Tobias Eckle, MD
Professor, Anesthesiology

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Medical School:
  • MD, Eberhard Karls University, Tübingen - Germany (2001)
Languages: English, German
Department: Anesthesiology

Professional Titles

  • Director Grand Rounds Department of Anesthesiology
  • Medical Director of Advanced Practice Providers

Research Interests

My research interests are primarily focused on investigating the effect of daylight/sunlight on human metabolism.


  • Oyama Y, Walker LA, Eckle T. Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury. Chronobiol Int. 2021 Sep;38(9):1262-1273. PubMed PMID: 34034593
  • Shuff S, Oyama Y, Walker L, Eckle T. Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease. Trends Mol Med. 2021 Jul;27(7):627-629. PubMed PMID: 33980464
  • Vohwinkel CU, Coit EJ, Burns N, Elajaili H, Hernandez-Saavedra D, Yuan X, Eckle T, Nozik E, Tuder RM, Eltzschig HK. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J. 2021 Apr;35(4):e21468. PubMed PMID: 33687752
  • Oyama Y, Shuff S, Maddry JK, Schauer SG, Bebarta VS, Eckle T. Intense Light Pretreatment Improves Hemodynamics, Barrier Function and Inflammation in a Murine Model of Hemorrhagic Shock Lung. Mil Med. 2020 Sep 18;185(9-10):e1542-e1550. PubMed PMID: 32515788
  • Gile J, Oyama Y, Shuff S, Eckle T. A role for the adenosine ADORA2B receptor in midazolam induced cognitive dysfunction. Curr Pharm Des. 2020 Apr 15. [Epub ahead of print] PubMed PMID: 32294028
  • Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):901-913. PubMed PMID: 32102568
  • Lee JW, Koeppen M, Seo SW, Bowser JL, Yuan X, Li J, Sibilia M, Ambardekar AV, Zhang X, Eckle T, Yoo SH, Eltzschig HK. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology. 2020 Apr;132(4):763-780. PubMed PMID: 31794514
  • Oyama Y, Shuff S, Davizon-Castillo P, Clendenen N, Eckle T. Intense light as anticoagulant therapy in humans. PLoS One. 2020;15(12):e0244792. PubMed PMID: 33382840
  • Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
  • Oyama Y, Blaskowsky J, Eckle T. Dose-dependent Effects of Esmolol-epinephrine Combination Therapy in Myocardial Ischemia and Reperfusion Injury. Curr Pharm Des. 2019;25(19):2199-2206. PubMed PMID: 31258066
  • Bartman CM, Eckle T. Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease. Curr Pharm Des. 2019;25(10):1075-1090. PubMed PMID: 31096895
  • Oyama Y, Bartman CM, Gile J, Sehrt D, Eckle T. The circadian PER2 enhancer Nobiletin reverses the deleterious effects of midazolam in myocardial ischemia and reperfusion injury. Curr Pharm Des. 2018 Sep 23. [Epub ahead of print] PubMed PMID: 30246635
  • Szolnoki J, Polaner DM, Eckle T. Diurnal variations in recovery times after general anaesthesia in children. Br J Anaesth. 2018 Oct;121(4):776-786. PubMed PMID: 30236240
  • A Comparison of Epinephrine, Esmolol, and the Combination of Both in Reperfusion Injury After Murine Myocardial Ischemia J Blaskowsky, T Eckle - FASEB JOURNAL, 2018
  • Bartman CM, Oyama Y, Eckle T. Daytime variations in perioperative myocardial injury. Lancet. 2018 May 26;391(10135):2104. PubMed PMID: 29856340
  • Gile J, Scott B, Eckle T. The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium. Crit Care Med. 2018 Jun;46(6):e600-e608. PubMed PMID: 29489460
  • Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018 Feb 26;9(1):816. PubMed PMID: 29483579
  • Oyama Y, Bartman CM, Gile J, Eckle T. Circadian MicroRNAs in Cardioprotection. Curr Pharm Des. 2017 Jul 7. [Epub ahead of print] PubMed PMID: 28699517
  • Koeppen M, Scott B, Morabito J, Fiegel M, Eckle T. Pneumomediastinum and Bilateral Pneumothoraces Causing Respiratory Failure after Thyroid Surgery. Case Rep Anesthesiol. 2017;2017:8206970. PubMed PMID: 28523194
  • Bartman CM, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M, Eckle T. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS One. 2017;12(4):e0176243. PubMed PMID: 28448534
  • Eckle T. New "Guidance" for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins. Crit Care Med. 2016 Aug;44(8):1623-4. PubMed PMID: 27428130
  • Scott B, Eckle T. The impact of sedation protocols on outcomes in critical illness. Ann Transl Med. 2016 Jan;4(2):33. PubMed PMID: 26889486
  • Gile J, Eckle T. ADORA2b Signaling in Cardioprotection. J Nat Sci. 2016;2(10). PubMed PMID: 27747290
  • Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy. Anesthesiology. 2015 Jan 29. [Epub ahead of print] PubMed PMID: 25635592
  • Koeppen M, Eckle T, Eltzschig HK. Next Generation of Cardiovascular Studies: Transcriptional Responses of the Human Myocardium during Cardiac Surgery. Anesthesiology. 2015 Jan 7. [Epub ahead of print] PubMed PMID: 25569809
  • Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15;195(4):1732-43. PubMed PMID: 26136425
  • Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. Health implications of disrupted circadian rhythms and the potential for daylight as therapy. Anesthesiology. 2015 May;122(5):1170-5. PubMed PMID: 25635592
  • Brainard J, Gobel M, Bartels K, Scott B, Koeppen M, Eckle T. Circadian rhythms in anesthesia and critical care medicine: potential importance of circadian disruptions. Semin Cardiothorac Vasc Anesth. 2015 Mar;19(1):49-60. PubMed PMID: 25294583
  • Eckle T. Editorial: Health Impact and Management of a Disrupted Circadian Rhythm and Sleep in Critical Illnesses. Curr Pharm Des. 2015;21(24):3428-30. PubMed PMID: 26156038
  • Koeppen M, Gravlee GP, Nasrallah F, Eckle T. Transesophageal echocardiography in the diagnosis of acute pericardial tamponade during hiatal hernia repair. J Cardiothorac Vasc Anesth. 2014 Feb;28(1):112-4. PubMed PMID: 23157738
  • Bonney S, Hughes K, Eckle T. Anesthetic Cardioprotection: The Role of Adenosine. Curr Pharm Des. 2014 Feb 3. [Epub ahead of print] PubMed PMID: 24502579
  • Brainard J, Gobel M, Bartels K, Scott B, Koeppen M, Eckle T. Circadian Rhythms in Anesthesia and Critical Care Medicine: Potential Importance of Circadian Disruptions. Semin Cardiothorac Vasc Anesth. 2014 Oct 7. [Epub ahead of print] PubMed PMID: 25294583
  • Eckle T. About Dogs, Mice, and Men: From Ischemic Preconditioning to Anesthetic Postconditioning of the Heart. Semin Cardiothorac Vasc Anesth. 2014 Jul 9;18(3):247-248. [Epub ahead of print] PubMed PMID: 25007799
  • Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol. 2014 Feb 1;192(3):1249-56. PubMed PMID: 24391213
  • Koeppen M, Gravlee GP, Nasrallah F, Eckle T. Transesophageal echocardiography in the diagnosis of acute pericardial tamponade during hiatal hernia repair. J Cardiothorac Vasc Anesth. 2014 Feb;28(1):112-4. PubMed PMID: 23157738
  • Trends in Molecular Medicine. 2013 Attenuating myocardial ischemia by targeting A2B adenosine receptors Eltzschig H, Bonney S, Eckle T
  • Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar;45(3):667-71. PubMed PMID: 23291353
  • Eltzschig HK, Bonney SK, Eckle T. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 2013 Jun;19(6):345-54. PubMed PMID: 23540714
  • Han J, Gagnon S, Eckle T, Borchers CH. Metabolomic analysis of key central carbon metabolism carboxylic acids as their 3-nitrophenylhydrazones by UPLC/ESI-MS. Electrophoresis. 2013 Oct;34(19):2891-900. PubMed PMID: 23580203
  • Eckle T, Hughes K, Ehrentraut H, Brodsky KS, Rosenberger P, Choi DS, Ravid K, Weng T, Xia Y, Blackburn MR, Eltzschig HK. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 2013 Aug;27(8):3078-89. PubMed PMID: 23603835
  • Han J, Tschernutter V, Yang J, Eckle T, Borchers CH. Analysis of selected sugars and sugar phosphates in mouse heart tissue by reductive amination and liquid chromatography-electrospray ionization mass spectrometry. Anal Chem. 2013 Jun 18;85(12):5965-73. PubMed PMID: 23682691
  • Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665. PubMed PMID: 24086109
  • Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP and Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 April 15;
  • Koeppen, M, Harter PN, Bonney S, Bonney M, Reithel S, Zachskorn C, Mittelbronn M and Eckle T. Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-reperfusion Injury. Anesthesiology June 2012.
  • Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial Ischemia Reperfusion Injury: From Basic Science to Clinical Bedside. Semin Cardiothorac Vasc Anesth. 2012 Feb 23. [Epub ahead of print]
  • Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med. 2011 Nov 7;17(11):1391-401. doi: 10.1038/nm.2507
  • Koeppen M, Eckle T, Eltzschig HK. The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol. 2011 Aug;24(4):363-9. PubMed PMID: 21659868
  • Koeppen M, Eckle T, Eltzschig HK. Interplay of hypoxia and A2B adenosine receptors in tissue protection. Adv Pharmacol. 2011;61:145-86. PubMed PMID: 21586359
  • Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol. 2010 May 1;184(9):5271-9. PubMed PMID: 20348420
  • Eckle T, Koeppen M, Eltzschig HK. Role of extracellular adenosine in acute lung injury. Physiology (Bethesda). 2009 Oct;24:298-306. PubMed PMID: 19815856
  • Eltzschig HK, Eckle T, Grenz A. PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med. 2009 Mar 26;360(13):1361-2; author reply 1362. PubMed PMID: 19321876
  • Eltzschig HK, Köhler D, Eckle T, Kong T, Robson SC, Colgan SP. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009 Jan 1;113(1):224-32. PubMed PMID: 18812468
  • Eckle T, Grenz A, Laucher S, Eltzschig HK. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 2008 Oct;118(10):3301-15. PubMed PMID: 18787641
  • Eckle T, Füllbier L, Grenz A, Eltzschig HK. Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L718-24. PubMed PMID: 18708630
  • Eltzschig HK, El Kasmi KC, Eckle T. The HIF2A gene in familial erythrocytosis. N Engl J Med. 2008 May 1;358(18):1965-6; author reply 1966-7. PubMed PMID: 18450610
  • Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med. 2008 Jun 24;5(6):e137. PubMed PMID: 18578565
  • Eckle T, Köhler D, Lehmann R, El Kasmi K, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation. 2008 Jul 8;118(2):166-75. PubMed PMID: 18591435
  • Redel A, Jazbutyte V, Smul TM, Lange M, Eckle T, Eltzschig H, Roewer N, Kehl F. Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo. Exp Biol Med (Maywood). 2008 Jan;233(1):84-93. PubMed PMID: 18156310
  • Eckle T, Faigle M, Grenz A, Laucher S, Thompson LF, Eltzschig HK. A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood. 2008 Feb 15;111(4):2024-35. PubMed PMID: 18056839
  • Hart ML, Köhler D, Eckle T, Kloor D, Stahl GL, Eltzschig HK. Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1477-83. PubMed PMID: 18511695
  • Grenz A, Zhang H, Hermes M, Eckle T, Klingel K, Huang DY, Müller CE, Robson SC, Osswald H, Eltzschig HK. Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 2007 Sep;21(11):2863-73. PubMed PMID: 17442731
  • Köhler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, Laucher S, Hart ML, Robson SC, Müller CE, Eltzschig HK. CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation. 2007 Oct 16;116(16):1784-94. PubMed PMID: 17909107
  • Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann J, Köhle C, Kloor D, Gleiter CH, Vallon V, Eltzschig HK, Osswald H. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1501-11. PubMed PMID: 17855480
  • Grenz A, Zhang H, Eckle T, Mittelbronn M, Wehrmann M, Köhle C, Kloor D, Thompson LF, Osswald H, Eltzschig HK. Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol. 2007 Mar;18(3):833-45. PubMed PMID: 17267736
  • Eckle T, Füllbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, Rosenberger P, Eltzschig HK. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15;178(12):8127-37. PubMed PMID: 17548651
  • Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27;115(12):1581-90. PubMed PMID: 17353435
  • Grenz A, Eckle T, Zhang H, Huang DY, Wehrmann M, Köhle C, Unertl K, Osswald H, Eltzschig HK. Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice. Am J Physiol Renal Physiol. 2007 Jan;292(1):F475-85. PubMed PMID: 16912063
  • Warth A, Eckle T, Köhler D, Faigle M, Zug S, Klingel K, Eltzschig HK, Wolburg H. Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction. Cardiology. 2007;107(4):402-10. PubMed PMID: 17284903
  • Eltzschig HK, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10;99(10):1100-8. PubMed PMID: 17038639
  • Eckle T, Grenz A, Köhler D, Redel A, Falk M, Rolauffs B, Osswald H, Kehl F, Eltzschig HK. Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2533-40. PubMed PMID: 16766632
  • Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal. 2006 Jun;2(2):351-60. PubMed PMID: 18404475
  • Eltzschig HK, Weissmüller T, Mager A, Eckle T. Nucleotide metabolism and cell-cell interactions. Methods Mol Biol. 2006;341:73-87. PubMed PMID: 16799190
  • Eckle T, Ghanayim N, Trick M, Unertl K, Eltzschig HK. Intraoperative metamizol as cause for acute anaphylactic collapse. Eur J Anaesthesiol. 2005 Oct;22(10):810-12. PubMed PMID: 16211791
  • Eltzschig HK, Eckle T, Felbinger TW. Management of chronic obstructive pulmonary disease. N Engl J Med. 2004 Sep 30;351(14):1461-3; author reply 1461-3. PubMed PMID: 15459312
  • Eckle T, Jahn G, Hamprecht K. The influence of mixed HCMV UL97 wildtype and mutant strains on ganciclovir susceptibility in a cell associated plaque reduction assay. J Clin Virol. 2004 May;30(1):50-6. PubMed PMID: 15072754
  • Hamprecht K, Eckle T, Prix L, Faul C, Einsele H, Jahn G. Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain. J Infect Dis. 2003 Jan 1;187(1):139-43. PubMed PMID: 12508158
  • Eckle T, Jahn G, Hamprecht K. High impact of an expanded restriction fragment length polymorphism assay on detection of ganciclovir-resistant UL97 mutants of human cytomegalovirus. Antimicrob Agents Chemother. 2003 Jan;47(1):442-3. PubMed PMID: 12499235
  • Eckle T, Lang P, Prix L, Jahn G, Klingebiel T, Handgretinger R, Selle B, Niethammer D, Hamprecht K. Rapid development of ganciclovir-resistant cytomegalovirus infection in children after allogeneic stem cell transplantation in the early phase of immune cell recovery. Bone Marrow Transplant. 2002 Oct;30(7):433-9. PubMed PMID: 12368955
  • Eckle T, Prix L, Jahn G, Klingebiel T, Handgretinger R, Selle B, Hamprecht K. Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. Blood. 2000 Nov 1;96(9):3286-9. PubMed PMID: 11050017
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Professional Memberships

  • Association of University Anesthesiologists (AUA), Member
  • American Society of Anesthesiologists (ASA), Member
  • International Anesthesia Research Society (IARS), Member
  • American Heart Association (AHA), Member
  • Society of Cardiovascular Anesthesiologists (SCA), Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

  • Anesthesiology, Board Certification (2008, 2018)
Care Philosophy
I strive to provide the best patient care possible.

Public Speaking

General Information

Medical Schools:
  • MD, Eberhard Karls University, Tübingen - Germany (2001)
Download CV
Languages: English, German
Department: Anesthesiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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