Jason Gien, MD
Associate Professor, Pediatrics-Neonatology

Photo
Medical School:
  • MD, University Of the Witwatersrand, Johannesburg, South Africa (1998)
Residencies:
  • Children's Hospital of Philadelphia Program, Pediatrics (2004)
  • Albert Einstein College of Medicine Program, Internal Medicine (2002)
Fellowships:
  • University of Colorado (University Hospital) Program, Neonatal-Perinatal Medicine (2007)
Languages: English
Department: Pediatrics-Neonatology

Recognition & Awards

  • F. Joseph Butterfield Award-Outstanding Fellow in Neonatal–Perinatal Medicine, F. Joseph Butterfield Foundation, (2007)
  • Fellows Travel Award, Pediatric Academic Societies , (2007)
  • Fellow Research Award for Outstanding Research Best, The Children's Hospital, (2006)
  • Dyson Award for Pediatric Advocacy, Dyson Award for Pediatric Advocacy, (2004)

Teaching

  • Assistant Professor (2008)
    School of Medicine, Pediatrics

Publications

  • Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 Jan;34(1):169-176. PubMed PMID: 30155763
  • Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2018 Oct 12. [Epub ahead of print] PubMed PMID: 30315405
  • Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR. Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30217691
  • Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. PubMed PMID: 29722560
  • Gien J, Meyers ML, Kinsella JP. Assessment of Carina Position Antenatally and Postnatally in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Jan;192:93-98.e1. PubMed PMID: 29246364
  • Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR. Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants With Congenital Diaphragmatic Hernia. Pediatr Infect Dis J. 2018 May;37(5):469-474. PubMed PMID: 29189614
  • Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2017 Oct 26. [Epub ahead of print] PubMed PMID: 29106923
  • Selewski DT, Akcan-Arikan A, Bonachea EM, Gist KM, Goldstein SL, Hanna M, Joseph C, Mahan JD, Nada A, Nathan AT, Reidy K, Staples A, Wintermark P, Boohaker LJ, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group. Pediatr Res. 2018 Sep 20. [Epub ahead of print] PubMed PMID: 30237572
  • Kraut EJ, Boohaker LJ, Askenazi DJ, Fletcher J, Kent AL. Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN]. Pediatr Res. 2018 Aug;84(2):279-289. PubMed PMID: 29795211
  • Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study. JAMA Pediatr. 2018 Jun 4;172(6):e180322. PubMed PMID: 29610830
  • Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2016 Jun 29. [Epub ahead of print] PubMed PMID: 27355979
  • Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2017 Oct 26. [Epub ahead of print] PubMed PMID: 29106923
  • Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR. Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Early Hum Dev. 2017 Mar - Apr;106-107:7-12. PubMed PMID: 28178582
  • Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2016 Nov 28. [Epub ahead of print] PubMed PMID: 27908648
  • Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2016 Jun 29. [Epub ahead of print] PubMed PMID: 27355979
  • Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2016 Nov 28. [Epub ahead of print] PubMed PMID: 27908648
  • Gien J, Tseng N, Seedorf GJ, Kuhn K, Abman SH. Endothelin-1 - Rho-kinase Interactions Impair Lung Structure and Cause Pulmonary Hypertension After Bleomycin Exposure in Neonatal Rat Pups. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 19;:ajplung.00066.2016. [Epub ahead of print] PubMed PMID: 27760762
  • Baker CD, Martin S, Thrasher J, Moore HM, Baker J, Abman SH, Gien J. A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children. Pediatrics. 2016 Apr;137(4). PubMed PMID: 26966133
  • Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2015 Oct 29. [Epub ahead of print] PubMed PMID: 26514398
  • Murthy K, Pallotto EK, Gien J, Brozanski BS, Porta NF, Zaniletti I, Keene S, Chicoine LG, Rintoul NE, Dykes FD, Asselin JM, Short BL, Padula MA, Durand DJ, Reber KM, Evans JR, Grover TR. Predicting death or extended length of stay in infants with congenital diaphragmatic hernia. J Perinatol. 2016 Aug;36(8):654-9. PubMed PMID: 26963428
  • Gien J, Kinsella JP. Management of pulmonary hypertension in infants with congenital diaphragmatic hernia. J Perinatol. 2016 Jun;36 Suppl 2:S28-31. PubMed PMID: 27225962
  • Aschner JL, Gien J, Ambalavanan N, Kinsella JP, Konduri GG, Lakshminrusimha S, Saugstad OD, Steinhorn RH. Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate. J Perinatol. 2016 Jun;36 Suppl 2:S32-6. PubMed PMID: 27225964
  • Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, Selewski DT, Abitbol CL, Kaskel FJ, Mhanna MJ, Ambalavanan N, Charlton JR. Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study. Front Pediatr. 2016 Jul 19;4:68. PubMed PMID: 27486571
  • Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered Pulmonary Artery Endothelial-Smooth Muscle Cell Interactions in Experimental Congenital Diaphragmatic Hernia. Pediatr Res. 2015 Jan 12. [Epub ahead of print] PubMed PMID: 25580737
  • Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan;166(1):178-83. PubMed PMID: 25306189
  • Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan;70(1):84-5. PubMed PMID: 25052575
  • Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2015 Oct 29. [Epub ahead of print] PubMed PMID: 26514398
  • Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L1018-26. PubMed PMID: 26342089
  • Grover TR, Murthy K, Brozanski B, Gien J, Rintoul N, Keene S, Najaf T, Chicoine L, Porta N, Zaniletti I, Pallotto EK. Short-Term Outcomes and Medical and Surgical Interventions in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2015 Sep;32(11):1038-44. PubMed PMID: 25825963
  • Guaman MC, Gien J, Baker CD, Zhang H, Austin ED, Collaco JM. Point Prevalence, Clinical Characteristics, and Treatment Variation for Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2015 Aug;32(10):960-7. PubMed PMID: 25738785
  • Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered Pulmonary Artery Endothelial-Smooth Muscle Cell Interactions in Experimental Congenital Diaphragmatic Hernia. Pediatr Res. 2015 Jan 12. [Epub ahead of print] PubMed PMID: 25580737
  • Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan;166(1):178-83. PubMed PMID: 25306189
  • Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan;70(1):84-5. PubMed PMID: 25052575
  • Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L1018-26. PubMed PMID: 26342089
  • Mandell E, Seedorf GJ, Gien J, Abman SH. Vitamin D Improves Infant Lung Injury and Structure After Intra-Amniotic Endotoxin Exposure in Rats: Potential Role for Prevention of Bronchopulmonary Dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Jan 10. [Epub ahead of print] PubMed PMID: 24414254
  • Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L299-308. PubMed PMID: 24375792
  • Gien J, Abman SH, Baker CD. Interdisciplinary care for ventilator-dependent infants with chronic lung disease. J Pediatr. 2014 Dec;165(6):1274-5. PubMed PMID: 25258147
  • Acker SN, Kinsella JP, Abman SH, Gien J. Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia. J Pediatr. 2014 Jul;165(1):53-58.e1. PubMed PMID: 24840762
  • Gien J, Ing RJ, Twite MD, Campbell D, Mitchell M, Kinsella JP. Successful Surgical Management of Airway Perforation in Preterm Infants. J Pediatr Surg Case Rep. 2014 Feb 1;2(2):47-51. PubMed PMID: 24791225
  • Mandell E, Seedorf GJ, Gien J, Abman SH. Vitamin D Improves Infant Lung Injury and Structure After Intra-Amniotic Endotoxin Exposure in Rats: Potential Role for Prevention of Bronchopulmonary Dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Jan 10. [Epub ahead of print] PubMed PMID: 24414254
  • Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L299-308. PubMed PMID: 24375792
  • Wolf D, Tseng N, Seedorf GJ, Roe GB, Abman SH, Gien J. Endothelin-1 decreases Endothelial PPAR gamma Signaling and Impairs Angiogenesis After Chronic Intrauterine Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Dec 13. [Epub ahead of print] PubMed PMID: 24337925
  • Wolf D, Tseng N, Seedorf GJ, Roe GB, Abman SH, Gien J. Endothelin-1 decreases Endothelial PPAR gamma Signaling and Impairs Angiogenesis After Chronic Intrauterine Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Dec 13. [Epub ahead of print] PubMed PMID: 24337925
  • Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Partrick DA, Gien J. Pulmonary artery endothelial cell dysfunction and decreased populations of highly proliferative endothelial cells in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L943-52. PubMed PMID: 24124189
  • Delaney C, Gien J, Roe G, Isenberg N, Kailey J, Abman SH. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L894-901. PubMed PMID: 23605003
  • Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2012 Nov 30. [Epub ahead of print] PubMed PMID: 23202724
  • Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2012 Nov 30. [Epub ahead of print] PubMed PMID: 23202724
View All (47 Total) View Less

Professional Memberships

  • American Medical Association , Member
  • American Academy of Pediatrics (AAP), Member

Practice Locations

UCHealth - Neonatal Intensive Care Unit - Anschutz
12605 E. 16th Avenue
Aurora, CO 80045
720-848-5224

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Colorado Fetal Care Center
13123 E 16th Ave
Aurora, CO 80045
855-413-3825

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Neonatal-Perinatal Medicine, Board Certification (2007)
  • Pediatrics
Conditions & Treatments
  • Child and Teen Health - Infant and Toddler Health
  • Lungs and Breathing - Pulmonary Hypertension
  • Pregnancy and Reproduction - Neonatal Intensive Care
  • Pregnancy and Reproduction - Maternal and Fetal Health
  • Child and Teen Health
  • Lungs and Breathing
  • Pregnancy and Reproduction

General Information

Medical Schools:
  • MD, University Of the Witwatersrand, Johannesburg, South Africa (1998)
Residency Programs:
  • Children's Hospital of Philadelphia Program, Pediatrics (2004)
  • Albert Einstein College of Medicine Program, Internal Medicine (2002)
Fellowships:
  • University of Colorado (University Hospital) Program, Neonatal-Perinatal Medicine (2007)
Languages: English
Department: Pediatrics-Neonatology
;