Clyde Wright, MD
Associate Professor, Pediatrics-Neonatology

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Medical School:
  • MD, Johns Hopkins University School of Medicine (2001)
Undergraduate School:
  • BA, Davidson College (NC) (1997)
Internship:
  • University of Wisconsin Hospital and Clinics Program (2002)
Residency:
  • University of Wisconsin Hospital and Clinics Program, Chief Resident, Pediatrics (2005)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Neonatal-Perinatal Medicine (2009)
Languages: English
Department: Pediatrics-Neonatology

Recognition & Awards

  • Thomas R. Boggs, Jr. Neonatal-Perinatal Research Award, Philadelphia Perinatal Society, (2009)
  • Outstanding Pediatric Resident Award, Awarded by 4th Year Medical Students, (2006)
  • Distinguished Teaching Award, Resident, Awarded by Medical Student Body, (2004)
  • Outstanding Resident Teaching Award, Awarded by Pediatric Residents, (2004)

Teaching

  • Assistant Professor (2011)
    School of Medicine, Pediatrics
    Neonatology

Publications

  • McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFNß Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018;9:2210. PubMed PMID: 30319651
  • Hwang SS, Burris HH, Collins JW Jr, Kirpalani H, Wright CJ. Moving beyond race and ethnicity to understand the effect of inhaled nitric oxide on bronchopulmonary dysplasia prevention. J Pediatr. 2018 Oct;201:298-300. PubMed PMID: 30029858
  • Wright CJ. Paracetamol for ductal closure: Inching closer, but cautiously!. J Pediatr. 2018 Jul;198:4. PubMed PMID: 29936969
  • Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants?. Acta Paediatr. 2018 Oct;107(10):1836. PubMed PMID: 29873417
  • Wright CJ. Midlife crisis? In its 50th year, BPD redefines itself. J Pediatr. 2018 Jun;197:3. PubMed PMID: 29801543
  • Wright CJ, Sherlock LG, Sahni R, Polin RA. Preventing Continuous Positive Airway Pressure Failure: Evidence-Based and Physiologically Sound Practices from Delivery Room to the Neonatal Intensive Care Unit. Clin Perinatol. 2018 Jun;45(2):257-271. PubMed PMID: 29747887
  • Wright CJ. Hey baby, slow down-what happens now matters!. J Pediatr. 2018 May;196:2-3. PubMed PMID: 29703356
  • El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 Apr 11;9(1):1393. PubMed PMID: 29643332
  • Jensen EA, Wright CJ. Bronchopulmonary Dysplasia: The Ongoing Search for One Definition to Rule Them All. J Pediatr. 2018 Jun;197:8-10. PubMed PMID: 29605396
  • Sherlock LG, Trumpie A, Hernandez-Lagunas L, McKenna S, Fisher S, Bowler R, Wright CJ, Delaney C, Nozik-Grayck E. Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia. Antioxidants (Basel). 2018 Mar 14;7(3). PubMed PMID: 29538340
  • Beard L, Wright CJ. Does non-invasive ventilation confer a lung protective effect and improve long-term pulmonary outcomes?. Acta Paediatr. 2018 Jun;107(6):1102. PubMed PMID: 29517827
  • Wright CJ. Tiny babies can be sugary sweet-how hard should we work to control this?. J Pediatr. 2018 Feb;193:2. PubMed PMID: 29389447
  • Delaney C, Sherlock L, Fisher S, Maltzahn J, Wright C, Nozik-Grayck E. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L871-L881. PubMed PMID: 29345193
  • Wright C. Is it the baby or the beds?. J Pediatr. 2018 Jan;192:2. PubMed PMID: 29246342
  • Dietz RM, Wright CJ. Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response. Am J Reprod Immunol. 2018 May;79(5):e12787. PubMed PMID: 29194835
  • Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
  • McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28753596
  • Wright CJ. Lessons from Goldilocks: maternal weight gain and neurocognitive outcomes of ELGAN. J Pediatr. 2017 Aug;187:1-2. PubMed PMID: 28750756
  • Wright CJ. Is more oxygen better for our smallest babies, or maybe just our smallest babies?. J Pediatr. 2017 Jul;186:3. PubMed PMID: 28648280
  • Ratcliffe SJ, Sherlock LG, Wright CJ. Oral paracetamol or oral ibuprofen to close the ductus arteriosus: both 'work', but do we know when to use them?. Acta Paediatr. 2017 Sep;106(9):1539. PubMed PMID: 28370568
  • Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 Aug;106(8):1364. PubMed PMID: 28370320
  • Sherlock LG, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Pneumomediastinum, a Silent Lesion in the Newborn. J Pediatr. 2017 Apr;183:93. PubMed PMID: 28343537
  • Wright CJ. Is preventing BPD the target, or should we strive for something else?. J Pediatr. 2017 Apr;183:2. PubMed PMID: 28343533
  • Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, Gossling M, Wright C. Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. Case Rep Pediatr. 2017;2017:7628946. PubMed PMID: 28280644
  • Wright CJ. Oxygen saturation targets: The wrinkle in the pulse oximeter calibration software provides another wrinkle. J Pediatr. 2017 Mar;182:3-4. PubMed PMID: 28237449
  • Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar;106(3):358. PubMed PMID: 28186374
  • Wright CJ. Too salty: biochemical markers to validate maternal concern of breastmilk supply. J Pediatr. 2017 Feb;181:3. PubMed PMID: 28129875
  • Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
  • McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28753596
  • Wright CJ. Lessons from Goldilocks: maternal weight gain and neurocognitive outcomes of ELGAN. J Pediatr. 2017 Aug;187:1-2. PubMed PMID: 28750756
  • Wright CJ. Is more oxygen better for our smallest babies, or maybe just our smallest babies?. J Pediatr. 2017 Jul;186:3. PubMed PMID: 28648280
  • Ratcliffe SJ, Sherlock LG, Wright CJ. Oral paracetamol or oral ibuprofen to close the ductus arteriosus: both 'work', but do we know when to use them?. Acta Paediatr. 2017 Sep;106(9):1539. PubMed PMID: 28370568
  • Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 Aug;106(8):1364. PubMed PMID: 28370320
  • Sherlock LG, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Pneumomediastinum, a Silent Lesion in the Newborn. J Pediatr. 2017 Apr;183:93. PubMed PMID: 28343537
  • Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, Gossling M, Wright C. Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. Case Rep Pediatr. 2017;2017:7628946. PubMed PMID: 28280644
  • Wright CJ. Is preventing BPD the target, or should we strive for something else?. J Pediatr. 2017 Apr;183:2. PubMed PMID: 28343533
  • Wright CJ. Oxygen saturation targets: The wrinkle in the pulse oximeter calibration software provides another wrinkle. J Pediatr. 2017 Mar;182:3-4. PubMed PMID: 28237449
  • Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar;106(3):358. PubMed PMID: 28186374
  • Wright CJ. Too salty: biochemical markers to validate maternal concern of breastmilk supply. J Pediatr. 2017 Feb;181:3. PubMed PMID: 28129875
  • Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia?. Clin Perinatol. 2016 Dec;43(4):783-798. PubMed PMID: 27837759
  • Wright CJ. More is not always better, at least when it comes to oxygen saturation target goals. J Pediatr. 2016 Nov;178:2. PubMed PMID: 27788834
  • Wright CJ. Working backwards: Can variations in neonatal outcomes help identify best practice?. J Pediatr. 2016 Oct;177:1. PubMed PMID: 27666070
  • Wright CJ. Blunted response: smoke, illicit substances, and how babies breathe. J Pediatr. 2016 Aug;175:1-4. PubMed PMID: 27507312
  • Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go?. Acta Paediatr. 2016 Aug;105(8):868-70. PubMed PMID: 27383516
  • McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016;8(4):386-99. PubMed PMID: 27160391
  • Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?. J Pediatr. 2016 Jun;173:17-24.e2. PubMed PMID: 27025910
  • Dietz RM, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Hypothermia and the Resuscitation of Asphyxiated Fetal Rhesus Monkeys. J Pediatr. 2016 Jan;168:87. PubMed PMID: 26719178
  • Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia?. Clin Perinatol. 2016 Dec;43(4):783-798. PubMed PMID: 27837759
  • Wright CJ. More is not always better, at least when it comes to oxygen saturation target goals. J Pediatr. 2016 Nov;178:2. PubMed PMID: 27788834
  • Wright CJ. Working backwards: Can variations in neonatal outcomes help identify best practice?. J Pediatr. 2016 Oct;177:1. PubMed PMID: 27666070
  • Wright CJ. Blunted response: smoke, illicit substances, and how babies breathe. J Pediatr. 2016 Aug;175:1-4. PubMed PMID: 27507312
  • Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go?. Acta Paediatr. 2016 Aug;105(8):868-70. PubMed PMID: 27383516
  • McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016;8(4):386-99. PubMed PMID: 27160391
  • Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?. J Pediatr. 2016 Jun;173:17-24.e2. PubMed PMID: 27025910
  • Dietz RM, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Hypothermia and the Resuscitation of Asphyxiated Fetal Rhesus Monkeys. J Pediatr. 2016 Jan;168:87. PubMed PMID: 26719178
  • McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ. Endotoxemia Induces I?Bß/NF-?B-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol. 2015 Oct 15;195(8):3866-79. PubMed PMID: 26342031
  • McKenna S, Wright CJ. Inhibiting I?Bß-NF?B signaling attenuates the expression of select pro-inflammatory genes. J Cell Sci. 2015 Jun 1;128(11):2143-55. PubMed PMID: 25908863
  • Wright CJ, Permar SR. Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost?. J Pediatr. 2015 Apr;166(4):795-8. PubMed PMID: 25662832
  • Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal Radiograph with Intravesical Air and Possible Small Bowel Atresia. J Pediatr. 2014 Jan 25. [Epub ahead of print] PubMed PMID: 24472230
  • DeMauro SB, Wright CJ. Acetaminophen: a possible alternative to ibuprofen in patent ductus arteriosus closure. J Pediatr. 2014 Jul;165(1):209-10. PubMed PMID: 24973162
  • McKenna S, Michaelis KA, Agboke F, Liu T, Han K, Yang G, Dennery PA, Wright CJ. Sustained hyperoxia-induced NF-?B activation improves survival and preserves lung development in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1078-89. PubMed PMID: 24748603
  • Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal Radiograph with Intravesical Air and Possible Small Bowel Atresia. J Pediatr. 2014 Jan 25. [Epub ahead of print] PubMed PMID: 24472230
  • Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. I?Bß-mediated NF-?B activation confers protection against hyperoxic lung injury. Am J Respir Cell Mol Biol. 2014 Feb;50(2):429-38. PubMed PMID: 24066808
  • Yang G, Wright CJ, Hinson MD, Fernando AP, Sengupta S, Biswas C, La P, Dennery PA. Oxidative stress and inflammation modulate Rev-erba signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24252172
  • Yang G, Wright CJ, Hinson MD, Fernando AP, Sengupta S, Biswas C, La P, Dennery PA. Oxidative stress and inflammation modulate Rev-erba signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24252172
  • Wright CJ, Agboke F, Muthu M, Michaelis KA, Mundy MA, La P, Yang G, Dennery PA. Nuclear factor-?B (NF-?B) inhibitory protein I?Bß determines apoptotic cell death following exposure to oxidative stress. J Biol Chem. 2012 Feb 24;287(9):6230-9. PubMed PMID: 22223647
  • Yang G, Hinson MD, Bordner JE, Lin QS, Fernando AP, La P, Wright CJ, Dennery PA. Silencing hyperoxia-induced C/EBPa in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L187-96. PubMed PMID: 21571903
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Professional Memberships

  • American Academy of Pediatrics (AAP), Member
  • Section of Perinatal Pediatrics, AAP, Member
  • Eastern Society of Pediatric Research, Member
  • Philadelphia Perinatal Society, Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Pediatrics, Board Certification (2004)
  • Neonatal-Perinatal Medicine, Board Certification (2010)
Conditions & Treatments
  • Pregnancy and Reproduction - Neonatal Intensive Care
  • Pregnancy and Reproduction - Prenatal Care
  • Pregnancy and Reproduction - Prenatal Testing
  • Pregnancy and Reproduction

General Information

Medical Schools:
  • MD, Johns Hopkins University School of Medicine (2001)
Undergraduate Schools:
  • BA, Davidson College (NC) (1997)
Internships:
  • University of Wisconsin Hospital and Clinics Program (2002)
Residency Programs:
  • University of Wisconsin Hospital and Clinics Program, Chief Resident, Pediatrics (2005)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Neonatal-Perinatal Medicine (2009)
Languages: English
Department: Pediatrics-Neonatology
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