Bettina Cuneo, MD
Professor, Pediatrics-Cardiology

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Medical School:
  • MD, Medical College of Wisconsin (1983)
Undergraduate School:
  • BA, Lawrence University (WI) (1978)
Residency:
  • Case Western Reserve University (MetroHealth) Program, Pediatrics (1986)
Fellowships:
  • McGaw Medical Center of Northwestern University/Children's Memorial Hospital Program, Pediatric Cardiology (1992)
Languages: English
Department: Pediatrics-Cardiology

Professional Titles

  • Professor of Pediatrics and Obstetrics
  • Director of Perinatal Cardiology and Fetal Cardiac Telemedicine

Publications

  • Home monitoring detects fetal supraventricular tachyarrhythmia recurrence during dose reduction of antiarrhythmic therapy. McIntosh A, Benson DW, von Alvensleben JC, Collins KK, Gilbert L, Cuneo BF. Ultrasound Obstet Gynecol. 2021 Feb;57(2):343-344. doi: 10.1002/uog.22172. PMID: 32830393
  • Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia. Wang S, Freud LR, Detterich J, Moon-Grady AJ, Donofrio MT, Jaeggi ET, Szwast AL, Morris SA, Kavanaugh-Mchugh A, Howley LW, van der Velde ME, Cuneo BF, Phoon CK, Tworetzky W, Pruetz JD. Prenat Diagn. 2021 Feb;41(3):332-340. doi: 10.1002/pd.5873. Epub 2021 Jan 9 PMID: 33242215
  • Improved detection of coarctation of the aorta using speckle-tracking analysis of fetal heart on last examination prior to delivery. DeVore GR, Haxel C, Satou G, Sklansky M, Pelka MJ, Jone PN, Cuneo BF. Ultrasound Obstet Gynecol. 2021 Feb;57(2):282-291. doi: 10.1002/uog.21989. PMID: 32022339
  • Classic and atypical Wenckebach periodicity in a late gestation fetus with maternal anti-Ro/SSA antibodies. Gropler MRF, von Alvensleben J, Benson DW, Cuneo BF. HeartRhythm Case Rep. 2021 Jun 22;7(9):611-614. doi: 10.1016/j.hrcr.2021.06.002. eCollection 2021 Sep. PMID: 34552853
  • Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy. Willner EC, Galan HL, Cuneo BF, Hoffman HA, Neltner B, Schuchardt EL, Karimpour-Fard A, Miyamoto SD, Sucharov CC. Am J Obstet Gynecol. 2021 Oct;225(4):439.e1-439.e10. doi: 10.1016/j.ajog.2021.06.066. Epub 2021 Jun 19. PMID: 34153234
  • Impact of Socioeconomic Status, Race and Ethnicity, and Geography on Prenatal Detection of Hypoplastic Left Heart Syndrome and Transposition of the Great Arteries. Krishnan A, Jacobs MB, Morris SA, Peyvandi S, Bhat AH, Chelliah A, Chiu JS, Cuneo BF, Freire G, Hornberger LK, Howley L, Husain N, Ikemba C, Kavanaugh-McHugh A, Kutty S, Lee C, Lopez KN, McBrien A, Michelfelder EC, Pinto NM, Schwartz R, Stern KWD, Taylor C, Thakur V, Tworetzky W, Wittlieb-Weber C, Woldu K, Donofrio MT; Fetal Heart Society. Circulation. 2021 May 25;143(21):2049-2060. doi: 10.1161/CIRCULATIONAHA.120.053062. Epub 2021 May 17. PMID: 33993718
  • Cuneo BF. Fetal Arrhythmias in: Fetal and Neonatal Surgery: Diagnosis and Managment of the Fetal and Neonatal Patient. Ed. Crombleholm T, Yen F, Peiro J, Rintou L, Simpson L. McGraw-Hill , New York, NY Publication date: 2021.
  • Freud L, Galloway S, Crowley BT, Philip-Sarles N, Swillen A, Breckpot J, Borrell A, Vora N, Cuneo BF. Et. al. Effect of Prenatal versus Postnatal Diagnosis on Outcomes in Patients with 22q11.2 Deletion Syndrome. Scientific sessions of the Maternal fetal medicine society, Feb 2021 Am J Obstet Gyneocol. .
  • Kaizer, AM, Buyon JP, Chiang M. Clancy R, Cuneo BF. Reducing the burden of fetal surveillance using the negative predictive value of anti-Ro antibody titer. Scientific sessions of the Maternal fetal medicine Soceity, Feb 2021. Am J Obstet Gynecol.
  • Gropler, MRF; Jone PNJ, Cassidy, C, DeVore, G, Cuneo BF. Fetal atrial and ventricular deformation analysis ysing 2D speckle tracing echocardiography in anti- Ro antibody mediated AV block.Scientific sessions of the American Society of Echocardiography, June 2021. Am J Echocardiography
  • Drewes B, Phoon CK, Sinkovskaya E, Howley, LW, Acherman R, Makhoul, M, Pinto N Masson M, Benson DW, Buyon JP, Cuneo BF The STOP BLOQ clinical trial: Fetal heart rate monitoring as an adjunct to echocardiography surveillance of Anti-Ro/SSA antibody positive pregnancies. Scientific sessions of the International Society of Ultrasound in Obstetrics and Gynecology, July 2021. Ultrasound Obstetrics and Gynecology.
  • 98. Drewes B, Phoon CK, Sinkovskaya E, Howley, LW, Acherman R, Makhoul, M, Pinto N, Masson M, Benson DW, Abuhamad A, Buyon JP, Cuneo BF. Home monitoring to detect emergent anti-Ro/SSA antibody mediated fetal AV block. Scientific sessions of the American Heart Association November 2021. Circulation
  • Masson M. Phoon c, Sinkovskaya E, Howley LW, Acherman R, Makhoul M, Pinto N, Chang M, Clancy R, Drewes B, Cuneo BF, Buyon JP. Ambulatory fetal heart rate monitoring (FHRM) to surveil pregnancies at risk for congenital heart block. Scientific sessions of the American College of Rheumatology. Arthritis Rheumatol 2021; 73 (supp 10).
  • 32678103
  • 31520628
  • 31132773
  • 32282083
  • 32674792
  • 32830393
  • 32907357
  • 32421437
  • 33076749
  • 32022339
  • Diagnosis and Management of Fetal Arrhythmias
  • Separating True from False-Positive Fetuses with Coarctation of the Aorta using Ventricular Speckle Tracking Analysis.
  • Abstract #273 Am J Obstet Gynecol 2020.
  • Abstract # 721834 Am J Obstet Gynecol 2020.
  • Analyzing flow distribution among twins using PC-MRI quantification of fetal aortic flow in early gestational age twin pregnancies complicated by TTTS and sIUGR SPR 2020 Annual Meeting May 2020.
  • Heart Rhythm 2020. 17; D- B17-01: S44.
  • Heart Rhythm 2020. 17; D- AB1702: S45.
  • Heart Rhythm 2020.17; D-AB1706:S46.
  • Cardiac Function in Fetal Growth Restriction: A Longitudinal study from in utero to 3-years of Age. ASE, 2020.
  • Faculty, Philadelphia Perinatal Conference, June 2020 (Virtual, due to COVID 19) Presentations: 1. Diagnosis and management of fetal arrhythmias 2. Genetics of fetal arrhythmias 3. Impact of extracardiac anomalies on outcome of fetal congenital heart disease 4. Improving detection of fetal CHD in underserved areas 5. Management of the Mother with Sjogren’s antibodies
  • Faculty, Scientific sessions of the American Institute in Ultrasound in Medicine. New York, March 2020. Presentation: Fetal Arrhythmias (canceled due to COVID-19).
  • Faculty, American Society of Echocardiography Scientific Sessions, June 2020 (Virtual, due to COVID19) Presentation: Fetal Arrhythmias
  • Faculty, Colorado Genetics Conference August 2020. (Virtual due to COVID 19) Presentation: Genetics of arrhythmias
  • Faculty, Neonatal Heart Meeting, October 2020 (Virtual, due to COVID 19) Presentation: Fetal arrhythmias: State of the art
  • Faculty, 11th Annual Course in Fetal Echocardiography: Normal and Abnormal Hearts Las Vegas, NE October 2020 (Virtual, due to COVID 19) Presentations: 1. Bradycardia and the channelopathies; 2. Updates on the management of the SSA-positive pregnancy; 3. Abnormalities of the cardiac chambers: Single ventricle; 4. Abnormalities of the cardiac chambers: Right ventricle
  • Cuneo BF, Bitant S, Strasburger JF, Kaizer AM, Wakai RT. Assessment and outcome of AV conduction in normal and anti-Ro/SSA antibody positive pregnancies evaluated by echocardiography and magnetocardiography. Ultrasound Obstet Gynecol. 2019 Feb 19. [Epub ahead of print] PubMed PMID: 30784137
  • Howley LW, Schuchardt E, Park D, Gilbert L, Gruenwald J, Cuneo BF. Reply. Ultrasound Obstet Gynecol. 2019 Feb;53(2):277-278. PubMed PMID: 30741453
  • Cuneo BF, Olson CA, Haxel C, Howley L, Gagnon A, Benson DW, Kaizer AM, Thomas JF. Risk Stratification of Fetal Cardiac Anomalies in an Underserved Population Using Telecardiology. Obstet Gynecol. 2019 Nov;134(5):1096-1103. PubMed PMID: 31599844
  • Cuneo BF, Kaizer AM, Ann Clur S, Swan H, Herberg U, Winbo A, Rydberg A, Haugaa K, Etheridge S, Ackerman MJ, Dagradi F, Killen SAS, Waker-Gussmann A, Benson DW, Wilde AAM, Pan Z, Lam A, Spazzolini C, Horigome H, Schwartz PJ. Mothers with long QT syndrome are at increased risk for fetal death: Findings from a multicenter international study. Am J Obstet Gynecol. 2019 Sep 11. [Epub ahead of print] PubMed PMID: 31520628
  • Cuneo BF, Buyon JP. Keeping upbeat to prevent the heartbreak of anti-Ro/SSA pregnancy. Ultrasound Obstet Gynecol. 2019 Jul;54(1):7-9. PubMed PMID: 31313868
  • DeVore GR, Jone PN, Satou G, Sklansky M, Cuneo BF. Aortic Coarctation: A Comprehensive Analysis of Shape, Size, and Contractility of the Fetal Heart. Fetal Diagn Ther. 2019 May 27;:1-11. [Epub ahead of print] PubMed PMID: 31132773
  • Cuneo BF, Bitant S, Strasburger JF, Kaizer AM, Wakai RT. Assessment of atrioventricular conduction by echocardiography and magnetocardiography in normal and anti-Ro/SSA-antibody-positive pregnancies. Ultrasound Obstet Gynecol. 2019 Nov;54(5):625-633. PubMed PMID: 30784137
  • Cuneo BF, Sonesson SE, Levasseur S, Moon-Grady AJ, Krishnan A, Donofrio MT, Raboisson MJ, Hornberger LK, Van Eerden P, Sinkovskaya E, Abuhamad A, Arya B, Szwast A, Gardiner H, Jacobs K, Freire G, Howley L, Lam A, Kaizer AM, Benson DW, Jaeggi E. Home Monitoring for Fetal Heart Rhythm During Anti-Ro Pregnancies. J Am Coll Cardiol. 2018 Oct 16;72(16):1940-1951. PubMed PMID: 30309472
  • Srinivasan S, Howley LW, Cuneo BF, Chatfield KC. In-utero idiopathic ductal constriction: a prenatal manifestation of Alagille and Williams syndrome arteriopathy. J Perinatol. 2018 Nov;38(11):1453-1456. PubMed PMID: 30202046
  • Howley LW, Chatterjee D, Patel SS, Cuneo BF, Crombleholme TM, Behrendt N, Zaretsky MV, Marwan AI, Zuk J, Galan HL, Wood C. Indomethacin Dosing and Constriction of the Ductus Arteriosus During Open Fetal Surgery for Myelomeningocele Repair. Fetal Diagn Ther. 2018 Aug 29;:1-6. [Epub ahead of print] PubMed PMID: 30157479
  • DeVore GR, Cuneo BF, Satou G, Sklansky M. How to determine the percent of study subjects below the 5th or above the 95th centiles of the control group when only the mean and standard deviations are provided. Ultrasound Obstet Gynecol. 2018 Aug 29. [Epub ahead of print] PubMed PMID: 30156342
  • Clur SB, Vink AS, Etheridge SP, Robles de Medina PG, Rydberg A, Ackerman MJ, Wilde AA, Blom NA, Benson DW, Herberg U, Donofrio MT, Cuneo BF. Left Ventricular Isovolumetric Relaxation Time Is Prolonged in Fetal Long-QT Syndrome. Circ Arrhythm Electrophysiol. 2018 Apr;11(4):e005797. PubMed PMID: 29654130
  • Howley LW, Schuchardt E, Park D, Gilbert L, Gruenwald J, Cuneo BF. Simultaneous recording of pulsed-wave Doppler signals in innominate vein and transverse aortic arch: new technique to evaluate atrioventricular conduction and fetal heart rhythm. Ultrasound Obstet Gynecol. 2018 Oct;52(4):544-545. PubMed PMID: 29393552
  • Cuneo BF, Moon-Grady AJ, Sonesson SE, Levasseur S, Hornberger L, Donofrio MT, Krishnan A, Szwast A, Howley L, Benson DW, Jaeggi E. Heart sounds at home: feasibility of an ambulatory fetal heart rhythm surveillance program for anti-SSA-positive pregnancies. J Perinatol. 2017 Mar;37(3):226-230. PubMed PMID: 27977016
  • Selamet Tierney ES, McElhinney DB, Freud LR, Tworetzky W, Cuneo BF, Escobar-Diaz MC, Ikemba C, Kalish BT, Komarlu R, Levasseur SM, Puchalski MD, Satou GM, Silverman NH, Moon-Grady AJ. Assessment of Progressive Pathophysiology After Early Prenatal Diagnosis of the Ebstein Anomaly or Tricuspid Valve Dysplasia. Am J Cardiol. 2017 Jan 1;119(1):106-111. PubMed PMID: 27793395
  • Cuneo BF, Strasburger JF, Wakai RT. The natural history of fetal long QT syndrome. J Electrocardiol. 2016 Nov - Dec;49(6):807-813. PubMed PMID: 27539165
  • Cuneo BF, Ambrose SE, Tworetzky W. Detection and successful treatment of emergent anti-SSA-mediated fetal atrioventricular block. Am J Obstet Gynecol. 2016 Oct;215(4):527-8. PubMed PMID: 27418449
  • Wacker-Gussmann A, Strasburger JF, Srinivasan S, Cuneo BF, Lutter W, Wakai RT. Fetal Atrial Flutter: Electrophysiology and Associations With Rhythms Involving an Accessory Pathway. J Am Heart Assoc. 2016 Jun 14;5(6). PubMed PMID: 27302699
  • Sathanandam SK, Philip R, Gamboa D, Van Bergen A, Ilbawi MN, Knott-Craig C, Waller BR, Javois AJ, Cuneo BF. Management of hypoplastic left heart syndrome with intact atrial septum: a two-centre experience. Cardiol Young. 2016 Aug;26(6):1072-81. PubMed PMID: 26346529
  • Bui YK, Howley LW, Ambrose SE, Galan HL, Crombleholme TM, Drose J, Bokowski J, Cuneo BF. Prominent coronary artery flow with normal coronary artery anatomy is a rare but ominous harbinger of poor outcome in the fetus. J Matern Fetal Neonatal Med. 2016;29(10):1536-40. PubMed PMID: 26153118
  • Cuneo BF. The beginnings of long QT syndrome. Curr Opin Cardiol. 2015 Jan;30(1):112-7. PubMed PMID: 25426817
  • Peters C, Wacker-Gussmann A, Strasburger JF, Cuneo BF, Gotteiner NL, Gulecyuz M, Wakai RT. Electrophysiologic features of fetal ventricular aneurysms and diverticula. Prenat Diagn. 2014 Oct 5. [Epub ahead of print] PubMed PMID: 25284224
  • Cuneo BF, Benson DW. Use of maternal flecainide concentration in management of fetal supraventricular tachycardia: a step in the right direction. Heart Rhythm. 2014 Nov;11(11):2054-5. PubMed PMID: 25128734
  • Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wakai RT. Diagnosis and treatment of fetal arrhythmia. Am J Perinatol. 2014 Aug;31(7):617-28. PubMed PMID: 24858320
  • Davey BT, Donofrio MT, Moon-Grady AJ, Fifer CG, Cuneo BF, Falkensammer CB, Szwast AL, Rychik J. Development and validation of a fetal cardiovascular disease severity scale. Pediatr Cardiol. 2014 Oct;35(7):1174-80. PubMed PMID: 24801674
  • Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J, American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation. 2014 May 27;129(21):2183-242. PubMed PMID: 24763516
  • Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wiggins DL, Gotteiner NL, Wakai RT. Fetal arrhythmias associated with cardiac rhabdomyomas. Heart Rhythm. 2014 Apr;11(4):677-83. PubMed PMID: 24333285
  • Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wiggins DL, Gotteiner NL, Wakai RT. Fetal arrhythmias associated with cardiac rhabdomyomas. Heart Rhythm. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24333285
  • Cuneo BF, Strasburger JF, Yu S, Horigome H, Hosono T, Kandori A, Wakai RT. In utero diagnosis of long QT syndrome by magnetocardiography. Circulation. 2013 Nov 12;128(20):2183-91. PubMed PMID: 24218437
  • Cuneo BF, Etheridge SP, Horigome H, Sallee D, Moon-Grady A, Weng HY, Ackerman MJ, Benson DW. Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: risk stratification of perinatal long-QT syndrome. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):946-51. PubMed PMID: 23995044
  • Wiggins DL, Strasburger JF, Gotteiner NL, Cuneo B, Wakai RT. Magnetophysiologic and echocardiographic comparison of blocked atrial bigeminy and 2:1 atrioventricular block in the fetus. Heart Rhythm. 2013 Aug;10(8):1192-8. PubMed PMID: 23619035
  • Crotti L, Johnson CN, Graf E, De Ferrari GM, Cuneo BF, Ovadia M, Papagiannis J, Feldkamp MD, Rathi SG, Kunic JD, Pedrazzini M, Wieland T, Lichtner P, Beckmann BM, Clark T, Shaffer C, Benson DW, Kääb S, Meitinger T, Strom TM, Chazin WJ, Schwartz PJ, George AL Jr. Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation. 2013 Mar 5;127(9):1009-17. PubMed PMID: 23388215
  • Wadi M, Moon-Grady A; Hornberger LK, Cuneo BF Raboisson MJ, Longheed, Parkman, Karim D, Silverman E, Jaeggi ET. Outcome of Antibody-Mediated Fetal Heart Disease with Standardized Anti-Inflammatory Transplacental Treatment. JAHA, Dec 2021, in press.
  • Gropler, MRF and Cuneo BF. Management of fetal arrhythmias. Current Treatment Options in Pediatrics. Nov. 2021, in press.
  • Kaplinski M and Cuneo BF. Novel approaches to diagnosis and management of fetuses at risk for congenital AV block. Seminars in Perinatology. Nov. 2021, in press
  • Giraldo-Isaza MA and Cuneo BF. Systemic lupus erythematosis. In: Maternal Fetal Evidence Based Guidelines. Ed. Berghella V. Taylor and Francis, London, Great Britian, in press
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado - Colorado Fetal Care Center
13123 E 16th Ave, B735
Aurora, CO 80045
720-777-4463

Children's Colorado Outpatient and Urgent Care at Uptown
1830 Franklin St
Denver, CO 80218
720-777-1360

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Pediatric Cardiology, Board Certification (1992, 2016)
  • Fetal Cardiology, Specialized Training (1992)
Conditions & Treatments
  • Heart and Circulation - Congenital Heart Disease
  • Heart and Circulation
  • Pregnancy and Reproduction - Prenatal Care
  • Pregnancy and Reproduction
  • Pregnancy and Reproduction - Prenatal Testing
  • Genetic Conditions and Testing
Clinical Interests
My beliefs: To advance the science and improve the practice of fetal cardiology. To detect life threatening fetal heart arrhythmia and provide effective treatment for a long and healthy life after birth. To provide excellent quality of care to mothers with limited access to subspecialty care via fetal cardiac telemedicine services. To educate obstetrical care providers and sonographers to recognize fetal cardiac abnormalities so mothers and fetuses can receive the best care. To empower the families whose fetus has cardiac disease to make choices consistent with their values. To questioning the status quo and advance the field of perinatal cardiology through single and multi-center research. To mentoring pediatric cardiology and maternal fetal medicine fellows/junior faculty who share the desire to excel in perinatal cardiology. When confronted with what never has been done before, to ask "why", not "why not".

General Information

Medical Schools:
  • MD, Medical College of Wisconsin (1983)
Undergraduate Schools:
  • BA, Lawrence University (WI) (1978)
Residency Programs:
  • Case Western Reserve University (MetroHealth) Program, Pediatrics (1986)
Fellowships:
  • McGaw Medical Center of Northwestern University/Children's Memorial Hospital Program, Pediatric Cardiology (1992)
Languages: English
Department: Pediatrics-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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