Adriana Weinberg, MD
Professor, Pediatrics-Infectious Diseases

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Medical School:
  • MD, University of Sao Paulo (1980)
Internship:
  • University of Sao Paulo (1981)
Residency:
  • University of Sao Paulo, Infectious Disease (1984)
Fellowships:
  • Stanford University Program, Infectious Disease (1987)
Languages: English
Department: Pediatrics-Infectious Diseases

Professional Titles

  • Professor, Pediatrics-Infectious Diseases
  • Medical Director, Clinical Molecular and Virology Laboratory, University of Colorado Hospital

Recognition & Awards

  • Constance B. Wofsy Women’s Health Investigator Award, AIDS Clinical Trial Group (ACTG), (2016)
    Recognition of Scientific Contributions to Research in HIV-Infected Women and Embodiment of Qualities Exemplified by Dr. Wofsy
  • IDSA fellow (FIDSA), Infectious Disease Society of America, (2007)

Teaching

  • Professor (1990)
    School of Medicine, Pediatrics
    Infectious Diseases-- Immune defenses Viral Infections Immune compromised hosts Vaccines
  • Professor (1990)
    School of Medicine, Medicine
    Infectious Diseases
  • Professor (1990)
    School of Medicine, Pathology
    Clinical Molecular and Virology Pathology

Publications

  • Levin MJ, Cai GY, Lee KS, Rouphael NG, Mehta AK, Canniff J, Mulligan MJ, Weinberg A. Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine. J Infect Dis. 2018 Mar 13;217(7):1055-1059. PubMed PMID: 29409017
  • Levin MJ, Kroehl ME, Johnson MJ, Hammes A, Reinhold D, Lang N, Weinberg A. Th1 memory differentiates recombinant from live herpes zoster vaccines. J Clin Invest. 2018 Oct 1;128(10):4429-4440. PubMed PMID: 30024861
  • Koay WLA, Lindsey JC, Uprety P, Bwakura-Dangarembizi M, Weinberg A, Levin MJ, Persaud D. Intestinal Integrity Biomarkers in Early Antiretroviral-Treated Perinatally HIV-1-Infected Infants. J Infect Dis. 2018 Aug 24;218(7):1085-1089. PubMed PMID: 29762690
  • Weinberg A, Popmihajlov Z, Schmader KE, Johnson MJ, Caldas Y, Salazar AT, Canniff J, McCarson BJ, Martin J, Pang L, Levin MJ. Persistence of varicella-zoster virus cell-mediated immunity after the administration of a second dose of live herpes zoster vaccine. J Infect Dis. 2018 Aug 28. [Epub ahead of print] PubMed PMID: 30165651
  • Hawkins KL, Gordon KS, Levin MJ, Weinberg A, Battaglia C, Rodriguez-Barradas MC, Brown ST, Rimland D, Justice A, Tate J, Erlandson KM. Herpes Zoster and Herpes Zoster Vaccine Rates Among Adults Living With and Without HIV in the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr. 2018 Dec 1;79(4):527-533. PubMed PMID: 30179984
  • Levin MJ, Huang S, Moscicki AB, Song LY, Read JS, Meyer WA, Saah AJ, Richardson K, Weinberg A. Four-year persistence of type-specific immunity after quadrivalent human papillomavirus vaccination in HIV-infected children: Effect of a fourth dose of vaccine. Vaccine. 2017 Mar 23;35(13):1712-1720. PubMed PMID: 28238631
  • Wagner TA, Huang HC, Salyer CE, Richardson KM, Weinberg A, Nachman S, Frenkel LM. H1N1 influenza vaccination in HIV-infected women on effective antiretroviral treatment did not induce measurable antigen-driven proliferation of the HIV-1 proviral reservoir. AIDS Res Ther. 2017 Feb 13;14(1):7. PubMed PMID: 28193244
  • Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, Mehta AK, Whitaker JA, Subramaniam S, Jones DP, Sette A, Vora K, Weinberg A, Mulligan MJ, Nakaya HI, Levin M, Ahmed R, Pulendran B. Metabolic Phenotypes of Response to Vaccination in Humans. Cell. 2017 May 18;169(5):862-877.e17. PubMed PMID: 28502771
  • Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017;8:470. PubMed PMID: 28484464
  • Currier JS, Britto P, Hoffman RM, Brummel S, Masheto G, Joao E, Santos B, Aurpibul L, Losso M, Pierre MF, Weinberg A, Gnanashanmugam D, Chakhtoura N, Klingman K, Browning R, Coletti A, Mofenson L, Shapiro D, Pilotto J. Randomized trial of stopping or continuing ART among postpartum women with pre-ART CD4 = 400 cells/mm3. PLoS One. 2017;12(5):e0176009. PubMed PMID: 28489856
  • Madhi SA, Nunes MC, Weinberg A, Kuwanda L, Hugo A, Jones S, van Niekerk N, Ortiz JR, Neuzil KM, Klugman KP, Simões EAF, Cutland CL. Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials. Clin Infect Dis. 2017 Jun 15;64(12):1773-1779. PubMed PMID: 28369198
  • Weinberg A, Canniff J, Rouphael N, Mehta A, Mulligan M, Whitaker JA, Levin MJ. Varicella-Zoster Virus-Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults. J Immunol. 2017 Jul 15;199(2):604-612. PubMed PMID: 28607114
  • Tovar-Salazar A, Weinberg A. Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity. PLoS One. 2017;12(7):e0180691. PubMed PMID: 28683106
  • Uprety P, Lindsey JC, Levin MJ, Rainwater-Lovett K, Ziemniak C, Bwakura-Dangarembizix M, Kaplan SS, Nelson M, Zadzilka A, Weinberg A, Persaud D. Inflammation and Immune Activation in Antiretroviral-Treated Human Immunodeficiency Virus Type 1-Infected African Infants and Rotavirus Vaccine Responses. J Infect Dis. 2017 Mar 15;215(6):928-932. PubMed PMID: 28453843
  • Nunes MC, Cutland CL, Jones S, Downs S, Weinberg A, Ortiz JR, Neuzil KM, Simões EAF, Klugman KP, Madhi SA. Efficacy of maternal influenza vaccination against all-cause lower respiratory tract infection hospitalizations in young infants: Results from a randomized controlled trial. Clin Infect Dis. 2017 May 29. [Epub ahead of print] PubMed PMID: 28575286
  • Levin MJ, Bresnitz E, Popmihajlov Z, Weinberg A, Liaw KL, Willis E, Curtis JR. Studies with herpes zoster vaccines in immune compromised patients. Expert Rev Vaccines. 2017 Dec;16(12):1217-1230. PubMed PMID: 29053937
  • Levin MJ, Lindsey JC, Kaplan SS, Schimana W, Lawrence J, McNeal MM, Bwakura-Dangarembizi M, Ogwu A, Mpabalwani EM, Sato P, Siberry G, Nelson M, Hille D, Weinberg GA, Weinberg A. Safety and immunogenicity of a live attenuated pentavalent rotavirus vaccine in HIV-exposed infants with or without HIV infection in Africa. AIDS. 2016 Sep 20. [Epub ahead of print] PubMed PMID: 27662551
  • Barron MA, Frank DN, Claypool D, Ir D, Ning MF, Curtis D, Weinberg A. Antibody responses to influenza a H1N1 vaccine compared to the circulating strain in influenza vaccine recipients during the 2013/2014 season in North America. J Clin Virol. 2016 Oct;83:56-60. PubMed PMID: 27591557
  • Nunes MC, Cutland CL, Jones S, Hugo A, Madimabe R, Simões EA, Weinberg A, Madhi SA. Duration of Infant Protection Against Influenza Illness Conferred by Maternal Immunization: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr. 2016 Sep 1;170(9):840-7. PubMed PMID: 27380464
  • Lazenby GB, Mmeje O, Fisher BM, Weinberg A, Aaron EK, Keating M, Luque AE, Willers D, Cohan D, Money D. Antiretroviral Resistance and Pregnancy Characteristics of Women with Perinatal and Nonperinatal HIV Infection. Infect Dis Obstet Gynecol. 2016;2016:4897501. PubMed PMID: 27413359
  • Mutsaerts E, Madhi SA, Cutland CL, Jones S, Hugo A, Trenor S, Treurnicht FK, Klipstein-Grobusch K, Weinberg A, Nunes MC. Influenza vaccination of pregnant women protects them over two consecutive influenza seasons in a randomized controlled trial. Expert Rev Vaccines. 2016 Aug;15(8):1055-62. PubMed PMID: 27212228
  • Weinberg A, Curtis D, Ning MF, Claypool DJ, Jalbert E, Patterson J, Frank DN, Ir D, Armon C. Immune Responses to Circulating and Vaccine Viral Strains in HIV-Infected and Uninfected Children and Youth Who Received the 2013/2014 Quadrivalent Live-Attenuated Influenza Vaccine. Front Immunol. 2016 Apr 15;7:142. PubMed PMID: 27148262
  • Beals CR, Railkar RA, Schaeffer AK, Levin Y, Kochba E, Meyer BK, Evans RK, Sheldon EA, Lasseter K, Lang N, Weinberg A, Canniff J, Levin MJ. Immune response and reactogenicity of intradermal administration versus subcutaneous administration of varicella-zoster virus vaccine: an exploratory, randomised, partly blinded trial. Lancet Infect Dis. 2016 Aug;16(8):915-22. PubMed PMID: 27061887
  • Smith C, Weinberg A, Forster JE, Levin MJ, Davies J, Pappas J, Kinzie K, Barr E, Paul S, McFarland EJ. Maternal Lopinavir/Ritonavir Is Associated with Fewer Adverse Events in Infants than Nelfinavir or Atazanavir. Infect Dis Obstet Gynecol. 2016;2016:9848041. PubMed PMID: 27127401
  • Weinberg A, Park JG, Bosch R, Cho A, Livingston E, Aweeka F, Cramer Y, Watts DH, Luque AE, Cohn SE. EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN. J Acquir Immune Defic Syndr. 2015 Sep 18. [Epub ahead of print] PubMed PMID: 26413850
  • Curtis DJ, Muresan P, Nachman S, Fenton T, Richardson KM, Dominguez T, Flynn PM, Spector SA, Cunningham CK, Bloom A, Weinberg A. Characterization of functional antibody and memory B-cell responses to pH1N1 monovalent vaccine in HIV-infected children and youth. PLoS One. 2015;10(3):e0118567. PubMed PMID: 25785995
  • Luque AE, Cohn SE, Park JG, Cramer Y, Weinberg A, Livingston E, Klingman KL, Aweeka F, Watts DH. Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the ACTG 5283 study. Antimicrob Agents Chemother. 2015 Apr;59(4):2094-101. PubMed PMID: 25624326
  • Weinberg A, Muresan P, Richardson KM, Fenton T, Dominguez T, Bloom A, Watts DH, Abzug MJ, Nachman SA, Levin MJ. Determinants of vaccine immunogenicity in HIV-infected pregnant women: analysis of B and T cell responses to pandemic H1N1 monovalent vaccine. PLoS One. 2015;10(4):e0122431. PubMed PMID: 25874544
  • Smith C, Forster JE, Levin MJ, Davies J, Pappas J, Kinzie K, Barr E, Paul S, McFarland EJ, Weinberg A. Serious adverse events are uncommon with combination neonatal antiretroviral prophylaxis: a retrospective case review. PLoS One. 2015;10(5):e0127062. PubMed PMID: 26000984
  • Kapetanovic S, Aaron L, Montepiedra G, Anthony P, Thuvamontolrat K, Pahwa S, Burchett S, Weinberg A, Kovacs A. Effect of cytomegalovirus co-infection on normalization of selected T-cell subsets in children with perinatally acquired HIV infection treated with combination antiretroviral therapy. PLoS One. 2015;10(3):e0120474. PubMed PMID: 25794163
  • Erlandson KM, Allshouse AA, Rapaport E, Palmer BE, Wilson CC, Weinberg A, MaWhinney S, Campbell TB. Physical Function Impairment of Older, HIV-Infected Adults Is Associated with Cytomegalovirus Immunoglobulin Response. AIDS Res Hum Retroviruses. 2015 Sep;31(9):905-12. PubMed PMID: 26061347
  • Nunes MC, Cutland CL, Dighero B, Bate J, Jones S, Hugo A, van Niekerk N, Kuwanda L, Izu A, Weinberg A, Madhi SA. Kinetics of Hemagglutination-Inhibiting Antibodies Following Maternal Influenza Vaccination Among Mothers With and Those Without HIV Infection and Their Infants. J Infect Dis. 2015 Jun 16. [Epub ahead of print] PubMed PMID: 26080370
  • Levin MJ, Schmader KE, Pang L, Williams-Diaz A, Zerbe G, Canniff J, Johnson MJ, Caldas Y, Cho A, Lang N, Su SC, Parrino J, Popmihajlov Z, Weinberg A. Administration of a Second Dose of Herpes Zoster Vaccine Ten Years After a First Dose. J Infect Dis. 2015 Oct 9. [Epub ahead of print] PubMed PMID: 26452397
  • Curtis D, Ning MF, Armon C, Li S, Weinberg A. Safety, immunogenicity and shedding of LAIV4 in HIV-infected and uninfected children. Vaccine. 2015 Sep 11;33(38):4790-7. PubMed PMID: 26241950
  • Weinberg A, Park JG, Bosch R, Cho A, Livingston E, Aweeka F, Cramer Y, Watts DH, Luque AE, Cohn SE. EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN. J Acquir Immune Defic Syndr. 2015 Sep 18. [Epub ahead of print] PubMed PMID: 26413850
  • Chiu C, McCausland M, Sidney J, Duh FM, Rouphael N, Mehta A, Mulligan M, Carrington M, Wieland A, Sullivan NL, Weinberg A, Levin MJ, Pulendran B, Peters B, Sette A, Ahmed R. Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog. 2014 Mar;10(3):e1004008. PubMed PMID: 24675761
  • Weinberg A, Bosch R, Bennett K, Tovar-Salazar A, Benson CA, Collier AC, Zolopa A, Gulick RM, Wohl D, Polsky B, Erice A, Jacobson MA. REGULATORY T CELLS AND THE RISK OF CMV END-ORGAN DISEASE IN AIDS PATIENTS. J Acquir Immune Defic Syndr. 2013 Dec 27. [Epub ahead of print] PubMed PMID: 24378728
  • Madhi SA, Cutland CL, Kuwanda L, Weinberg A, Hugo A, Jones S, Adrian PV, van Niekerk N, Treurnicht F, Ortiz JR, Venter M, Violari A, Neuzil KM, Simões EA, Klugman KP, Nunes MC, Maternal Flu Trial (Matflu) Team. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med. 2014 Sep 4;371(10):918-31. PubMed PMID: 25184864
  • Abzug MJ, Nachman SA, Muresan P, Handelsman E, Watts DH, Fenton T, Heckman B, Petzold E, Weinberg A, Levin MJ, International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1086 Protocol Team. Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women. Clin Infect Dis. 2013 May;56(10):1488-97. PubMed PMID: 23378284
  • Weinberg A, Muresan P, Fenton T, Richardson K, Dominguez T, Bloom A, Petzold E, Anthony P, Cunningham CK, Spector SA, Nachman S, Siberry GK, Handelsman E, Flynn PM, IMPAACT P1088 study team. High proportions of regulatory B and T cells are associated with decreased cellular responses to pH1N1 influenza vaccine in HIV-infected children and youth (IMPAACT P1088). Hum Vaccin Immunother. 2013 May;9(5):957-68. PubMed PMID: 23370281
  • Mathias RA, Weinberg A, Boguniewicz M, Zaccaro DJ, Armstrong B, Schneider LC, Hata TR, Hanifin JM, Beck LA, Barnes KC, Leung DY. Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-?-producing CD8 T cells. Br J Dermatol. 2013 Sep;169(3):700-3. PubMed PMID: 23600999
  • Simões EA, Patel C, Sung WK, Lee CW, Loh KH, Lucero M, Nohynek H, Nai G, Thien PL, Koh CW, Chan YS, Ma J, Maurer-Stroh S, Carosone-Link P, Hibberd ML, Wong CW, ARIVAC Consortium. Pathogen chip for respiratory tract infections. J Clin Microbiol. 2013 Mar;51(3):945-53. PubMed PMID: 23303493
  • Weinberg A, Boulware D, Dighero B, Orban T, Type 1 Diabetes TrialNet Abatacept Study Group. Effect of abatacept on immunogenicity of vaccines in individuals with type 1 diabetes. Vaccine. 2013 Oct 1;31(42):4791-4. PubMed PMID: 23962535
  • Weinberg A, Bosch R, Bennett K, Tovar-Salazar A, Benson CA, Collier AC, Zolopa A, Gulick RM, Wohl D, Polsky B, Erice A, Jacobson MA. REGULATORY T CELLS AND THE RISK OF CMV END-ORGAN DISEASE IN AIDS PATIENTS. J Acquir Immune Defic Syndr. 2013 Dec 27. [Epub ahead of print] PubMed PMID: 24378728
  • Flynn PM, Nachman S, Muresan P, Fenton T, Spector SA, Cunningham CK, Pass R, Yogev R, Burchett S, Heckman B, Bloom A, Utech LJ, Anthony P, Petzold E, Levy W, Siberry GK, Ebiasah R, Miller J, Handelsman E, Weinberg A, IMPAACT P1088 Team. Safety and immunogenicity of 2009 pandemic H1N1 influenza vaccination in perinatally HIV-1-infected children, adolescents, and young adults. J Infect Dis. 2012 Aug 1;206(3):421-30. PubMed PMID: 22615311
  • Fisher BM, Van Bockern J, Hart J, Lynch AM, Winn VD, Gibbs RS, Weinberg A. Pandemic influenza A H1N1 2009 infection versus vaccination: a cohort study comparing immune responses in pregnancy. PLoS One. 2012;7(3):e33048. PubMed PMID: 22457731
  • Henao-Martínez AF, Weinberg A, Waldman WJ, Levi ME. Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. J Clin Virol. 2012 Jul;54(3):276-8. PubMed PMID: 22465339
  • Katsumata K, Weinberg A, Chono K, Takakura S, Kontani T, Suzuki H. Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor. Antimicrob Agents Chemother. 2012 Jul;56(7):3587-91. PubMed PMID: 22526302
  • Weinberg A, Song LY, Saah A, Brown M, Moscicki AB, Meyer WA 3rd, Bryan J, Levin MJ, IMPAACT/PACTG P1047 Team. Humoral, mucosal, and cell-mediated immunity against vaccine and nonvaccine genotypes after administration of quadrivalent human papillomavirus vaccine to HIV-infected children. J Infect Dis. 2012 Oct;206(8):1309-18. PubMed PMID: 22859825
  • Weinberg A, Huang S, Song LY, Fenton T, Williams P, Patterson J, Tovar-Salazar A, Levin MJ. Immune correlates of herpes zoster in HIV-infected children and youth. J Virol. 2012 Mar;86(5):2878-81. PubMed PMID: 22171274
  • Madhi SA, Dittmer S, Kuwanda L, Venter M, Cassim H, Lazarus E, Thomas T, Liberty A, Treurnich F, Cutland CL, Weinberg A, Violari A. Efficacy and immunogenicity of influenza vaccine in HIV-infected children: a randomized, double-blind, placebo controlled trial. AIDS. 2013 Jan 28;27(3):369-79. PubMed PMID: 23032417
  • Loechelt BJ, Boulware D, Green M, Baden LR, Gottlieb P, Krause-Steinrauf H, Weinberg A, Type 1 Diabetes TrialNet Daclizumab/Mycophenolic Acid Study Group. Epstein-Barr and other herpesvirus infections in patients with early onset type 1 diabetes treated with daclizumab and mycophenolate mofetil. Clin Infect Dis. 2013 Jan;56(2):248-54. PubMed PMID: 23042974
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Professional Memberships

  • Infectious Diseases Society of America (IDSA), Fellow
  • American Association of Immunologists (AAI), Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1991)
  • Infectious Disease
Conditions & Treatments
  • Infections - Viral Infections
  • Infections
  • Immune System - AIDS
  • Immune System
  • Immune System - AIDS / HIV Disease
  • Immune System - AIDS Immunization
Clinical Interest for Patients
My main clinical interest is in taking care of pregnant women and children living with HIV and in women who plan to become pregnant with a partner living with HIV.

Care Philosophy
I strive to provide the best care for my patients. I believe in treating the person as a whole, taking every aspect of a patient’s body and health into consideration during diagnosis and treatment.

General Information

Medical Schools:
  • MD, University of Sao Paulo (1980)
Internships:
  • University of Sao Paulo (1981)
Residency Programs:
  • University of Sao Paulo, Infectious Disease (1984)
Fellowships:
  • Stanford University Program, Infectious Disease (1987)
Languages: English
Department: Pediatrics-Infectious Diseases
;