Laurent Gapin, PhD, MS
Professor, Immunology and Microbiology

Publications

  • Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
  • Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020;11:610010. PubMed PMID: 33312179
  • Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 Dec 7;11(1):6238. PubMed PMID: 33288744
  • Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct;50(10):1454-1467. PubMed PMID: 32460359
  • Krovi SH, Kappler JW, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22252-22261. PubMed PMID: 31570608
  • Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 Apr 5;4(34). PubMed PMID: 30952805
  • Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Jan 19. [Epub ahead of print] PubMed PMID: 29351991
  • Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Nov;462:65-73. PubMed PMID: 30165064
  • Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L. TCR signal strength controls thymic differentiation of iNKT cell subsets. Nat Commun. 2018 Jul 9;9(1):2650. PubMed PMID: 29985393
  • Krovi SH, Gapin L. Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates. Front Immunol. 2018;9:1393. PubMed PMID: 29973936
  • Tuttle KD, Gapin L. Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry. Methods Mol Biol. 2018;1799:121-133. PubMed PMID: 29956149
  • Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. PubMed PMID: 29351991
  • Krovi SH, Gapin L. iNKT cells need UTX-tra demethylation. Nat Immunol. 2017 Jan 19;18(2):148-150. PubMed PMID: 28102220
  • Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB. CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. Eur J Immunol. 2017 Sep;47(9):1525-1534. PubMed PMID: 28665555
  • Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J. The somatically generated portion of T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor. Elife. 2017 Nov 17;6. PubMed PMID: 29148973
  • Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
  • Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
  • Gapin L. Development of invariant natural killer T cells. Curr Opin Immunol. 2016 Apr;39:68-74. PubMed PMID: 26802287
  • Krovi SH, Gapin L. Revealing the TCR bias for MHC molecules. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2809-11. PubMed PMID: 26933216
  • Zhang J, Bedel R, Krovi SH, Tuttle KD, Zhang B, Gross J, Gapin L, Matsuda JL. Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. Sci Rep. 2016 Jun 3;6:27375. PubMed PMID: 27256918
  • Krovi SH, Gapin L. Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics. 2016 Aug;68(8):549-59. PubMed PMID: 27448212
  • Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW. Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. PubMed PMID: 27588903
  • Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun. 2016 Oct 27;7:13257. PubMed PMID: 27807341
  • Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
  • Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
  • Gapin L. Check MAIT. J Immunol. 2014 May 15;192(10):4475-80. PubMed PMID: 24795465
  • Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. PubMed PMID: 25267651
  • Young MH, Gapin L. Mucosal associated invariant T cells: don't forget your vitamins. Cell Res. 2013 Apr;23(4):460-2. PubMed PMID: 23208418
  • Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One. 2013;8(1):e53789. PubMed PMID: 23342002
  • Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a dendritic cell trans presentation of IL-15 to naive CD8 T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 1;190(5):1936-47. PubMed PMID: 23355737
  • Gapin L, Godfrey DI, Rossjohn J. Natural Killer T cell obsession with self-antigens. Curr Opin Immunol. 2013 Apr;25(2):168-73. PubMed PMID: 23384972
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General Information

Department: Immunology and Microbiology
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