Uyen Truong, MD
Associate Professor, Pediatrics-Cardiology

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Medical School:
  • MD, University of California, San Diego School of Medicine (2003)
Undergraduate School:
  • BS, University of California–Los Angeles (CA) (1999)
Internship:
  • University of California (Davis) Health System Program (2004)
Residency:
  • University of California (Davis) Health System Program, Pediatrics (2006)
Fellowships:
  • Children's National Medical Center/George Washington University Program, Pediatric Cardiology (2009)
  • Oregon Health & Science University, Pediatric Cardiology (2010)
  • Stanford Hospital and Clinics Program, Pediatric Cardiology (2011)
Languages: English
Department: Pediatrics-Cardiology

Professional Titles

  • Associate Professor, Pediatrics-Cardiology
  • Associate Professor

Research Interests

My research interests are focused on: a. Pulmonary hypertension: Pulmonary arterial hypertension (PAH) is an incurable, progressive disease that affects both adults and children. While there are some similarities between adult and pediatric pathophysiology, the number of life years lost in children is much greater given limited long-term survival. Pediatric pulmonary hypertension differs from adult disease also in terms of vascular function and structure, natural history, genetics, and possibly response to PAH therapies. In pediatric PAH, the vascular insult occurs at a critical time in development between birth and adulthood, during which time expansion of the alveolar and capillary surface area may increase by 20-folds via intussusceptive angiogenesis. Disruption of normal development results in the development of chronic pulmonary vascular disease later in life. Despite significant unique factors in pediatric PAH, research in pediatric PAH, compared to adults, has been stalled, forcing clinicians to use adult guidelines (including right heart cardiac catheterization (RHC) for diagnosis and serial monitoring) and therapies approved for adults in children. Due to the risks of catheterization in the young, catheterization is not an option as a research tool in pediatric PAH. Recently, the FDA excluded catheterization as an end-point in clinical trials in children with PAH, making outcome studies even more difficult. Over the past decade, there have been 5 medications approved for adult pulmonary hypertension by the U.S. Food and Drug Administration. None have been approved for pediatric use. This means that there are no safe dosages established in children and inadequate evidence that children responds similarly to drugs approved for adults. My overall goal in the next few years is to show the early vascular changes during childhood in PAH patients, which make them particularly susceptible to insults later in life and is what distinguishes these patients from adult patients. I also want to show that MRI is able to yield hemodynamic data previously obtained via catheterization. Success in replacing catheterization with MRI has the potential of shifting the paradigm of pediatric PH care towards a safer, noninvasive monitoring modality and significantly improve quality of life in children with PH. Furthermore, it will add a powerful tool to push pediatric research efforts ahead, particularly in clinical trials. I have described abnormal pulmonary artery dilation, both by ultrasound and by MRI, in association to severely abnormal wall shear stress (WSS). WSS is the primary component of mechanotransduction forces that is significantly decreased in proximal pulmonary conduit in adults with PH. Studies investigating the changes in the endothelial function and morphology revealed flow and WSS association with altered cellular signaling, gene expression, and endothelial cell geometry The characterization of the stiffness and mechanotransduction events in the proximal pulmonary conduit vessels is then of great importance in order to assess the possibly ongoing pathophysiologic phenomena in children and young adolescents with PH. I also looked at the ventricular vascular coupling ratio (VVCR), which describes the interaction between the vascular afterload and the ventricular contractility. Conventionally, VVCR is laboriously determined in the cardiac catheterization laboratory with the establishment of the pressure-volume loop under varying loading conditions and clamping of the inferior vena cava. This is virtually impossible in children due to the size of catheter needed and the cost. We showed exciting preliminary data that this value could be estimated by only MRI data. The most state-of-the-art MRI sequence is 4D flow, in which we can describe the properties of flow in the ventricle and the major arteries with one single sequence. Preliminary data support significant correlation between 4D flow parameters and pressure data derived by catheterization. In the year coming, we will explore the use of this in pediatric PAH. b. Diabetes: I have been working with Dr. Kristen Nadeau from Endocrinology looking at the early cardiovascular risks in adolescents with type I diabetes mellitus (T1D). We have alarming findings showing that there is already arterial stiffness in youths with T1D compared to those without diabetes. We are further exploring the cardiovascular effects of therapeutic medications.

Teaching

  • Associate Professor (2011)
    School of Medicine, Pediatrics

Publications

  • Schäfer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson N. Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI. Pediatr Cardiol. 2017 Oct 17. [Epub ahead of print] PubMed PMID: 29043395
  • Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545
  • Malone L, Fonseca B, Fagan T, Gralla J, Wilson N, Vargas D, DiMaria M, Truong U, Browne LP. Erratum to: Preprocedural Risk Assessment Prior to PPVI with CMR and Cardiac CT. Pediatr Cardiol. 2017 Aug;38(6):1315. PubMed PMID: 28589406
  • Malone L, Fonseca B, Fagan T, Gralla J, Wilson N, DiMaria M, Truong U, Browne LP. Preprocedural Risk Assessment Prior to PPVI with CMR and Cardiac CT. Pediatr Cardiol. 2017 Apr;38(4):746-753. PubMed PMID: 28210769
  • Schäfer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong U. Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency?. Circ Cardiovasc Imaging. 2017 Feb;10(2). PubMed PMID: 28193613
  • Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 Jan 1;:1358863X16682107. [Epub ahead of print] PubMed PMID: 28095749
  • Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2016 Jul 21. [Epub ahead of print] PubMed PMID: 27444679
  • Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A 0-D Model and Protocol for Simulating Patient Specific Pulmonary Hemodynamics from Limited Clinical Data. J Biomech Eng. 2016 Sep 29. [Epub ahead of print] PubMed PMID: 27684888
  • Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2016 Jul 21. [Epub ahead of print] PubMed PMID: 27444679
  • Aldoss O, Fonseca BM, Truong UT, Bracken J, Darst JR, Guo R, Jones TL, Fagan TE. Diagnostic Utility of Three-Dimensional Rotational Angiography in Congenital Cardiac Catheterization. Pediatr Cardiol. 2016 Oct;37(7):1211-21. PubMed PMID: 27278632
  • Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
  • Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
  • Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A 0-D Model and Protocol for Simulating Patient Specific Pulmonary Hemodynamics from Limited Clinical Data. J Biomech Eng. 2016 Sep 29. [Epub ahead of print] PubMed PMID: 27684888
  • Aldoss O, Fonseca BM, Truong UT, Bracken J, Darst JR, Guo R, Jones TL, Fagan TE. Diagnostic Utility of Three-Dimensional Rotational Angiography in Congenital Cardiac Catheterization. Pediatr Cardiol. 2016 Oct;37(7):1211-21. PubMed PMID: 27278632
  • Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
  • Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
  • Kheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas R. Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2015 Dec;5(4):658-66. PubMed PMID: 26697173
  • Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16;17(1):81. PubMed PMID: 26376972
  • Truong UT, Fagan TE, Deterding R, Ing RJ, Fonseca BM. Use of rotational angiography in assessing relationship of the airway to vasculature during cardiac catheterization. Catheter Cardiovasc Interv. 2015 Aug 17. [Epub ahead of print] PubMed PMID: 26279410
  • Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16;17(1):81. PubMed PMID: 26376972
  • Truong UT, Fagan TE, Deterding R, Ing RJ, Fonseca BM. Use of rotational angiography in assessing relationship of the airway to vasculature during cardiac catheterization. Catheter Cardiovasc Interv. 2015 Aug 17. [Epub ahead of print] PubMed PMID: 26279410
  • Fagan TE, Truong UT, Jone PN, Bracken J, Quaife R, Hazeem AA, Salcedo EE, Fonseca BM. Multimodality 3-dimensional image integration for congenital cardiac catheterization. Methodist Debakey Cardiovasc J. 2014 Apr-Jun;10(2):68-76. PubMed PMID: 25114757
  • Ishii T, McElhinney DB, Harrild DM, Marcus EN, Sahn DJ, Truong U, Tworetzky W. Ventricular Strain in Fetuses with Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome before and after Prenatal Aortic Valvuloplasty. Fetal Diagn Ther. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24280672
  • Fagan TE, Truong UT, Jone PN, Bracken J, Quaife R, Hazeem AA, Salcedo EE, Fonseca BM. Multimodality 3-dimensional image integration for congenital cardiac catheterization. Methodist Debakey Cardiovasc J. 2014 Apr-Jun;10(2):68-76. PubMed PMID: 25114757
  • Ishii T, McElhinney DB, Harrild DM, Marcus EN, Sahn DJ, Truong U, Tworetzky W. Ventricular Strain in Fetuses with Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome before and after Prenatal Aortic Valvuloplasty. Fetal Diagn Ther. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24280672
  • Ishii T, McElhinney DB, Harrild DM, Marcus EN, Sahn DJ, Truong U, Tworetzky W. Ventricular Strain in Fetuses with Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome before and after Prenatal Aortic Valvuloplasty. Fetal Diagn Ther. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24280672
  • Truong U, Fonseca B, Dunning J, Burgett S, Lanning C, Ivy DD, Shandas R, Hunter K, Barker AJ. Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2013 Sep 13;15:81. PubMed PMID: 24034144
  • Truong UT, Sun HY, Tacy TA. Myocardial deformation in the fetal single ventricle. J Am Soc Echocardiogr. 2013 Jan;26(1):57-63. PubMed PMID: 23140844
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Professional Memberships

  • American Medical Association, Member
  • American Academy of Pediatrics (AAP), Member
  • American Heart Association (AHA), Member
  • American College of Cardiology, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatrics, Board Certification
  • Pediatric Cardiology
Conditions & Treatments
  • Child and Teen Health
  • Heart and Circulation
  • Heart and Circulation - Congenital Heart Disease
Care Philosophy
I believe the care of the family is integral to the care of the child. I strive to give families opportunities to be involved in their children's care, which means that part of my job is to clearly convey the diagnoses, the potential options for care, as well as the risks and benefits.

General Information

Medical Schools:
  • MD, University of California, San Diego School of Medicine (2003)
Undergraduate Schools:
  • BS, University of California–Los Angeles (CA) (1999)
Internships:
  • University of California (Davis) Health System Program (2004)
Residency Programs:
  • University of California (Davis) Health System Program, Pediatrics (2006)
Fellowships:
  • Children's National Medical Center/George Washington University Program, Pediatric Cardiology (2009)
  • Oregon Health & Science University, Pediatric Cardiology (2010)
  • Stanford Hospital and Clinics Program, Pediatric Cardiology (2011)
Languages: English
Department: Pediatrics-Cardiology
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