Sally Stabler, MD
Professor, Medicine-Hematology

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Medical School:
  • MD, Baylor College of Medicine (1978)
Undergraduate School:
  • BS, Earlham College (IN) (1975)
Internship:
  • Baylor College of Medicine Program (1979)
Residency:
  • Baylor College of Medicine Program, Internal Medicine (1981)
Fellowships:
  • University of Colorado, Hematology and Oncology (1982)
  • University of Colorado, Hematology and Oncology (1984)
Languages: English
Department: Medicine-Hematology

Professional Titles

  • Former Co-Head, Division of Hematology

Recognition & Awards

  • Invited Participant and Speaker, 10th International Conference - One-Carbon Metabolism, Vitamins B and Homocysteine in Nancy, France (2015)
  • Elected to be Co-organizer, FASEB Summer Research Conference: Folic Acid, Vitamin B12 and One-Carbon Metabolism (2014)
  • Elected to be Co-organizer, FASEB Summer Research Conference: Folic Acid, Vitamin B12 and One-Carbon Metabolism (2012)

Research Interests

My research focuses on: - Anemia - Cytopenias - Chronic leukemias - Myeloproliferative diseases - Congenital bleeding disorders - Hematology - Internal medicine - Medical oncology

Publications

  • Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Mol Genet Metab. 2021 Feb;132(2):128-138. PubMed PMID: 33483253
  • Fiddler JL, Xiu Y, Blum JE, Lamarre SG, Phinney WN, Stabler SP, Brosnan ME, Brosnan JT, Thalacker-Mercer AE, Field MS. Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA. J Nutr. 2021 Oct 1;151(10):2882-2893. PubMed PMID: 34383924
  • Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. PubMed PMID: 33485059
  • Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Mol Genet Metab. 2021 Feb;132(2):128-138. PubMed PMID: 33483253
  • Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2020 Dec 8;40:101827. [Epub ahead of print] PubMed PMID: 33485059
  • Maruvada P, Stover PJ, Mason JB, Bailey RL, Davis CD, Field MS, Finnell RH, Garza C, Green R, Gueant JL, Jacques PF, Klurfeld DM, Lamers Y, MacFarlane AJ, Miller JW, Molloy AM, O'Connor DL, Pfeiffer CM, Potischman NA, Rodricks JV, Rosenberg IH, Ross SA, Shane B, Selhub J, Stabler SP, Trasler J, Yamini S, Zappalà G. Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop. Am J Clin Nutr. 2020 Nov 11;112(5):1390-1403. PubMed PMID: 33022704
  • Stabler SP. Alterations in Sulfur Amino Acids as Biomarkers of Disease. J Nutr. 2020 Oct 1;150(Suppl 1):2532S-2537S. PubMed PMID: 33000156
  • Kingsley MC, Xie HM, Chen BR, Riedel SS, Pastuer T, Bollig MK, Shank T, Libbrecht C, Stabler SP, Deshpande AJ, Intlekofer AM, Bernt KM. Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Blood Adv. 2020 Jul 14;4(13):3109-3122. PubMed PMID: 32634241
  • Lachenauer ER, Stabler SP, Field MS, Stover PJ. p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice. J Nutr. 2020 Jul 1;150(7):1705-1712. PubMed PMID: 32271909
  • Porter AC, Gumina DL, Armstrong M, Maclean KN, Reisdorph N, Galan HL, Stabler SP, Bailey BA, Hobbins JC, Hurt KJ. Maternal Amino Acid Profiles to Distinguish Constitutionally Small versus Growth-Restricted Fetuses Defined by Doppler Ultrasound: A Pilot Study. Am J Perinatol. 2020 Sep;37(11):1084-1093. PubMed PMID: 32120425
  • Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Taurine alleviates repression of betaine-homocysteine S -methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ß-synthase-deficient homocystinuria. FASEB J. 2019 May;33(5):6339-6353. PubMed PMID: 30768359
  • Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
  • Kelly CJ, Alexeev EE, Farb L, Vickery TW, Zheng L, Eric L C, Kitzenberg DA, Battista KD, Kominsky DJ, Robertson CE, Frank DN, Stabler SP, Colgan SP. Oral vitamin B(12) supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice. Gut Microbes. 2019;10(6):654-662. PubMed PMID: 31062653
  • Eyring KR, Pedersen BS, Maclean KN, Stabler SP, Yang IV, Schwartz DA. Methylene-tetrahydrofolate reductase contributes to allergic airway disease. PLoS One. 2018;13(1):e0190916. PubMed PMID: 29329322
  • Xiao S, Tang YS, Kusumanchi P, Stabler SP, Zhang Y, Antony AC. Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes. J Nutr. 2018 Mar 1;148(3):389-400. PubMed PMID: 29546304
  • Tang YS, Khan RA, Xiao S, Hansen DK, Stabler SP, Kusumanchi P, Jayaram HN, Antony AC. Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells. J Nutr. 2017 Apr;147(4):482-498. PubMed PMID: 28250194
  • Stabler SP, Freehauf C, Allen RH, Thomas J, Gallagher R. Potential Misdiagnosis of Hyperhomocysteinemia due to Cystathionine Beta-Synthase Deficiency During Pregnancy. JIMD Rep. 2017;37:55-61. PubMed PMID: 28275971
  • Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN. Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria. Mol Genet Metab. 2017 Apr;120(4):325-336. PubMed PMID: 28291718
  • Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C. Vitamin B(12) deficiency. Nat Rev Dis Primers. 2017 Jun 29;3:17040. PubMed PMID: 28660890
  • Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR. Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. FASEB J. 2017 Nov 3. [Epub ahead of print] PubMed PMID: 29101223
  • McDonald MK, Fritz JA, Jia D, Scheuchner D, Snyder FF, Stanislaus A, Curle J, Li L, Stabler SP, Allen RH, Mains PE, Gravel RA. Identification of ABC transporters acting in vitamin B(12) metabolism in Caenorhabditis elegans. Mol Genet Metab. 2017 Dec;122(4):160-171. PubMed PMID: 29153845
  • Sørensen JT, Gaustadnes M, Stabler SP, Allen RH, Mudd SH, Hvas AM. Molecular and biochemical investigations of patients with intermediate or severe hyperhomocysteinemia. Mol Genet Metab. 2016 Mar;117(3):344-50. PubMed PMID: 26750749
  • Kelly KB, Kennelly JP, Ordonez M, Nelson R, Leonard K, Stabler S, Gomez-Muñoz A, Field CJ, Jacobs RL. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats. Nutrients. 2016 Sep 23;8(10). PubMed PMID: 27669293
  • Sørensen JT, Gaustadnes M, Stabler SP, Allen RH, Mudd SH, Hvas AM. Molecular and biochemical investigations of patients with intermediate or severe hyperhomocysteinemia. Mol Genet Metab. 2015 Dec 23. [Epub ahead of print] PubMed PMID: 26750749
  • Chien YH, Abdenur JE, Baronio F, Bannick AA, Corrales F, Couce M, Donner MG, Ficicioglu C, Freehauf C, Frithiof D, Gotway G, Hirabayashi K, Hofstede F, Hoganson G, Hwu WL, James P, Kim S, Korman SH, Lachmann R, Levy H, Lindner M, Lykopoulou L, Mayatepek E, Muntau A, Okano Y, Raymond K, Rubio-Gozalbo E, Scholl-Bürgi S, Schulze A, Singh R, Stabler S, Stuy M, Thomas J, Wagner C, Wilson WG, Wortmann S, Yamamoto S, Pao M, Blom HJ. Mudd's disease (MAT I/III deficiency): a survey of data for MAT1A homozygotes and compound heterozygotes. Orphanet J Rare Dis. 2015 Aug 20;10:99. PubMed PMID: 26289392
  • Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN. Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap. Biol Open. 2015 Aug 14;4(9):1154-62. PubMed PMID: 26276101
  • Blatch SA, Stabler SP, Harrison JF. The effects of folate intake on DNA and single-carbon pathway metabolism in the fruit fly Drosophila melanogaster compared to mammals. Comp Biochem Physiol B Biochem Mol Biol. 2015 Nov;189:34-9. PubMed PMID: 26219578
  • Davenport C, Yan J, Taesuwan S, Shields K, West AA, Jiang X, Perry CA, Malysheva OV, Stabler SP, Allen RH, Caudill MA. Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites. J Nutr Biochem. 2015 Sep;26(9):903-11. PubMed PMID: 26025328
  • Bae S, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Stabler SP, Allen RH, Caudill MA. Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. J Nutr. 2015 Jul;145(7):1507-14. PubMed PMID: 25995278
  • Blom HJ, Stabler S, Wagner C. In memoriam: S. Harvey Mudd. Am J Med Genet A. 2015 May;167A(5):994-6. PubMed PMID: 25820490
  • Kurnat-Thoma EL, Pangilinan F, Matteini AM, Wong B, Pepper GA, Stabler SP, Guralnik JM, Brody LC. Association of Transcobalamin II (TCN2) and Transcobalamin II-Receptor (TCblR) Genetic Variations With Cobalamin Deficiency Parameters in Elderly Women. Biol Res Nurs. 2015 Jul;17(4):444-54. PubMed PMID: 25657319
  • Stabler SP. Anemias due to essential nutrient deficiencies. World Rev Nutr Diet. 2015;111:164-8. PubMed PMID: 25418407
  • Brito A, Chiquette J, Stabler SP, Allen RH, Girard CL. Supplementing lactating dairy cows with a vitamin B12 precursor, 5,6-dimethylbenzimidazole, increases the apparent ruminal synthesis of vitamin B12. Animal. 2015 Jan;9(1):67-75. PubMed PMID: 25171056
  • Jiang H, Stabler SP, Allen RH, Abman SH, Maclean KN. Altered hepatic sulfur metabolism in cystathionine ß-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways. FASEB J. 2014 Jun 2. [Epub ahead of print] PubMed PMID: 24891521
  • Quintana AM, Geiger EA, Achilly N, Rosenblatt DS, Maclean KN, Stabler SP, Artinger KB, Appel B, Shaikh TH. Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression. Dev Biol. 2014 Dec 1;396(1):94-106. PubMed PMID: 25281006
  • Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Brenna JT, Stabler SP, Allen RH, Gregory JF 3rd, Caudill MA. Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. Am J Clin Nutr. 2013 Dec;98(6):1459-67. PubMed PMID: 24132975
  • Joachim E, Goldenberg NA, Bernard TJ, Armstrong-Wells J, Stabler S, Manco-Johnson MJ. The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism. Thromb Res. 2013 Aug;132(2):170-4. PubMed PMID: 23866722
  • Stabler SP, Korson M, Jethva R, Allen RH, Kraus JP, Spector EB, Wagner C, Mudd SH. Metabolic profiling of total homocysteine and related compounds in hyperhomocysteinemia: utility and limitations in diagnosing the cause of puzzling thrombophilia in a family. JIMD Rep. 2013;11:149-63. PubMed PMID: 23733603
  • Abarinov EV, Beaudin AE, Field MS, Perry CA, Allen RH, Stabler SP, Stover PJ. Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. J Nutr. 2013 Jul;143(7):1028-35. PubMed PMID: 23700346
  • Delaney C, Garg SK, Fernandes C, Hoeltzel M, Allen RH, Stabler S, Yung R. Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice. PLoS One. 2013;8(2):e56253. PubMed PMID: 23437105
  • Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Green RC, Allen RH, Stabler SP, Poon LW, Georgia Centenarian. Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis. Exp Aging Res. 2013;39(2):125-44. PubMed PMID: 23421635
  • Field MS, Shields KS, Abarinov EV, Malysheva OV, Allen RH, Stabler SP, Ash JA, Strupp BJ, Stover PJ, Caudill MA. Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration. J Nutr. 2013 Jan;143(1):41-5. PubMed PMID: 23190757
  • Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013 May 23;368(21):2041-2. PubMed PMID: 23697526
  • Stabler, SP Megaloblastic Anemias, Goldman-Cecil Medicine 27th Edition chapter 150
  • Stabler, SP Megaloblastic Anemias: Disorders of Impaired DNA Synthesis, Wintrobe's Clinical Hematology , 15th Edition, chapter 37.
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Professional Memberships

  • American Federation for Clinical Research, Member
  • Western Society for Clinical Investigation, Member
  • American Society of Hematology, Member

Practice Locations

UCHealth Hematology Clinic - Anschutz Medical Campus
1665 Aurora Ct
2nd Floor, Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-0300

Hemophilia & Thrombosis Center
13199 E. Montview Blvd
Suite 100
Aurora, CO 80045
303-724-0724

UCH - Anschutz Inpatient Pavilion
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1982)
  • Medical Oncology, Board Certification (1983)
  • Hematology, Board Certification (1984)
  • Hemophilia, Other (0001)
Conditions & Treatments
  • Blood / Lymphatic System - Bleeding Disorders
  • Blood / Lymphatic System
Clinical Interests
I am interested in anemia, cytopenias, chronic leukemias, myeloproliferative diseases and congenital bleeding disorders.

Personal Interests
Dr. Stabler completed her bachelor’s degree at Earlham College, Richmond, Indiana followed by medical school at Baylor College of Medicine in Houston, Texas. She completed Internal Medicine Internship and Residency in Houston at Baylor Affiliated Hospitals and then moved to Denver for a Fellowship in Hematology and Medical Oncology. After one year as a clinical fellow she pursued three years as a research fellow partially funded by the award of an individual fellowship from the NIH. In 1984 she was appointed Instructor in Medicine, Division of Hematology and also became the Adult Hemophilia Care Coordinator for the Mountain States Regional Hemophilia and Thrombosis Program. Further promotions followed to Assistant Professor in 1986; Associate Professor with award of Tenure in 1992 and she became the Co-Division Head of Hematology in 1998, which from which she stepped down in 2013. She received the Cleo Scott and Mitchell Vincent Allen Endowed Chair in Hematology Research in 2004 and was promoted to Professor of Medicine in 2005. She has had an NIH and endowment-funded research laboratory during the last 33 years. She is the co-inventor on nine patents dealing with diagnosis and treatment of folate and vitamin B12 deficiency. She has been an invited expert and/or speaker for many national workshops and panels pertaining to folic acid and vitamin B12 nutrition policy and measurement of relevant metabolites. She is the author of more than 200 peer-reviewed manuscripts, book chapters and review articles. Most recently she published a Clinical Practice article in the New England Journal of Medicine on vitamin B12 deficiency. She plays an active role in the combined Hematology – Oncology Fellowship Program including the selection, evaluation, didactic and supervisory teaching of 10-12 fellows. She helped in the design of the first year medical student curriculum and teaches them on the pathophysiology of hematologic disorders in lectures and small group sessions. She has mentored PhD students and Post-Doc fellows in successful research collaborations resulting in numerous publications both at the University of Colorado and at other institutions. She has a long association with the Mountain States Hemophilia and Thrombosis Center and oversees the care of many of the adult hemophilia patients in a four-state region. She is a member of the Western Society of Clinical Investigation and the American Society of Hematology. She is the past chairman of the Institutional Animal Care and Use Committee for the University of Colorado, she has served on the Vice Chancellor’s Advisory Committee. She was the Chair of the Post-Tenure Review Committee for the Department of Medicine for five years.

General Information

Medical Schools:
  • MD, Baylor College of Medicine (1978)
Undergraduate Schools:
  • BS, Earlham College (IN) (1975)
Internships:
  • Baylor College of Medicine Program (1979)
Residency Programs:
  • Baylor College of Medicine Program, Internal Medicine (1981)
Fellowships:
  • University of Colorado, Hematology and Oncology (1982)
  • University of Colorado, Hematology and Oncology (1984)
Download CV
Languages: English
Department: Medicine-Hematology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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