Kenneth MacLean, PhD
Professor, Pediatrics-Clinical Genetics and Metabolism

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Languages: English
Department: Pediatrics-Clinical Genetics and Metabolism

Publications

  • Kendra M. Prutton, John O. Marentette, Kenneth N. Maclean, James R. Roede. Characterization of mitochondrial and metabolic alterations induced by trisomy 21 during neural differentiation Free Radical Biology and Medicine 196 (2023) 11-21
  • Kenneth N Maclean, Hua Jiang, Jan Pícha and Jirí Jirácek, Sally P. Stabler. Characterization of aberrant hepatic and hippocampal one-carbon metabolism in CBS deficient homocystinuria yields new insights into pathogenesis and dramatically improved treatment: The end of methionine restriction? HCY2023/CluB-12 conference. Old divinity school, St John’s college, University of Cambridge, September 17th -20th,2023
  • Kristofer Fritz, Hua Jiang, David Orlicky, Rima Rosen, Alana K. Majors, Sally P Stabler James R Roede, Kenneth N Maclean. Protein carbonylation of cysteine residues in classical Homocystinuria:A mechanism to explain the HCU specific Marfanoid Habitus and ectopia lentis. 4th International conference on Rare Diseases, Vienna, December 7-8th 2022
  • 1. Damian D. Guerra, Rachael Bok, Kelsey Breen, Vibhuti Vyas, Hua Jiang, Kenneth N. MacLean, and K. Joseph Hurt. Estrogen regulates local cysteine metabolism in mouse myometrium. Reproductive Sciences 2021 Jan;28(1):79-90.
  • 2. Rachael Bok, Abhishek K. Rauniyar, Peter S. Harris, Sara A. Wennersten, Sally P. Stabler, Laura D. Brown, James R. Roede, Kenneth N. MacLean and K. Joseph Hurt. Redox Regulation of Estrogen-Stimulated Uterine Blood Flow: A Mechanism of Fetal Growth Restriction. Redox Biology. 2021 Apr;40:101827
  • 3. Kenneth N. Maclean, Hua Jiang, Whitney N. Phinney, Bailey M. Mclagan, James R. Roede, Sally P. Stabler. Metabolic derangement of hepatic polyamine, folate and methionine cycle metabolism in cystathionine ß-Synthase-Deficient Homocystinuria in the Presence and Absence of Treatment: Possible Implications for Pathogenesis. Molecular Genetics and Metabolism 2021 Feb;132(2):128-138.
  • 4. S. Gupta. L. Wang, M. Slifker ,K. Qi, K.N. Maclean., T. Bottiglieri, W.D.Kruger. Analysis of neonatal lethality in CBS deficient mice using metabolic profiling. FASEB J. 2021 Jun;35(6):e21629.
  • 5. Anderson C.C., Marentette J.O., Prutton K.M., Rauniyar A.K., Reisz J.A., D’Alessandro A., Maclean K.N., Roede J.R. Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism. Free Radical Biology and Medicine 172 (2021) 201-212.
  • Maclean KN, Jiang H, Stabler SP. Can a better understanding of the impact of HCU upon one-carbon metabolism lead to improved betaine treatment and the end of methionine restriction? 13th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine. September 9th to 13th 20201, Poznan, Poland.
  • Maclean K.N. How elucidating regulatory cross-talk between folate and thiol metabolism can lead to improved treatment in classical homocystinuria: A possible route to the end of methionine restriction? NIH Webinar on Organic Acidemias and Homocystinurias - June 24-25th, 2021
  • Maclean K.N. Oxidative Stress and epigenetic alteration of gene expression: Towards a unifying theory of pathogenesis in CBS deficient homocystinuria. Travere Advisory Board conference on the Pathophysiology of Homocysteine. August 2021
  • Navigating the effects of altered drug metabolism in classical homocystinuria. The 4th International Homocystinurias Patient - Expert Meeting, Melbourne, Australia. 30th November 2021
  • Marisa W. Friederich, Austin A. Larson, Aaron Landry, David Dimmock, Hua Jiang, Kenneth N. MacLean, Ruma Bannerjee, Johan L.K. Van Hove. Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease. In Press at Journal of Inherited Metabolic Disease. 2020 Sep;43(5):1024-1036. PMID: 32160317
  • Anne C Porter, Diane L Gumina, Rachael Bok, Kenneth N Maclean, Nichole Reisdorph, Henry L Galan, Sally P Stablem+r, Beth A Bailey, John C Hobbins, K. Joseph Hurt. Maternal amino acid profiles to distinguish pathologic versus constitutional fetal growth restriction defined by Doppler ultrasound: a pilot study. American Journal of Perinatology 2020 Sep;37(11):1084-1093.
  • Rachael Bok, Abhishek K. Rauniyar, Peter S. Harris, Sara A. Wennersten, Sally P. Stabler, Laura D. Brown, James R. Roede, Kenneth N. MacLean and K. Joseph Hurt. Redox Regulation of Estrogen-Stimulated Uterine Blood Flow: A Mechanism of Fetal Growth Restriction. Annual Meeting of the Society for Reproductive Investigation. Vancouver, Canada. 10-14 Mar 2020.
  • Damian D. Guerra, Rachael Bok, Kelsey Breen, Vibhuti Vyas, Hua Jiang, Kenneth N. MacLean, and K. Joseph Hurt. Estrogen regulates local cysteine metabolism in mouse myometrium. Reproductive Sciences 2021 Jan;28(1):79-90.
  • Rachael Bok, Abhishek K. Rauniyar, Peter S. Harris, Sara A. Wennersten, Sally P. Stabler, Laura D. Brown, James R. Roede, Kenneth N. MacLean and K. Joseph Hurt. Redox Regulation of Estrogen-Stimulated Uterine Blood Flow: A Mechanism of Fetal Growth Restriction. In Press at Redox Biology.
  • Kenneth N. Maclean, Hua Jiang, Whitney N. Phinney, Bailey M. Mclagan, James R. Roede, Sally P. Stabler. Metabolic derangement of hepatic polyamine, folate and methionine cycle metabolism in cystathionine ß-Synthase-Deficient Homocystinuria in the Presence and Absence of Treatment: Possible Implications for Pathogenesis. In Press at Molecular Genetics and Metabolism.
  • 2. Kendra M. Prutton, John O. Marentette, Brice A. Leifheit, Hector Esquer, Daniel V. LaBarbera, Colin C. Anderson, Kenneth N. Maclean and James R. Roede Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to Trisomy 21 In Press at Free Radical Biology and Medicine 2022 Jun;186:32-42.
  • Celeste Bouchard, Tamana R. Yousof, Mihnea Alb, Edward G. Lynn, Sárka Lhoták, Kenneth N. Maclean, Hui Li, Nathan Cherrington, Joan C. Krepinsky, Alistair J. Ingram, Gregory R. Steinberg, Richard C. Austin. Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mice. In Press at. J. Biol. Chem
  • Kendra M. Prutton, John O. Marentette, Kenneth N. Maclean, James R. Roede. Mitochondrial dynamics in 2-D neural differentiation of Down syndrome induced pluripotent stem cells. In Press at Free Radical Biology and Medicine
  • Tamana R. Yousof, Celeste C. Bouchard, Mihnea Alb, Edward G. Lynn, Sárka Lhoták, Hua Jiang, Melissa MacDonald, Jae H. Byun, Yumna Makda, Maria Athanasopoulos, Hui Li, Kenneth N. Maclean, Nathan Cherrington, Asghar Naqvi, Suleiman Igdoura, Joan C. Krepinsky, Gregory R. Steinberg, and Richard C. Austin. The restoration of TDAG551 in hepatocytes reduces obesity in mice with NAFLD. In Press at J. Biol. Chem..
  • Kenneth N. Maclean, Hua Jiang, Philip D. Neill, Ryan R. Chanin, K. Joseph Hurt, David J. Orlicky, Teodoro Bottiglieri, James R. Roede, Sally P. Stabler. Dysregulation of hepatic one-carbon metabolism in classical homocystinuria: Implications of redox-sensitive DHFR repression and THF depletion for pathogenesis and treatment. In Press at FASEB J.
  • 6. Colin C. Anderson, Abhishek K. Rauniyar, Abhilasha Jain, Stefanos Aivazidis, John O. Marentette, Kenneth N. Maclean and James R. Roede. The impact of trisomy 21 on the peroxiredoxin-thioredoxin-thioredoxin reductase thiol redox system In Press at Antioxidants
  • 7. Celeste Bouchard, Tamana R. Yousof, Mihnea Alb, Edward G. Lynn, Sárka Lhoták, Kenneth N. Maclean, Hui Li, Nathan Cherrington, Joan C. Krepinsky, Alistair J. Ingram, Gregory R. Steinberg, Richard C. Austin. Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mice. In Press at. J. Biol. Chem
  • 8. Kendra M. Prutton, John O. Marentette, Brice A. Leifheit, Hector Esquer, Daniel V. LaBarbera, Colin C. Anderson, Kenneth N. Maclean and James R. Roede Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to Trisomy 21 In Press at Stem Cell Reports
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Clinical Genetics and Genomics (MD)
Conditions & Treatments
  • Genetic Conditions and Testing
  • Food, Nutrition and Metabolism

General Information

Languages: English
Department: Pediatrics-Clinical Genetics and Metabolism
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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