Jorge DiPaola, MD
Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

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Medical School:
  • MD, University of Buenos Aires (1989)
Residency:
  • Children's Hospital of Orange County Program, Pediatrics (1999)
Fellowships:
  • Children's Hospital of Orange County Program, Pediatric Hematology / Oncology (2000)
Languages: English, Spanish
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Professional Titles

  • Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation
  • Associate Director Medial Scientist Training Program (MSTP)
  • The Postle Chair in Pediatric Cancer and Blood Disorders
  • Program Leader Hematology

Recognition & Awards

  • Vice-President, President Elect: Hemophilia and Thrombosis Research Society (HTRS), Hemophilia and Thrombosis Research Society, (2010)
  • Postle Family Chair in Pediatric Cancer and Blood Disorders , TCH, (2009)
  • Permanent Member Hemostasis and Thrombosis Study Section, NIH, (2009)
  • Best Doctors in America, Best Doctors, (2009)
  • James C. Taylor Teaching Award, University of Iowa, Department of Pediatrics, (2003)
Research interests for Patients:
My research focuses on pediatrics, pediatric hematology, Inherited/genetic disorders, bleeding/clotting disorders and oncology.

Teaching

  • Faculty Member (2008)
    School of Medicine, Pediatrics
    Human Medical Genetics Program
  • Associate Professor (2008)
    School of Medicine, Pediatrics

Publications

  • Lehmann M, Ashworth K, Manco-Johnson M, Di Paola J, Neeves KB, Ng CJ. Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost. 2017 Oct 24. [Epub ahead of print] PubMed PMID: 29064615
  • Riemondy KA, Ransom M, Alderman C, Gillen AE, Fu R, Finlay-Schultz J, Kirkpatrick GD, Di Paola J, Kabos P, Sartorius CA, Hesselberth JR. Recovery and analysis of transcriptome subsets from pooled single-cell RNA-seq libraries. Nucleic Acids Res. 2018 Nov 29. [Epub ahead of print] PubMed PMID: 30496484
  • Di Paola J, Bray PF. One over PAR or one under PAR: vive la différence. Blood. 2018 Nov 8;132(19):2007-2008. PubMed PMID: 30409895
  • Smith N, Bornikova L, Noetzli L, Guglielmone H, Minoldo S, Backos DS, Jacobson L, Thornburg CD, Escobar M, White-Adams TC, Wolberg AS, Manco-Johnson M, Di Paola J. Identification and characterization of novel mutations implicated in congenital fibrinogen disorders. Res Pract Thromb Haemost. 2018 Oct;2(4):800-811. PubMed PMID: 30349899
  • Fisher MH, Di Paola J. Genomics and transcriptomics of megakaryocytes and platelets: Implications for health and disease. Res Pract Thromb Haemost. 2018 Oct;2(4):630-639. PubMed PMID: 30349880
  • Kim JS, Kaufman J, Patel SS, Manco-Johnson M, Di Paola J, da Cruz EM. Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2018 Nov;9(6):651-658. PubMed PMID: 30322371
  • Link KG, Stobb MT, Di Paola J, Neeves KB, Fogelson AL, Sindi SS, Leiderman K. A local and global sensitivity analysis of a mathematical model of coagulation and platelet deposition under flow. PLoS One. 2018;13(7):e0200917. PubMed PMID: 30048479
  • Ng CJ, McCrae KR, Ashworth K, Sosa LJ, Betapudi V, Manco-Johnson MJ, Liu A, Dong JF, Chung D, White-Adams TC, López JA, Di Paola J. Effects of anti-ß2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity. Res Pract Thromb Haemost. 2018 Apr;2(2):380-389. PubMed PMID: 30046742
  • Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O'Connell NM, O'Sullivan JM, Di Paola J, James PD, O'Donnell JS. Significant gynecological bleeding in women with low von Willebrand factor levels. Blood Adv. 2018 Jul 24;2(14):1784-1791. PubMed PMID: 30042144
  • Pluthero FG, Di Paola J, Carcao MD, Kahr WHA. NBEAL2 mutations and bleeding in patients with gray platelet syndrome. Platelets. 2018 Sep;29(6):632-635. PubMed PMID: 29869935
  • Law LA, Graham DK, Di Paola J, Branchford BR. GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis. Front Med (Lausanne). 2018;5:137. PubMed PMID: 29868590
  • Ng CJ, Di Paola J. von Willebrand Disease: Diagnostic Strategies and Treatment Options. Pediatr Clin North Am. 2018 Jun;65(3):527-541. PubMed PMID: 29803281
  • Shan Z, Liu X, Chen Y, Wang M, Gao YR, Xu L, Dar WA, Lee CG, Elias JA, Castillo PD, Di Paola J, Ju C. Chitinase 3-like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice. Hepatology. 2017 Dec 18. [Epub ahead of print] PubMed PMID: 29251791
  • Lehmann M, Ashworth K, Manco-Johnson M, Di Paola J, Neeves KB, Ng CJ. Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost. 2017 Oct 24. [Epub ahead of print] PubMed PMID: 29064615
  • Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Earp HS, DeRyckere D, Brass LF, Graham DK, Di Paola JA. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2017 Oct 17. [Epub ahead of print] PubMed PMID: 29045015
  • Shan Z, Liu X, Chen Y, Wang M, Gao YR, Xu L, Dar WA, Lee CG, Elias JA, Castillo PD, Di Paola J, Ju C. Chitinase 3-like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice. Hepatology. 2017 Dec 18. [Epub ahead of print] PubMed PMID: 29251791
  • Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Earp HS, DeRyckere D, Brass LF, Graham DK, Di Paola JA. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2017 Oct 17. [Epub ahead of print] PubMed PMID: 29045015
  • McGraw MD, Osborne CM, Mastej EJ, Di Paola JA, Anderson DR, Holmes WW, Paradiso DC, Garlick RB, Hendry-Hofer TB, Rancourt RC, Smith RW, Burns C, Roe GB, Rioux JS, White CW, Veress LA. Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard. Toxicol Sci. 2017 Oct 1;159(2):461-469. PubMed PMID: 28962529
  • Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O'Donnell JS. Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels. Blood. 2017 Sep 15. [Epub ahead of print] PubMed PMID: 28916584
  • Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 Jun 27;7(1):4275. PubMed PMID: 28655899
  • Schoeman RM, Rana K, Danes N, Lehmann M, Di Paola JA, Fogelson AL, Leiderman K, Neeves KB. A microfluidic model of hemostasis sensitive to platelet function and coagulation. Cell Mol Bioeng. 2017 Feb;10(1):3-15. PubMed PMID: 28529666
  • Davizon-Castillo P, Di Paola J. Tamoxifen Suppresses Platelet Activation-Supported Angiogenesis and Metastasis. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):611-612. PubMed PMID: 28330945
  • Moreira DC, Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. J Thromb Haemost. 2017 Apr;15(4):827-828. PubMed PMID: 28182327
  • Maloney JP, Branchford BR, Brodsky GL, Cosmic MS, Calabrese DW, Aquilante CL, Maloney KW, Gonzalez JR, Zhang W, Moreau KL, Wiggins KL, Smith NL, Broeckel U, Di Paola J. The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk. FASEB J. 2017 Jul;31(7):2771-2784. PubMed PMID: 28302652
  • McGraw MD, Osborne CM, Mastej EJ, Di Paola JA, Anderson DR, Holmes WW, Paradiso DC, Garlick RB, Hendry-Hofer TB, Rancourt RC, Smith RW, Burns C, Roe GB, Rioux JS, White CW, Veress LA. Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard. Toxicol Sci. 2017 Oct 1;159(2):461-469. PubMed PMID: 28962529
  • Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O'Donnell JS. Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels. Blood. 2017 Sep 15. [Epub ahead of print] PubMed PMID: 28916584
  • Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 Jun 27;7(1):4275. PubMed PMID: 28655899
  • Schoeman RM, Rana K, Danes N, Lehmann M, Di Paola JA, Fogelson AL, Leiderman K, Neeves KB. A microfluidic model of hemostasis sensitive to platelet function and coagulation. Cell Mol Bioeng. 2017 Feb;10(1):3-15. PubMed PMID: 28529666
  • Davizon-Castillo P, Di Paola J. Tamoxifen Suppresses Platelet Activation-Supported Angiogenesis and Metastasis. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):611-612. PubMed PMID: 28330945
  • Maloney JP, Branchford BR, Brodsky GL, Cosmic MS, Calabrese DW, Aquilante CL, Maloney KW, Gonzalez JR, Zhang W, Moreau KL, Wiggins KL, Smith NL, Broeckel U, Di Paola J. The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk. FASEB J. 2017 Jul;31(7):2771-2784. PubMed PMID: 28302652
  • Moreira DC, Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. J Thromb Haemost. 2017 Apr;15(4):827-828. PubMed PMID: 28182327
  • Moreira DC, Ng CJ, Quinones R, Liang X, Chung DW, Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome. J Thromb Haemost. 2016 Sep 13. [Epub ahead of print] PubMed PMID: 27622772
  • Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R. Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor. Nat Commun. 2016 Sep 27;7:12863. PubMed PMID: 27670775
  • White-Adams TC, Ng CJ, Jacobi PM, Haberichter SL, Di Paola JA. Mutations in the D'D3 region of VWF traditionally associated with type 1 VWD lead to quantitative and qualitative deficiencies of VWF. Thromb Res. 2016 Sep;145:112-8. PubMed PMID: 27533707
  • Gupta S, Heiman M, Duncan N, Hinckley J, Di Paola J, Shapiro AD. Variable bleeding phenotype in an Amish pedigree with von Willebrand disease. Am J Hematol. 2016 Oct;91(10):E431-5. PubMed PMID: 27414491
  • Guglielmone HA, Smith N, Minoldo S, Jarchum GD, White-Adams T, Di Paola J. Platelet abnormalities in a family with von Willebrand disease type 2B (V1316M) and association with bleeding score. Haemophilia. 2016 Sep;22(5):e455-8. PubMed PMID: 27385556
  • Tomberg K, Khoriaty R, Westrick RJ, Fairfield HE, Reinholdt LG, Brodsky GL, Davizon-Castillo P, Ginsburg D, Di Paola J. Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice. PLoS One. 2016 Mar 7;11(3):e0150852. PubMed PMID: 26950939
  • Othman M, Kaur H, Favaloro EJ, Lillicrap D, Di Paola J, Harrison P, Gresele P. Platelet type von Willebrand disease and registry report: communication from the SSC of the ISTH. J Thromb Haemost. 2016 Feb;14(2):411-4. PubMed PMID: 26882161
  • Boylan B, Rice AS, Dunn AL, Tarantino MD, Brettler DB, Barrett JC, Miller CH, Hemophilia Inhibitor Research Study Investigators, Hemophilia Inhibitor Research Study Investigators. Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay. J Thromb Haemost. 2015 Jan;13(1):47-53. PubMed PMID: 25354263
  • Di Paola J. Paris-Trousseau: evidence keeps pointing to FLI1. Blood. 2015 Oct 22;126(17):1973-4. PubMed PMID: 26494917
  • Kirkpatrick G, Noetzli L, Di Paola J, Porter CC. ETV6 mutations define a new cancer predisposition syndrome. Oncotarget. 2015 Jul 10;6(19):16830-1. PubMed PMID: 26219557
  • Chen J, Hinckley JD, Haberichter S, Jacobi P, Montgomery R, Flood VH, Wong R, Interlandi G, Chung DW, López JA, Di Paola J. Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease. Blood. 2015 Jul 9;126(2):262-9. PubMed PMID: 26019279
  • Branchford BR, Ng CJ, Neeves KB, Di Paola J. Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis. Thromb Res. 2015 Jul;136(1):13-9. PubMed PMID: 26014643
  • Bodó I, Eikenboom J, Montgomery R, Patzke J, Schneppenheim R, Di Paola J. Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH. J Thromb Haemost. 2015 Jul;13(7):1345-50. PubMed PMID: 25858564
  • Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015 Mar 25. [Epub ahead of print] PubMed PMID: 25807284
  • Ng C, Motto DG, Di Paola J. Diagnostic approach to von Willebrand disease. Blood. 2015 Mar 26;125(13):2029-37. PubMed PMID: 25712990
  • Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 2014 Jan 1;533(1):447-50. PubMed PMID: 24103481
  • Gonzalez-Alegre P, Di Paola J, Wang K, Fabbro S, Yu HC, Shaikh TH, Darbro BW, Bassuk AG. Evaluating Familial Essential Tremor with Novel Genetic Approaches: Is it a Genotyping or Phenotyping Issue?. Tremor Other Hyperkinet Mov (N Y). 2014;4:258. PubMed PMID: 25374765
  • Di Paola J. Understanding congenital platelet disorders. Clin Adv Hematol Oncol. 2014 Jul;12(7):461-3. PubMed PMID: 25322327
  • Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Di Paola J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014 Aug 1;124(8):3590-600. PubMed PMID: 24983320
  • Boulden Warren B, Di Paola JA. Platelets join the world of "Omics". Blood. 2014 Apr 17;123(16):2446-7. PubMed PMID: 24744250
  • Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, Manco-Johnson M. FVIII/VWF ratio is not a reliable predictor of VWD in children. Pediatr Blood Cancer. 2013 Nov 26. [Epub ahead of print] PubMed PMID: 24281894
  • Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 2014 Jan 1;533(1):447-50. PubMed PMID: 24103481
  • Soucie JM, Miller CH, Kelly FM, Payne AB, Creary M, Bockenstedt PL, Kempton CL, Manco-Johnson MJ, Neff AT, the Haemophilia Inhibitor Research Study Investigators. A study of prospective surveillance for inhibitors among persons with haemophilia in the United States. Haemophilia. 2013 Nov 22. [Epub ahead of print] PubMed PMID: 24261612
  • Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, Manco-Johnson M. FVIII/VWF ratio is not a reliable predictor of VWD in children. Pediatr Blood Cancer. 2013 Nov 26. [Epub ahead of print] PubMed PMID: 24281894
  • Zhang W, McIver AL, Stashko MA, Deryckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700. PubMed PMID: 24219778
  • Mannuccio Mannucci P, Kyrle PA, Schulman S, Di Paola J, Schneppenheim R, Cox Gill J. Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials. Blood Transfus. 2013 Oct;11(4):533-40. PubMed PMID: 23736911
  • Flood VH, Friedman KD, Gill JC, Haberichter SL, Christopherson PA, Branchford BR, Hoffmann RG, Abshire TC, Dunn AL, Di Paola JA, Hoots WK, Brown DL, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR. No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation. Blood. 2013 May 2;121(18):3742-4. PubMed PMID: 23520336
  • Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan;48(1):94-104. PubMed PMID: 23065128
  • Branchford BR, Di Paola J. Making a diagnosis of VWD. Hematology Am Soc Hematol Educ Program. 2012;2012:161-7. PubMed PMID: 23233576
  • Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan;48(1):94-104. PubMed PMID: 23065128
  • Marchi R, Walton BL, McGary CS, Lin FC, Ma AD, Pawlinski R, Mackman N, Campbell RA, Di Paola J, Wolberg AS. Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans. Thromb Haemost. 2012 Sep;108(3):516-26. PubMed PMID: 22836883
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Professional Memberships

  • American Society of Hematology, Member
  • National Hemophilia Foundation, Member
  • International Society of Thrombosis and Haemostasis, Member
  • American Society of Pediatric Hematology/Oncology, Member
  • Hemophilia and Thrombosis Research Society, Member
  • Iowa Medical Society, Member
  • Society For Pediatric Research (SPR), Member
  • Midwest Society for Pediatric Research (MWSPR), Member

Practice Locations

Hemophilia & Thrombosis Center
13199 E. Montview Blvd
Suite 100
Aurora, CO 80045
303-724-0724

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Pediatric Hematology / Oncology, Board Certification (2008)
Conditions & Treatments
  • Blood / Lymphatic System - Blood Disorders
  • Cancers
  • Blood / Lymphatic System - Bleeding Disorders
  • Blood / Lymphatic System - Clotting Disorders
  • Blood / Lymphatic System
Clinical Interest for Patients
I am interested in bleeding and thrombotic disorders. My research interests include the study of genetics of Von Willebrand disease and platelet disorders.

Personal Interests
I enjoy the great outdoors with my family. Climbing, snowboarding and biking.

General Information

Medical Schools:
  • MD, University of Buenos Aires (1989)
Residency Programs:
  • Children's Hospital of Orange County Program, Pediatrics (1999)
Fellowships:
  • Children's Hospital of Orange County Program, Pediatric Hematology / Oncology (2000)
Languages: English, Spanish
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
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