Tomas Majtan, PharmD, PhD
Assistant Research Professor, Pediatrics-Clinical Genetics and Metabolism

Photo
Languages: English, Slovak, Czech
Department: Pediatrics-Clinical Genetics and Metabolism

Professional Titles

  • Assistant Research Professor, Pediatrics-Clinical Genetics and Metabolism
  • Assistant Research Professor

Publications

  • Majtan T, Bublil EM, Park I, Arning E, Bottiglieri T, Glavin F, Kraus JP. Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria. Life Sci. 2018 May 1;200:15-25. PubMed PMID: 29526799
  • Majtan T, Jones W Jr, Krijt J, Park I, Kruger WD, Kožich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther. 2018 Mar 7;26(3):834-844. PubMed PMID: 29398487
  • Collard R, Majtan T, Park I, Kraus JP. Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia. Mol Cell Biol. 2018 Mar 15;38(6). PubMed PMID: 29378828
  • Giménez-Mascarell P, Majtan T, Oyenarte I, Ereño-Orbea J, Majtan J, Klaudiny J, Kraus JP, Martínez-Cruz LA. Crystal structure of cystathionine ß-synthase from honeybee Apis mellifera. J Struct Biol. 2018 Apr;202(1):82-93. PubMed PMID: 29275181
  • Majtan T, Pey AL, Gimenez-Mascarell P, Martínez-Cruz LA, Szabo C, Kožich V, Kraus JP. Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria. Handb Exp Pharmacol. 2017 Nov 10. [Epub ahead of print] PubMed PMID: 29119254
  • Majtan T, Park I, Bublil EM, Kraus JP. Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria. Hum Mutat. 2017 Oct 16. [Epub ahead of print] PubMed PMID: 29044829
  • Majtan T, Krijt J, Sokolova J, Krizkova M, Ralat M, Kent J, Gregory Iii JF, Kozich V, Kraus J. Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase. Antioxid Redox Signal. 2017 Sep 6. [Epub ahead of print] PubMed PMID: 28874062
  • Bublil EM, Majtan T, Park I, Carrillo RS, Hulková H, Krijt J, Kožich V, Kraus JP. Enzyme replacement with PEGylated cystathionine ß-synthase ameliorates homocystinuria in murine model. J Clin Invest. 2016 Jun 1;126(6):2372-84. PubMed PMID: 27183385
  • Majtan T, Pey AL, Kraus JP. Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria. Biochimie. 2016 Jul;126:6-13. PubMed PMID: 26805382
  • Kožich V, Krijt J, Sokolová J, Melenovská P, Ješina P, Vozdek R, Majtán T, Kraus JP. Thioethers as markers of hydrogen sulfide production in homocystinurias. Biochimie. 2016 Jul;126:14-20. PubMed PMID: 26791043
  • Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM. Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1064-6. PubMed PMID: 25666819
  • Pey AL, Majtan T, Kraus JP. The role of surface electrostatics on the stability, function and regulation of human cystathionine ß-synthase, a complex multidomain and oligomeric protein. Biochim Biophys Acta. 2014 Sep;1844(9):1453-62. PubMed PMID: 24780582
  • Majtan J, Bohova J, Garcia-Villalba R, Tomas-Barberan FA, Madakova Z, Majtan T, Majtan V, Klaudiny J. Fir honeydew honey flavonoids inhibit TNF-a-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. Arch Dermatol Res. 2013 Sep;305(7):619-27. PubMed PMID: 23812412
  • Thorson MK, Majtan T, Kraus JP, Barrios AM. Identification of cystathionine ß-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. PubMed PMID: 23512751
  • Su Y, Majtan T, Freeman KM, Linck RC, Ponter S, Kraus JP, Burstyn JN. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine beta-synthases. Biochemistry. 2012 Sep 24. [Epub ahead of print] PubMed PMID: 23002992
  • Pey AL, Majtan T, Sanchez-Ruiz JM, Kraus JP. Human cystathionine ß-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM. Biochem J. 2013 Jan 1;449(1):109-21. PubMed PMID: 22985361
  • Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Klaudiny J, Majtan J, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine ß-synthase from Apis mellifera. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1323-8. PubMed PMID: 23143241
  • Oyenarte I, Majtan T, Ereño J, Corral-Rodríguez MA, Kraus JP, Martínez-Cruz LA. Purification, crystallization and preliminary crystallographic analysis of human cystathionine ß-synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1318-22. PubMed PMID: 23143240
  • Su Y, Majtan T, Freeman KM, Linck RC, Ponter S, Kraus JP, Burstyn JN. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine beta-synthases. Biochemistry. 2012 Sep 24. [Epub ahead of print] PubMed PMID: 23002992
  • Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine ß-synthase. Biochemistry. 2012 Aug 14;51(32):6360-70. PubMed PMID: 22738154
  • Hni´zda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodi´cek M, Kožich V, Kraus JP. Correction to Conformational Properties of Nine Purified Cystathionine ß-Synthase Mutants. Biochemistry. 2012 Jul 10;51(27):5540. PubMed PMID: 22734603
  • Hnízda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodícek M, Kožich V, Kraus JP. Conformational properties of nine purified cystathionine ß-synthase mutants. Biochemistry. 2012 Jun 12;51(23):4755-63. PubMed PMID: 22612060
  • Majtan T, Kraus JP. Folding and activity of mutant cystathionine ß-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant. Protein Expr Purif. 2012 Apr;82(2):317-24. PubMed PMID: 22333527
View All (23 Total) View Less

General Information

Languages: English, Slovak, Czech
Department: Pediatrics-Clinical Genetics and Metabolism
;