Kevin Chapman, MD
Associate Professor, Pediatrics-Neurology

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Medical School:
  • MD, University of Texas Medical Branch School of Medicine (1996)
Undergraduate School:
  • BS, University of Texas–Austin (TX) (1992)
Residencies:
  • Baylor College of Medicine Program, Child Neurology (2001)
  • Baylor College of Medicine Program, Pediatrics (1998)
Fellowships:
  • Cleveland Clinic Foundation Program, Clinical Neurophysiology (2003)
Languages: English
Department: Pediatrics-Neurology

Research Interests

My research interests focus on identifying risk factors and treatments for status epilepticus as well as electrical status epileptics during sleep (ESES).

Publications

  • Knupp KG, Rice JD, Helmkamp LJ, Galinkin J, Sempio C, Jost K, Chapman KE. Prospective evaluation of oral cannabis extracts in children with epilepsy. Seizure. 2019 Sep 16;72:23-27. [Epub ahead of print] PubMed PMID: 31550641
  • Sánchez Fernández I, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Davis Gaillard W, Glauser TA, Goldstein J, Goodkin HP, Guerriero RM, Hecox K, Jackson M, Kapur K, Kelley SA, Kossoff EHW, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ Jr, Sannagowdara K, Stafstrom CE, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure. 2019 Aug;70:90-96. PubMed PMID: 31323566
  • Bear JJ, Chapman KE, Tregellas JR. The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies. Epilepsia. 2019 Aug;60(8):1491-1507. PubMed PMID: 31247129
  • Sansevere AJ, Arya R, Sánchez Fernández I, Gaillard WD, Tasker RC, Lai YC, Anderson AE, Tchapyjnikov D, Chapman KE, Brenton JN, Carpenter JL, Gaínza-Lein M, Goldstein JL, Goodkin HP, Jackson MC, Kapur K, Mikati MA, Peariso K, Glauser TA, Topjian AA, Wainwright M, Wilfong AA, Williams KL, Loddenkemper T, Abend NS. Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep;36(5):365-370. PubMed PMID: 31166226
  • Press CA, Chapman KE. Status epilepticus: Will we capture the moment or continue without evidence of efficacy or costs?. Neurology. 2019 May 14;92(20):931-932. PubMed PMID: 31068483
  • Jobst BC, Ben-Menachem E, Chapman KE, Fu A, Goldman A, Hirsch LJ, Jehi LE, Kossoff EH, Plueger M, Rho JM, Schevon CA, Shinnar S, Sperling MR, Simeone TA, Wagner JL, Lado F. Highlights From the Annual Meeting of the American Epilepsy Society 2018. Epilepsy Curr. 2019 May-Jun;19(3):152-158. PubMed PMID: 31050308
  • Jafarpour S, Stredny CM, Piantino J, Chapman KE. Baseline and outcome assessment in pediatric status epilepticus. Seizure. 2018 Apr 27. [Epub ahead of print] PubMed PMID: 29747930
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2019 May 21;:1-5. [Epub ahead of print] PubMed PMID: 31111749
  • Domen CH, Shrestha A, Chapman K, Drees C. The impact of cannabis use on intracarotid amobarbital testing. Epilepsy Behav Rep. 2019;12:100328. PubMed PMID: 31497755
  • Joshi CN, Chapman KE, Bear JJ, Wilson SB, Walleigh DJ, Scheuer ML. Semiautomated Spike Detection Software Persyst 13 Is Noninferior to Human Readers When Calculating the Spike-Wave Index in Electrical Status Epilepticus in Sleep. J Clin Neurophysiol. 2018 Sep;35(5):370-374. PubMed PMID: 29933261
  • Jafarpour S, Stredny CM, Piantino J, Chapman KE. Baseline and outcome assessment in pediatric status epilepticus. Seizure. 2018 Apr 27. [Epub ahead of print] PubMed PMID: 29747930
  • Sánchez Fernández I, Gaínza-Lein M, Abend NS, Anderson AE, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Helseth AR, Jackson MC, Kapur K, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello JJ Jr, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 May 8;90(19):e1692-e1701. PubMed PMID: 29643084
  • Dingman AL, Stence NV, O'Neill BR, Sillau SH, Chapman KE. Seizure Severity Is Correlated With Severity of Hypoxic-Ischemic Injury in Abusive Head Trauma. Pediatr Neurol. 2018 May;82:29-35. PubMed PMID: 29625848
  • Gaínza-Lein M, Sánchez Fernández I, Jackson M, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Kapur K, Mikati MA, Peariso K, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus. JAMA Neurol. 2018 Apr 1;75(4):410-418. PubMed PMID: 29356811
  • Vega C, Sánchez Fernández I, Peters J, Thome-Souza MS, Jackson M, Takeoka M, Wilkening GN, Pearl PL, Chapman K, Loddenkemper T. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 Mar;60(3):283-289. PubMed PMID: 29168169
  • Vasquez A, Gaínza-Lein M, Sánchez Fernández I, Abend NS, Anderson A, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein J, Goodkin HP, Lai YC, Loddenkemper T, McDonough TL, Mikati MA, Nayak A, Payne E, Riviello J, Tchapyjnikov D, Topjian AA, Wainwright MS, Tasker RC. Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers. Pediatr Neurol. 2018 Jul 11. [Epub ahead of print] PubMed PMID: 30075875
  • Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27859038
  • Ruzas CM, DeWitt PE, Bennett KS, Chapman KE, Harlaar N, Bennett TD. EEG Monitoring and Antiepileptic Drugs in Children with Severe TBI. Neurocrit Care. 2016 Nov 21. [Epub ahead of print] PubMed PMID: 27873234
  • Sánchez Fernández I, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J Jr, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24;88(4):386-394. PubMed PMID: 28011930
  • Sánchez Fernández I, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J Jr, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24;88(4):386-394. PubMed PMID: 28011930
  • Ruzas CM, DeWitt PE, Bennett KS, Chapman KE, Harlaar N, Bennett TD. EEG Monitoring and Antiepileptic Drugs in Children with Severe TBI. Neurocrit Care. 2016 Nov 21. [Epub ahead of print] PubMed PMID: 27873234
  • Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27859038
  • Kessler SK, Shinnar S, Cnaan A, Dlugos D, Conry J, Hirtz DG, Hu F, Liu C, Mizrahi EM, Moshé SL, Clark P, Glauser TA. Pretreatment seizure semiology in childhood absence epilepsy. Neurology. 2017 Jul 19. [Epub ahead of print] PubMed PMID: 28724582
  • Tasker RC, Goodkin HP, Sánchez Fernández I, Chapman KE, Abend NS, Arya R, Brenton JN, Carpenter JL, Gaillard WD, Glauser TA, Goldstein J, Helseth AR, Jackson MC, Kapur K, Mikati MA, Peariso K, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T. Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 Oct;17(10):968-975. PubMed PMID: 27500721
  • Tasker RC, Goodkin HP, Sánchez Fernández I, Chapman KE, Abend NS, Arya R, Brenton JN, Carpenter JL, Gaillard WD, Glauser TA, Goldstein J, Helseth AR, Jackson MC, Kapur K, Mikati MA, Peariso K, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T. Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 Oct;17(10):968-975. PubMed PMID: 27500721
  • Kruse CA, Pardo CA, Hartman AL, Jallo G, Vining EP, Voros J, Gaillard WD, Liu J, Oluigbo C, Malone S, Bleasel AF, Dexter M, Micati A, Velasco TR, Machado HR, Martino AM, Huang A, Wheatley BM, Grant GA, Granata T, Freri E, Garbelli R, Koh S, Nordli DR, Campos AR, O'Neill B, Handler MH, Chapman KE, Wilfong AA, Curry DJ, Yaun A, Madsen JR, Smyth MD, Mercer D, Bingaman W, Harvey AS, Leventer RJ, Lockhart PJ, Gillies G, Pope K, Giller CA, Park YD, Rojiani AM, Sharma SJ, Jenkins P, Tung S, Huynh MN, Chirwa TW, Cepeda C, Levine MS, Chang JW, Owens GC, Vinters HV, Mathern GW. Rasmussen encephalitis tissue transfer program. Epilepsia. 2016 Jun;57(6):1005-7. PubMed PMID: 27286752
  • Chapman KE, Specchio N, Shinnar S, Holmes GL. Seizing control of epileptic activity can improve outcome. Epilepsia. 2015 Oct;56(10):1482-5. PubMed PMID: 26293783
  • O'Neill BR, Handler MH, Tong S, Chapman KE. Incidence of seizures on continuous EEG monitoring following traumatic brain injury in children. J Neurosurg Pediatr. 2015 Aug;16(2):167-76. PubMed PMID: 25955809
  • Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goodkin HP, Kapur K, Mikati MA, Peariso K, Ream M, Riviello J Jr, Tasker RC, Loddenkemper T. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015 Jun 9;84(23):2304-11. PubMed PMID: 25948729
  • Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav. 2015 Apr;45:49-52. PubMed PMID: 25845492
  • Herman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, Gerard EE, Hahn CD, Husain AM, Kaplan PW, LaRoche SM, Nuwer MR, Quigg M, Riviello JJ, Schmitt SE, Simmons LA, Tsuchida TN, Hirsch LJ. Consensus statement on continuous EEG in critically ill adults and children, part I: indications. J Clin Neurophysiol. 2015 Apr;32(2):87-95. PubMed PMID: 25626778
  • Herman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, Gerard EE, Hahn CD, Husain AM, Kaplan PW, LaRoche SM, Nuwer MR, Quigg M, Riviello JJ, Schmitt SE, Simmons LA, Tsuchida TN, Hirsch LJ. Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice. J Clin Neurophysiol. 2015 Apr;32(2):96-108. PubMed PMID: 25626777
  • Yang A, Arndt DH, Berg RA, Carpenter JL, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, Nash KB, Payne ET, Sánchez Fernández I, Shults J, Topjian AA, Williams K, Wusthoff CJ, Abend NS. Development and validation of a seizure prediction model in critically ill children. Seizure. 2014 Oct 5. [Epub ahead of print] PubMed PMID: 25458097
  • Shinnar S, Cnaan A, Hu F, Clark P, Dlugos D, Hirtz DG, Masur D, Mizrahi EM, Moshé SL, Glauser TA. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology. 2015 Sep 29;85(13):1108-14. PubMed PMID: 26311751
  • Gaspard N, Foreman BP, Alvarez V, Cabrera Kang C, Probasco JC, Jongeling AC, Meyers E, Espinera A, Haas KF, Schmitt SE, Gerard EE, Gofton T, Kaplan PW, Lee JW, Legros B, Szaflarski JP, Westover BM, LaRoche SM, Hirsch LJ. New-onset refractory status epilepticus: Etiology, clinical features, and outcome. Neurology. 2015 Aug 21. [Epub ahead of print] PubMed PMID: 26296517
  • Yang A, Arndt DH, Berg RA, Carpenter JL, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, Nash KB, Payne ET, Sánchez Fernández I, Shults J, Topjian AA, Williams K, Wusthoff CJ, Abend NS. Development and validation of a seizure prediction model in critically ill children. Seizure. 2014 Oct 5. [Epub ahead of print] PubMed PMID: 25458097
  • Press C, Wallace A, Chapman KE. The Janus-faced nature of Rasmussen's encephalitis. Semin Pediatr Neurol. 2014 Jun;21(2):129-36. PubMed PMID: 25149947
  • Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello JJ Jr, Tasker RC, Williams K, Loddenkemper T, Pediatric Status Epilepticus Research Group (pSERG). Gaps and opportunities in refractory status epilepticus research in children: A multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2013 Oct 16. [Epub ahead of print] PubMed PMID: 24183923
  • Sánchez Fernández I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Williams K, Loddenkemper T. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study. J Pediatr. 2013 Oct 22. [Epub ahead of print] PubMed PMID: 24161223
  • Sánchez Fernández I, Chapman K, Peters JM, Klehm J, Jackson MC, Berg AT, Loddenkemper T. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul;55(7):1099-108. PubMed PMID: 24917485
  • Klassen TL, Bomben VC, Patel A, Drabek J, Chen TT, Gu W, Zhang F, Chapman K, Lupski JR, Noebels JL, Goldman AM. High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile. Epilepsia. 2014 Feb;55(2):e6-12. PubMed PMID: 24372310
  • Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello JJ Jr, Tasker RC, Williams K, Loddenkemper T, Pediatric Status Epilepticus Research Group (pSERG). Gaps and opportunities in refractory status epilepticus research in children: A multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2013 Oct 16. [Epub ahead of print] PubMed PMID: 24183923
  • Sánchez Fernández I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Williams K, Loddenkemper T. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study. J Pediatr. 2013 Oct 22. [Epub ahead of print] PubMed PMID: 24161223
  • Sánchez Fernández I, Chapman KE, Peters JM, Harini C, Rotenberg A, Loddenkemper T. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013;2013:583531. PubMed PMID: 23991336
  • Chapman KE. The challenge of treating spikes. Pediatr Neurol. 2013 Sep;49(3):147-8. PubMed PMID: 23953950
  • Sánchez SM, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez Fernández I, Shults J, Williams K, Yang A, Abend NS. Electroencephalography monitoring in critically ill children: current practice and implications for future study design. Epilepsia. 2013 Aug;54(8):1419-27. PubMed PMID: 23848569
  • Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Fernández IS, Shults J, Williams K, Yang A, Dlugos DJ. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 2013 Jul 23;81(4):383-91. PubMed PMID: 23794680
  • Crepeau AZ, Kerrigan JF, Gerber P, Parikh G, Jahnke H, Nakaji P, Little A, Chapman KE. Rhythmical and periodic EEG patterns do not predict short-term outcome in critically ill patients with subarachnoid hemorrhage. J Clin Neurophysiol. 2013 Jun;30(3):247-54. PubMed PMID: 23733088
  • Sanchez SM, Carpenter J, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Kessler SK, Loddenkemper T, Riviello JJ Jr, Abend NS, Pediatric Critical Care EEG Group. Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada. J Clin Neurophysiol. 2013 Apr;30(2):156-60. PubMed PMID: 23545766
  • Arrington DK, Ng YT, Troester MM, Kerrigan JF, Chapman KE. Utility and safety of prolonged video-EEG monitoring in a tertiary pediatric epilepsy monitoring unit. Epilepsy Behav. 2013 May;27(2):346-50. PubMed PMID: 23542538
  • Fernández IS, Chapman KE, Peters JM, Kothare SV, Nordli DR Jr, Jensen FE, Berg AT, Loddenkemper T. The tower of Babel: Survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2012 Nov 16. [Epub ahead of print] PubMed PMID: 23163318
  • Fernández IS, Chapman KE, Peters JM, Kothare SV, Nordli DR Jr, Jensen FE, Berg AT, Loddenkemper T. The tower of Babel: Survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2012 Nov 16. [Epub ahead of print] PubMed PMID: 23163318
  • Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci. 2012 Jun;35(12):1857-65. PubMed PMID: 22708596
  • Drees C, Chapman K, Prenger E, Baxter L, Maganti R, Rekate H, Shetter A, Bobrowitz M, Kerrigan JF. Seizure outcome and complications following hypothalamic hamartoma treatment in adults: endoscopic, open, and Gamma Knife procedures. J Neurosurg. 2012 Aug;117(2):255-61. PubMed PMID: 22680243
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Professional Memberships

  • American Epilepsy Society, Member
  • Child Neurology Society, Member
  • American Academy of Neurology, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Child Neurology, Board Certification (2002, 2011)
  • Clinical Neurophysiology, Board Certification (2003, 2014)
  • Epilepsy, Board Certification (2014)
Conditions & Treatments
  • Brain and Nervous System
  • Brain and Nervous System - Epilepsy
Clinical Interests
My clinical focus is caring for patients with complex epilepsy utilizing medical management, Vagus Nerve Stimulation (VNS) therapy, ketogenic diet, and epilepsy surgery. I have a special interest in electrical status epileptics during sleep (ESES).

General Information

Medical Schools:
  • MD, University of Texas Medical Branch School of Medicine (1996)
Undergraduate Schools:
  • BS, University of Texas–Austin (TX) (1992)
Residency Programs:
  • Baylor College of Medicine Program, Child Neurology (2001)
  • Baylor College of Medicine Program, Pediatrics (1998)
Fellowships:
  • Cleveland Clinic Foundation Program, Clinical Neurophysiology (2003)
Languages: English
Department: Pediatrics-Neurology
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