Matthew Taylor, MD
Professor, Medicine-Cardiology

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Medical School:
  • MD, Keck School of Medicine of the University of Southern California (1995)
Graduate School :
  • PhD, University of Colorado Denver (2005)
Undergraduate School:
  • BA, University of California–Berkeley (CA) (1990)
Internship:
  • University of Colorado (University Hospital) Program (1996)
Residencies:
  • University of Colorado (University Hospital) Program, Chief Resident, Internal Medicine (1999)
  • University of Colorado (University Hospital) Program, Internal Medicine (1998)
Fellowships:
  • University of Colorado (University Hospital) Program, Clinical Genetics and Genomics (MD) (2001)
Languages: English
Department: Medicine-Cardiology

Professional Titles

  • Director, Adult Medical Genetics Program
  • Associate Director, Colorado Center for Personalized Medicine

Recognition & Awards

  • Top Doctor Nomination in Denver 5280 Magazine, 5280 Magazine (2017)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?" Included in TopDoc issue continuously since 2005

Teaching

  • Block Director, Molecules to Medicine (2007)
    School of Medicine, Medicine
  • Director, BA-BS/MD Program (2015)
    School of Medicine, Medicine

Publications

  • Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 Feb;188(2):600-605. PubMed PMID: 34652067
  • Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC Jr, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 9;16(3):519-533. PubMed PMID: 33636116
  • Oates S, Absoud M, Goyal S, Bayley S, Baulcomb J, Sims A, Riddett A, Allis K, Brasch-Andersen C, Balasubramanian M, Bai R, Callewaert B, Hüffmeier U, Le Duc D, Radtke M, Korff C, Kennedy J, Low K, Møller RS, Nielsen JEK, Popp B, Quteineh L, Rønde G, Schönewolf-Greulich B, Shillington A, Taylor MR, Todd E, Torring PM, Tümer Z, Vasileiou G, Yates TM, Zweier C, Rosch R, Basson MA, Pal DK. ZMYND11 variants are a novel cause of centrotemporal and generalised epilepsies with neurodevelopmental disorder. Clin Genet. 2021 Oct;100(4):412-429. PubMed PMID: 34216016
  • Gigli M, Stolfo D, Graw SL, Merlo M, Gregorio C, Nee Chen S, Dal Ferro M, PaldinoMD A, De Angelis G, Brun F, Jirikowic J, Salcedo EE, Turja S, Fatkin D, Johnson R, van Tintelen JP, Te Riele ASJM, Wilde AAM, Lakdawala NK, Picard K, Miani D, Muser D, Maria Severini G, Calkins H, James CA, Murray B, Tichnell C, Parikh VN, Ashley EA, Reuter C, Song J, Judge DP, McKenna WJ, Taylor MRG, Sinagra G, Mestroni L. Phenotypic Expression, Natural History, and Risk Stratification of Cardiomyopathy Caused by Filamin C Truncating Variants. Circulation. 2021 Nov 16;144(20):1600-1611. PubMed PMID: 34587765
  • Hyson P, Barahona LV, Pedraza-Arévalo LC, Schultz J, Mestroni L, da Consolação Moreira M, Taylor M, Franco-Paredes C, Benamu E, Ramanan P, Rassi A Jr, Hawkins K, Henao-Martínez AF. Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital-Clinical Features of Patients with Positive Screening Serologic Testing. Trop Med Infect Dis. 2021 May 31;6(2). PubMed PMID: 34072787
  • Hong KN, Battikha C, John S, Lin A, Bui QM, Brambatti M, Storm G, Boynton K, Medina-Hernandez D, Garcia-Alvarez A, Castel MA, Garcia-Guereta L, Diez Lopez C, Perez-Gomez L, Miani D, Symanski JD, Taylor MR, Garcia-Pavia P, Adler ED. Cardiac Transplantation in Danon Disease. J Card Fail. 2021 Nov 11. [Epub ahead of print] PubMed PMID: 34775111
  • Fraley C, Milgrom SA, Kondapalli L, Taylor MRG, Mestroni L, Miyamoto SD. Mechanisms and Insights for the Development of Heart Failure Associated with Cancer Therapy. Children (Basel). 2021 Sep 21;8(9). PubMed PMID: 34572260
  • Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial. Nat Med. 2021 Oct;27(10):1818-1824. PubMed PMID: 34556856
  • Lachaize V, Peña B, Ciubotaru C, Cojoc D, Chen SN, Taylor MRG, Mestroni L, Sbaizero O. Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation. Int J Mol Sci. 2021 Aug 25;22(17). PubMed PMID: 34502098
  • Eldemire R, Tharp CA, Taylor MRG, Sbaizero O, Mestroni L. The Sarcomeric Spring Protein Titin: Biophysical Properties, Molecular Mechanisms, and Genetic Mutations Associated with Heart Failure and Cardiomyopathy. Curr Cardiol Rep. 2021 Jul 16;23(9):121. PubMed PMID: 34269900
  • Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, Köttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O'Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S... Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299. PubMed PMID: 33568819
  • Keramati AR, Chen MH, Rodriguez BAT, Yanek LR, Bhan A, Gaynor BJ, Ryan K, Brody JA, Zhong X, Wei Q, Kammers K, Kanchan K, Iyer K, Kowalski MH, Pitsillides AN, Cupples LA, Li B, Schlaeger TM, Shuldiner AR, O'Connell JR, Ruczinski I, Mitchell BD, Faraday N, Taub MA, Becker LC, Lewis JP, Mathias RA, Johnson AD. Genome sequencing unveils a regulatory landscape of platelet reactivity. Nat Commun. 2021 Jun 15;12(1):3626. PubMed PMID: 34131117
  • Chen SN, Mestroni L, Taylor MRG. Genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2021 May 1;36(3):288-294. PubMed PMID: 33769382
  • Sofer T, Zheng X, Laurie CA, Gogarten SM, Brody JA, Conomos MP, Bis JC, Thornton TA, Szpiro A, O'Connell JR, Lange EM, Gao Y, Cupples LA, Psaty BM, Rice KM. Variant-specific inflation factors for assessing population stratification at the phenotypic variance level. Nat Commun. 2021 Jun 9;12(1):3506. PubMed PMID: 34108454
  • Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Peña B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 Oct 8;6(19). PubMed PMID: 34383712
  • Jenkins BD, Fischer CG, Polito CA, Maiese DR, Keehn AS, Lyon M, Edick MJ, Taylor MRG, Andersson HC, Bodurtha JN, Blitzer MG, Muenke M, Watson MS. The 2019 US medical genetics workforce: a focus on clinical genetics. Genet Med. 2021 Aug;23(8):1458-1464. PubMed PMID: 33941882
  • Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R 3rd, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 Apr 21;13(1):66. PubMed PMID: 33883027
  • Luo Y, Kanai M, Choi W, Li X, Sakaue S, Yamamoto K, Ogawa K, Gutierrez-Arcelus M, Gregersen PK, Stuart PE, Elder JT, Forer L, Schönherr S, Fuchsberger C, Smith AV, Fellay J, Carrington M, Haas DW, Guo X, Palmer ND, Chen YI, Rotter JI, Taylor KD, Rich SS, Correa A, Wilson JG, Kathiresan S, Cho MH, Metspalu A, Esko T, Okada Y, Han B, McLaren PJ, Raychaudhuri S. A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet. 2021 Oct;53(10):1504-1516. PubMed PMID: 34611364
  • Zanetti M, Chen SN, Conti M, Taylor MRG, Sbaizero O, Mestroni L, Lazzarino M. Microfabricated cantilevers for parallelized cell-cell adhesion measurements. Eur Biophys J. 2021 Jul 25. [Epub ahead of print] PubMed PMID: 34304293
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Jan 18;139:124-134. [Epub ahead of print] PubMed PMID: 31958463
  • Brun F, Gigli M, Graw SL, Judge DP, Merlo M, Murray B, Calkins H, Sinagra G, Taylor MR, Mestroni L, James CA. FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2020 Jan 10. [Epub ahead of print] PubMed PMID: 31924696
  • Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Baseline Characteristics of the VANISH Cohort. Circ Heart Fail. 2019 Dec;12(12):e006231. PubMed PMID: 31813281
  • Hershberger RE, Givertz MM, Ho CY, Judge DP, Kantor PF, McBride KL, Morales A, Taylor MRG, Vatta M, Ware SM. Correction: Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2019 Oct;21(10):2406-2409. PubMed PMID: 31040388
  • Gigli M, Merlo M, Graw SL, Barbati G, Rowland TJ, Slavov DB, Stolfo D, Haywood ME, Dal Ferro M, Altinier A, Ramani F, Brun F, Cocciolo A, Puggia I, Morea G, McKenna WJ, La Rosa FG, Taylor MRG, Sinagra G, Mestroni L. Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2019 Sep 17;74(11):1480-1490. PubMed PMID: 31514951
  • Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 Sep 11;11(509). PubMed PMID: 31511425
  • Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019 Jul 2;129(8):3171-3184. PubMed PMID: 31264976
  • Addison J, Taylor MRG, Mestroni L. Genotype-phenotype correlations in ARVC: Toward a precision medicine approach. Int J Cardiol. 2019 Jul 1;286:115-116. PubMed PMID: 30898427
  • Brambatti M, Caspi O, Maolo A, Koshi E, Greenberg B, Taylor MRG, Adler ED. Danon disease: Gender differences in presentation and outcomes. Int J Cardiol. 2019 Jul 1;286:92-98. PubMed PMID: 30857840
  • Schwartz GG, Taylor MRG. PCSK9 Function and Cardiovascular Death: The Knot Tightens. J Am Coll Cardiol. 2019 Jun 25;73(24):3115-3117. PubMed PMID: 31221260
  • Saben JL, Shelton SK, Hopkinson AJ, Sonn BJ, Mills EB, Welham M, Westmoreland M, Zane R, Ginde AA, Bookman K, Oeth J, Chavez M, DeVivo M, Lakin A, Heldens J, Romero LB, Ames MJ, Roberts ER, Taylor M, Crooks K, Wicks SJ, Barnes KC, Monte AA. The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care. Acad Emerg Med. 2019 Jun;26(6):639-647. PubMed PMID: 30239069
  • Ahmad F, McNally EM, Ackerman MJ, Baty LC, Day SM, Kullo IJ, Madueme PC, Maron MS, Martinez MW, Salberg L, Taylor MR, Wilcox JE. Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting Standards: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2019 Jun;12(6):e000054. PubMed PMID: 31117808
  • Peña B, Maldonado M, Bonham AJ, Aguado BA, Dominguez-Alfaro A, Laughter M, Rowland TJ, Bardill J, Farnsworth NL, Alegret Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications. ACS Appl Mater Interfaces. 2019 May 22;11(20):18671-18680. PubMed PMID: 31021594
  • Cheedipudi SM, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet M, Taylor M, Mestroni L, Cleveland J, Willerson JT, Gurha P, Marian AJ. Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 Apr 12;124(8):1198-1213. PubMed PMID: 30739589
  • Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
  • Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 Mar 15;124(6):856-873. PubMed PMID: 30696354
  • Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T, Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E. Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Circ Heart Fail. 2019 Mar;12(3):e005371. PubMed PMID: 30871351
  • Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K. LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. PubMed PMID: 30584088
  • Hershberger RE, Givertz MM, Ho CY, Judge DP, Kantor PF, McBride KL, Morales A, Taylor MRG, Vatta M, Ware SM. Genetic Evaluation of Cardiomyopathy-A Heart Failure Society of America Practice Guideline. J Card Fail. 2018 May;24(5):281-302. PubMed PMID: 29567486
  • Chen SN, Taylor MRG, Mestroni L. Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Genom Precis Med. 2018 Mar;11(3):e002088. PubMed PMID: 29545481
  • Hershberger RE, Givertz MM, Ho CY, Judge DP, Kantor PF, McBride KL, Morales A, Taylor MRG, Vatta M, Ware SM. Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2018 Sep;20(9):899-909. PubMed PMID: 29904160
  • Saben JL, Shelton SK, Hopkinson AJ, Sonn BJ, Mills EB, Welham M, Westmoreland M, Zane R, Ginde AA, Bookman K, Oeth J, Chavez M, DeVivo M, Lakin A, Heldens J, Romero LB, Ames MJ, Roberts ER, Taylor M, Crooks K, Wicks SJ, Barnes KC, Monte AA. The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care. Acad Emerg Med. 2018 Sep 21. [Epub ahead of print] PubMed PMID: 30239069
  • Sweet ME, Mestroni L, Taylor MRG. Genetic Infiltrative Cardiomyopathies. Heart Fail Clin. 2018 Apr;14(2):215-224. PubMed PMID: 29525649
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NH. Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. G3 (Bethesda). 2018 Jul 31;8(8):2663-2672. PubMed PMID: 29930198
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Peña B, Laughter M, Jett S, Rowland TJ, Taylor MRG, Mestroni L, Park D. Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci. 2018 Jun;18(6):e1800079. PubMed PMID: 29733514
  • Coors ME, Westfall N, Zittleman L, Taylor M, Westfall JM. Translating Biobank Science into Patient-Centered Language. Biopreserv Biobank. 2018 Feb;16(1):59-63. PubMed PMID: 29190122
  • Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 May 1;114(6):846-857. PubMed PMID: 29432544
  • Friesen RH, Slavov D, Miyamoto SD, John Ing R, LaRiviere WB, Taylor MRG. Lack of Association Between Adrenoreceptor Genotype and the Vasoconstriction Response to Dexmedetomidine. Semin Cardiothorac Vasc Anesth. 2017 Dec;21(4):341-344. PubMed PMID: 28482761
  • Chen SN, Taylor MRG, Mestroni L. Unraveling Missing Genes and Missing Inheritance in Arrhythmogenic Cardiomyopathy. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). PubMed PMID: 29038109
  • D'souza RS, Mestroni L, Taylor MRG. Danon disease for the cardiologist: case report and review of the literature. J Community Hosp Intern Med Perspect. 2017 Mar;7(2):107-114. PubMed PMID: 28638575
  • Peña B, Bosi S, Aguado BA, Borin D, Farnsworth NL, Dobrinskikh E, Rowland TJ, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31645-31656. PubMed PMID: 28895403
  • D'Souza RS, Slavov D, Graw S, Jirikowic J, Todd E, Rogers RK, Taylor MR. Clinical and genetic characterization of adult patients presenting with non-syndromic vascular aneurysms and dissections. Int Angiol. 2017 Oct;36(5):417-427. PubMed PMID: 28139901
  • Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
  • Ho JE, Shi L, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy A, Taylor M, Mestroni L, Cirino AL, Sleeper LA, Jarolim P, Lopez B, Gonzalez A, Diez J, Orav EJ, Ho CY. Biomarkers of cardiovascular stress and fibrosis in preclinical hypertrophic cardiomyopathy. Open Heart. 2017;4(2):e000615. PubMed PMID: 29177058
  • Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ. The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study. JAMA Cardiol. 2017 Apr 1;2(4):419-428. PubMed PMID: 28241245
  • Rowland TJ, Graw SL, Sweet ME, Gigli M, Taylor MR, Mestroni L. Obscurin Variants in Patients With Left Ventricular Noncompaction. J Am Coll Cardiol. 2016 Nov 15;68(20):2237-2238. PubMed PMID: 27855815
  • Bovet C, Carlson M, Taylor M. Quality of life, unmet needs, and iatrogenic injuries in rehabilitation of patients with Ehlers-Danlos Syndrome hypermobility type/Joint Hypermobility Syndrome. Am J Med Genet A. 2016 Aug;170(8):2044-51. PubMed PMID: 27273746
  • Porto AG, Brun F, Severini GM, Losurdo P, Fabris E, Taylor MR, Mestroni L, Sinagra G. Clinical Spectrum of PRKAG2 Syndrome. Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003121. PubMed PMID: 26729852
  • Begay RL, Tharp CA, Martin A, Graw SL, Sinagra G, Miani D, Sweet ME, Slavov DB, Stafford N, Zeller MJ, Alnefaie R, Rowland TJ, Brun F, Jones KL, Gowan K, Mestroni L, Garrity DM, Taylor MR. FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. JACC Basic Transl Sci. 2016 Aug;1(5):344-359. PubMed PMID: 28008423
  • Mestroni L, Sweet ME, Taylor MR. Pediatric Cardiomyopathy: New Insight Into Potential Disease Mechanisms. J Am Coll Cardiol. 2016 Feb 9;67(5):526-8. PubMed PMID: 26846951
  • Peña B, Martinelli V, Jeong M, Bosi S, Lapasin R, Taylor MR, Long CS, Shandas R, Park D, Mestroni L. Biomimetic Polymers for Cardiac Tissue Engineering. Biomacromolecules. 2016 May 9;17(5):1593-601. PubMed PMID: 27073119
  • Rowland TJ, Sweet ME, Mestroni L, Taylor MR. Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathy. J Cell Sci. 2016 Jun 1;129(11):2135-43. PubMed PMID: 27165304
  • Lanzicher T, Martinelli V, Puzzi L, Del Favero G, Codan B, Long CS, Mestroni L, Taylor MR, Sbaizero O. The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Sci Rep. 2015 Sep 1;5:13388. PubMed PMID: 26323789
  • Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus. 2015 Aug 26;:0. [Epub ahead of print] PubMed PMID: 26309016
  • Hopkin RJ, Jefferies JL, Laney DA, Lawson VH, Mauer M, Taylor MR, Wilcox WR. The management and treatment of children with Fabry disease: A United States-based perspective. Mol Genet Metab. 2015 Oct 23. [Epub ahead of print] PubMed PMID: 26546059
  • Schiffmann R, Forni S, Swift C, Brignol N, Wu X, Lockhart DJ, Blankenship D, Wang X, Grayburn PA, Taylor MR, Lowes BD, Fuller M, Benjamin ER, Sweetman L. Risk of death in heart disease is associated with elevated urinary globotriaosylceramide. J Am Heart Assoc. 2014 Feb 4;3(1):e000394. PubMed PMID: 24496231
  • Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. Functional Prostacyclin Synthase Promoter Polymorphisms: Impact in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2014 Mar 7. [Epub ahead of print] PubMed PMID: 24605778
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy. J Cell Physiol. 2014 Mar 13. [Epub ahead of print] PubMed PMID: 24623017
  • Salian-Mehta S, Xu M, Knox A, Plummer L, Slavov D, Taylor M, Bevers S, Hodges R, Crowley W Jr, Wierman M. Functional Consequences of AXL Sequence Variants in Idiopathic Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. 2014 Jan 29;:jc20133426. [Epub ahead of print] PubMed PMID: 24476074
  • Schiffmann R, Forni S, Swift C, Brignol N, Wu X, Lockhart DJ, Blankenship D, Wang X, Grayburn PA, Taylor MR, Lowes BD, Fuller M, Benjamin ER, Sweetman L. Risk of death in heart disease is associated with elevated urinary globotriaosylceramide. J Am Heart Assoc. 2014 Feb 4;3(1):e000394. PubMed PMID: 24496231
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol. 2014 Nov;229(11):1697-702. PubMed PMID: 24623017
  • Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF Jr, Wierman ME. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Apr;99(4):1452-60. PubMed PMID: 24476074
  • Mestroni L, Begay RL, Graw SL, Taylor MR. Pharmacogenetics of heart failure. Curr Opin Cardiol. 2014 May;29(3):227-34. PubMed PMID: 24717669
  • Davern MS, Sandsmark E, Schwan J, Ayres L, Mehner L, Gilmer R, Odom J, Guiton G, Taylor M. Mobile learning: students' novel approach to practice problems. Med Educ. 2014 Nov;48(11):1106-7. PubMed PMID: 25307642
  • Brun F, Barnes CV, Sinagra G, Slavov D, Barbati G, Zhu X, Graw SL, Spezzacatene A, Pinamonti B, Merlo M, Salcedo EE, Sauer WH, Taylor MR, Mestroni L, Familial Cardiomyopathy Registry. Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2014 Oct;51(10):669-76. PubMed PMID: 25157032
  • Baschal EE, Wethey CI, Swindle K, Baschal RM, Gowan K, Tang NL, Alvarado DM, Haller GE, Dobbs MB, Taylor MR, Gurnett CA, Jones KL, Miller NH. Exome Sequencing Identifies a Rare HSPG2 Variant Associated with Familial Idiopathic Scoliosis. G3 (Bethesda). 2014 Dec 12;5(2):167-74. PubMed PMID: 25504735
  • D'souza RS, Levandowski C, Slavov D, Graw SL, Allen LA, Adler E, Mestroni L, Taylor MR. Danon disease: clinical features, evaluation, and management. Circ Heart Fail. 2014 Sep;7(5):843-9. PubMed PMID: 25228319
  • Taylor MR, Sun AY, Davis G, Fiuzat M, Liggett SB, Bristow MR. Race, common genetic variation, and therapeutic response disparities in heart failure. JACC Heart Fail. 2014 Dec;2(6):561-72. PubMed PMID: 25443111
  • Enduri S, Taylor MR, Liewluck T. Clinical reasoning: a 52-year-old woman with progressive proximal weakness. Neurology. 2014 Sep 2;83(10):e106-9. PubMed PMID: 25180003
  • Baschal EE, Wethey CI, Swindle K, Baschal RM, Gowan K, Tang NL, Alvarado DM, Haller GE, Dobbs MB, Taylor MR, Gurnett CA, Jones KL, Miller NH. Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis. G3 (Bethesda). 2014 Dec 12;5(2):167-74. PubMed PMID: 25504735
  • Merlo M, Sinagra G, Carniel E, Slavov D, Zhu X, Barbati G, Spezzacatene A, Ramani F, Salcedo E, Di Lenarda A, Mestroni L, Taylor MR, Familial Cardiomyopathy Registry. Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy. Clin Transl Sci. 2013 Dec;6(6):424-8. PubMed PMID: 24119082
  • Campbell N, Sinagra G, Jones KL, Slavov D, Gowan K, Merlo M, Carniel E, Fain PR, Aragona P, Di Lenarda A, Mestroni L, Taylor MR. Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy. PLoS One. 2013;8(10):e78104. PubMed PMID: 24205113
  • Mestroni L, Taylor MR. Genetics and genetic testing of dilated cardiomyopathy: a new perspective. Discov Med. 2013 Jan;15(80):43-9. PubMed PMID: 23375013
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Adult Genetics Clinic - Anschutz Medical Campus
12605 E. 16th Ave
3rd floor
Aurora, CO 80045
720-848-0782

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1998, 2018)
  • Clinical Genetics and Genomics (MD), Board Certification (2003, 2013)
Conditions & Treatments
  • Genetic Conditions and Testing
  • Heart and Circulation - Hypertrophic Cardiomyopathy
  • Heart and Circulation
Clinical Interests
Genetic Conditions Affecting Adults (Genetic Diagnosis, Management of Genetic Conditions, Genetic Counseling), Genetic Cardiovascular Diseases, Lysosomal Storage Diseases, Precision Medicine, Pharmacogenetics

Public Speaking
Yes
Medical Genetics, Cardiovascular Genetics, Precision Medicine, Medical Education, Pharmacogenetics

General Information

Medical Schools:
  • MD, Keck School of Medicine of the University of Southern California (1995)
Graduate Schools:
  • PhD, University of Colorado Denver (2005)
Undergraduate Schools:
  • BA, University of California–Berkeley (CA) (1990)
Internships:
  • University of Colorado (University Hospital) Program (1996)
Residency Programs:
  • University of Colorado (University Hospital) Program, Chief Resident, Internal Medicine (1999)
  • University of Colorado (University Hospital) Program, Internal Medicine (1998)
Fellowships:
  • University of Colorado (University Hospital) Program, Clinical Genetics and Genomics (MD) (2001)
Languages: English
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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