Adam Green, MD
Associate Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

Photo
Medical School:
  • MD, New York University School of Medicine (2006)
Undergraduate School:
  • BA, Dartmouth College (NH) (2002)
Internship:
  • University of Colorado (Children's Hospital Colorado) Program (2007)
Residencies:
  • University of Colorado (Children's Hospital Colorado) Program, Chief Resident, Pediatrics (2010)
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2009)
Fellowships:
  • Dana-Farber Cancer Institute/Boston Children’s Hospital/Harvard Medical School Program, Pediatric Hematology / Oncology (2013)
Languages: English, Spanish
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Professional Titles

  • Attending Physician

Recognition & Awards

  • Young Investigator Award, American Society of Pediatric Hematology-Oncology (2017)
    Awarded to two pediatric hematology-oncology investigators in the United States each year for early career research accomplishment

Research Interests

My research focuses on a specific type of cancer called high-grade glioma, an aggressive brain tumor affecting both children and adults. We focus especially on two pediatric subtypes called diffuse intrinsic pontine glioma and pediatric glioblastoma. I work in the lab to find new treatments for these tumors; we then study the treatments in laboratory models of the tumors, including mouse models, and then bring the treatments most likely to be successful to clinical trials in children.

Teaching

  • Assistant Professor (2016)
    School of Medicine, Pediatrics

Publications

  • Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, Sanford B, Birks DK, Davidson N, Metselaar DS, Meel MH, Lemma R, Donson A, Vijmasi T, Katagi H, Sola I, Fosmire S, Alimova I, Steiner J, Gilani A, Hulleman E, Serkova NJ, Hashizume R, Hawkins C, Carcaboso AM, Gupta N, Monje M, Jabado N, Jones K, Foreman N, Green A, Vibhakar R, Venkataraman S. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. Cell Rep. 2020 Oct 20;33(3):108286. PubMed PMID: 33086074
  • Grob ST, Nobre L, Campbell KR, Davies KD, Ryall S, Aisner DL, Hoffman L, Zahedi S, Morin A, Crespo M, Nellan A, Green AL, Foreman N, Vibhakar R, Hankinson TC, Handler MH, Hawkins C, Tabori U, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa103. PubMed PMID: 33063010
  • Green AL, Flannery P, Hankinson TC, O'Neill B, Amani V, DeSisto J, Knox A, Chatwin H, Lemma R, Hoffman LM, Mulcahy Levy J, Raybin J, Hemenway M, Gilani A, Koschmann C, Dahl N, Handler M, Pierce A, Venkataraman S, Foreman N, Vibhakar R, Wempe MF, Dorris K. Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa021. PubMed PMID: 32642682
  • Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD. The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol Carcinog. 2020 Sep;59(9):1064-1075. PubMed PMID: 32567728
  • Faulk KE, Anderson-Mellies A, Cockburn M, Green AL. Assessment of enrollment characteristics for Children's Oncology Group (COG) upfront therapeutic clinical trials 2004-2015. PLoS One. 2020;15(4):e0230824. PubMed PMID: 32324751
  • Dahl NA, Danis E, Balakrishnan I, Wang D, Pierce A, Walker FM, Gilani A, Serkova NJ, Madhavan K, Fosmire S, Green AL, Foreman NK, Venkataraman S, Vibhakar R. Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma. Cell Rep. 2020 Apr 7;31(1):107485. PubMed PMID: 32268092
  • Moreira DC, Venkataraman S, Subramanian A, Desisto J, Balakrishnan I, Prince E, Pierce A, Griesinger A, Green A, Eberhardt CG, Foreman NK, Vibhakar R. Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine. J Neurooncol. 2020 May;147(3):531-545. PubMed PMID: 32180106
  • Fineberg R, Zahedi S, Eguchi M, Hart M, Cockburn M, Green AL. Population-Based Analysis of Demographic and Socioeconomic Disparities in Pediatric CNS Cancer Survival in the United States. Sci Rep. 2020 Mar 12;10(1):4588. PubMed PMID: 32165703
  • Whiteway SL, Betts AM, O'Neil ER, Green AL, Gilani A, Orr BA, Mathis DA. Oncogenic GOPC-ROS1 Fusion Identified in a Congenital Glioblastoma Case. J Pediatr Hematol Oncol. 2020 Nov;42(8):e813-e818. PubMed PMID: 31929384
  • Gilani A, Donson A, Davies KD, Whiteway SL, Lake J, DeSisto J, Hoffman L, Foreman NK, Kleinschmidt-DeMasters BK, Green AL. Targetable molecular alterations in congenital glioblastoma. J Neurooncol. 2020 Jan;146(2):247-252. PubMed PMID: 31875306
  • Green AL, DeSisto J, Flannery P, Lemma R, Knox A, Lemieux M, Sanford B, O'Rourke R, Ramkissoon S, Jones K, Perry J, Hui X, Moroze E, Balakrishnan I, O'Neill AF, Dunn K, DeRyckere D, Danis E, Safadi A, Gilani A, Hubbell-Engler B, Nuss Z, Levy JMM, Serkova N, Venkataraman S, Graham DK, Foreman N, Ligon K, Jones K, Kung AL, Vibhakar R. BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene. 2020 Mar;39(11):2305-2327. PubMed PMID: 31844250
  • Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL, Mulcahy Levy J, Dorris K, Vibhakar R, Hankinson TC, Foreman NK, Ewalt MD, Kleinschmidt-DeMasters BK, Hoffman LM, Gilani A. Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer. 2020 Jan;67(1):e28028. PubMed PMID: 31595628
  • DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-?B Pathway in Preclinical Models of Pediatric High-Grade Glioma. Mol Cancer Ther. 2020 Feb;19(2):540-551. PubMed PMID: 31594826
  • Hart M, Mellies A, Beltrami A. Gilani A, Green A. "A population-based analysis of CNS tumor diagnoses, treatment, and survival in congenital and infant age groups." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Greer H, Campbell K, Samay S, Green A. "Investigation of white blood cell characteristics in CSF samples at pediatric brain tumor diagnosis." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Chatwin H, Lema R, DeSisto J, Knox A, Mestnik S, Reid A, Vibhakar R, Venkataraman S, Green A. "H3K27M induces epigenetic and oncogenic changes that are partially reversed by small molecule Aurora kinase B/C inhibition." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Knox AJ, Gilani A, van Court B, Oweida A, Flannery P, DeSisto J, Lemma R, Chatwin H, Gamboni F, Brown B, SerkovaN, Vibhakar R, Dorris K, Reisz JA, Karam SD, Green AL. "Toward multimodality therapy for DIPG/DMG: Development and investigation of craniospinal irradiation and convection-enhanced delivery PDX models." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Knox AJ, Flannery P, Zukosky A, DeSisto J, Sanford B, van Court B, Donson A, Lemma R, Chatwin H, Karam SD, Vibhakar R, Jones K, Green AL. "Radiation-derived treatment-resistant PDX and cell culture models recapitulate the characteristics of matched primary/recurrent pediatric high-grade glioma." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Lind K, Mellies A, Green A. "Retrospective patient-level study of early death from childhood cancer in Colorado." American Society of Pediatric Hematology-Oncology Annual Meeting, 2020.
  • Lucas J, DeSisto J, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schuller U, Hoffman LM, Dorris K, Mulcahy Levy J, Hankinson TC, Handler M, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. "Pediatric treatment induced high-grade gliomas have molecular alterations and a mutational signature which distinguish it from de novo pediatric high-grade gliomas." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
  • Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL, Mulcahy Levy J, Dorris K, Vibhakar R, Hankinson TC, Foreman NK, Ewalt MD, Kleinschmidt-DeMasters BK, Hoffman LM, Gilani A. Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer. 2019 Oct 8;:e28028. [Epub ahead of print] PubMed PMID: 31595628
  • DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL. Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma. Mol Cancer Ther. 2019 Oct 8. [Epub ahead of print] PubMed PMID: 31594826
  • Zahedi S, Fitzwalter BE, Morin A, Grob S, Desmarais M, Nellan A, Green AL, Vibhakar R, Hankinson TC, Foreman NK, Mulcahy Levy JM. Effect of early-stage autophagy inhibition in BRAF(V600E) autophagy-dependent brain tumor cells. Cell Death Dis. 2019 Sep 12;10(9):679. PubMed PMID: 31515514
  • Norris GA, Garcia J, Hankinson TC, Handler M, Foreman N, Mirsky D, Stence N, Dorris K, Green AL. Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors. Pediatr Blood Cancer. 2019 Jun;66(6):e27680. PubMed PMID: 30848081
  • Gilani A, Donson A, Whiteway S, DeSisto J, Hoffman L, Foreman N, Kleinschmidt-DeMasters BK, Green A. “Targetable molecular alterations in congenital glioblastoma.” Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, San Francisco, May 2019.
  • Faulk K, Anderson-Mellies A, Cockburn M, Green A. “Assessment of enrollment characteristics for Children’s Oncology Group (COG) upfront therapeutic clinical trials 2004-2015.” American Society of Clinical Oncology Annual Meeting, Chicago, June 2019.
  • Colton MD, Goulding D, Beltrami A, Cost C, Franklin A, Cockburn MG, Green AL. A U.S. population-based study of insurance disparities in cancer survival among adolescents and young adults. Cancer Med. 2019 Aug;8(10):4867-4874. PubMed PMID: 31240865
  • Colton MD, Hawkins M, Goulding D, Cockburn M, Green AL. Socioeconomics, Race, and Ethnicity in Childhood Cancer Survival: Accessing and Addressing Root Causes of Disparities. Cancer. 2018 Aug 20. [Epub ahead of print] PubMed PMID: 30125347
  • Flannery PC, DeSisto JA, Amani V, Venkataraman S, Lemma RT, Prince EW, Donson A, Moroze EE, Hoffman L, Levy JMM, Foreman N, Vibhakar R, Green AL. Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. Oncol Rep. 2018 Feb;39(2):455-464. PubMed PMID: 29207163
  • Marini BL, Benitez LL, Zureick AH, Salloum R, Gauthier AC, Brown J, Wu YM, Robinson DR, Kumar C, Lonigro R, Vats P, Cao X, Kasaian K, Anderson B, Mullan B, Chandler B, Linzey JR, Camelo-Piragua SI, Venneti S, McKeever PE, McFadden KA, Lieberman AP, Brown N, Shao L, Leonard MAS, Junck L, McKean E, Maher CO, Garton HJL, Muraszko KM, Hervey-Jumper S, Mulcahy-Levy JM, Green A, Hoffman LM, Dorris K, Vitanza NA, Wang J, Schwartz J, Lulla R, Smiley NP, Bornhorst M, Haas-Kogan DA, Robertson PL, Chinnaiyan AM, Mody R, Koschmann C. Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. Transl Res. 2017 Oct;188:27.e1-27.e14. PubMed PMID: 28860053
  • McEvoy M, Robison N, Manley P, Yock T, Konopka K, Brown RE, Wolff J, Green AL. Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma. J Pediatr Hematol Oncol. 2017 Aug 30. [Epub ahead of print] PubMed PMID: 28859040
  • Green AL, Mulcahy Levy JM, Vibhakar R, Hemenway M, Madden J, Foreman N, Dorris K. Tumor treating fields in pediatric high-grade glioma. Childs Nerv Syst. 2017 Jul;33(7):1043-1045. PubMed PMID: 28470383
  • Green AL, Furutani E, Ribeiro KB, Rodriguez Galindo C. Death Within 1 Month of Diagnosis in Childhood Cancer: An Analysis of Risk Factors and Scope of the Problem. J Clin Oncol. 2017 Apr 20;35(12):1320-1327. PubMed PMID: 28414926
  • Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 Jan 17;6. PubMed PMID: 28094001
  • Green AL, Chintagumpala M, Krailo M, Langholz B, Albert D, Eagle R, Cockburn M, Chevez-Barrios P, Rodriguez-Galindo C. Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study. Ophthalmology. 2016 Aug;123(8):1817-23. doi: 10.1016/j.ophtha.2016.04.043. PubMed PMID: 27262763.
  • Green AL, Yi J, Bezler N, Pikman Y, Tubman VN, Obeng EA, O'Neil T, Mersereau R, Morrissey L, Billett AL. A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients. Pediatr Blood Cancer. 2016 Jan;63(1):112-7. doi: 10.1002/pbc.25712. PubMed PMID: 26292080.
  • Hankinson TC, Patibandla MR, Green A, Hemenway M, Foreman N, Handler M, Liu AK. Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas. Pediatr Blood Cancer. 2016 Apr;63(4):716-8. PubMed PMID: 26544789
  • Truong B, Green AL, Friedrich P, Ribeiro KB, Rodriguez-Galindo C. Ethnic, Racial, and Socioeconomic Disparities in Retinoblastoma. JAMA Pediatr. 2015 Oct 5;:1-9. [Epub ahead of print] PubMed PMID: 26436436
  • Green AL, Kieran MW. Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors. Curr Oncol Rep. 2015 Mar;17(3):436. PubMed PMID: 25702179
  • Green AL, Ramkissoon SH, McCauley D, Jones K, Perry JA, Hsu JH, Ramkissoon LA, Maire CL, Hubbell-Engler B, Knoff DS, Shacham S, Ligon KL, Kung AL. Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. Neuro Oncol. 2015 May;17(5):697-707. PubMed PMID: 25366336
  • Hankinson TC, Patibandla MR, Green A, Hemenway M, Foreman N, Handler M, Liu AK. Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas. Pediatr Blood Cancer. 2015 Nov 6. [Epub ahead of print] PubMed PMID: 26544789
  • Green AL, Srivatsa A, Rodriguez-Galindo C. Delayed diagnosis and false relapse due to paternal testosterone use in adrenocortical carcinoma. Pediatrics. 2014 Jun;133(6):e1772-6. PubMed PMID: 24799542
  • Ross SG, Northman L, Morris M, Green AL, Ullrich NJ. Cerebellar mutism after posterior fossa tumor resection: case discussion and recommendations for psychoeducational intervention. J Pediatr Oncol Nurs. 2014 Mar-Apr;31(2):78-83. PubMed PMID: 24608700
  • Gardner SL, Asgharzadeh S, Green A, Horn B, McCowage G, Finlay J. Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. Pediatr Blood Cancer. 2008 Aug;51(2):235-40. PubMed PMID: 18381756
  • Taylor NC, Li A, Green A, Kinney HC, Nattie EE. Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2. J Appl Physiol (1985). 2004 Nov;97(5):1763-73. PubMed PMID: 15273241
View All (45 Total) View Less

Professional Memberships

  • Children's Oncology Group, Member, CNS Committee
  • University of Colorado Cancer Center, Mentored Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatrics, Board Certification (2010)
  • Pediatric Hematology / Oncology, Board Certification (2015)
Conditions & Treatments
  • Brain and Nervous System - Brain Tumors
  • Cancers - Pediatric Cancer
  • Brain and Nervous System
  • Cancers
  • Cancers - Brain Cancer
  • Child and Teen Health
Clinical Interests
I help lead national clinical trials and give second opinions for other institutions for pediatric high-grade glioma, diffuse intrinsic pontine glioma (DIPG), and diffuse midline glioma. I also specialize in the diagnosis and management of other childhood tumors of the brain and spinal cord. In addition, I have expertise in other childhood cancers, benign blood disorders, and stem cell transplant.

Care Philosophy
I am committed to providing exceptional child- and family-centered care to my patients. I strive to communicate information truthfully to families at all times, and in an age-appropriate way to patients throughout childhood. As part of a team that includes physicians, nurse practitioners, nurses, social workers, and others, I aim to provide the highest quality, most innovative care to all patients from Colorado and beyond, to maximize cure rates and minimize adverse effects of treatment.

Personal Interests
Spending time with my wife and three children, playing piano, singing, road cycling, running, tennis, and triathlon.

Volunteer Activities
I enjoy educating the community on childhood cancer research and advocating for our patients. I am also a volunteer youth soccer and baseball coach.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, New York University School of Medicine (2006)
Undergraduate Schools:
  • BA, Dartmouth College (NH) (2002)
Internships:
  • University of Colorado (Children's Hospital Colorado) Program (2007)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Chief Resident, Pediatrics (2010)
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2009)
Fellowships:
  • Dana-Farber Cancer Institute/Boston Children’s Hospital/Harvard Medical School Program, Pediatric Hematology / Oncology (2013)
Languages: English, Spanish
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
;