Danielle Soranno, MD
Associate Professor, Pediatrics-Nephrology

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Medical School:
  • MD, Case Western Reserve University School of Medicine (2007)
Undergraduate School:
  • BSE, Case Western Reserve University (OH) (2003)
Internship:
  • University of Colorado (Children's Hospital Colorado) Program (2008)
Residency:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2010)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Nephrology (2013)
Languages: English
Department: Pediatrics-Nephrology

Publications

  • Searns JB, Gist KM, Brinton JT, Pickett K, Todd J, Birkholz M, Soranno DE. Impact of acute kidney injury and nephrotoxic exposure on hospital length of stay. Pediatr Nephrol. 2020 May;35(5):799-806. PubMed PMID: 31940070
  • Gien J, Soranno D. Identifying the Patient at Risk for Acute Kidney Injury: Pediatric Sepsis Biomarker Risk Model Study. Am J Respir Crit Care Med. 2020 Apr 1;201(7):764-766. PubMed PMID: 32032496
  • Barhight MF, Brinton JT, Soranno DE, Faubel S, Mourani PM, Gist KM. Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury. Pediatr Nephrol. 2020 Jul;35(7):1331-1339. PubMed PMID: 32152726
  • Ayalon I, Woo JG, Basu RK, Kaddourah A, Goldstein SL, Kaplan JM. Weight as a Risk Factor for Mortality in Critically Ill Patients. Pediatrics. 2020 Aug;146(2). PubMed PMID: 32620676
  • Khailova L, Robison J, Jaggers J, Ing R, Lawson S, Treece A, Soranno D, Osorio Lujan S, Davidson JA. Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest. J Inflamm (Lond). 2020;17:27. PubMed PMID: 32817746
  • Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun. 2020 Sep;19:100635. PubMed PMID: 33294724
  • Selewski DT, Akcan-Arikan A, Bonachea EM, Gist KM, Goldstein SL, Hanna M, Joseph C, Mahan JD, Nada A, Nathan AT, Reidy K, Staples A, Wintermark P, Boohaker LJ, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group. Pediatr Res. 2019 Jan;85(1):79-85. PubMed PMID: 30237572
  • Askenazi D, Abitbol C, Boohaker L, Griffin R, Raina R, Dower J, Davis TK, Ray PE, Perazzo S, DeFreitas M, Milner L, Ambalavanan N, Cole FS, Rademacher E, Zappitelli M, Mhanna M. Optimizing the AKI definition during first postnatal week using Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) cohort. Pediatr Res. 2019 Feb;85(3):329-338. PubMed PMID: 30643188
  • Lee DJ, Cavasin MA, Rocker AJ, Soranno DE, Meng X, Shandas R, Park D. An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction. J Biol Eng. 2019;13:6. PubMed PMID: 30675179
  • Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
  • Hasson DC, Brinton JT, Cowherd E, Soranno DE, Gist KM. Risk Factors for Recurrent Acute Kidney Injury in Children Who Undergo Multiple Cardiac Surgeries: A Retrospective Analysis. Pediatr Crit Care Med. 2019 Jul;20(7):614-620. PubMed PMID: 30925574
  • Selewski DT, Gist KM, Nathan AT, Goldstein SL, Boohaker LJ, Akcan-Arikan A, Bonachea EM, Hanna M, Joseph C, Mahan JD, Mammen C, Nada A, Reidy K, Staples A, Wintermark P, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group. Pediatr Res. 2019 Sep 19. [Epub ahead of print] PubMed PMID: 31537009
  • Davidson JA, Khailova L, Treece A, Robison J, Soranno DE, Jaggers J, Ing RJ, Lawson S, Lujan SO. Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest. Sci Rep. 2019 Oct 2;9(1):14175. PubMed PMID: 31578351
  • Kirelik D, Fisher M, DiMaria M, Soranno DE, Gist KM. Comparison of creatinine and cystatin C for estimation of glomerular filtration rate in pediatric patients after Fontan operation. Congenit Heart Dis. 2019 Sep;14(5):760-764. PubMed PMID: 30993817
  • Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2018 Oct 12. [Epub ahead of print] PubMed PMID: 30315405
  • Basu RK, Kaddourah A, Goldstein SL. Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study. Lancet Child Adolesc Health. 2018 Feb;2(2):112-120. PubMed PMID: 30035208
  • SooHoo M, Griffin B, Jovanovich A, Soranno DE, Mack E, Patel SS, Faubel S, Gist KM. Acute kidney injury is associated with subsequent infection in neonates after the Norwood procedure: a retrospective chart review. Pediatr Nephrol. 2018 Jul;33(7):1235-1242. PubMed PMID: 29508077
  • Barhight MF, Lusk J, Brinton J, Stidham T, Soranno DE, Faubel S, Goebel J, Mourani PM, Gist KM. Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy. Pediatr Nephrol. 2018 Jun;33(6):1079-1085. PubMed PMID: 29404689
  • Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study. JAMA Pediatr. 2018 Jun 4;172(6):e180322. PubMed PMID: 29610830
  • Gist KM, Goldstein SL, Wrona J, Alten JA, Basu RK, Cooper DS, Soranno DE, Duplantis J, Altmann C, Gao Z, Faubel S. Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery. Pediatr Nephrol. 2017 Apr 5. [Epub ahead of print] PubMed PMID: 28382566
  • Altmann C, Ahuja N, Kiekhaefer CM, Andres Hernando A, Okamura K, Bhargava R, Duplantis J, Kirkbride-Romeo LA, Huckles J, Fox BM, Kahn K, Soranno D, Gil HW, Teitelbaum I, Faubel S. Early peritoneal dialysis reduces lung inflammation in mice with ischemic acute kidney injury. Kidney Int. 2017 Aug;92(2):365-376. PubMed PMID: 28318621
  • Andres-Hernando A, Okamura K, Bhargava R, Kiekhaefer CM, Soranno D, Kirkbride-Romeo LA, Gil HW, Altmann C, Faubel S. Circulating IL-6 upregulates IL-10 production in splenic CD4( ) T cells and limits acute kidney injury-induced lung inflammation. Kidney Int. 2017 May;91(5):1057-1069. PubMed PMID: 28214022
  • Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL. Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults. N Engl J Med. 2017 Jan 5;376(1):11-20. PubMed PMID: 27959707
  • Jetton JG, Boohaker LJ, Sethi SK, Wazir S, Rohatgi S, Soranno DE, Chishti AS, Woroniecki R, Mammen C, Swanson JR, Sridhar S, Wong CS, Kupferman JC, Griffin RL, Askenazi DJ. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. Lancet Child Adolesc Health. 2017 Nov;1(3):184-194. PubMed PMID: 29732396
  • Gist KM, Goldstein SL, Wrona J, Alten JA, Basu RK, Cooper DS, Soranno DE, Duplantis J, Altmann C, Gao Z, Faubel S. Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery. Pediatr Nephrol. 2017 Sep;32(9):1611-1619. PubMed PMID: 28382566
  • Gist KM, Goldstein SL, Wrona J, Alten JA, Basu RK, Cooper DS, Soranno DE, Duplantis J, Altmann C, Gao Z, Faubel S. Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery. Pediatr Nephrol. 2017 Sep;32(9):1611-1619. PubMed PMID: 28382566
  • Soranno DE, Rodell CB, Altmann C, Duplantis J, Andres-Hernando A, Burdick JA, Faubel S. Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F362-72. PubMed PMID: 26962109
  • Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, Selewski DT, Abitbol CL, Kaskel FJ, Mhanna MJ, Ambalavanan N, Charlton JR. Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study. Front Pediatr. 2016 Jul 19;4:68. PubMed PMID: 27486571
  • Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, Selewski DT, Abitbol CL, Kaskel FJ, Mhanna MJ, Ambalavanan N, Charlton JR. Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study. Front Pediatr. 2016;4:68. PubMed PMID: 27486571
  • Rodell CB, Rai R, Faubel S, Burdick JA, Soranno DE. Local immunotherapy via delivery of interleukin-10 and transforming growth factor ß antagonist for treatment of chronic kidney disease. J Control Release. 2015 May 28;206:131-9. PubMed PMID: 25804871
  • Rao S, Abzug MJ, Carosone-Link P, Peterson T, Child J, Siparksy G, Soranno D, Cadnapaphornchai MA, Simões EA. Intravenous acyclovir and renal dysfunction in children: a matched case control study. J Pediatr. 2015 Jun;166(6):1462-8.e1-4. PubMed PMID: 25708691
  • Rodell CB, Rai R, Faubel S, Burdick JA, Soranno DE. Local immunotherapy via delivery of interleukin-10 and transforming growth factor ß antagonist for treatment of chronic kidney disease. J Control Release. 2015 May 28;206:131-9. PubMed PMID: 25804871
  • Rao S, Abzug MJ, Carosone-Link P, Peterson T, Child J, Siparksy G, Soranno D, Cadnapaphornchai MA, Simões EA. Intravenous acyclovir and renal dysfunction in children: a matched case control study. J Pediatr. 2015 Jun;166(6):1462-8.e1-4. PubMed PMID: 25708691
  • Andres-Hernando A, Altmann C, Bhargava R, Okamura K, Bacalja J, Hunter B, Ahuja N, Soranno D, Faubel S. Prolonged acute kidney injury exacerbates lung inflammation at 7 days post-acute kidney injury. Physiol Rep. 2014 Jul 1;2(7). PubMed PMID: 25052489
  • Soranno DE, Lu HD, Weber HM, Rai R, Burdick JA. Immunotherapy with injectable hydrogels to treat obstructive nephropathy. J Biomed Mater Res A. 2013 Jul 31. [Epub ahead of print] PubMed PMID: 23913854
  • Lu HD, Soranno DE, Rodell CB, Kim IL, Burdick JA. Secondary photocrosslinking of injectable shear-thinning dock-and-lock hydrogels. Adv Healthc Mater. 2013 Jul;2(7):1028-36. PubMed PMID: 23299998
  • Stenson EK, Brinton J, Soranno DE, Gist KM. Modification of the Renal Angina Index for identifying the need for renal replacement therapy in critically ill pediatric patients. Journal of Clinical Nephrology, accepted 2020.
  • Soranno DE, Kirkbride-Romeo L, Wennersten SA, Ding K, Cavasin MA, Baer P, Altmann C, Bagchi RA, Haefner KR, Steinkuhler C, Montford J, Keith B, Gist KM, McKinsey TA, Faubel S. Acute kidney injury results in long-term diastolic dysfunction that is prevented by histone deacetylase inhibition. JACC: Basic to Translational Science, accepted, 2020.
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Nephrology, Board Certification (, 2014)
Conditions & Treatments
  • Kidneys and Urinary System - Nephropathy (Nephrosis)
  • Kidneys and Urinary System - Nephrotic Syndrome
  • Kidneys and Urinary System - Polycystic Kidney Disease
  • Kidneys and Urinary System - Kidney Failure
  • Kidneys and Urinary System - Kidney Disease
  • Kidneys and Urinary System - Interstitial Nephritis
  • Kidneys and Urinary System - Proteinuria
  • Kidneys and Urinary System
Care Philosophy
I strive to make sure my patients and their families have a good understanding of what the kidneys do, why they are important to normal growth and development, and what, if anything might be wrong with their kidney function. I know that going to the doctor's can be intimidating and scary, and I always try to make my pediatric patients, and their caregivers feel at ease.

General Information

Medical Schools:
  • MD, Case Western Reserve University School of Medicine (2007)
Undergraduate Schools:
  • BSE, Case Western Reserve University (OH) (2003)
Internships:
  • University of Colorado (Children's Hospital Colorado) Program (2008)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2010)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Nephrology (2013)
Languages: English
Department: Pediatrics-Nephrology
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