Kelly Knupp, MD
Associate Professor, Pediatrics-Neurology

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Medical School:
  • MD, University of New Mexico School of Medicine (1997)
Graduate School :
  • MSCS, University of Colorado Health Sciences Center (2017)
Undergraduate School:
  • Other, University of New Mexico (NM)
Residency:
  • New York Presbyterian Hospital Program, Child Neurology (2002)
Fellowships:
  • New York Presbyterian Hospital Program, Clinical Neurophysiology (2003)
Languages: English
Department: Pediatrics-Neurology

Publications

  • Van Nuland A, Ivanenko A, Meskis MA, Villas N, Knupp KG, Berg AT. Sleep in Dravet syndrome: A parent-driven survey. Seizure. 2021 Jan 7;85:102-110. [Epub ahead of print] PubMed PMID: 33453590
  • Pellinen J, Snyder E, Knupp KG. The language of seizure identification: A qualitative investigation. Epilepsy Behav. 2021 Dec 13;126:108484. [Epub ahead of print] PubMed PMID: 34915429
  • Pellinen J, French J, Knupp KG. Diagnostic Delay in Epilepsy: the Scope of the Problem. Curr Neurol Neurosci Rep. 2021 Nov 24;21(12):71. PubMed PMID: 34817723
  • Andrade DM, Berg AT, Hood V, Knupp KG, Koh S, Laux L, Meskis MA, Miller I, Perry MS, Scheffer IE, Sullivan J, Villas N, Wirrell E. Dravet syndrome: A quick transition guide for the adult neurologist. Epilepsy Res. 2021 Nov;177:106743. PubMed PMID: 34624600
  • Helms JA, Smith J, Clark S, Knupp K, Haddad NM. Ant Communities and Ecosystem Services in Organic Versus Conventional Agriculture in the U.S. Corn Belt. Environ Entomol. 2021 Dec 17;50(6):1276-1285. PubMed PMID: 34554252
  • Isom LL, Knupp KG. Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy. Neurotherapeutics. 2021 Jul;18(3):1524-1534. PubMed PMID: 34378168
  • Gil-Nagel A, Sullivan J, Ceulemans B, Wirrell E, Devinsky O, Nabbout R, Knupp KG, Scott Perry M, Polster T, Davis R, Lock M, Cortes RM, Gammaiton AR, Farfel G, Galer BS, Agarwal A. Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth. Epilepsy Behav. 2021 Sep;122:108212. PubMed PMID: 34352670
  • Min JY, Knupp KG, Patel AD, Shellhaas RA, Zhang M, Grinspan ZM. Medication selection, health services outcomes, and cost trajectories for Medicaid beneficiaries with infantile spasms. Epilepsy Res. 2021 Oct;176:106733. PubMed PMID: 34333373
  • Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell E, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell W, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Jul 15. [Epub ahead of print] PubMed PMID: 34266919
  • Nelson JA, Demarest S, Thomas J, Juarez-Colunga E, Knupp KG. Evolution of Infantile Spasms to Lennox-Gastaut Syndrome: What Is There to Know?. J Child Neurol. 2021 Aug;36(9):752-759. PubMed PMID: 33764203
  • Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma. J Anal Toxicol. 2021 Mar 23. [Epub ahead of print] PubMed PMID: 33754154
  • Van Nuland A, Ivanenko A, Meskis MA, Villas N, Knupp KG, Berg AT. Sleep in Dravet syndrome: A parent-driven survey. Seizure. 2021 Feb;85:102-110. PubMed PMID: 33453590
  • Berg AT, Gaebler-Spira D, Wilkening G, Zelko F, Knupp K, Dixon-Salazar T, Villas N, Meskis MA, Harwell V, Thompson T, Sims S, Nesbitt G. Nonseizure consequences of Dravet syndrome, KCNQ2-DEE, KCNB1-DEE, Lennox-Gastaut syndrome, ESES: A functional framework. Epilepsy Behav. 2020 Oct;111:107287. PubMed PMID: 32759067
  • Wirrell EC, Grinspan ZM, Knupp KG, Jiang Y, Hammeed B, Mytinger JR, Patel AD, Nabbout R, Specchio N, Cross JH, Shellhaas RA. Care Delivery for Children With Epilepsy During the COVID-19 Pandemic: An International Survey of Clinicians. J Child Neurol. 2020 Nov;35(13):924-933. PubMed PMID: 32666891
  • Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Management of Infantile Spasms During the COVID-19 Pandemic. J Child Neurol. 2020 Oct;35(12):828-834. PubMed PMID: 32576057
  • Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Pomeroy SL, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Crisis Standard of Care: Management of Infantile Spasms during COVID-19. Ann Neurol. 2020 Aug;88(2):215-217. PubMed PMID: 32445204
  • Messer R, Knupp KG. Infantile Spasms: Opportunities to Improve Care. Semin Neurol. 2020 Apr;40(2):236-245. PubMed PMID: 32143232
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
  • Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S. Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial. JAMA Neurol. 2020 Mar 1;77(3):300-308. PubMed PMID: 31790543
  • McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2020 Mar;35(3):215-220. PubMed PMID: 31769329
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
  • McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2019 Nov 26;:883073819886244. [Epub ahead of print] PubMed PMID: 31769329
  • Sorin LM, Knupp KG, Berg AT. New-onset seizure survey of epilepsy centers in the United States. Epilepsy Behav. 2019 Dec;101(Pt A):106579. PubMed PMID: 31677582
  • Knupp KG, Rice JD, Helmkamp LJ, Galinkin J, Sempio C, Jost K, Chapman KE. Prospective evaluation of oral cannabis extracts in children with epilepsy. Seizure. 2019 Sep 16;72:23-27. [Epub ahead of print] PubMed PMID: 31550641
  • Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 Aug;97:44-50. PubMed PMID: 31181428
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2019 May 21;:1-5. [Epub ahead of print] PubMed PMID: 31111749
  • Eschbach K, Knupp KG. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. PubMed PMID: 31017478
  • Daniels D, Knupp K, Benke T, Wolter-Warmerdam K, Moran M, Hickey F. Infantile Spasms in Children With Down Syndrome: Identification and Treatment Response. Glob Pediatr Health. 2019;6:2333794X18821939. PubMed PMID: 30671494
  • Ziobro J, Eschbach K, Sullivan JE, Knupp KG. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Curr Treat Options Neurol. 2018 Oct 13;20(12):52. PubMed PMID: 30315507
  • Tolete P, Knupp K, Karlovich M, DeCarlo E, Bluvstein J, Conway E, Friedman D, Dugan P, Devinsky O. Lorcaserin therapy for severe epilepsy of childhood onset: A case series. Neurology. 2018 Oct 30;91(18):837-839. PubMed PMID: 30258026
  • Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Sep;142(3). PubMed PMID: 30089657
  • Knupp KG, Wirrell EC. Correction to: Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Aug;32(8):783. PubMed PMID: 30027402
  • Kelley SA, Knupp KG. Infantile Spasms-Have We Made Progress?. Curr Neurol Neurosci Rep. 2018 Apr 19;18(5):27. PubMed PMID: 29671077
  • Knupp KG, Wirrell EC. Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Apr;32(4):335-350. PubMed PMID: 29594870
  • Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018;13(3):e0193599. PubMed PMID: 29518120
  • Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 Apr 1;172(4):352-360. PubMed PMID: 29435578
  • Campbell JD, Whittington MD, Kim CH, VanderVeen GR, Knupp KG, Gammaitoni A. Assessing the impact of caring for a child with Dravet syndrome: Results of a caregiver survey. Epilepsy Behav. 2018 Mar;80:152-156. PubMed PMID: 29414545
  • Whittington MD, Knupp KG, Vanderveen G, Kim C, Gammaitoni A, Campbell JD. The direct and indirect costs of Dravet Syndrome. Epilepsy Behav. 2018 Mar;80:109-113. PubMed PMID: 29414539
  • Eschbach K, Scarbro S, Juarez-Colunga E, Allen V, Hsu S, Knupp K. Growth and endocrine function in children with Dravet syndrome. Seizure. 2017 Sep 29;52:117-122. [Epub ahead of print] PubMed PMID: 29031192
  • Knupp KG, Scarbro S, Wilkening G, Juarez-Colunga E, Kempe A, Dempsey A. Parental Perception of Comorbidities in Children With Dravet Syndrome. Pediatr Neurol. 2017 Jun 20. [Epub ahead of print] PubMed PMID: 28982531
  • Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct;75:73-79. PubMed PMID: 28807611
  • Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 1;171(9):863-871. PubMed PMID: 28759667
  • Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062
  • Wallace A, Allen V, Park K, Knupp K. Infantile Spasms and Injuries of Prematurity: Short-Term Treatment-Based Response and Long-Term Outcomes. J Child Neurol. 2017 Sep;32(10):861-866. PubMed PMID: 28635418
  • Knupp KG. Hormonal therapy with vigabatrin is superior to hormonal therapy alone in infantile spasms. J Pediatr. 2017 May;184:235-238. PubMed PMID: 28434569
  • Jensen MP, Brunklaus A, Dorris L, Zuberi SM, Knupp KG, Galer BS, Gammaitoni AR. The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research. Epilepsy Behav. 2017 May;70(Pt A):104-109. PubMed PMID: 28431364
  • Bramswig NC, Lüdecke HJ, Hamdan FF, Altmüller J, Beleggia F, Elcioglu NH, Freyer C, Gerkes EH, Demirkol YK, Knupp KG, Kuechler A, Li Y, Lowenstein DH, Michaud JL, Park K, Stegmann APA, Veenstra-Knol HE, Wieland T, Wollnik B, Engels H, Strom TM, Kleefstra T, Wieczorek D. Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability. Hum Genet. 2017 Jul;136(7):821-834. PubMed PMID: 28393272
  • Wirrell EC, Laux L, Donner E, Jette N, Knupp K, Meskis MA, Miller I, Sullivan J, Welborn M, Berg AT. Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel. Pediatr Neurol. 2017 Mar;68:18-34.e3. PubMed PMID: 28284397
  • Griffin A, Hamling KR, Knupp K, Hong S, Lee LP, Baraban SC. Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. Brain. 2017 Mar 1;140(3):669-683. PubMed PMID: 28073790
  • Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2017 Jan;58(1):123-127. PubMed PMID: 27859038
  • Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27859038
  • Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov;57(11):1834-1842. PubMed PMID: 27615012
  • Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar;79(3):475-84. PubMed PMID: 26704170
  • Kumar RM, Koh S, Knupp K, Handler MH, O'Neill BR. Surgery for infants with catastrophic epilepsy: an analysis of complications and efficacy. Childs Nerv Syst. 2015 Sep;31(9):1479-91. PubMed PMID: 26022500
  • Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav. 2015 Apr;45:49-52. PubMed PMID: 25845492
  • Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG. How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia. 2015 Apr;56(4):617-25. PubMed PMID: 25779538
  • Knupp K, Wirrell E. Progressive myoclonic epilepsies: It takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
  • Knupp K, Wirrell E. Progressive myoclonic epilepsies: it takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
  • Knupp K, Wirrell E. Progressive myoclonic epilepsies: it takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
  • Barberio M, Reiter PD, Kaufman J, Knupp K, Dobyns EL. Continuous infusion pentobarbital for refractory status epilepticus in children. J Child Neurol. 2012 Jun;27(6):721-6. PubMed PMID: 22156786
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Child Neurology, Board Certification (2004, 2013)
  • Clinical Neurophysiology, Board Certification (2007, 2018)
  • Epilepsy, Board Certification (2014)
Conditions & Treatments
  • Child and Teen Health
  • Brain and Nervous System - Epilepsy
  • Brain and Nervous System
Clinical Interests
Dravet Syndrome Infantile Spasms

General Information

Medical Schools:
  • MD, University of New Mexico School of Medicine (1997)
Graduate Schools:
  • MSCS, University of Colorado Health Sciences Center (2017)
Undergraduate Schools:
  • Other, University of New Mexico (NM) (0001)
Residency Programs:
  • New York Presbyterian Hospital Program, Child Neurology (2002)
Fellowships:
  • New York Presbyterian Hospital Program, Clinical Neurophysiology (2003)
Languages: English
Department: Pediatrics-Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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