Paul Rozance, MD
Professor, Pediatrics-Neonatology

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Medical School:
  • MD, Georgetown University School of Medicine (1998)
Undergraduate School:
  • BA, University of California–Berkeley (CA) (1994)
Internship:
  • Stanford University Program (1999)
Residency:
  • Stanford University Program, Pediatrics (2001)
Fellowships:
  • University of Colorado, Neonatal-Perinatal Medicine (2004)
Languages: English
Department: Pediatrics-Neonatology

Recognition & Awards

  • Recognized as one of the best UpToDate authors, “Pathogenesis, Screening, and Diagnosis of Neonatal Hypoglycemia” and “Management and Outcome of Neonatal Hypoglycemia.”, (2016)
  • Hypoglycemia Awareness Award, Congenital Hyperinsulinism International, (2015)
  • President, Western Society for Pediatric Research, WSPR, (2015)
  • Young Investigator Research Award, Western Society for Pediatric Research, (2011)
  • Rising Investigator, Perinatal Research Society, (2008)
  • President’s Award for Working Together , University of Colorado Health Sciences Center, (2007)
  • Outstanding Clinical Research Training Program Student Award, University of Colorado Health Sciences Center, (2004)
  • Pediatric Loan Repayment Award, National Institutes of Health, (2003)
  • Faustino R. Suarez Award, Georgetown University School of Medicine, (1998)
  • William H. Homer Award, Georgetown University School of Medicine, (1998)
  • Oscar Bentwood Hunter Award , Georgetown University School of Medicine, (1998)
  • Association of Pathology Chairs Honor Society, Georgetown University School of Medicine, (1996)
  • American Society of Clinical Pathologists Award for Academic Excellence and Achievement, Georgetown University School of Medicine, (1996)
  • Dean’s Academic Honor Roll, University of California at Berkeley, (1994)

Teaching

  • Faculty Member Training Grant in Perinatal Medicine and Biology (2004)
    School of Medicine, Pediatrics
  • Assistant Professor (2004)
    School of Medicine, Pediatrics
    Division of Neonatology
  • Associate Professor (2011)
    School of Medicine, Pediatrics

Publications

  • Hernandez TL, Hay WW Jr, Rozance PJ. Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. [Epub ahead of print] PubMed PMID: 30425111
  • Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30205012
  • White A, Louey S, Chang EI, Boehmer BH, Goldstrohm D, Jonker SS, Rozance PJ. A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep. Physiol Rep. 2018 Sep;6(17):e13840. PubMed PMID: 30175552
  • Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
  • Kaiser JR, Bai S, Rozance PJ. Reply to the Letter to the Editor "The Postnatal Glucose Concentration Nadir Is Not Abnormal and Does Not Need to Be Treated". Neonatology. 2018;114(2):164. PubMed PMID: 29894996
  • Hay WW Jr, Rozance PJ. Neonatal Hyperglycemia-Causes, Treatments, and Cautions. J Pediatr. 2018 Sep;200:6-8. PubMed PMID: 29753545
  • Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. PubMed PMID: 29722560
  • Kaiser JR, Bai S, Rozance PJ. Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group. Neonatology. 2018;113(4):353-359. PubMed PMID: 29510404
  • Beune IM, Bloomfield FH, Ganzevoort W, Embleton ND, Rozance PJ, van Wassenaer-Leemhuis AG, Wynia K, Gordijn SJ. Consensus Based Definition of Growth Restriction in the Newborn. J Pediatr. 2018 May;196:71-76.e1. PubMed PMID: 29499988
  • Bourque SL, Rozance PJ, Hay WW. 50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy. J Pediatr. 2017 Oct;189:53. PubMed PMID: 28947056
  • Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
  • Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
  • Boehmer BH, Limesand SW, Rozance PJ. The impact of IUGR on pancreatic islet development and ß-cell function. J Endocrinol. 2017 Nov;235(2):R63-R76. PubMed PMID: 28808079
  • Bourque SL, Rozance PJ. Does dextrose gel prevent treatment failure in infants with neonatal hypoglycaemia?. Acta Paediatr. 2017 Jul;106(7):1201. PubMed PMID: 28220533
  • Limesand SW, Rozance PJ. Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. J Physiol. 2017 Aug 1;595(15):5103-5113. PubMed PMID: 28194805
  • Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. PubMed PMID: 28179229
  • Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. PubMed PMID: 28100476
  • Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy C, Garza NG, Hay W, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Jan 4. [Epub ahead of print] PubMed PMID: 28053000
  • Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct;157(10):3788-3799. PubMed PMID: 27501184
  • Kamath-Rayne BD, Rozance PJ, Goldenberg RL, Jobe AH. Antenatal corticosteroids beyond 34 weeks gestation: What do we do now?. Am J Obstet Gynecol. 2016 Oct;215(4):423-30. PubMed PMID: 27342043
  • Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. PubMed PMID: 27170658
  • Rozance PJ, Hay WW Jr. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016 May 10;2:3. PubMed PMID: 27168942
  • Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun;157(6):2447-60. PubMed PMID: 27049667
  • Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug;105(8):881-9. PubMed PMID: 27028695
  • Rozance PJ. 50 Years Ago in The Journal of Pediatrics: Perinatal Stress and the Premature Neonate. II. Effect of Fluid and Calorie Deprivation on Blood Glucose. J Pediatr. 2016 Mar;170:89. PubMed PMID: 26922762
  • Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW Jr. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 Apr;241(8):839-47. PubMed PMID: 26873920
  • Rozance PJ, Hay WW Jr. Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses. Mol Cell Endocrinol. 2016 Nov 5;435:78-84. PubMed PMID: 26820125
  • Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar;170:10-2. PubMed PMID: 26746122
  • Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
  • Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. PubMed PMID: 26224688
  • Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children. J Pediatr. 2015 Aug;167(2):238-45. PubMed PMID: 25957977
  • Stanley CA, Rozance PJ, Thornton PS, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management. J Pediatr. 2015 Jun;166(6):1520-5.e1. PubMed PMID: 25819173
  • Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
  • Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
  • Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. Diabetes. 2014 Sep 23. [Epub ahead of print] PubMed PMID: 25249573
  • Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
  • Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
  • Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. Diabetes. 2014 Sep 23. [Epub ahead of print] PubMed PMID: 25249573
  • Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
  • Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. Diabetes. 2014 Sep 23. [Epub ahead of print] PubMed PMID: 25249573
  • Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
  • Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
  • Houin S, Rozance PJ. 50 years ago in the Journal of pediatrics: The incidence of neonatal hypoglycemia in a nursery for premature infants. J Pediatr. 2014 Jun;164(6):1485. PubMed PMID: 24855928
  • Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL. Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted (IUGR) fetal sheep. Am J Physiol Heart Circ Physiol. 2013 Dec 6. [Epub ahead of print] PubMed PMID: 24322609
  • Rozance PJ. Update on neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):45-50. PubMed PMID: 24275620
  • Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
  • Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
  • Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL. Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted (IUGR) fetal sheep. Am J Physiol Heart Circ Physiol. 2013 Dec 6. [Epub ahead of print] PubMed PMID: 24322609
  • Dodson RB, Rozance PJ, Reina-Romo E, Ferguson VL, Hunter KS. Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus. J Biomech. 2013 Mar 15;46(5):956-63. PubMed PMID: 23332229
  • Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW Jr. Reductions in Insulin Concentrations and ß-Cell Mass Precede Growth Restriction in Sheep Fetuses with Placental Insufficiency. Am J Physiol Endocrinol Metab. 2012 Dec 31. [Epub ahead of print] PubMed PMID: 23277186
  • Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
  • Dodson RB, Rozance PJ, Fleenor BS, Petrash CC, Shoemaker LG, Hunter KS, Ferguson VL. Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep. Pediatr Res. 2012 Nov 15. [Epub ahead of print] PubMed PMID: 23154756
  • Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
  • Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
  • Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW Jr. Reductions in Insulin Concentrations and ß-Cell Mass Precede Growth Restriction in Sheep Fetuses with Placental Insufficiency. Am J Physiol Endocrinol Metab. 2012 Dec 31. [Epub ahead of print] PubMed PMID: 23277186
  • Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
  • Dodson RB, Rozance PJ, Fleenor BS, Petrash CC, Shoemaker LG, Hunter KS, Ferguson VL. Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep. Pediatr Res. 2012 Nov 15. [Epub ahead of print] PubMed PMID: 23154756
  • Frost MS, Zehri AH, Limesand SW, Hay WW Jr, Rozance PJ. Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic ß-Cells. J Pregnancy. 2012;2012:812094. PubMed PMID: 23133755
  • Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. PubMed PMID: 22933022
  • Rozance PJ, Hay WW Jr. Neonatal hypoglycemia--answers, but more questions. J Pediatr. 2012 Nov;161(5):775-6. PubMed PMID: 22809663
  • Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
  • Chen X, Rozance PJ, Hay WW Jr, Limesand SW. Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas. Exp Biol Med (Maywood). 2012 May 1;237(5):524-9. PubMed PMID: 22581814
  • Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1483-92. PubMed PMID: 22454287
  • Delaney CA, Rozance PJ, Sandoval JA, Bealer JF, Kinsella JP. Late onset diaphragmatic hernia complicated by intestinal strangulation. Curr Opin Pediatr. 2012 Apr;24(2):274-6. PubMed PMID: 22327952
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Professional Memberships

  • Alpha Omega Alpha, Member
  • Western Society for Pediatric Research (WSPR), Member
  • American Academy of Pediatrics (AAP), Fellow
  • American Diabetes Association, Professional Member
  • Society For Pediatric Research (SPR), Member
  • Perinatal Research Society (PRS), Member
  • American Physiological Society, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Ultrasound/Prenatal Diagnosis/Genetics - Anschutz
1635 Aurora Ct
3rd Floor
Aurora, CO 80045
720-848-0011

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Pediatrics, Board Certification (2001)
  • Neonatal-Perinatal Medicine, Board Certification (2005)
Conditions & Treatments
  • Pregnancy and Reproduction - Neonatal Intensive Care
  • Pregnancy and Reproduction - Maternal and Fetal Health
  • Pregnancy and Reproduction - High-Risk Pregnancy
  • Pregnancy and Reproduction
Clinical Interest for Patients
I am interested in neonatal hypoglycemia and intrauterine growth restriction.

General Information

Medical Schools:
  • MD, Georgetown University School of Medicine (1998)
Undergraduate Schools:
  • BA, University of California–Berkeley (CA) (1994)
Internships:
  • Stanford University Program (1999)
Residency Programs:
  • Stanford University Program, Pediatrics (2001)
Fellowships:
  • University of Colorado, Neonatal-Perinatal Medicine (2004)
Download CV
Languages: English
Department: Pediatrics-Neonatology
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