Ed Hoffenberg, MD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

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Medical School:
  • MD, Case Western Reserve University School of Medicine (1986)
Undergraduate School:
  • BA, Johns Hopkins University (MD) (1982)
Internship:
  • University Hospitals Case Medical Center Program (1987)
Residency:
  • University Hospitals Case Medical Center Program, Pediatrics (1989)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Gastroenterology (1992)
Languages: English, Portuguese, Spanish
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition

Professional Titles

  • Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition
  • Director, Center for Pediatric Inflammatory Bowel Diseases

Recognition & Awards

  • Gastroenterology SubBoard, American Board of Pediatrics, (2016)
  • member, American Pediatric Society, (2014)

Research Interests

Inflammatory bowel disease, celiac disease, polyposis syndromes, quality improvement

Teaching

  • Professor (2016)
    School of Medicine, Pediatrics

Publications

  • Swaminath A, Berlin EP, Cheifetz A, Hoffenberg E, Kinnucan J, Wingate L, Buchanan S, Zmeter N, Rubin DT. The Role of Cannabis in the Management of Inflammatory Bowel Disease: A Review of Clinical, Scientific, and Regulatory Information: Commissioned by the Crohn's and Colitis Foundation. Inflamm Bowel Dis. 2018 Oct 24. [Epub ahead of print] PubMed PMID: 30358848
  • Hoffenberg EJ, McWilliams SK, Mikulich-Gilbertson SK, Murphy BV, Lagueux M, Robbins K, Hoffenberg AS, de Zoeten E, Hopfer CJ. Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease. J Pediatr. 2018 Apr 16. [Epub ahead of print] PubMed PMID: 29673723
  • Barfield E, Sockolow R, Hoffenberg E, Saeed S, Kim S, Siebold L, Picoraro J, Moses J, Dykes D, Grossman A, Wahbeh G, Park KT. Assuring Quality for Non-hospital-based Biologic Infusions in Pediatric Inflammatory Bowel Disease: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Apr;66(4):680-686. PubMed PMID: 29324477
  • O'Gorman MA, Michaels MG, Kaplan SL, Otley A, Kociolek LK, Hoffenberg EJ, Kim KS, Nachman S, Pfefferkorn MD, Sentongo T, Sullivan JE, Sears P. Safety and Pharmacokinetic Study of Fidaxomicin in Children With Clostridium difficile-Associated Diarrhea: A Phase 2a Multicenter Clinical Trial. J Pediatric Infect Dis Soc. 2017 May 31. [Epub ahead of print] PubMed PMID: 28575523
  • Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Ionization MS/MS Assay using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Jun 19. [Epub ahead of print] PubMed PMID: 28640062
  • O'Gorman MA, Michaels MG, Kaplan SL, Otley A, Kociolek LK, Hoffenberg EJ, Kim KS, Nachman S, Pfefferkorn MD, Sentongo T, Sullivan JE, Sears P. Safety and Pharmacokinetic Study of Fidaxomicin in Children With Clostridium difficile-Associated Diarrhea: A Phase 2a Multicenter Clinical Trial. J Pediatric Infect Dis Soc. 2017 May 31. [Epub ahead of print] PubMed PMID: 28575523
  • Liu E, Dong F, Barón AE, Taki I, Norris JM, Frohnert BI, Hoffenberg EJ, Rewers M. High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes. Gastroenterology. 2017 May;152(6):1329-1336.e1. PubMed PMID: 28188747
  • Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB. Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. Inflamm Bowel Dis. 2017 Feb;23(2):192-199. PubMed PMID: 28079617
  • Hoffenberg EJ, Newman H, Collins C, Leinwand K, Tarbell S. Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms A Mile High. J Pediatr Gastroenterol Nutr. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27579692
  • Hoffenberg EJ, Newman H, Collins C, Leinwand K, Tarbell S. Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms A Mile High. J Pediatr Gastroenterol Nutr. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27579692
  • Hill ID, Fasano A, Guandalini S, Hoffenberg E, Levy J, Reilly N, Verma R. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):156-65. PubMed PMID: 27035374
  • Sheiko MA, Hoffenberg EJ. Massive Hematemesis as Presentation of Congenital Aortic Coarctation With Superinfected Aneurysm and Aortoesophageal Fistula. J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):e4-5. PubMed PMID: 24625966
  • Flass T, Tong S, Frank DN, Wagner BD, Robertson CE, Kotter CV, Sokol RJ, Zemanick E, Accurso F, Hoffenberg EJ, Narkewicz MR. Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis. PLoS One. 2015;10(2):e0116967. PubMed PMID: 25658710
  • Kulungowski AM, Acker SN, Hoffenberg EJ, Neigut D, Partrick DA. Initial operative treatment of isolated ileal Crohn's disease in adolescents. Am J Surg. 2014 Oct 13. [Epub ahead of print] PubMed PMID: 25457242
  • Noel G, Diamond B, Auerbach S, de Zoeten E, Hoffenberg E. Colonic Crohn's Disease after Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2015 Dec 10. [Epub ahead of print] PubMed PMID: 26655937
  • Flass T, Tong S, Frank DN, Wagner BD, Robertson CE, Kotter CV, Sokol RJ, Zemanick E, Accurso F, Hoffenberg EJ, Narkewicz MR. Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis. PLoS One. 2015;10(2):e0116967. PubMed PMID: 25658710
  • Kulungowski AM, Acker SN, Hoffenberg EJ, Neigut D, Partrick DA. Initial operative treatment of isolated ileal Crohn's disease in adolescents. Am J Surg. 2014 Oct 13. [Epub ahead of print] PubMed PMID: 25457242
  • Puthoor PR, Hoffenberg E, Friedlander J. A Penny's Worth of Advice: Deep Esophageal Injury from a Coin. J Pediatr Gastroenterol Nutr. 2014 Feb 28. [Epub ahead of print] PubMed PMID: 24590218
  • Park KT, Crandall WV, Fridge J, Leibowitz IH, Tsou M, Dykes DM, Hoffenberg EJ, Kappelman MD, Colletti RB. Implementable Strategies and Exploratory Considerations to Reduce Costs Associated with Anti-TNF Therapy in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2014 Jan 21. [Epub ahead of print] PubMed PMID: 24451222
  • Colson SB, Siparsky GL, Capocelli KE, Pan Z, Sokol RJ, Hoffenberg EJ. Inflammatory bowel disease in pediatric patients with cerebral palsy. J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):e50. PubMed PMID: 23518488
  • Goldstein SA, Hoffenberg EJ. Peutz-Jegher syndrome in childhood: need for updated recommendations?. J Pediatr Gastroenterol Nutr. 2013 Feb;56(2):191-5. PubMed PMID: 23325439
  • Van Der Werf CS, Wabbersen TD, Hsiao NH, Paredes J, Etchevers HC, Kroisel PM, Tibboel D, Babarit C, Schreiber RA, Hoffenberg EJ, Vekemans M, Zeder SL, Ceccherini I, Lyonnet S, Ribeiro AS, Seruca R, Te Meerman GJ, van Ijzendoorn SC, Shepherd IT, Verheij JB, Hofstra RM. CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome. Gastroenterology. 2012 Mar;142(3):453-462.e3. PubMed PMID: 22155368
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Professional Memberships

  • AGA, Fellow
  • NASPGHAN, Member
  • CCFA, Member
  • ACG, Member
  • SSCD, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatric Gastroenterology, Board Certification (2007, 2015)
Conditions & Treatments
  • Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
  • Digestive System - Inflammatory Bowel Disease (IBD): Crohn’s disease, ulcerative colitis, microscopic colitis
  • Digestive System
  • Digestive System - Celiac Disease
  • Digestive System - Gastroesophageal Reflux
Clinical Interests
My main clinical interest is in inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease and gluten related disorders, and polyposis syndromes such as Peutz- Jegher syndrome, juvenile polyposis, and familial polyposis.

Personal Interests
Soccer, tennis, my children's activities

Volunteer Activities
Temple Emanuel, Round up River Ranch Camp, Crohn's and Colitis Foundation of America, Celiac Foundation, Beyond Celiac

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Case Western Reserve University School of Medicine (1986)
Undergraduate Schools:
  • BA, Johns Hopkins University (MD) (1982)
Internships:
  • University Hospitals Case Medical Center Program (1987)
Residency Programs:
  • University Hospitals Case Medical Center Program, Pediatrics (1989)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Gastroenterology (1992)
Download CV
Languages: English, Portuguese, Spanish
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
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