Luisa Mestroni, MD
Professor, Medicine-Cardiology

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Medical School:
  • MD, University of Trieste, School of Medicine, Italy (1979)
Undergraduate School:
  • BS, University of Trieste, School of Medicine, Italy (1979)
Internship:
  • University of Trieste, School of Medicine, Italy (1980)
Residency:
  • University of Trieste, School of Medicine, Italy, Cardiology (1980)
Fellowships:
  • University of Trieste, School of Medicine, Italy, Interventional Cardiology (1984)
Languages: English, Italian
Department: Medicine-Cardiology

Professional Titles

  • Professor of Medicine/Cardiology
  • Co-Director, Molecular Genetics Program, University of Colorado Cardiovascular Institute
  • Principal Investigator, International Familial Cardiomyopathy Registry

Recognition & Awards

  • 2018 Distinguished Fellowship Award, International Academy of Cardiology (2018)
  • Fondation Leducq Transatlantic Network of Excellence, Fondation Leducq (2014)
    Prestigious International Award to conduct research on inherited arrhythmogenic cardiomyopathies.
  • Academic Achievement Award, Western Society of Clinical Investigation (2014)
  • Permanent Study Section Member, NIH/CRS/CCHF (2011)
    Cardiac Contractility, Hypertrophy, and Failure ( CCHF), from 2011-2017
  • Dean’s Mentoring Award in Recognition of Exemplary Thesis Advising, Graduate School, University of Colorado Health Sciences Center (2005)

Research Interests

My research is dedicated to the study of genetics of heart muscle diseases, called cardiomyopathies. Since 1991, we have collected clinical information and DNA of over 2000 subjects from families with cardiomyopathies, initially in Italy and subsequently in the USA. Data and materials are collected in the International Familial Registry which has been supported by various grants of the NIH, AHA, UN, MDA. Through our researches on the molecular genetics of cardiomyopathies and analysis on genotype-phenotype correlations, several genes and pathways causing heart disease have been investigated in my laboratory, from cytoskeletal and sarcomeric genes, to ion channels. We are interested in the genes causing dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia, left ventricular noncompaction and hypertrophic cardiomyopathy. Our ongoing research has shown that specific genes may have a different prognosis and may suggest different management strategies. Functional studies of mutant cardiomyopathy genes are also performed to evaluate the consequences of the defective proteins on cellular models. We are currently exploring applications of nanotechnology, biophysics and bioengineering to the study of heart function and cardiomyopathies.

Teaching

  • Professor of Medicine (1998)
    School of Medicine, Medicine
    Heart Failure, Cardiomyopathies, Genetic of Heart Disease

Publications

  • Chen SN, Mestroni L, Taylor MRG. Genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2021 May 1;36(3):288-294. PubMed PMID: 33769382
  • Eldemire R, Taylor MRG, Mestroni L. Precision medicine in laminopathies: insights from the REDLAMINA registry. Rev Esp Cardiol (Engl Ed). 2021 Mar;74(3):208-209. PubMed PMID: 33162390
  • Eldemire R, Taylor MRG, Mestroni L. Understanding the role of titin in dilated cardiomyopathy. Int J Cardiol. 2020 Oct 1;316:186-187. PubMed PMID: 32634495
  • Merlo M, Cannatà A, Pio Loco C, Stolfo D, Barbati G, Artico J, Gentile P, De Paris V, Ramani F, Zecchin M, Gigli M, Pinamonti B, Korcova R, Di Lenarda A, Giacca M, Mestroni L, Camici PG, Sinagra G. Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail. 2020 Jul;22(7):1111-1121. PubMed PMID: 32452075
  • Finocchiaro G, Merlo M, Sheikh N, De Angelis G, Papadakis M, Olivotto I, Rapezzi C, Carr-White G, Sharma S, Mestroni L, Sinagra G. The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy. Eur J Heart Fail. 2020 Jul;22(7):1097-1107. PubMed PMID: 32243666
  • Borin D, Peña B, Chen SN, Long CS, Taylor MRG, Mestroni L, Sbaizero O. Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C. Heliyon. 2020 Jan;6(1):e03175. PubMed PMID: 32021920
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • Merlo M, Cappelletto C, De Angelis G, Porcari A, Caiffa T, Lardieri G, Pagnan L, Severini GM, Dal Ferro M, Stolfo D, Vitrella G, De Luca A, Korkova R, Massa L, Tavc?ar I, Aleksova A, Barbati G, Zanchi C, Ramani F, Di Lenarda A, Perkan A, Mestroni L, Zecchin M, Pinamonti B, Bussani R, Sinagra G. [Diagnostic work-up and clinical management of cardiomyopathies: the operative protocol from the Cardiothoracovascular Department of Trieste, Italy]. G Ital Cardiol (Rome). 2020 Dec;21(12):935-953. PubMed PMID: 33231213
  • Bui QM, Hong KN, Kraushaar M, Ma GS, Brambatti M, Kahn AM, Bougault C, Boynton K, Mestroni L, Taylor MRG, Adler E. Apical Sparing Strain Pattern in Danon Disease: Insights From a Global Registry. JACC Cardiovasc Imaging. 2020 Dec;13(12):2689-2691. PubMed PMID: 32739374
  • Corrado D, van Tintelen PJ, McKenna WJ, Hauer RNW, Anastastakis A, Asimaki A, Basso C, Bauce B, Brunckhorst C, Bucciarelli-Ducci C, Duru F, Elliott P, Hamilton RM, Haugaa KH, James CA, Judge D, Link MS, Marchlinski FE, Mazzanti A, Mestroni L, Pantazis A, Pelliccia A, Marra MP, Pilichou K, Platonov PGA, Protonotarios A, Rampazzo A, Saffitz JE, Saguner AM, Schmied C, Sharma S, Tandri H, Te Riele ASJM, Thiene G, Tsatsopoulou A, Zareba W, Zorzi A, Wichter T, Marcus FI, Calkins H. Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis. Eur Heart J. 2020 Apr 7;41(14):1414-1429. PubMed PMID: 31637441
  • Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 Apr;13(2):e002800. PubMed PMID: 32164419
  • Brun F, Gigli M, Graw SL, Judge DP, Merlo M, Murray B, Calkins H, Sinagra G, Taylor MR, Mestroni L, James CA. FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2020 Apr;57(4):254-257. PubMed PMID: 31924696
  • Borin D, Peña B, Taylor MRG, Mestroni L, Lapasin R, Sbaizero O. Viscoelastic behavior of cardiomyocytes carrying LMNA mutations. Biorheology. 2020;57(1):1-14. PubMed PMID: 32083564
  • Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T, Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E. Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Circ Heart Fail. 2019 Mar;12(3):e005371. PubMed PMID: 30871351
  • Marreddy Cheedipudi S, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet ME, Taylor M, Mestroni L, Cleveland JC, Willerson JT, Gurha P, Marian AJ. Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes is Associated with Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 Feb 11. [Epub ahead of print] PubMed PMID: 30739589
  • Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 Mar 15;124(6):856-873. PubMed PMID: 30696354
  • Gigli M, Merlo M, Graw SL, Barbati G, Rowland TJ, Slavov DB, Stolfo D, Haywood ME, Dal Ferro M, Altinier A, Ramani F, Brun F, Cocciolo A, Puggia I, Morea G, McKenna WJ, La Rosa FG, Taylor MRG, Sinagra G, Mestroni L. Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2019 Sep 17;74(11):1480-1490. PubMed PMID: 31514951
  • Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 Nov;16(11):e373-e407. PubMed PMID: 31676023
  • Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 Nov;16(11):e301-e372. PubMed PMID: 31078652
  • Peña B, Maldonado M, Bonham AJ, Aguado BA, Dominguez-Alfaro A, Laughter M, Rowland TJ, Bardill J, Farnsworth NL, Alegret Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications. ACS Appl Mater Interfaces. 2019 May 22;11(20):18671-18680. PubMed PMID: 31021594
  • Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019 Jul 2;129(8):3171-3184. PubMed PMID: 31264976
  • Addison J, Taylor MRG, Mestroni L. Genotype-phenotype correlations in ARVC: Toward a precision medicine approach. Int J Cardiol. 2019 Jul 1;286:115-116. PubMed PMID: 30898427
  • Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Baseline Characteristics of the VANISH Cohort. Circ Heart Fail. 2019 Dec;12(12):e006231. PubMed PMID: 31813281
  • Tharp CA, Haywood ME, Sbaizero O, Taylor MRG, Mestroni L. The Giant Protein Titin's Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease. Front Physiol. 2019;10:1436. PubMed PMID: 31849696
  • Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 Feb 8. [Epub ahead of print] PubMed PMID: 29432544
  • Puzzi L, Borin D, Martinelli V, Mestroni L, Kelsell DP, Sbaizero O. Cellular biomechanics impairment in keratinocytes is associated with a C-terminal truncated desmoplakin: An atomic force microscopy investigation. Micron. 2018 Mar;106:27-33. PubMed PMID: 29291530
  • Cortez D, Svensson A, Carlson J, Graw S, Sharma N, Brun F, Spezzacatene A, Mestroni L, Platonov PG. The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype. J Electrocardiol. 2018 Nov - Dec;51(6):1003-1008. PubMed PMID: 30497719
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Paldino A, De Angelis G, Merlo M, Gigli M, Dal Ferro M, Severini GM, Mestroni L, Sinagra G. Genetics of Dilated Cardiomyopathy: Clinical Implications. Curr Cardiol Rep. 2018 Aug 13;20(10):83. PubMed PMID: 30105555
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Peña B, Laughter M, Jett S, Rowland TJ, Taylor MRG, Mestroni L, Park D. Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci. 2018 Jun;18(6):e1800079. PubMed PMID: 29733514
  • Mestroni L, Sbaizero O. Arrhythmogenic Cardiomyopathy: Mechanotransduction Going Wrong. Circulation. 2018 Apr 10;137(15):1611-1613. PubMed PMID: 29632153
  • Chen SN, Taylor MRG, Mestroni L. Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Genom Precis Med. 2018 Mar;11(3):e002088. PubMed PMID: 29545481
  • Sweet ME, Mestroni L, Taylor MRG. Genetic Infiltrative Cardiomyopathies. Heart Fail Clin. 2018 Apr;14(2):215-224. PubMed PMID: 29525649
  • Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 May 1;114(6):846-857. PubMed PMID: 29432544
  • Puzzi L, Borin D, Martinelli V, Mestroni L, Kelsell DP, Sbaizero O. Cellular biomechanics impairment in keratinocytes is associated with a C-terminal truncated desmoplakin: An atomic force microscopy investigation. Micron. 2018 Mar;106:27-33. PubMed PMID: 29291530
  • Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ. The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study. JAMA Cardiol. 2017 Feb 22. [Epub ahead of print] PubMed PMID: 28241245
  • Te Riele AS, Agullo-Pascual E, James CA, Leo-Macias A, Cerrone M, Zhang M, Lin X, Lin B, Sobreira NL, Amat-Alarcon N, Marsman RF, Murray B, Tichnell C, van der Heijden JF, Dooijes D, van Veen TA, Tandri H, Fowler SJ, Hauer RN, Tomaselli G, van den Berg MP, Taylor MR, Brun F, Sinagra G, Wilde AA, Mestroni L, Bezzina CR, Calkins H, Peter van Tintelen J, Bu L, Delmar M, Judge DP. Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis. Cardiovasc Res. 2017 Jan;113(1):102-111. PubMed PMID: 28069705
  • Ho JE, Shi L, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy A, Taylor M, Mestroni L, Cirino AL, Sleeper LA, Jarolim P, Lopez B, Gonzalez A, Diez J, Orav EJ, Ho CY. Biomarkers of cardiovascular stress and fibrosis in preclinical hypertrophic cardiomyopathy. Open Heart. 2017;4(2):e000615. PubMed PMID: 29177058
  • Chen SN, Taylor MRG, Mestroni L. Unraveling Missing Genes and Missing Inheritance in Arrhythmogenic Cardiomyopathy. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). PubMed PMID: 29038109
  • Cortez D, Svensson A, Carlson J, Graw S, Sharma N, Brun F, Spezzacatene A, Mestroni L, Platonov PG. Right precordial-directed electrocardiographical markers identify arrhythmogenic right ventricular cardiomyopathy in the absence of conventional depolarization or repolarization abnormalities. BMC Cardiovasc Disord. 2017 Oct 13;17(1):261. PubMed PMID: 29029613
  • McNally EM, Mestroni L. Dilated Cardiomyopathy: Genetic Determinants and Mechanisms. Circ Res. 2017 Sep 15;121(7):731-748. PubMed PMID: 28912180
  • Peña B, Bosi S, Aguado BA, Borin D, Farnsworth NL, Dobrinskikh E, Rowland TJ, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31645-31656. PubMed PMID: 28895403
  • D'souza RS, Mestroni L, Taylor MRG. Danon disease for the cardiologist: case report and review of the literature. J Community Hosp Intern Med Perspect. 2017 Mar;7(2):107-114. PubMed PMID: 28638575
  • Dal Ferro M, Stolfo D, Altinier A, Gigli M, Perrieri M, Ramani F, Barbati G, Pivetta A, Brun F, Monserrat L, Giacca M, Mestroni L, Merlo M, Sinagra G. Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy. Heart. 2017 Nov;103(21):1704-1710. PubMed PMID: 28416588
  • Gigli M, Sinagra G, Mestroni L. [Gene therapy in heart failure: the unexpected results from the CUPID 2 trial]. G Ital Cardiol (Rome). 2017 Feb;18(2):101-105. PubMed PMID: 28398363
  • Te Riele AS, Agullo-Pascual E, James CA, Leo-Macias A, Cerrone M, Zhang M, Lin X, Lin B, Sobreira NL, Amat-Alarcon N, Marsman RF, Murray B, Tichnell C, van der Heijden JF, Dooijes D, van Veen TA, Tandri H, Fowler SJ, Hauer RN, Tomaselli G, van den Berg MP, Taylor MR, Brun F, Sinagra G, Wilde AA, Mestroni L, Bezzina CR, Calkins H, Peter van Tintelen J, Bu L, Delmar M, Judge DP. Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis. Cardiovasc Res. 2017 Jan;113(1):102-111. PubMed PMID: 28069705
  • Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ. The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study. JAMA Cardiol. 2017 Apr 1;2(4):419-428. PubMed PMID: 28241245
  • Begay RL, Tharp CA, Martin A, Graw SL, Sinagra G, Miani D, Sweet ME, Slavov DB, Stafford N, Zeller MJ, Alnefaie R, Rowland TJ, Brun F, Jones KL, Gowan K, Mestroni L, Garrity DM, Taylor MR. FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. JACC Basic Transl Sci. 2016 Aug;1(5):344-359. PubMed PMID: 28008423
  • Rowland TJ, Graw SL, Sweet ME, Gigli M, Taylor MR, Mestroni L. Obscurin Variants in Patients With Left Ventricular Noncompaction. J Am Coll Cardiol. 2016 Nov 15;68(20):2237-2238. PubMed PMID: 27855815
  • Brun F, Groeneweg JA, Gear K, Sinagra G, van der Heijden J, Mestroni L, Hauer RN, Borgstrom M, Marcus FI, Hughes T. Risk Stratification in Arrhythmic Right Ventricular Cardiomyopathy Without Implantable Cardioverter-Defibrillators. JACC Clin Electrophysiol. 2016 Oct;2(5):558-564. PubMed PMID: 27790640
  • Seriani S, Del Favero G, Mahaffey J, Marko D, Gallina P, Long CS, Mestroni L, Sbaizero O. The cell-stretcher: A novel device for the mechanical stimulation of cell populations. Rev Sci Instrum. 2016 Aug;87(8):084301. PubMed PMID: 27587132
  • Gigli M, Begay RL, Morea G, Graw SL, Sinagra G, Taylor MR, Granzier H, Mestroni L. A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies. Front Cardiovasc Med. 2016 Jul 21;3:21. PubMed PMID: 27493940
  • Puggia I, Merlo M, Barbati G, Rowland TJ, Stolfo D, Gigli M, Ramani F, Di Lenarda A, Mestroni L, Sinagra G. Natural History of Dilated Cardiomyopathy in Children. J Am Heart Assoc. 2016 Jun 30;5(7). PubMed PMID: 27364989
  • Cortez D, Graw S, Mestroni L. In Hypertrophic Cardiomyopathy, the Spatial Peaks QRS-T Angle Identifies Those With Sustained Ventricular Arrhythmias. Clin Cardiol. 2016 Aug;39(8):459-63. PubMed PMID: 27175825
  • Rowland TJ, Sweet ME, Mestroni L, Taylor MR. Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathy. J Cell Sci. 2016 Jun 1;129(11):2135-43. PubMed PMID: 27165304
  • Peña B, Martinelli V, Jeong M, Bosi S, Lapasin R, Taylor MR, Long CS, Shandas R, Park D, Mestroni L. Biomimetic Polymers for Cardiac Tissue Engineering. Biomacromolecules. 2016 May 9;17(5):1593-601. PubMed PMID: 27073119
  • Mohanraj J, Puzzi L, Capria E, Corvaglia S, Casalis L, Mestroni L, Sbaizero O, Fraleoni-Morgera A. Easy fabrication of aligned PLLA nanofibers-based 2D scaffolds suitable for cell contact guidance studies. Mater Sci Eng C Mater Biol Appl. 2016 May;62:301-6. PubMed PMID: 26952427
  • Disertori M, Gulizia MM, Casolo G, Delise P, Di Lenarda A, Di Tano G, Lunati M, Mestroni L, Salerno-Uriarte J, Tavazzi L. Improving the appropriateness of sudden arrhythmic death primary prevention by implantable cardioverter-defibrillator therapy in patients with low left ventricular ejection fraction. Point of view. J Cardiovasc Med (Hagerstown). 2016 Apr;17(4):245-55. PubMed PMID: 26895401
  • Mestroni L, Sweet ME, Taylor MR. Pediatric Cardiomyopathy: New Insight Into Potential Disease Mechanisms. J Am Coll Cardiol. 2016 Feb 9;67(5):526-8. PubMed PMID: 26846951
  • Porto AG, Brun F, Severini GM, Losurdo P, Fabris E, Taylor MR, Mestroni L, Sinagra G. Clinical Spectrum of PRKAG2 Syndrome. Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003121. PubMed PMID: 26729852
  • Losurdo P, Stolfo D, Merlo M, Barbati G, Gobbo M, Gigli M, Ramani F, Pinamonti B, Zecchin M, Finocchiaro G, Mestroni L, Sinagra G. Early Arrhythmic Events in Idiopathic Dilated Cardiomyopathy. JACC Clin Electrophysiol. 2016 Oct;2(5):535-543. PubMed PMID: 29759572
  • Brun F, Mestroni L, Sinagra G. [Molecular genetic testing according to the latest European guidelines on hypertrophic cardiomyopathy]. G Ital Cardiol (Rome). 2015 Mar;16(3):138-42. PubMed PMID: 25837456
  • Sbaizero O, DelFavero G, Martinelli V, Long CS, Mestroni L. Analysis of long- and short-range contribution to adhesion work in cardiac fibroblasts: an atomic force microscopy study. Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:217-24. PubMed PMID: 25686942
  • Disertori M, Gulizia MM, Casolo G, Delise P, Di Lenarda A, Di Tano G, Lunati M, Mestroni L, Salerno-Uriarte JA, Tavazzi L. [Remarks on polyparametric assessment of sudden death risk for primary prevention ICD implantation in patients with left ventricular dysfunction of ischemic and non ischemic etiology. Italian Association of Hospital Cardiologists (ANMCO) Experts Position Paper]. G Ital Cardiol (Rome). 2015 Nov;16(11):651-66. PubMed PMID: 26571481
  • Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus. 2015;6(5):394-407. PubMed PMID: 26309016
  • Sweet M, Taylor MR, Mestroni L. Diagnosis, prevalence, and screening of familial dilated cardiomyopathy. Expert Opin Orphan Drugs. 2015;3(8):869-876. PubMed PMID: 27547593
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy. J Cell Physiol. 2014 Mar 13. [Epub ahead of print] PubMed PMID: 24623017
  • Mestroni L, Nguyen DT. Inhibition of Proto-Oncogene c-Src Tyrosine Kinase: Toward a New Antiarrhythmic Strategy?. J Am Coll Cardiol. 2014 Mar 11;63(9):935-7. PubMed PMID: 24412447
  • Mestroni L, Brun F, Spezzacatene A, Sinagra G, Taylor MR. GENETIC CAUSES OF DILATED CARDIOMYOPATHY. Prog Pediatr Cardiol. 2014 Dec;37(1-2):13-18. PubMed PMID: 25584016
  • Pinamonti B, Brun F, Mestroni L, Sinagra G. Arrhythmogenic right ventricular cardiomyopathy: From genetics to diagnostic and therapeutic challenges. World J Cardiol. 2014 Dec 26;6(12):1234-44. PubMed PMID: 25548613
  • D'souza RS, Levandowski C, Slavov D, Graw SL, Allen LA, Adler E, Mestroni L, Taylor MR. Danon disease: clinical features, evaluation, and management. Circ Heart Fail. 2014 Sep;7(5):843-9. PubMed PMID: 25228319
  • Brun F, Barnes CV, Sinagra G, Slavov D, Barbati G, Zhu X, Graw SL, Spezzacatene A, Pinamonti B, Merlo M, Salcedo EE, Sauer WH, Taylor MR, Mestroni L, Familial Cardiomyopathy Registry. Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2014 Oct;51(10):669-76. PubMed PMID: 25157032
  • Nguyen DT, Barham W, Zheng L, Shillinglaw B, Tzou WS, Neltner B, Mestroni L, Bosi S, Ballerini L, Prato M, Sauer WH. Carbon nanotube facilitation of myocardial ablation with radiofrequency energy. J Cardiovasc Electrophysiol. 2014 Dec;25(12):1385-90. PubMed PMID: 25091811
  • Marcus F, Mestroni L. Family members of patients with ARVC: who is at risk? At what age? When and how often should we evaluate to determine risk?. J Am Coll Cardiol. 2014 Jul 22;64(3):302-3. PubMed PMID: 25034068
  • Codan B, Del Favero G, Martinelli V, Long CS, Mestroni L, Sbaizero O. Exploring the elasticity and adhesion behavior of cardiac fibroblasts by atomic force microscopy indentation. Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:427-34. PubMed PMID: 24857511
  • Mestroni L, Begay RL, Graw SL, Taylor MR. Pharmacogenetics of heart failure. Curr Opin Cardiol. 2014 May;29(3):227-34. PubMed PMID: 24717669
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol. 2014 Nov;229(11):1697-702. PubMed PMID: 24623017
  • Mestroni L, Nguyen DT. Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?. J Am Coll Cardiol. 2014 Mar 11;63(9):935-7. PubMed PMID: 24412447
  • Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA, American Heart Association Council on Functional Genomics and Translational Biology, American Heart Association Council on Epidemiology and Prevention, American Heart Association Council on Basic Cardiovascular Sciences, American Heart Association Council on Cardiovascular Disease in the Young, American Heart Association Council on Cardiovascular and Stroke Nursing, American Heart Association Stroke Council. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. Circulation. 2013 Dec 24;128(25):2813-51. PubMed PMID: 24297835
  • Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA, American Heart Association Council on Functional Genomics and Translational Biology, American Heart Association Council on Epidemiology and Prevention, American Heart Association Council on Basic Cardiovascular Sciences, American Heart Association Council on Cardiovascular Disease in the Young, American Heart Association Council on Cardiovascular and Stroke Nursing, American Heart Association Stroke Council. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. Circulation. 2013 Dec 24;128(25):2813-51. PubMed PMID: 24297835
  • Campbell N, Sinagra G, Jones KL, Slavov D, Gowan K, Merlo M, Carniel E, Fain PR, Aragona P, Di Lenarda A, Mestroni L, Taylor MR. Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy. PLoS One. 2013;8(10):e78104. PubMed PMID: 24205113
  • Merlo M, Sinagra G, Carniel E, Slavov D, Zhu X, Barbati G, Spezzacatene A, Ramani F, Salcedo E, Di Lenarda A, Mestroni L, Taylor MR, Familial Cardiomyopathy Registry. Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy. Clin Transl Sci. 2013 Dec;6(6):424-8. PubMed PMID: 24119082
  • Martinelli V, Cellot G, Fabbro A, Bosi S, Mestroni L, Ballerini L. Improving cardiac myocytes performance by carbon nanotubes platforms. Front Physiol. 2013;4:239. PubMed PMID: 24027533
  • Fabris E, Brun F, Porto AG, Losurdo P, Vitali Serdoz L, Zecchin M, Severini GM, Mestroni L, Di Chiara A, Sinagra G. Cardiac hypertrophy, accessory pathway, and conduction system disease in an adolescent: the PRKAG2 cardiac syndrome. J Am Coll Cardiol. 2013 Aug 27;62(9):e17. PubMed PMID: 23810891
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes instruct physiological growth and functionally mature syncytia: nongenetic engineering of cardiac myocytes. ACS Nano. 2013 Jul 23;7(7):5746-56. PubMed PMID: 23734857
  • Codan B, Martinelli V, Mestroni L, Sbaizero O. Atomic force microscopy of 3T3 and SW-13 cell lines: an investigation of cell elasticity changes due to fixation. Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3303-8. PubMed PMID: 23706214
  • Mestroni L, Taylor MR. Genetics and genetic testing of dilated cardiomyopathy: a new perspective. Discov Med. 2013 Jan;15(80):43-9. PubMed PMID: 23375013
  • Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16;366(7):619-28. PubMed PMID: 22335739
  • Miani D, Taylor M, Mestroni L, D'Aurizio F, Finato N, Fanin M, Brigido S, Proclemer A. Sudden death associated with danon disease in women. Am J Cardiol. 2012 Feb 1;109(3):406-11. PubMed PMID: 22074992
  • Steckman DA, Schneider PM, Schuller JL, Aleong RG, Nguyen DT, Sinagra G, Vitrella G, Brun F, Cova MA, Pagnan L, Mestroni L, Varosy PD, Sauer WH. Utility of cardiac magnetic resonance imaging to differentiate cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol. 2012 Aug 15;110(4):575-9. PubMed PMID: 22595349
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes promote growth and spontaneous electrical activity in cultured cardiac myocytes. Nano Lett. 2012 Apr 11;12(4):1831-8. PubMed PMID: 22432413
  • Bortot B, Athanasakis E, Brun F, Rizzotti D, Mestroni L, Sinagra G, Severini GM. High-throughput genotyping robot-assisted method for mutation detection in patients with hypertrophic cardiomyopathy. Diagn Mol Pathol. 2011 Sep;20(3):175-9. PubMed PMID: 21817903
  • McNair WP, Sinagra G, Taylor MR, Di Lenarda A, Ferguson DA, Salcedo EE, Slavov D, Zhu X, Caldwell JH, Mestroni L. SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism. J Am Coll Cardiol. 2011 May 24;57(21):2160-8. PubMed PMID: 21596231
  • Pinamonti B, Dragos AM, Pyxaras SA, Merlo M, Pivetta A, Barbati G, Di Lenarda A, Morgera T, Mestroni L, Sinagra G. Prognostic predictors in arrhythmogenic right ventricular cardiomyopathy: results from a 10-year registry. Eur Heart J. 2011 May;32(9):1105-13. PubMed PMID: 21362707
  • Mestroni L, Taylor MR. Hearing the noise the challenges of human genome variation in genetic testing. J Am Coll Cardiol. 2011 Jun 7;57(23):2328-9. PubMed PMID: 21636033
  • Mestroni L, Taylor MR. Pharmacogenomics, personalized medicine, and heart failure. Discov Med. 2011 Jun;11(61):551-61. PubMed PMID: 21712021
  • Mestroni L, Merlo M, Taylor MR, Camerini F, Sinagra G. Heart failure and personalized medicine. J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):6-12. PubMed PMID: 20814312
  • Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L. Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation. 2011 Aug 23;124(8):876-85. PubMed PMID: 21810661
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Professional Memberships

  • American Heart Association (AHA), Fellow
  • American College of Cardiology, Fellow
  • European Society of cardiology, Fellow
  • American College of Physician, Fellow
  • American Society of Human Genetics, Member
  • European Society of Human Genetics, Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

UCHealth Heart Failure Program - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Cardiovascular Disease (1989)
  • Cardiology (1989)
  • Medical Genetics and Genomics
  • ECFMG/USMLE, License (2000)
  • National Board of Cardiology, International Certificate (1989)
Conditions & Treatments
  • Heart and Circulation
  • Heart and Circulation - Heart Failure
  • Heart and Circulation - Cardiomyopathy
  • Heart and Circulation - Heart Diseases
  • Heart and Circulation - Hypertrophic Cardiomyopathy
Clinical Interests
I am Professor of Medicine/Cardiology, Director of the International Familial Cardiomyopathy Registry and Co-Director of the Molecular Genetics Program of the Cardiovascular Institute. My clinical expertise is in inherited cardiomyopathies, including arrhythmogenic cardiomyopathies, familial cardiomyopathies (arrhythmogenic right ventricular cardiomyopathy, arrhythmogenic dilated cardiomyopathy, left ventricular noncompaction, familial restrictive cardiomyopathy), muscular dystrophies with cardiac involvement, and other genetic disease affecting the heart muscle. In my Inherited Cardiomyopathy Management Clinic, I provide comprehensive evaluation and treatment of inherited cardiomyopathies, working in close collaboration with other experienced clinicians, genetic counselors, cardiovascular nurses, and study coordinators to provide a state-of-the-art team-based approach: these include the Adult Genetics Clinic, Electrophysiology Clinic, Advanced Heart Failure Clinic, HCM Clinic, Neuromuscular Clinic, Advanced Imaging, Sarcoidosis Clinic at National Jewish Hospital, and the Colorado Children's Hospital. I offer the opportunity of enrollment in National and International research programs, including novel clinical trials, and the International Familial Cardiomyopathy Registry (NIH founded, IRB 99-177, founded in 1999) to continue identifying the genes behind inherited disease, and discover novel therapies.

Care Philosophy
I strive to provide the best care for my patients. I believe in treating the person as a whole, taking every aspect of a patient’s body and health into consideration during diagnosis and treatment.

Personal Interests
In my spare time, I enjoy skiing, hiking, reading and spending time with my family.

Volunteer Activities
I volunteer as physician in sports activities of high school students.

General Information

Medical Schools:
  • MD, University of Trieste, School of Medicine, Italy (1979)
Undergraduate Schools:
  • BS, University of Trieste, School of Medicine, Italy (1979)
Internships:
  • University of Trieste, School of Medicine, Italy (1980)
Residency Programs:
  • University of Trieste, School of Medicine, Italy, Cardiology (1980)
Fellowships:
  • University of Trieste, School of Medicine, Italy, Interventional Cardiology (1984)
Download CV
Languages: English, Italian
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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