Jose Castillo-Mancilla, MD
Associate Clinical Professor, Medicine-Infectious Disease

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Medical School:
  • MD, Universidad La Salle-Facultad Mexicana de Medicina, Mexico City, Mexico (1999)
Internship:
  • Mount Sinai Medical Center of Florida Program (2001)
Residency:
  • Mount Sinai Medical Center of Florida Program, Internal Medicine (2003)
Fellowships:
  • Cleveland Clinic Foundation Program, Infectious Disease (2005)
Languages: English, Spanish
Department: Medicine-Infectious Disease

Professional Titles

  • Associate Professor of Medicine

Recognition & Awards

  • DOM-Rising Star, University of Colorado-AMC Department of Medicine (2016)
  • Esperanza Award, Camino de Vida Center for HIV Services (2008)

Publications

  • Morrow M, MaWhinney S, Brooks KM, Huntley R, Castillo-Mancilla JR, Anderson PL, Kiser JJ. Improving the accuracy of adherence data collected using medication monitoring technology in clinical research. Contemp Clin Trials. 2022 Dec 15;125:107051. [Epub ahead of print] PubMed PMID: 36528338
  • Joseph Davey D, Nyemba DC, Castillo-Mancilla J, Wiesner L, Norman J, Mvududu R, Mashele N, Johnson LF, Bekker LG, Gorbach P, Coates TJ, Myer L. Adherence challenges with daily oral pre-exposure prophylaxis during pregnancy and the postpartum period in South African women: a cohort study. J Int AIDS Soc. 2022 Dec;25(12):e26044. PubMed PMID: 36480171
  • Grinsteiner E, Morrow M, Mawhinney S, Coyle RP, Coleman SS, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, Castillo-Mancilla JR. Demographic and Clinical Characteristics of Persons with HIV with Viral Load:Adherence Mismatch Who Are at Risk of Future Viremia. AIDS Res Hum Retroviruses. 2022 Nov 18. [Epub ahead of print] PubMed PMID: 36301917
  • Coburn SB, Lang R, Zhang J, Palella FJ, Horberg MA, Castillo-Mancilla J, Gebo K, Galaviz KI, Gill MJ, Silverberg MJ, Hulgan T, Elion RA, Justice AC, Moore RD, Althoff KN. Statins Utilization in Adults With HIV: The Treatment Gap and Predictors of Statin Initiation. J Acquir Immune Defic Syndr. 2022 Dec 15;91(5):469-478. PubMed PMID: 36053091
  • Castillo-Mancilla JR, Anderson PL. Long-acting injectable Cabotegravir: How drug concentrations could help guide patient management. Br J Clin Pharmacol. 2022 Oct;88(10):4384-4386. PubMed PMID: 35971819
  • Coyle RP, Morrow M, MaWhinney S, Coleman SS, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, Castillo-Mancilla JR. Cumulative tenofovir diphosphate exposure in persons with HIV taking single- vs. multiple-tablet regimens. Pharmacotherapy. 2022 Aug;42(8):641-650. PubMed PMID: 35707973
  • Adje YH, Brooks KM, Castillo-Mancilla JR, Wyles DL, Anderson PL, Kiser JJ. The use of technology-based adherence monitoring in the treatment of hepatitis C virus. Ther Adv Infect Dis. 2022 Jan-Dec;9:20499361221095664. PubMed PMID: 35591885
  • Capin JJ, Wilson MP, Hare K, Vempati S, Little CE, McGregor D, Castillo-Mancilla J, Stevens-Lapsley JE, Jolley SE, Erlandson KM. Prospective telehealth analysis of functional performance, frailty, quality of life, and mental health after COVID-19 hospitalization. BMC Geriatr. 2022 Mar 26;22(1):251. PubMed PMID: 35337276
  • Brooks KM, Castillo-Mancilla JR, Morrow M, Mawhinney S, Rowan SE, Wyles D, Blum J, Huntley R, Salah L, Tehrani A, Jimmerson LC, Roon L, Bushman LR, Anderson PL, Kiser JJ. Predictors of 007 triphosphate concentrations in dried blood spots in persons with hepatitis C and active drug or alcohol use. J Antimicrob Chemother. 2022 Apr 27;77(5):1396-1403. PubMed PMID: 35194648
  • Pandey S, Hu Y, Bushman LR, Castillo-Mancilla J, Anderson PL, Cooks RG. Miniature mass spectrometer-based point-of-care assay for cabotegravir and rilpivirine in whole blood. Anal Bioanal Chem. 2022 May;414(11):3387-3395. PubMed PMID: 35169905
  • Jennings L, Robbins RN, Nguyen N, Ferraris C, Leu CS, Dolezal C, Hsiao NY, Mgbako O, Joska J, Castillo-Mancilla JR, Myer L, Anderson PL, Remien RH, Orrell C. Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in South Africa. AIDS. 2022 Jun 1;36(7):933-940. PubMed PMID: 35131960
  • Brijkumar J, Edwards JA, Johnson BA, Ordonez C, Sunpath H, Lee M, Dudgeon MR, Rautman L, Pillay S, Moodley P, Sun YV, Castillo-Mancilla J, Li JZ, Kuritzkes DR, Moosa MYS, Marconi VC. Comparing effectiveness of first-line antiretroviral therapy between peri-urban and rural clinics in KwaZulu-Natal, South Africa. HIV Med. 2022 Aug;23(7):727-737. PubMed PMID: 35023287
  • Odayar J, Orrell C, Phillips TK, Hu NC, Kabanda S, Malaba TR, Allerton J, Wiesner L, Hsiao NY, Castillo-Mancilla J, Lesosky M, Myer L. Use of Tenofovir Diphosphate Levels to Predict Viremia During the Postpartum Period in Women Living With Human Immunodeficiency Virus (HIV): A Nested Case-Control Study. Clin Infect Dis. 2022 Sep 14;75(5):761-767. PubMed PMID: 34979553
  • Abuogi LL, Castillo-Mancilla J, Hampanda K, Owuor K, Odwar T, Onono M, Helova A, Turan JM, Anderson PL. Tenofovir Diphosphate in Dried Blood Spots in Pregnant and Postpartum Women With HIV in Kenya: A Novel Approach to Measuring Peripartum Adherence. J Acquir Immune Defic Syndr. 2022 Mar 1;89(3):310-317. PubMed PMID: 34889866
  • Goodman A, Patten L, Castillo-Mancilla J, Zimmer S, Madinger N, Frasca K. Factors Associated with Retention and Adherence in a Comprehensive, Diverse HIV Pre-Exposure Prophylaxis Clinic. AIDS Res Hum Retroviruses. 2022 Apr;38(4):327-335. PubMed PMID: 34861765
  • Chai PR, Mohamed Y, Bustamante MJ, Goodman GR, Najarro J, Castillo-Mancilla J, Baez A, Bronzi O, Sullivan MC, Pereira LM, Baumgartner SL, Carnes TC, Mayer KH, Rosen RK, Boyer EW, O'Cleirigh C. DigiPrEP: A Pilot Trial to Evaluate the Feasibility, Acceptability, and Accuracy of a Digital Pill System to Measure PrEP Adherence in Men Who Have Sex With Men Who Use Substances. J Acquir Immune Defic Syndr. 2022 Feb 1;89(2):e5-e15. PubMed PMID: 34753871
  • Castillo-Mancilla JR, Musinguzi N, Asiimwe S, Siedner MJ, Orrell C, Bangsberg DR, Haberer JE. High residual inflammation despite HIV viral suppression: Lessons learned from real-time adherence monitoring among people with HIV in Africa. HIV Med. 2022 May;23(5):465-473. PubMed PMID: 34704355
  • Castillo-Mancilla JR, Edwards JA, Brijkumar J, Moosa MY, Zhao Y, Ofotokun I, Johnson BA, Lee MH, Pillay S, Pillay M, Moodley P, Kuritzkes DR, Sunpath H, Bushman LR, Ellison L, Anderson PL, Marconi VC. Tenofovir diphosphate levels in dried blood spots are associated with virologic failure and resistance to first-line therapy in South Africa: a case-control cohort study. J Int AIDS Soc. 2021 Dec;24(12):e25849. PubMed PMID: 34910844
  • Abuogi LL, Castillo-Mancilla J, Hampanda K, Owuor K, Odwar T, Onono M, Helova A, Turan JM, Anderson PL. Tenofovir Diphosphate in Dried Blood Spots in pregnant and postpartum women with HIV in Kenya: a novel approach to measuring peripartum adherence. J Acquir Immune Defic Syndr. 2021 Dec 9. [Epub ahead of print] PubMed PMID: 34889866
  • Chai PR, Goodman G, Bustamante MJ, Mohamed Y, Castillo-Mancilla J, Boyer EW, Mayer KH, Rosen RK, Baumgartner SL, Buffkin E, O'Cleirigh C. Long-Term Stability of the Electronic Sensor Component of a Digital Pill System in Real-World Storage Settings. J Pharm Technol. 2021 Jun;37(3):135-139. PubMed PMID: 34752557
  • Castillo-Mancilla JR, Musinguzi N, Asiimwe S, Siedner MJ, Orrell C, Bangsberg DR, Haberer JE. High residual inflammation despite HIV viral suppression: Lessons learned from real-time adherence monitoring among people with HIV in Africa. HIV Med. 2021 Oct 26. [Epub ahead of print] PubMed PMID: 34704355
  • Castillo-Mancilla JR, Morrow M, Coyle RP, Coleman SS, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, MaWhinney S. Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV. Open Forum Infect Dis. 2021 Sep;8(9):ofab463. PubMed PMID: 34584902
  • Yager JL, Brooks KM, Castillo-Mancilla JR, Nemkov C, Morrow M, Peterson S, Ibrahim M, Bushman L, Kiser JJ, MaWhinney S, Anderson PL. Tenofovir-diphosphate in peripheral blood mononuclear cells during low, medium and high adherence to emtricitabine/ tenofovir alafenamide vs. emtricitabine/ tenofovir disoproxil fumarate. AIDS. 2021 Dec 1;35(15):2481-2487. PubMed PMID: 34482350
  • Kamkwalala AR, Garg A, Roy U, Matthews A, Castillo-Mancilla J, Lake JE, Sebastiani G, Yin M, Brown TT, Kamer AR, Jabs DA, Ellis RJ, Boffito M, Greene M, Schmalzle S, Siegler E, Erlandson KM, Moore DJ. Current Considerations for Clinical Management and Care of People with HIV: Findings from the 11th Annual International HIV and Aging Workshop. AIDS Res Hum Retroviruses. 2021 Nov;37(11):807-820. PubMed PMID: 34405689
  • Johnson KA, Niu X, Glidden DV, Castillo-Mancilla JR, Yager J, MaWhinney S, Morrow M, Okochi H, Cressey TR, Drain PK, Gandhi M, Anderson PL, Spinelli MA. Lower Urine Tenofovir Concentrations Among Individuals Taking Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate: Implications for Point-of-Care Testing. Open Forum Infect Dis. 2021 Jul;8(7):ofab200. PubMed PMID: 34285929
  • Morrow M, MaWhinney S, Coyle RP, Coleman SS, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, Castillo-Mancilla JR. Emtricitabine triphosphate in dried blood spots predicts future viremia in persons with HIV and identifies mismatch with self-reported adherence. AIDS. 2021 Oct 1;35(12):1949-1956. PubMed PMID: 34127580
  • Kristofich M, Anderson PL, Castillo-Mancilla JR. Beyond HIV viral load: application of pharmacologic measures to identify ART adherence mismatch. Ther Adv Infect Dis. 2021 Jan-Dec;8:20499361211010596. PubMed PMID: 34035910
  • Chai PR, Bustamante MJ, Goodman G, Mohamed Y, Najarro J, Sullivan MC, Castillo-Mancilla J, Coyle RP, Mayer KH, Rosen RK, Baumgartner SL, Alpert PE, Boyer EW, O'Cleirigh C. A Brief Training Program to Support the Use of a Digital Pill System for Medication Adherence: Pilot Descriptive Study. JMIR Form Res. 2021 Apr 23;5(4):e26213. PubMed PMID: 33890863
  • Lofgren SM, Nicol MR, Kandole TK, Castillo-Mancilla J, Anderson PL, Mpoza E, Tugume L, Bangdiwala AS, Ssebambulidde K, Hullsiek KH, Rhein J, Meya DB, Boulware DR. Short Communication: A Descriptive Analysis of Dried Blood Spot Adherence Testing Among Ugandans with HIV Presenting with Cryptococcal Meningitis. AIDS Res Hum Retroviruses. 2021 Jul;37(7):529-533. PubMed PMID: 33677986
  • Castillo-Mancilla JR, Cavassini M, Schneider MP, Furrer H, Calmy A, Battegay M, Scanferla G, Bernasconi E, Günthard HF, Glass TR. Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort Study. Open Forum Infect Dis. 2021 Feb;8(2):ofab032. PubMed PMID: 33604408
  • Saderup AM, Morrow M, Libby AM, Coyle RP, Coleman SS, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR. Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots. Pharmacotherapy. 2021 Mar;41(3):291-298. PubMed PMID: 33594735
  • Abdo M, Coyle RP, Seifert SM, Castillo-Mancilla JR, Jankowski CM, Mawhinney S, Anderson PL, Erlandson KM. Associations Between Tenofovir Diphosphate in Dried Blood Spots, Impaired Physical Function, and Fracture Risk. Open Forum Infect Dis. 2021 Jan;8(1):ofaa577. PubMed PMID: 33447638
  • Brooks KM, Castillo-Mancilla JR, Morrow M, MaWhinney S, Rowan SE, Wyles D, Blum J, Huntley R, Salah LM, Tehrani A, Bushman LR, Anderson PL, Kiser JJ. Adherence to Direct-Acting Antiviral Therapy in People Actively Using Drugs and Alcohol: The INCLUD Study. Open Forum Infect Dis. 2021 Jan;8(1):ofaa564. PubMed PMID: 33447634
  • Ibrahim ME, Castillo-Mancilla JR, Yager J, Brooks KM, Bushman L, Saba L, Kiser JJ, MaWhinney S, Anderson PL. Individualized Adherence Benchmarks for HIV Pre-Exposure Prophylaxis. AIDS Res Hum Retroviruses. 2021 Jun;37(6):421-428. PubMed PMID: 33191774
  • Mann SC, Castillo-Mancilla JR. HIV, aging, and adherence: an update and future directions. Curr Opin HIV AIDS. 2020 Mar;15(2):134-141. PubMed PMID: 31977338
  • Coyle RP, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR. Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV. J Antimicrob Chemother. 2020 Jun 1;75(6):1591-1598. PubMed PMID: 32211787
  • Castillo-Mancilla JR, Brown TT, Palella FJ Jr, Macatangay BJC, Breen EC, Jacobson LP, Wada NI. Partial Normalization of Biomarkers of Inflammation and Immune Activation Among Virally Suppressed Men With HIV Infection and High ART Adherence. Open Forum Infect Dis. 2020 Apr;7(4):ofaa099. PubMed PMID: 32322603
  • Rana AI, Castillo-Mancilla JR, Tashima KT, Landovitz RL. Advances in Long-Acting Agents for the Treatment of HIV Infection. Drugs. 2020 Apr;80(6):535-545. PubMed PMID: 32180205
  • Ibrahim ME, Castillo-Mancilla JR, Yager J, Brooks KM, Bushman L, Saba L, Kiser JJ, MaWhinney S, Anderson PL. Individualized Adherence Benchmarks for HIV Pre-Exposure Prophylaxis. AIDS Res Hum Retroviruses. 2020 Dec 10. [Epub ahead of print] PubMed PMID: 33191774
  • Mann SC, Morrow M, Coyle RP, Coleman SS, Saderup A, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR. Lower Cumulative Antiretroviral Exposure in People Living With HIV and Diabetes Mellitus. J Acquir Immune Defic Syndr. 2020 Dec 1;85(4):483-488. PubMed PMID: 33136749
  • Vernon F, Morrow M, MaWhinney S, Coyle R, Coleman S, Ellison L, Zheng JH, Bushman L, Kiser JJ, Galárraga O, Anderson PL, Castillo-Mancilla J. Income Inequality Is Associated With Low Cumulative Antiretroviral Adherence in Persons With Human Immunodeficiency Virus. Open Forum Infect Dis. 2020 Oct;7(10):ofaa391. PubMed PMID: 33072812
  • Hussen SA, Kuppalli K, Castillo-Mancilla J, Bedimo R, Fadul N, Ofotokun I. Cultural Competence and Humility in Infectious Diseases Clinical Practice and Research. J Infect Dis. 2020 Sep 14;222(Supplement_6):S535-S542. PubMed PMID: 32926742
  • Canfield GS, Reingold S, Ho A, Thor AD, Pecen PE, DeSanto K, Chastain DB, Franco-Paredes C, Castillo-Mancilla JR, Henao-Martinez AF. AIDS-related Cryptococcus neoformans choroiditis. IDCases. 2020;22:e00931. PubMed PMID: 32884904
  • Brooks KM, Castillo-Mancilla JR, Morrow M, MaWhinney S, Blum J, Wyles DL, Rowan SE, Ibrahim ME, Zheng JH, Johnson B, Gomez J, Choi YJ, Cendali F, Haas H, Roon L, Bushman LR, Anderson PL, Kiser JJ. Pharmacokinetics and renal safety of tenofovir alafenamide with boosted protease inhibitors and ledipasvir/sofosbuvir. J Antimicrob Chemother. 2020 Nov 1;75(11):3303-3310. PubMed PMID: 32766700
  • Yager J, Castillo-Mancilla J, Ibrahim ME, Brooks KM, McHugh C, Morrow M, McCallister S, Bushman LR, MaWhinney S, Kiser JJ, Anderson PL. Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study. J Acquir Immune Defic Syndr. 2020 Jul 1;84(3):323-330. PubMed PMID: 32539288
  • Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M. Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions. Curr HIV/AIDS Rep. 2020 Aug;17(4):301-314. PubMed PMID: 32424549
  • Castillo-Mancilla JR, Brown TT, Palella FJ Jr, Macatangay BJC, Breen EC, Jacobson LP, Wada NI. Partial Normalization of Biomarkers of Inflammation and Immune Activation Among Virally Suppressed Men With HIV Infection and High ART Adherence. Open Forum Infect Dis. 2020 Apr;7(4):ofaa099. PubMed PMID: 32322603
  • Coyle RP, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR. Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV. J Antimicrob Chemother. 2020 Jun 1;75(6):1591-1598. PubMed PMID: 32211787
  • Rana AI, Castillo-Mancilla JR, Tashima KT, Landovitz RL. Advances in Long-Acting Agents for the Treatment of HIV Infection. Drugs. 2020 Apr;80(6):535-545. PubMed PMID: 32180205
  • Mann SC, Castillo-Mancilla JR. HIV, aging, and adherence: an update and future directions. Curr Opin HIV AIDS. 2020 Mar;15(2):134-141. PubMed PMID: 31977338
  • Castillo-Mancilla JR. Adherence to Antiretroviral Therapy and Pre-exposure Prophylaxis: TARGETing the Ideal Measure. Clin Infect Dis. 2020 May 6;70(10):2152-2154. PubMed PMID: 31314075
  • Castillo-Mancilla JR, Coyle RP, Coleman SS, Morrow M, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL. Short Communication: Cascade of Antiretroviral Therapy Adherence in Virologically Suppressed Persons Living with HIV. AIDS Res Hum Retroviruses. 2020 Mar;36(3):173-175. PubMed PMID: 31204866
  • Yager JL, Coyle RP, Coleman SS, Ellison L, Zheng JH, Bushman L, Gardner EM, Morrow M, MaWhinney S, Anderson PL, Justice Kiser J, Castillo-Mancilla JR. Moderately High Tenofovir Diphosphate in Dried Blood Spots Indicates Drug Resistance in Viremic Persons Living with HIV. J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219888457. PubMed PMID: 31750768
  • Musinguzi N, Castillo-Mancilla J, Morrow M, Byakwaga H, Mawhinney S, Burdo TH, Boum Y, Muzoora C, Bwana BM, Siedner MJ, Martin JN, Hunt PW, Bangsberg DR, Haberer JE. Antiretroviral Therapy Adherence Interruptions Are Associated With Systemic Inflammation Among Ugandans Who Achieved Viral Suppression. J Acquir Immune Defic Syndr. 2019 Dec 1;82(4):386-391. PubMed PMID: 31658181
  • Castillo-Mancilla JR. Adherence to ART and PrEP: TARGETing the Ideal Measure. Clin Infect Dis. 2019 Jul 17. [Epub ahead of print] PubMed PMID: 31314075
  • Siedner MJ, Bwana MB, Asiimwe S, Musinguzi N, Castillo-Mancilla J, Amanyire G, Tracy RP, Bangsberg DR, Orrell C, Haberer JE. Inflammatory biomarkers prior to antiretroviral therapy as prognostic markers of 12-month mortality in South Africa and Uganda. AIDS. 2019 Nov 1;33(13):2043-2048. PubMed PMID: 31274541
  • Castillo-Mancilla JR, Phillips AN, Neaton JD, Neuhaus J, Sharma S, Baker JV, Collins S, Mannheimer S, Pett S, Touzeau-Römer V, Polizzotto MN, Lundgren JD, Gardner EM. Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study. J Int AIDS Soc. 2019 Jun;22(6):e25297. PubMed PMID: 31250552
  • Castillo-Mancilla JR, Coyle RP, Coleman SS, Morrow M, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL. Cascade of Antiretroviral Therapy Adherence in Virologically Suppressed Persons Living with HIV. AIDS Res Hum Retroviruses. 2019 Jul 30. [Epub ahead of print] PubMed PMID: 31204866
  • Siedner MJ, Bwana MB, Asiimwe S, Amanyire G, Musinguzi N, Castillo-Mancilla J, Tracy RP, Katz IT, Bangsberg DR, Hunt PW, Orrell C, Haberer JE. Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study. J Infect Dis. 2019 Aug 30;220(7):1172-1177. PubMed PMID: 31188451
  • Brooks KM, Ibrahim ME, Castillo-Mancilla JR, MaWhinney S, Alexander K, Tilden S, Kerr BJ, Ellison L, McHugh C, Bushman LR, Kiser JJ, Hosek S, Huhn GD, Anderson PL. Pharmacokinetics of tenofovir monoester and association with intracellular tenofovir diphosphate following single-dose tenofovir disoproxil fumarate. J Antimicrob Chemother. 2019 Aug 1;74(8):2352-2359. PubMed PMID: 31093649
  • Brooks KM, Castillo-Mancilla JR, Blum J, Huntley R, MaWhinney S, Alexander K, Kerr BJ, Ellison L, Bushman LR, MacBrayne CE, Anderson PL, Kiser JJ. Increased tenofovir monoester concentrations in patients receiving tenofovir disoproxil fumarate with ledipasvir/sofosbuvir. J Antimicrob Chemother. 2019 Aug 1;74(8):2360-2364. PubMed PMID: 31081036
  • Frasca K, Castillo-Mancilla J, McNulty MC, Connors S, Sweitzer E, Zimmer S, Madinger N. A Mixed Methods Evaluation of an Inclusive Sexual History Taking and HIV Prevention Curriculum for Trainees. J Gen Intern Med. 2019 Jul;34(7):1279-1288. PubMed PMID: 31037543
  • Morrow M, MaWhinney S, Coyle RP, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, Castillo-Mancilla JR. Predictive Value of Tenofovir Diphosphate in Dried Blood Spots for Future Viremia in Persons Living With HIV. J Infect Dis. 2019 Jul 19;220(4):635-642. PubMed PMID: 30942881
  • Velásquez GE, Huaman MA, Powell KR, Cohn SE, Swaminathan S, Outlaw M, Schulte G, McNeil Q, Currier JS, Del Rio C, Castillo-Mancilla J. Outcomes of a Career Development Program for Underrepresented Minority Investigators in the AIDS Clinical Trials Group. Open Forum Infect Dis. 2019 Mar;6(3):ofz069. PubMed PMID: 30895207
  • Coyle RP, Schneck CD, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Mawhinney S, Anderson PL, Castillo-Mancilla JR. Engagement in Mental Health Care is Associated with Higher Cumulative Drug Exposure and Adherence to Antiretroviral Therapy. AIDS Behav. 2019 Dec;23(12):3493-3502. PubMed PMID: 30798457
  • Frasca K, Morrow M, Coyle RP, Coleman SS, Ellison L, Bushman LR, Kiser JJ, Zheng JH, Mawhinney S, Anderson PL, Castillo-Mancilla J. Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy. J Antimicrob Chemother. 2019 May 1;74(5):1395-1401. PubMed PMID: 30668713
  • Castillo-Mancilla JR, Morrow M, Coyle RP, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Mawhinney S, Anderson PL. Tenofovir Diphosphate in Dried Blood Spots Is Strongly Associated With Viral Suppression in Individuals With Human Immunodeficiency Virus Infections. Clin Infect Dis. 2019 Apr 8;68(8):1335-1342. PubMed PMID: 30137238
  • Ibrahim ME, Brooks KM, Castillo-Mancilla JR, McHugh C, Morrow M, Brothers J, MaWhinney S, Hosek S, Huhn G, Anderson PL. Short Communication: Bioequivalence of Tenofovir and Emtricitabine After Coencapsulation with the Proteus Ingestible Sensor. AIDS Res Hum Retroviruses. 2018 Oct;34(10):835-837. PubMed PMID: 30047286
  • Koss CA, Liu AY, Castillo-Mancilla J, Bacchetti P, Mchugh C, Kuncze K, Morrow M, Louie A, Seifert S, Okochi H, Mawhinney S, Gandhi M, Anderson PL. Similar tenofovir hair concentrations in men and women after directly-observed: dosing of TDF/FTC: implications for PrEP adherence monitoring. AIDS. 2018 Jul 12. [Epub ahead of print] PubMed PMID: 30005019
  • MacBrayne CE, Marks KM, Fierer DS, Naggie S, Chung RT, Hughes MD, Kim AY, Peters MG, Brainard DM, Seifert SM, Castillo-Mancilla JR, Bushman LR, Anderson PL, Kiser JJ. Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother. 2018 Aug 1;73(8):2112-2119. PubMed PMID: 29746648
  • Seifert SM, Castillo-Mancilla JR, Erlandson K, Morrow M, Gandhi M, Kuncze K, Horng H, Zheng JH, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL. Brief Report: Adherence Biomarker Measurements in Older and Younger HIV-Infected Adults Receiving Tenofovir-Based Therapy. J Acquir Immune Defic Syndr. 2018 Mar 1;77(3):295-298. PubMed PMID: 29189417
  • Anderson PL, Liu AY, Castillo-Mancilla JR, Gardner EM, Seifert SM, McHugh C, Wagner T, Campbell K, Morrow M, Ibrahim M, Buchbinder S, Bushman LR, Kiser JJ, MaWhinney S. Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy. Antimicrob Agents Chemother. 2018 Jan;62(1). PubMed PMID: 29038282
  • MacBrayne CE, Castillo-Mancilla J, Burton JR Jr, MaWhinney S, Wagner CB, Micke K, Fey J, Huntley RT, Larson B, Bushman LR, Kiser JJ. Small increase in dolutegravir trough, but equivalent total dolutegravir exposure with simeprevir in HIV/HCV seronegative volunteers. J Antimicrob Chemother. 2018 Jan 1;73(1):156-159. PubMed PMID: 29029135
  • Castillo-Mancilla JR, Phillips AN, Neaton JD, Neuhaus J, Collins S, Mannheimer S, Pett S, Touzeau-Römer V, Polizzotto MN, Lundgren JD, Gardner EM. Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. Open Forum Infect Dis. 2018 Jan;5(1):ofx275. PubMed PMID: 29362724
  • Castillo-Mancilla JR, Haberer JE. Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring. Curr HIV/AIDS Rep. 2018 Feb;15(1):49-59. PubMed PMID: 29380227
  • Koss CA, Liu AY, Castillo-Mancilla J, Bacchetti P, McHugh C, Kuncze K, Morrow M, Louie A, Seifert S, Okochi H, MaWhinney S, Gandhi M, Anderson PL. Similar tenofovir hair concentrations in men and women after directly observed dosing of tenofovir disoproxil fumarate/emtricitabine: implications for preexposure prophylaxis adherence monitoring. AIDS. 2018 Sep 24;32(15):2189-2194. PubMed PMID: 30212404
  • Castillo-Mancilla JR, Morrow M, Boum Y, Byakwaga H, Haberer JE, Martin JN, Bangsberg D, Mawhinney S, Musinguzi N, Huang Y, Tracy RP, Burdo TH, Williams K, Muzzora C, Hunt PW, Siedner MJ. Brief Report: Higher ART Adherence Is Associated With Lower Systemic Inflammation in Treatment-Naive Ugandans Who Achieve Virologic Suppression. J Acquir Immune Defic Syndr. 2018 Apr 15;77(5):507-513. PubMed PMID: 29346185
  • Erlandson KM, Kitch D, Wester CW, Kalayjian RC, Overton ET, Castillo-Mancilla J, Koletar SL, Benson CA, Campbell TB, Robertson K, Lok JJ. The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 Nov 29;65(12):2042-2049. PubMed PMID: 29020174
  • Seifert SM, Castillo-Mancilla JR, Erlandson KM, Anderson PL. Inflammation and pharmacokinetics: potential implications for HIV-infection. Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):641-650. PubMed PMID: 28335648
  • Chen X, Seifert SM, Castillo-Mancilla JR, Bushman LR, Zheng JH, Kiser JJ, MaWhinney S, Anderson PL. Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates. PLoS One. 2016 Nov 10;11(11):e0165505. PubMed PMID: 27832147
  • Seifert SM, Chen X, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Clayton C, Austin G, Palmer BE, Zheng JH, Klein B, Kerr BJ, Guida LA, Rower C, Rower JE, Kiser JJ, Bushman LR, MaWhinney S, Anderson PL. Intracellular Tenofovir and Emtricitabine Anabolites in Genital, Rectal, and Blood Compartments from First Dose to Steady State. AIDS Res Hum Retroviruses. 2016 Oct Nov;32(10-11):981-991. PubMed PMID: 27526873
  • Chen X, Castillo-Mancilla JR, Seifert SM, McAllister KB, Zheng JH, Bushman LR, MaWhinney S, Anderson PL. Analysis of the Endogenous Deoxynucleoside Triphosphate Pool in HIV-Positive and -Negative Individuals Receiving Tenofovir-Emtricitabine. Antimicrob Agents Chemother. 2016 Sep;60(9):5387-92. PubMed PMID: 27353267
  • Zheng JH, Rower C, McAllister K, Castillo-Mancilla J, Klein B, Meditz A, Guida LA, Kiser JJ, Bushman LR, Anderson PL. Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. J Pharm Biomed Anal. 2016 Apr 15;122:16-20. PubMed PMID: 26829517
  • Castillo-Mancilla J, Seifert S, Campbell K, Coleman S, McAllister K, Zheng JH, Gardner EM, Liu A, Glidden DV, Grant R, Hosek S, Wilson CM, Bushman LR, MaWhinney S, Anderson PL. Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing. Antimicrob Agents Chemother. 2016 Nov;60(11):6692-6697. PubMed PMID: 27572401
  • Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL. Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342). J Antimicrob Chemother. 2016 Jun;71(6):1609-18. PubMed PMID: 26892777
  • Castillo-Mancilla JR, Brown TT, Erlandson KM, Palella FJ Jr, Gardner EM, Macatangay BJ, Breen EC, Jacobson LP, Anderson PL, Wada NI. Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression. Clin Infect Dis. 2016 Dec 15;63(12):1661-1667. PubMed PMID: 27660234
  • Anderson PL, Reirden D, Castillo-Mancilla J. Pharmacologic Considerations for Preexposure Prophylaxis in Transgender Women. J Acquir Immune Defic Syndr. 2016 Aug 15;72 Suppl 3:S230-4. PubMed PMID: 27429188
  • Castillo-Mancilla JR, Searls K, Caraway P, Zheng JH, Gardner EM, Predhomme J, Bushman LR, Anderson PL, Meditz AL. Short communication: Tenofovir diphosphate in dried blood spots as an objective measure of adherence in HIV-infected women. AIDS Res Hum Retroviruses. 2015 Apr;31(4):428-32. PubMed PMID: 25328112
  • Seifert SM, Glidden DV, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Rower C, Klein B, Kerr BJ, Guida LA, Zheng JH, Bushman LR, Anderson PL. Dose response for starting and stopping HIV preexposure prophylaxis for men who have sex with men. Clin Infect Dis. 2015 Mar 1;60(5):804-10. PubMed PMID: 25409469
  • Heumann C, Cohn SE, Krishnan S, Castillo-Mancilla JR, Cespedes M, Floris-Moore M, Smith KY. Regional variation in HIV clinical trials participation in the United States. South Med J. 2015 Feb;108(2):107-16. PubMed PMID: 25688896
  • Castillo-Mancilla JR, Meditz A, Wilson C, Zheng JH, Palmer BE, Lee EJ, Gardner EM, Seifert S, Kerr B, Bushman LR, MaWhinney S, Anderson PL. Reduced immune activation during tenofovir-emtricitabine therapy in HIV-negative individuals. J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):495-501. PubMed PMID: 25763783
  • Chai PR, Castillo-Mancilla J, Buffkin E, Darling C, Rosen RK, Horvath KJ, Boudreaux ED, Robbins GK, Hibberd PL, Boyer EW. Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence. J Med Toxicol. 2015 Dec;11(4):439-44. PubMed PMID: 26245878
  • Seifert SM, Glidden DV, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Rower C, Klein B, Kerr BJ, Guida LA, Zheng JH, Bushman LR, Anderson PL. Dose Response for Starting and Stopping HIV Preexposure Prophylaxis for Men Who Have Sex With Men. Clin Infect Dis. 2014 Nov 18. [Epub ahead of print] PubMed PMID: 25409469
  • Castillo-Mancilla JR, Searls K, Caraway P, Zheng JH, Gardner EM, Predhomme J, Bushman LR, Anderson PL, Meditz AL. Tenofovir Diphosphate in Dried Blood Spots As an Objective Measure of Adherence in HIV-Infected Women. AIDS Res Hum Retroviruses. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25328112
  • Castillo-Mancilla JR, Cohn SE, Krishnan S, Cespedes M, Floris-Moore M, Schulte G, Pavlov G, Mildvan D, Smith KY, Actg Underrepresented Populations Survey Group. Minorities remain underrepresented in HIV/AIDS research despite access to clinical trials. HIV Clin Trials. 2014 Jan-Feb;15(1):14-26. PubMed PMID: 24518211
  • Zheng JH, Guida LA, Rower C, Castillo-Mancilla J, Meditz A, Klein B, Kerr BJ, Langness J, Bushman L, Kiser J, Anderson PL. Quantitation of tenofovir and emtricitabine in dried blood spots (DBS) with LC-MS/MS. J Pharm Biomed Anal. 2014 Jan;88:144-51. PubMed PMID: 24055850
  • Henao-Martínez AF, Castillo-Mancilla JR, Barron MA, Nichol AC. Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections. Case Rep Infect Dis. 2013;2013:589490. PubMed PMID: 23738164
  • Henao-Martínez AF, González-Fontal GR, Castillo-Mancilla JR, Yang IV. Enterobacteriaceae bacteremias among cancer patients: an observational cohort study. Int J Infect Dis. 2013 Jun;17(6):e374-8. PubMed PMID: 23313157
  • Henao-Martínez AF, Castillo-Mancilla JR. The Hispanic HIV Epidemic. Curr Infect Dis Rep. 2013 Feb;15(1):46-51. PubMed PMID: 23184612
  • Castillo-Mancilla JR, Zheng JH, Rower JE, Meditz A, Gardner EM, Predhomme J, Fernandez C, Langness J, Kiser JJ, Bushman LR, Anderson PL. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013 Feb;29(2):384-90. PubMed PMID: 22935078
  • Carten ML, Castillo-Mancilla JR, Allshouse AA, Johnson SC. Characteristics of foreign-born HIV infected individuals and differences by region of origin and gender. J Immigr Minor Health. 2013 Aug;15(4):667-72. PubMed PMID: 22562621
  • Kile DA, MaWhinney S, Aquilante CL, Rower JE, Castillo-Mancilla JR, Anderson PL. A population pharmacokinetic-pharmacogenetic analysis of atazanavir. AIDS Res Hum Retroviruses. 2012 Oct;28(10):1227-34. PubMed PMID: 22394315
  • Castillo-Mancilla JR, Campbell TB. Comparative effectiveness of efavirenz-based antiretroviral regimens in resource-limited settings. J Comp Eff Res. 2012 Mar;1(2):157-170. PubMed PMID: 22707879
  • Castillo-Mancilla J, Allshouse A, Collins C, Hastings-Tolsma M, Campbell TB, Mawhinney S. Differences in sexual risk behavior and HIV/AIDS risk factors among foreign-born and US-born Hispanic women. J Immigr Minor Health. 2012 Feb;14(1):89-99. PubMed PMID: 21932002
  • Castillo-Mancilla JR, Carten M. The need for a US registry of HIV in foreign-born people. Lancet Infect Dis. 2010 Jun;10(6):370-1. PubMed PMID: 20510276
  • Christensen JB, Vitko NP, Voskuil MI, Castillo-Mancilla JR. Implantable cardiac defibrillator pocket infection due to a previously undescribed Cupriavidus species. J Clin Microbiol. 2010 Jul;48(7):2623-5. PubMed PMID: 20427695
  • Castillo-Mancilla JR. The changing HIV epidemic in Mexico. JAMA. 2008 Dec 3;300(21):2484. PubMed PMID: 19050189
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Professional Memberships

  • IDSA, Member
  • HIVMA, Member
  • CO-IDSA, Member
  • NHMA, Member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Infectious Disease, Board Certification (2005, 2015)
  • Internal Medicine, Board Certification (2003)
Conditions & Treatments
  • Infections
  • Infections - Influenza
  • Infections - Pneumonia
  • Infections - Sexually Transmitted Diseases
  • Immune System
  • Immune System - Immunodeficiency
  • Immune System - AIDS
  • Immune System - AIDS / HIV Disease
  • Immune System - AIDS Immunization

General Information

Medical Schools:
  • MD, Universidad La Salle-Facultad Mexicana de Medicina, Mexico City, Mexico (1999)
Internships:
  • Mount Sinai Medical Center of Florida Program (2001)
Residency Programs:
  • Mount Sinai Medical Center of Florida Program, Internal Medicine (2003)
Fellowships:
  • Cleveland Clinic Foundation Program, Infectious Disease (2005)
Languages: English, Spanish
Department: Medicine-Infectious Disease
SOM Resources
CU Resources
Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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