Tobias Eckle, MD
Professor, Anesthesiology

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Medical School:
  • MD, Eberhard Karls University, Tübingen - Germany (2001)
Languages: English, German
Department: Anesthesiology

Professional Titles

  • Director Grand Rounds Department of Anesthesiology

Research Interests

My research interests are primarily focused on investigating the effect of daylight/sunlight on human metabolism.

Publications

  • Oyama Y, Shuff S, Maddry JK, Schauer SG, Bebarta VS, Eckle T. Intense Light Pretreatment Improves Hemodynamics, Barrier Function and Inflammation in a Murine Model of Hemorrhagic Shock Lung. Mil Med. 2020 Sep 18;185(9-10):e1542-e1550. PubMed PMID: 32515788
  • Gile J, Oyama Y, Shuff S, Eckle T. A role for the adenosine ADORA2B receptor in midazolam induced cognitive dysfunction. Curr Pharm Des. 2020 Apr 15. [Epub ahead of print] PubMed PMID: 32294028
  • Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):901-913. PubMed PMID: 32102568
  • Lee JW, Koeppen M, Seo SW, Bowser JL, Yuan X, Li J, Sibilia M, Ambardekar AV, Zhang X, Eckle T, Yoo SH, Eltzschig HK. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology. 2020 Apr;132(4):763-780. PubMed PMID: 31794514
  • Oyama Y, Shuff S, Davizon-Castillo P, Clendenen N, Eckle T. Intense light as anticoagulant therapy in humans. PLoS One. 2020;15(12):e0244792. PubMed PMID: 33382840
  • Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
  • Oyama Y, Blaskowsky J, Eckle T. Dose-dependent Effects of Esmolol-epinephrine Combination Therapy in Myocardial Ischemia and Reperfusion Injury. Curr Pharm Des. 2019;25(19):2199-2206. PubMed PMID: 31258066
  • Bartman CM, Eckle T. Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease. Curr Pharm Des. 2019;25(10):1075-1090. PubMed PMID: 31096895
  • Oyama Y, Bartman CM, Gile J, Sehrt D, Eckle T. The circadian PER2 enhancer Nobiletin reverses the deleterious effects of midazolam in myocardial ischemia and reperfusion injury. Curr Pharm Des. 2018 Sep 23. [Epub ahead of print] PubMed PMID: 30246635
  • Szolnoki J, Polaner DM, Eckle T. Diurnal variations in recovery times after general anaesthesia in children. Br J Anaesth. 2018 Oct;121(4):776-786. PubMed PMID: 30236240
  • A Comparison of Epinephrine, Esmolol, and the Combination of Both in Reperfusion Injury After Murine Myocardial Ischemia J Blaskowsky, T Eckle - FASEB JOURNAL, 2018
  • Bartman CM, Oyama Y, Eckle T. Daytime variations in perioperative myocardial injury. Lancet. 2018 May 26;391(10135):2104. PubMed PMID: 29856340
  • Gile J, Scott B, Eckle T. The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium. Crit Care Med. 2018 Jun;46(6):e600-e608. PubMed PMID: 29489460
  • Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018 Feb 26;9(1):816. PubMed PMID: 29483579
  • Oyama Y, Bartman CM, Gile J, Eckle T. Circadian MicroRNAs in Cardioprotection. Curr Pharm Des. 2017 Jul 7. [Epub ahead of print] PubMed PMID: 28699517
  • Koeppen M, Scott B, Morabito J, Fiegel M, Eckle T. Pneumomediastinum and Bilateral Pneumothoraces Causing Respiratory Failure after Thyroid Surgery. Case Rep Anesthesiol. 2017;2017:8206970. PubMed PMID: 28523194
  • Bartman CM, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M, Eckle T. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS One. 2017;12(4):e0176243. PubMed PMID: 28448534
  • Eckle T. New "Guidance" for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins. Crit Care Med. 2016 Aug;44(8):1623-4. PubMed PMID: 27428130
  • Scott B, Eckle T. The impact of sedation protocols on outcomes in critical illness. Ann Transl Med. 2016 Jan;4(2):33. PubMed PMID: 26889486
  • Gile J, Eckle T. ADORA2b Signaling in Cardioprotection. J Nat Sci. 2016;2(10). PubMed PMID: 27747290
  • Eckle T. New "Guidance" for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins. Crit Care Med. 2016 Aug;44(8):1623-4. PubMed PMID: 27428130
  • Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy. Anesthesiology. 2015 Jan 29. [Epub ahead of print] PubMed PMID: 25635592
  • Koeppen M, Eckle T, Eltzschig HK. Next Generation of Cardiovascular Studies: Transcriptional Responses of the Human Myocardium during Cardiac Surgery. Anesthesiology. 2015 Jan 7. [Epub ahead of print] PubMed PMID: 25569809
  • Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15;195(4):1732-43. PubMed PMID: 26136425
  • Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. Health implications of disrupted circadian rhythms and the potential for daylight as therapy. Anesthesiology. 2015 May;122(5):1170-5. PubMed PMID: 25635592
  • Brainard J, Gobel M, Bartels K, Scott B, Koeppen M, Eckle T. Circadian rhythms in anesthesia and critical care medicine: potential importance of circadian disruptions. Semin Cardiothorac Vasc Anesth. 2015 Mar;19(1):49-60. PubMed PMID: 25294583
  • Koeppen M, Gravlee GP, Nasrallah F, Eckle T. Transesophageal echocardiography in the diagnosis of acute pericardial tamponade during hiatal hernia repair. J Cardiothorac Vasc Anesth. 2014 Feb;28(1):112-4. PubMed PMID: 23157738
  • Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury. J Immunol. 2014 Feb 1;192(3):1249-56. PubMed PMID: 24391213
  • Bonney S, Hughes K, Eckle T. Anesthetic Cardioprotection: The Role of Adenosine. Curr Pharm Des. 2014 Feb 3. [Epub ahead of print] PubMed PMID: 24502579
  • Brainard J, Gobel M, Bartels K, Scott B, Koeppen M, Eckle T. Circadian Rhythms in Anesthesia and Critical Care Medicine: Potential Importance of Circadian Disruptions. Semin Cardiothorac Vasc Anesth. 2014 Oct 7. [Epub ahead of print] PubMed PMID: 25294583
  • Eckle T. About Dogs, Mice, and Men: From Ischemic Preconditioning to Anesthetic Postconditioning of the Heart. Semin Cardiothorac Vasc Anesth. 2014 Jul 9;18(3):247-248. [Epub ahead of print] PubMed PMID: 25007799
  • Bonney S, Hughes K, Eckle T. Anesthetic cardioprotection: the role of adenosine. Curr Pharm Des. 2014;20(36):5690-5. PubMed PMID: 24502579
  • Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol. 2014 Feb 1;192(3):1249-56. PubMed PMID: 24391213
  • Koeppen M, Gravlee GP, Nasrallah F, Eckle T. Transesophageal echocardiography in the diagnosis of acute pericardial tamponade during hiatal hernia repair. J Cardiothorac Vasc Anesth. 2014 Feb;28(1):112-4. PubMed PMID: 23157738
  • Trends in Molecular Medicine. 2013 Attenuating myocardial ischemia by targeting A2B adenosine receptors Eltzschig H, Bonney S, Eckle T
  • Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar;45(3):667-71. PubMed PMID: 23291353
  • Eltzschig HK, Bonney SK, Eckle T. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 2013 Jun;19(6):345-54. PubMed PMID: 23540714
  • Han J, Gagnon S, Eckle T, Borchers CH. Metabolomic analysis of key central carbon metabolism carboxylic acids as their 3-nitrophenylhydrazones by UPLC/ESI-MS. Electrophoresis. 2013 Oct;34(19):2891-900. PubMed PMID: 23580203
  • Eckle T, Hughes K, Ehrentraut H, Brodsky KS, Rosenberger P, Choi DS, Ravid K, Weng T, Xia Y, Blackburn MR, Eltzschig HK. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 2013 Aug;27(8):3078-89. PubMed PMID: 23603835
  • Han J, Tschernutter V, Yang J, Eckle T, Borchers CH. Analysis of selected sugars and sugar phosphates in mouse heart tissue by reductive amination and liquid chromatography-electrospray ionization mass spectrometry. Anal Chem. 2013 Jun 18;85(12):5965-73. PubMed PMID: 23682691
  • Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013;8(8):e71493. PubMed PMID: 23977055
  • Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665. PubMed PMID: 24086109
  • Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP and Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 April 15;
  • Koeppen, M, Harter PN, Bonney S, Bonney M, Reithel S, Zachskorn C, Mittelbronn M and Eckle T. Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-reperfusion Injury. Anesthesiology June 2012.
  • Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial Ischemia Reperfusion Injury: From Basic Science to Clinical Bedside. Semin Cardiothorac Vasc Anesth. 2012 Feb 23. [Epub ahead of print]
  • Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med. 2011 Nov 7;17(11):1391-401. doi: 10.1038/nm.2507
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Professional Memberships

  • Association of University Anesthesiologists (AUA), Member
  • American Society of Anesthesiologists (ASA), Member
  • International Anesthesia Research Society (IARS), Member
  • American Heart Association (AHA), Member
  • Society of Cardiovascular Anesthesiologists (SCA), Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Anesthesiology, Board Certification (2008, 2018)
Care Philosophy
I strive to provide the best patient care possible.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Eberhard Karls University, Tübingen - Germany (2001)
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Languages: English, German
Department: Anesthesiology
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