Amanda Law, PhD
Professor, Psychiatry-Psychopharmacology

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Languages: English
Department: Psychiatry-Psychopharmacology

Professional Titles

  • Professor, Psychiatry-Psychopharmacology
  • Tenured Professor
  • Vice Chair-Research, Department of Psychiatry

Recognition & Awards

  • Dr. Nancy L. Gary Endowed Chair in Children’s Mental Disorders Research, Institute Children’s Mental Disorders Research/Piton Foundation (2012)
  • Sidney R. Baer, Jr. Research Award. Outstanding Schizophrenia Research, Brain and Behavior Research Foundation (2012)
  • NIMH, NIH Scientific Directors Special Achievement Award, NIMH, NIH (2011)

Research Interests

My translational research program focuses on the developmental mechanisms underlying genetic and environmental risk for schizophrenia with the aim of identifying novel biological pathways for treatment development.

Publications

  • Deakin IH, Godlewska BR, Walker MA, Huang GJ, Schwab MH, Nave KA, Law AJ, Harrison PJ. Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I. Transl Psychiatry. 2018 Oct 22;8(1):229. PubMed PMID: 30348978
  • Paterson C, Law AJ. Toward Better Strategies for Understanding Disrupted Cortical Excitatory/Inhibitory Balance in Schizophrenia. Biol Psychiatry. 2018 Apr 15;83(8):632-634. PubMed PMID: 29559094
  • Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2015 Dec 7;:appiajp201515091188. [Epub ahead of print] PubMed PMID: 26651393
  • Jenkins AK, Paterson C, Wang Y, Hyde TM, Kleinman JE, Law AJ. Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging. Mol Psychiatry. 2015 Jul 28. [Epub ahead of print] PubMed PMID: 26216298
  • Jenkins A, Apud JA, Zhang F, Decot H, Weinberger DR, Law AJ. Identification of Candidate Single-nucleotide Polymorphisms in NRXN1 Related to Antipsychotic Treatment Response in Patients with Schizophrenia. Neuropsychopharmacology. 2014 Mar 14. [Epub ahead of print] PubMed PMID: 24633560
  • Tost H, Callicott JH, Rasetti R, Vakkalanka R, Mattay VS, Weinberger DR, Law AJ. Effects of neuregulin 3 genotype on human prefrontal cortex physiology. J Neurosci. 2014 Jan 15;34(3):1051-6. PubMed PMID: 24431462
  • Gothelf D, Law AJ, Frisch A, Chen J, Zarchi O, Michaelovsky E, Ren-Patterson R, Lipska BK, Carmel M, Kolachana B, Weizman A, Weinberger DR. Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome. Biol Psychiatry. 2014 Mar 1;75(5):406-13. PubMed PMID: 23992923
  • Paterson C, Law AJ. Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood. PLoS One. 2014;9(8):e104172. PubMed PMID: 25093331
  • Law AJ. Genetic mouse models of neuregulin 1: gene dosage effects, isoform-specific functions, and relevance to schizophrenia. Biol Psychiatry. 2014 Jul 15;76(2):89-90. PubMed PMID: 24948382
  • Paterson C, Wang Y, Kleinman JE, Law AJ. Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry. 2014 Sep;171(9):979-89. PubMed PMID: 24935406
  • Morita Y, Callicott JH, Testa LR, Mighdoll MI, Dickinson D, Chen Q, Tao R, Lipska BK, Kolachana B, Law AJ, Ye T, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. J Neurosci. 2014 Apr 2;34(14):4929-40. PubMed PMID: 24695712
  • Jenkins A, Apud JA, Zhang F, Decot H, Weinberger DR, Law AJ. Identification of Candidate Single-nucleotide Polymorphisms in NRXN1 Related to Antipsychotic Treatment Response in Patients with Schizophrenia. Neuropsychopharmacology. 2014 Mar 14. [Epub ahead of print] PubMed PMID: 24633560
  • Tost H, Callicott JH, Rasetti R, Vakkalanka R, Mattay VS, Weinberger DR, Law AJ. Effects of neuregulin 3 genotype on human prefrontal cortex physiology. J Neurosci. 2014 Jan 15;34(3):1051-6. PubMed PMID: 24431462
  • Gothelf D, Law AJ, Frisch A, Chen J, Zarchi O, Michaelovsky E, Ren-Patterson R, Lipska BK, Carmel M, Kolachana B, Weizman A, Weinberger DR. Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome. Biol Psychiatry. 2014 Mar 1;75(5):406-13. PubMed PMID: 23992923
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Professional Memberships

  • American College of Neuropsychopharmacology, Fellow
  • Society for Neuroscience, Member
  • Society of Biological Psychaitry, Member
  • Brain and Behavior Research Foundation, Scientific Council
  • American Society for Biochemistry and Molecular Biology, Member

Specialty Information

Specialties
  • Medical Genetics and Genomics
  • Neuroscience
  • Psychiatry

General Information

Languages: English
Department: Psychiatry-Psychopharmacology
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