Diego Restrepo, PhD, MSc
Professor, Cell & Developmental Biology

Publications

  • Nicholas M George, Wendy B Macklin, Diego Restrepo. Excitable axonal domains adapt to sensory deprivation in the olfactory system bioRxiv 2021.01.25.428132; doi: https://doi.org/10.1101/2021.01.25.428132
  • Guthman EM, Garcia JD, Ma M, Chu P, Baca SM, Smith KR, Restrepo D, Huntsman MM. Cell type specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition. Elife. 2020 Jan 9;9. [Epub ahead of print] PubMed PMID: 31916940
  • Li A, Rao X, Zhou Y, Restrepo D. Complex neural representation of odour information in the olfactory bulb. Acta Physiol (Oxf). 2020 Jan;228(1):e13333. PubMed PMID: 31188539
  • Losacco J, George NM, Hiratani N, Restrepo D. The Olfactory Bulb Facilitates Use of Category Bounds for Classification of Odorants in Different Intensity Groups. Front Cell Neurosci. 2020;14:613635. PubMed PMID: 33362477
  • Ma M, Futia GL, de Souza FMS, Ozbay BN, Llano I, Gibson EA, Restrepo D. Molecular layer interneurons in the cerebellum encode for valence in associative learning. Nat Commun. 2020 Aug 31;11(1):4217. PubMed PMID: 32868778
  • Nunez-Parra A, Cea-Del Rio CA, Huntsman MM, Restrepo D. The Basal Forebrain Modulates Neuronal Response in an Active Olfactory Discrimination Task. Front Cell Neurosci. 2020;14:141. PubMed PMID: 32581716
  • Cea-Del Rio CA, Nunez-Parra A, Freedman SM, Kushner JK, Alexander AL, Restrepo D, Huntsman MM. Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome. Neurobiol Dis. 2020 Aug;142:104959. PubMed PMID: 32512151
  • Baxter BD, Larson ED, Feinstein P, Polese AG, Bubak AN, Niemeyer CS, Merle L, Shepherd D, Ramakrishnan VR, Nagel MA, Restrepo D. Transcriptional profiling reveals TRPM5-expressing cells involved in viral infection in the olfactory epithelium. bioRxiv. 2020 May 15. PubMed PMID: 32511400
  • Losacco J, Ramirez-Gordillo D, Gilmer J, Restrepo D. Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb. Elife. 2020 Jan 28;9. PubMed PMID: 31990271
  • Guthman EM, Garcia JD, Ma M, Chu P, Baca SM, Smith KR, Restrepo D, Huntsman MM. Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition. Elife. 2020 Jan 9;9. PubMed PMID: 31916940
  • Li A, Rao X, Zhou Y, Restrepo D. Complex neural representation of odour information in the olfactory bulb. Acta Physiol (Oxf). 2020 Jan;228(1):e13333. PubMed PMID: 31188539
  • Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, Cooper KW, Bouysset C, Pirastu N, Dibattista M, Kaur R, Liuzza MT, Pepino MY, Schöpf V, Pereda-Loth V, Olsson SB, Gerkin RC, Rohlfs Domínguez P, Albayay J, Farruggia MC, Bhutani S, Fjaeldstad AW, Kumar R, Menini A, Bensafi M, Sandell M, Konstantinidis I, Di Pizio A, Genovese F, Öztürk L, Thomas-Danguin T, Frasnelli J, Boesveldt S, Saatci Ö, Saraiva LR, Lin C, Golebiowski J, Hwang LD, Ozdener MH, Guàrdia MD, Laudamiel C, Ritchie M, Havlícek J, Pierron D, Roura E, Navarro M, Nolden AA, Lim J, Whitcroft KL, Colquitt LR, Ferdenzi C, Brindha EV, Altundag A, Macchi A, Nunez-Parra A, Patel ZM, Fiorucci S, Philpott CM, Smith BC, Lundström JN, Mucignat C, Parker JK, van den Brink M, Schmuker M, Fischmeister FPS, Heinbockel T, Shields VDC, Faraji F, Santamaría E, Fredborg WEA, Morini G, Olofsson JK, Jalessi M, Karni N, D'Errico A, Alizadeh R, Pellegrino R, Meyer P, Huart C, Chen B, Soler GM, Alwashahi MK, Welge-Lüssen A, Freiherr J, de Groot JHB, Klein H, Okamoto M, Singh PB, Hsieh JW, Reed DR, Hummel T, Munger SD, Hayes JE. More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chem Senses. 2020 Oct 9;45(7):609-622. PubMed PMID: 32564071
  • Arjun K. Fontaine, Gregory L. Futia, Pradeep S. Rajendran, Samuel Littich, Naoko Mizoguchi, Kalyanam Shivkumar, Jeffrey L. Ardell, Diego Restrepo, John H. Caldwell, Emily A. Gibson, Richard F. Weir. Selective Modulation of Heart and Respiration by Optical Control of Vagus Nerve Axons Innervating the Heart. bioRxiv 2020.06.26.173898; doi: https://doi.org/10.1101/2020.06.26.173898
  • Heffernan BM, Meyer SA, Restrepo D, Siemens ME, Gibson EA, Gopinath JT. A Fiber-Coupled Stimulated Emission Depletion Microscope for Bend-Insensitive Through-Fiber Imaging. Sci Rep. 2019 Jul 31;9(1):11137. PubMed PMID: 31366899
  • Kennel C, Gould EA, Larson ED, Salcedo E, Vickery T, Restrepo D, Ramakrishnan VR. Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium. Chem Senses. 2019 Sep 7;44(7):511-521. PubMed PMID: 31300812
  • Ozbay BN, Futia GL, Ma M, Bright VM, Gopinath JT, Hughes EG, Restrepo D, Gibson EA. Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep. 2018 May 25;8(1):8108. PubMed PMID: 29802371
  • Ramirez-Gordillo D, Ma M, Restrepo D. Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. Front Cell Neurosci. 2018;12:48. PubMed PMID: 29551964
  • Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB. Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife. 2018 Feb 13;7. PubMed PMID: 29436368
  • Li A, Guthman EM, Doucette WT, Restrepo D. Behavioral status influences the dependence of odorant-induced change in firing on pre-stimulus firing rate. J Neurosci. 2017 Jan 16. [Epub ahead of print] PubMed PMID: 28093474
  • Supekar OD, Ozbay BN, Zohrabi M, Nystrom PD, Futia GL, Restrepo D, Gibson EA, Gopinath JT, Bright VM. Two-photon laser scanning microscopy with electrowetting-based prism scanning. Biomed Opt Express. 2017 Dec 1;8(12):5412-5426. PubMed PMID: 29296477
  • Zhou Y, Wang X, Cao T, Xu J, Wang D, Restrepo D, Li A. Insulin Modulates Neural Activity of Pyramidal Neurons in the Anterior Piriform Cortex. Front Cell Neurosci. 2017;11:378. PubMed PMID: 29234275
  • Ryan DP, Gould EA, Seedorf GJ, Masihzadeh O, Abman SH, Vijayaraghavan S, Macklin WB, Restrepo D, Shepherd DP. Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy. Nat Commun. 2017 Sep 20;8(1):612. PubMed PMID: 28931809
  • Mura CV, Delgado R, Delgado MG, Restrepo D, Bacigalupo J. A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca(2 )-activated Cl(-) current when transfected into HEK293. BMC Neurosci. 2017 Aug 11;18(1):61. PubMed PMID: 28800723
  • Pouille F, McTavish TS, Hunter LE, Restrepo D, Schoppa NE. Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network. J Physiol. 2017 Sep 1;595(17):5965-5986. PubMed PMID: 28640508
  • Soltys JN, Meyer SA, Schumann H, Gibson EA, Restrepo D, Bennett JL. Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J. 2017 Apr 25;112(8):1692-1702. PubMed PMID: 28445760
  • Li A, Guthman EM, Doucette WT, Restrepo D. Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate. J Neurosci. 2017 Feb 15;37(7):1835-1852. PubMed PMID: 28093474
  • Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D. The human olfactory transcriptome. BMC Genomics. 2016 Aug 11;17(1):619. PubMed PMID: 27515280
  • Meyer SA, Ozbay BN, Potcoava M, Salcedo E, Restrepo D, Gibson EA. Super-resolution imaging of ciliary microdomains in isolated olfactory sensory neurons using a custom two-color stimulated emission depletion microscope. J Biomed Opt. 2016 Jun 1;21(6):66017. PubMed PMID: 27367253
  • Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M, German Mouse Clinic Consortium, Beckers J, Wurst W, Klingenspor M, Restrepo D, de Angelis MH, Sikela JM. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Mamm Genome. 2015 Feb;26(1-2):33-42. PubMed PMID: 25308000
  • Ozbay BN, Losacco JT, Cormack R, Weir R, Bright VM, Gopinath JT, Restrepo D, Gibson EA. Miniaturized fiber-coupled confocal fluorescence microscope with an electrowetting variable focus lens using no moving parts. Opt Lett. 2015 Jun 1;40(11):2553-6. PubMed PMID: 26030555
  • Li A, Gire DH, Restrepo D. ? spike-field coherence in a population of olfactory bulb neurons differentiates between odors irrespective of associated outcome. J Neurosci. 2015 Apr 8;35(14):5808-22. PubMed PMID: 25855190
  • Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M, Beckers J, Wurst W, Klingenspor M, Restrepo D, de Angelis MH, Sikela JM. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Mamm Genome. 2015 Feb;26(1-2):33-42. PubMed PMID: 25308000
  • López F, Delgado R, López R, Bacigalupo J, Restrepo D. Transduction for Pheromones in the Main Olfactory Epithelium Is Mediated by the Ca2 -Activated Channel TRPM5. J Neurosci. 2014 Feb 26;34(9):3268-78. PubMed PMID: 24573286
  • Li A, Gire DH, Bozza T, Restrepo D. Precise detection of direct glomerular input duration by the olfactory bulb. J Neurosci. 2014 Nov 26;34(48):16058-64. PubMed PMID: 25429146
  • Nunez-Parra A, Li A, Restrepo D. Coding odor identity and odor value in awake rodents. Prog Brain Res. 2014;208:205-22. PubMed PMID: 24767484
  • Rolen SH, Salcedo E, Restrepo D, Finger TE. Differential localization of NT-3- and TrpM5 in glomeruli of the olfactory bulb of mice. J Comp Neurol. 2013 Nov 29. [Epub ahead of print] PubMed PMID: 24288162
  • Restrepo D, Hellier JL, Salcedo E. Complex metabolically demanding sensory processing in the olfactory system: Implications for epilepsy. Epilepsy Behav. 2013 Oct 7. [Epub ahead of print] PubMed PMID: 24113565
  • Gonzalez-Silva C, Vera J, Bono MR, González-Billault C, Baxter B, Hansen A, Lopez R, Gibson EA, Restrepo D, Bacigalupo J. Ca2 -activated Cl- channels of the ClCa family express in the cilia of a subset of rat olfactory sensory neurons. PLoS One. 2013;8(7):e69295. PubMed PMID: 23874937
  • Gire DH, Whitesell JD, Doucette W, Restrepo D. Information for decision-making and stimulus identification is multiplexed in sensory cortex. Nat Neurosci. 2013 Aug;16(8):991-3. PubMed PMID: 23792942
  • Salcedo E, Cruz NM, Ly X, Welander BA, Hanson K, Kronberg E, Restrepo D. A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli. Open Biol. 2013 May 22;3(5):130044. PubMed PMID: 23697805
  • Gire DH, Restrepo D, Sejnowski TJ, Greer C, De Carlos JA, Lopez-Mascaraque L. Temporal processing in the olfactory system: can we see a smell?. Neuron. 2013 May 8;78(3):416-32. PubMed PMID: 23664611
  • Oshimoto A, Wakabayashi Y, Garske A, Lopez R, Rolen S, Flowers M, Arevalo N, Restrepo D. Potential role of transient receptor potential channel M5 in sensing putative pheromones in mouse olfactory sensory neurons. PLoS One. 2013;8(4):e61990. PubMed PMID: 23613997
  • Keydar I, Ben-Asher E, Feldmesser E, Nativ N, Oshimoto A, Restrepo D, Matsunami H, Chien MS, Pinto JM, Gilad Y, Olender T, Lancet D. General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. Hum Mutat. 2013 Jan;34(1):32-41. PubMed PMID: 22936402
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General Information

Department: Cell & Developmental Biology
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