Genevieve Sparagna, PhD
Associate Research Professor, Medicine-Cardiology

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Department: Medicine-Cardiology

Publications

  • Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher RL, Patel S, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of Cardiolipin Biosynthesis and Remodeling in Single Right Ventricle Congenital Heart Disease. Am J Physiol Heart Circ Physiol. 2020 Feb 14. [Epub ahead of print] PubMed PMID: 32056460
  • Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ. Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem. 2020 Aug 28;295(35):12485-12497. PubMed PMID: 32665401
  • Cole LK, Mejia EM, Sparagna GC, Vandel M, Xiang B, Han X, Dedousis N, Kaufman BA, Dolinsky VW, Hatch GM. Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2020 Jul;144:24-34. PubMed PMID: 32418915
  • Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H787-H800. PubMed PMID: 32056460
  • Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
  • Chung DJ, Healy TM, McKenzie JL, Chicco AJ, Sparagna GC, Schulte PM. Mitochondria, Temperature, and the Pace of Life. Integr Comp Biol. 2018 Sep 1;58(3):578-590. PubMed PMID: 29718252
  • Chung DJ, Sparagna GC, Chicco AJ, Schulte PM. Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol. 2018 Apr 11;221(Pt 7). PubMed PMID: 29643174
  • Sullivan EM, Pennington ER, Sparagna GC, Torres MJ, Neufer PD, Harris M, Washington J, Anderson EJ, Zeczycki TN, Brown DA, Shaikh SR. Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome. J Biol Chem. 2018 Jan 12;293(2):466-483. PubMed PMID: 29162722
  • Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 Jan 5;122(1):58-73. PubMed PMID: 29092894
  • Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM. Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight. 2018 Nov 2;3(21). [Epub ahead of print] PubMed PMID: 30385731
  • Sullivan EM, Fix A, Crouch MJ, Sparagna GC, Zeczycki TN, Brown DA, Shaikh SR. Murine diet-induced obesity remodels cardiac and liver mitochondrial phospholipid acyl chains with differential effects on respiratory enzyme activity. J Nutr Biochem. 2017 Jul;45:94-103. PubMed PMID: 28437736
View All (11 Total) View Less

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

General Information

Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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