Colleen Julian, PhD
Associate Professor, Medicine-Bioinformatics

Publications

  • Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 Jan 12;104:267-276. [Epub ahead of print] PubMed PMID: 33472134
  • Mundo W, Wolfson G, Moore LG, Houck JA, Park D, Julian CG. Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 Jan 8. [Epub ahead of print] PubMed PMID: 33416457
  • Reyes LM, Usselman CW, Khurana R, Chari RS, Stickland MK, Davidge ST, Julian CG, Steinback CD, Davenport MH. Preeclampsia is not associated with elevated muscle sympathetic reactivity. J Appl Physiol (1985). 2021 Jan 1;130(1):139-148. PubMed PMID: 33211599
  • Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG. Uteroplacental Ischemia Is Associated with Increased PAPP-A2. Reprod Sci. 2020 Jan 28. [Epub ahead of print] PubMed PMID: 31994005
  • Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 Jan 23. [Epub ahead of print] PubMed PMID: 31970838
  • Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891
  • Grant I, Soria R, Julian CG, Vargas E, Moore LG, Aiken CE, Giussani DA. Parental ancestry and risk of early pregnancy loss at high altitude. FASEB J. 2020 Oct;34(10):13741-13749. PubMed PMID: 32856356
  • Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 Sep;598(18):4093-4105. PubMed PMID: 32592403
  • Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H203-H212. PubMed PMID: 32502374
  • Bailey B, Euser AG, Bol KA, Julian CG, Moore LG. High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy. J Matern Fetal Neonatal Med. 2020 Mar 30;:1-8. [Epub ahead of print] PubMed PMID: 32228111
  • Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG. Uteroplacental Ischemia Is Associated with Increased PAPP-A2. Reprod Sci. 2020 Feb;27(2):529-536. PubMed PMID: 31994005
  • Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 Mar;34(3):4283-4292. PubMed PMID: 31970838
  • Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891
  • Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction†. Biol Reprod. 2020 Mar 13;102(3):660-670. PubMed PMID: 31711123
  • San-Millán I, Julian CG, Matarazzo C, Martinez J, Brooks GA. Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. Front Oncol. 2019;9:1536. PubMed PMID: 32010625
  • Julian CG. An Aptitude for Altitude: Are Epigenomic Processes Involved?. Front Physiol. 2019;10:1397. PubMed PMID: 31824328
  • Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction. Biol Reprod. 2019 Nov 11. [Epub ahead of print] PubMed PMID: 31711123
  • Bailey BA, Donnelly M, Bol K, Moore LG, Julian CG. High Altitude Continues to Reduce Birth Weights in Colorado. Matern Child Health J. 2019 Nov;23(11):1573-1580. PubMed PMID: 31243627
  • Steinback CD, Fraser GM, Usselman CW, Reyes LM, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH. Blunted sympathetic neurovascular transduction during normotensive pregnancy. J Physiol. 2019 Jul;597(14):3687-3696. PubMed PMID: 31106429
  • Toledo-Jaldin L, Bull S, Contag S, Escudero C, Gutierrez P, Heath A, Roberts JM, Scandlyn J, Julian CG, Moore LG. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia. Pregnancy Hypertens. 2019 Apr;16:139-144. PubMed PMID: 31056149
  • Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 Aug;33(8):8999-9007. PubMed PMID: 31039323
  • Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 Jun;73(6):1319-1326. PubMed PMID: 31006328
  • Julian CG, Moore LG. Human Genetic Adaptation to High Altitude: Evidence from the Andes. Genes (Basel). 2019 Feb 15;10(2). PubMed PMID: 30781443
  • San-Millán I, Julian CG, Matarazzo C, Martinez J, Brooks GA. Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. Front Oncol. 2019;9:1536. PubMed PMID: 32010625
  • Euser AG, Hammes A, Ahrendsen JT, Neshek B, Weitzenkamp DA, Gutierrez J, Koivunen P, Julian CG, Moore LG. Gestational Diabetes Prevalence at Moderate and High Altitude. High Alt Med Biol. 2018 Dec;19(4):367-372. PubMed PMID: 30281336
  • Schmidt SML, Usselman CW, Martinek E, Stickland MK, Julian CG, Chari R, Khurana R, Davidge ST, Davenport MH, Steinback CD. Activity of muscle sympathetic neurons during normotensive pregnancy. Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R153-R160. PubMed PMID: 29046311
  • Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R. Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans. Am J Hum Genet. 2017 Nov 2;101(5):752-767. PubMed PMID: 29100088
  • Schmidt SML, Usselman CW, Martinek E, Stickland MK, Julian CG, Chari RS, Khurana R, Davidge ST, Davenport MH, Steinback CD. Activity of Muscle Sympathetic Neurons during Normotensive Pregnancy. Am J Physiol Regul Integr Comp Physiol. 2017 Oct 18;:ajpregu001212016. [Epub ahead of print] PubMed PMID: 29046311
  • Julian CG. Epigenomics and human adaptation to high altitude. J Appl Physiol (1985). 2017 Nov 1;123(5):1362-1370. PubMed PMID: 28819001
  • Charkoudian N, Usselman CW, Skow RJ, Staab JS, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH, Steinback CD. Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H782-H787. PubMed PMID: 28733450
  • Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R. Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2a) polymorphism lowers hemoglobin concentration in Tibetan highlanders. J Mol Med (Berl). 2017 Jun;95(6):665-670. PubMed PMID: 28233034
  • Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017 Feb 7;8:14108. PubMed PMID: 28169986
  • Wolfson GH, Vargas E, Browne VA, Moore LG, Julian CG. Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy. J Clin Endocrinol Metab. 2017 Jan 1;102(1):242-250. PubMed PMID: 27809650
  • D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. J Proteome Res. 2016 Oct 7;15(10):3883-3895. PubMed PMID: 27646145
  • Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia. Circulation. 2016 Aug 2;134(5):405-21. PubMed PMID: 27482003
  • Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia. Nat Commun. 2016 Jul 15;7:12086. PubMed PMID: 27417539
  • Julian CG, Pedersen BS, Salmon CS, Yang IV, Gonzales M, Vargas E, Moore LG, Schwartz DA. Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin Transl Sci. 2015 Dec;8(6):740-5. PubMed PMID: 26546417
  • Usselman CW, Wakefield PK, Skow RJ, Stickland MK, Chari RS, Julian CG, Steinback CD, Davenport MH. Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women. Hypertension. 2015 Oct;66(4):858-64. PubMed PMID: 26259593
  • Usselman CW, Skow RJ, Matenchuk BA, Chari RS, Julian CG, Stickland MK, Davenport MH, Steinback CD. Sympathetic baroreflex gain in normotensive pregnant women. J Appl Physiol (1985). 2015 Sep 1;119(5):468-74. PubMed PMID: 26139215
  • Julian CG, Gonzales M, Rodriguez A, Bellido D, Salmon CS, Ladenburger A, Reardon L, Vargas E, Moore LG. Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H565-73. PubMed PMID: 26092986
  • Browne VA, Julian CG, Toledo-Jaldin L, Cioffi-Ragan D, Vargas E, Moore LG. Uterine artery blood flow, fetal hypoxia and fetal growth. Philos Trans R Soc Lond B Biol Sci. 2015 Mar 5;370(1663):20140068. PubMed PMID: 25602072
  • Ryan BJ, Wachsmuth NB, Schmidt WF, Byrnes WC, Julian CG, Lovering AT, Subudhi AW, Roach RC. AltitudeOmics: rapid hemoglobin mass alterations with early acclimatization to and de-acclimatization from 5260 m in healthy humans. PLoS One. 2014;9(10):e108788. PubMed PMID: 25271637
  • Bigham AW, Julian CG, Wilson MJ, Vargas E, Browne VA, Shriver MD, Moore LG. Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude. Physiol Genomics. 2014 Sep 15;46(18):687-97. PubMed PMID: 25225183
  • Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, Chan SY. An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells. Biochim Biophys Acta. 2014 Nov;1843(11):2528-42. PubMed PMID: 24983771
  • Charles SM, Julian CG, Vargas E, Moore LG. Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity. J Clin Endocrinol Metab. 2014 Aug;99(8):2908-16. PubMed PMID: 24684460
  • Subudhi AW, Bourdillon N, Bucher J, Davis C, Elliott JE, Eutermoster M, Evero O, Fan JL, Jameson-Van Houten S, Julian CG, Kark J, Kark S, Kayser B, Kern JP, Kim SE, Lathan C, Laurie SS, Lovering AT, Paterson R, Polaner DM, Ryan BJ, Spira JL, Tsao JW, Wachsmuth NB, Roach RC. AltitudeOmics: the integrative physiology of human acclimatization to hypobaric hypoxia and its retention upon reascent. PLoS One. 2014;9(3):e92191. PubMed PMID: 24658407
  • Subudhi AW, Fan JL, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Panerai RB, Roach RC. AltitudeOmics: cerebral autoregulation during ascent, acclimatization, and re-exposure to high altitude and its relation with acute mountain sickness. J Appl Physiol (1985). 2014 Apr 1;116(7):724-9. PubMed PMID: 24371013
  • Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, Schwartz DA. Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2014 Mar;28(3):1268-79. PubMed PMID: 24307415
  • Julian CG, Subudhi AW, Hill RC, Wilson MJ, Dimmen AC, Hansen KC, Roach RC. Exploratory proteomic analysis of hypobaric hypoxia and acute mountain sickness in humans. J Appl Physiol (1985). 2014 Apr 1;116(7):937-44. PubMed PMID: 24265281
  • Subudhi AW, Fan JL, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Roach RC. AltitudeOmics: effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery. Exp Physiol. 2014 May 1;99(5):772-81. PubMed PMID: 24243839
  • Subudhi AW, Fan JL, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Panerai RB, Roach RC. AltitudeOmics: Cerebral autoregulation during ascent, acclimatization, and re-exposure to high altitude and its relation with acute mountain sickness. J Appl Physiol (1985). 2013 Dec 26. [Epub ahead of print] PubMed PMID: 24371013
  • Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, Schwartz DA. Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2013 Dec 4. [Epub ahead of print] PubMed PMID: 24307415
  • Julian CG, Subudhi AW, Hill RC, Wilson MJ, Dimmen AC, Hansen KC, Roach RC. Exploratory proteomic analysis of hypobaric hypoxia and acute mountain sickness and in humans. J Appl Physiol (1985). 2013 Nov 21. [Epub ahead of print] PubMed PMID: 24265281
  • Subudhi AW, Fan JL, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Roach RC. AltitudeOmics: Effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery. Exp Physiol. 2013 Nov 15. [Epub ahead of print] PubMed PMID: 24243839
  • Soria R, Julian CG, Vargas E, Moore LG, Giussani DA. Graduated effects of high-altitude hypoxia and highland ancestry on birth size. Pediatr Res. 2013 Dec;74(6):633-8. PubMed PMID: 23999073
  • Schwartz J, Cioffi-Ragan D, Wilson MJ, Julian CG, Beatty B, Moore LG, Galan HL. Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation. Am J Hum Biol. 2013 Jul-Aug;25(4):544-9. PubMed PMID: 23754523
  • Julian CG, Vargas E, Gonzales M, Dávila RD, Ladenburger A, Reardon L, Schoo C, Powers RW, Lee-Chiong T, Moore LG. Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis). Respir Physiol Neurobiol. 2013 Apr 1;186(2):188-96. PubMed PMID: 23380170
  • Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol. 2013 Mar-Apr;25(2):190-7. PubMed PMID: 23348729
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General Information

Department: Medicine-Bioinformatics
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