Peter Dempsey, PhD
Associate Professor, Pediatrics-Developmental Biology

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Department: Pediatrics-Developmental Biology

Publications

  • Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. J Exp Med. 2018 Apr 2;215(4):1205-1225. PubMed PMID: 29472497
  • Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin ß Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. PubMed PMID: 29166602
  • Dempsey PJ. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2228-2239. PubMed PMID: 28739265
  • Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):447-468. PubMed PMID: 28462383
  • Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23;8(2):e2622. PubMed PMID: 28230865
  • Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin ß Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. PubMed PMID: 29166602
  • Dempsey PJ. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2228-2239. PubMed PMID: 28739265
  • Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):447-468. PubMed PMID: 28462383
  • Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23;8(2):e2622. PubMed PMID: 28230865
  • Jones JC, Dempsey PJ. Enterocyte progenitors can dedifferentiate to replace lost Lgr5( ) intestinal stem cells revealing that many different progenitor populations can regain stemness. Stem Cell Investig. 2016 Oct 21;3:61. PubMed PMID: 27868043
  • Dempsey PJ. Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?. Gastroenterology. 2016 Jul;151(1):27-9. PubMed PMID: 27237596
  • Jones JC, Rustagi S, Dempsey PJ. ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol. 2016;78:243-76. PubMed PMID: 26667078
  • Jones JC, Dempsey PJ. Enterocyte progenitors can dedifferentiate to replace lost Lgr5( ) intestinal stem cells revealing that many different progenitor populations can regain stemness. Stem Cell Investig. 2016 Oct 21;3:61. PubMed PMID: 27868043
  • Jones JC, Rustagi S, Dempsey PJ. ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol. 2016;78:243-76. PubMed PMID: 26667078
  • Dempsey PJ. Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?. Gastroenterology. 2016 Jul;151(1):27-9. PubMed PMID: 27237596
  • Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Mol Cell Biol. 2015 Nov 1;35(21):3604-21. PubMed PMID: 26283731
  • Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26050928
  • Freeman JJ, Feng Y, Demehri FR, Dempsey PJ, Teitelbaum DH. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015 Jul;29(7):2943-58. PubMed PMID: 25782989
  • Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 2014 Oct;147(4):822-834.e13. PubMed PMID: 25038433
  • Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 2014 Oct;147(4):822-834.e13. PubMed PMID: 25038433
  • Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18;288(42):30742-51. PubMed PMID: 24043629
  • Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar;14(3):262-70. PubMed PMID: 23377202
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General Information

Department: Pediatrics-Developmental Biology
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