sprouty4 in tumor suppressive Wnt signaling, methylation of Wn7a, the importance of Frizzled 9 for activity of the lung cancer chemoprevention drug iloprost, primary tumor vs breast metastasis determination, and lung tumor associated macrophages. Translational research projects allow us to pursue prevention research that includes strong collaborations with clinicians at the University of Colorado Anschutz Medical Campus and the Rocky Mountain Regional VA Medical Center. The Tennis Lab is also committed to mentoring young scientists from all backgrounds who are interested in cancer research and we promote STEM outreach and education through involvement with CU Science Discovery and other community programs.

Publications

  • https://www.ncbi.nlm.nih.gov/myncbi/meredith%20a..tennis.1/bibliography/public/
  • Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 Sep 1;78(17):4971-4983. PubMed PMID: 29997230
  • New ML, White CM, McGonigle P, McArthur DG, Dwyer-Nield LD, Merrick DT, Keith RL, Tennis MA. Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention. Cancer Prev Res (Phila). 2018 Oct;11(10):643-654. PubMed PMID: 30045935
  • Bauer AK, Upham BL, Rondini EA, Tennis MA, Velmuragan K, Wiese D. Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease. Oncotarget. 2017 Nov 3;8(54):91860-91875. PubMed PMID: 29190881
  • Dwyer-Nield L, Hickey GA, Friedman M, Choo K, McArthur DG, Tennis MA, New ML, Geraci M, Keith RL. The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model. Cancer Prev Res (Phila). 2017 Nov;10(11):671-679. PubMed PMID: 28851689
  • Tennis MA, New ML, McArthur DG, Merrick DT, Dwyer-Nield LD, Keith RL. Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31. Sci Rep. 2016 Jun 24;6:28519. PubMed PMID: 27339092
  • Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front Immunol. 2014;5:587. PubMed PMID: 25505466
  • Tennis MA, Vanscoyk MM, Wilson LA, Kelley N, Winn RA. Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer. PLoS One. 2012;7(3):e32921. PubMed PMID: 22403725
  • Tennis MA, Van Scoyk M, Freeman S, Vandervest K, Nemenoff R, Winn RA. Sprouty-4 inhibits transformed cell growth, migration and invasion, and EMT and is regulated by Wnt7A through PPAR? in NSCLC. Mol Cancer Res. 2010 Jun;8(6):833-43.
  • Tennis MA, Van Scoyk M, Winn RA. The Role of Prostacyclin in Lung Cancer. Transl Res. 2010 Feb; 155(2):57-61.
  • Tennis M, Singh B, Hjerpe A, Prochazka M, Czene K, Hall P, Shields PG. Pathological confirmation of primary lung cancer following breast cancer. Lung Cancer. 2010 Jul;69(1):40-5.
  • Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia. 2010 Mar;12(3):244-53. PubMed PMID: 20234818
  • Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA. Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Mol Cancer Res. 2010 Jun;8(6):833-43. PubMed PMID: 20501643
  • Van Scoyk M, Randall J, Sergew A, Williams LM, Tennis MA, Winn RA. Wnt signaling pathway and lung disease. Transl Res. 2008 Apr;151(4):175-80.
  • Tennis MA, Van Scoyk M. Winn RA. Role of the wnt signaling pathway and lung cancer. J Thorac Oncol. 2007 Oct;2(10):889-92.
  • Tennis M, Krishnan S, Bonner M, Ambrosone CB, Vena JE, Moysich K, Swede H, McCann S, Hall P, Shields PG, Freudenheim JL. p53 mutation analysis in breast tumors by DNA microarray. Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):80-5.
  • Prochazka M, Hall P, Gagliardi G, Granath F, Nilsson BN, Shields PG, Tennis M, Czene K. Ionizing radiation and tobacco use increases the risk of a subsequent lung carcinoma in women with breast cancer: case-only design. J Clin Oncol 2005 Oct 20;23(30):7467-74.
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Professional Memberships

  • American Thoracic Society, Member
  • American Association for Cancer Research, Member
  • International Association for the Study of Lung Cancer, Member
Public Speaking
Yes
Presentations on personalized medicine, translational lung cancer research, and lung cancer chemoprevention.

General Information

Graduate Schools:
  • PhD, Georgetown University (2006)
Undergraduate Schools:
  • BS, Gonzaga University (WA) (1997)
Department: Medicine-Pulmonary Sciences & Critical Care
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