Kristi Kuhn, MD, PhD
Associate Professor, Medicine-Rheumatology

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Medical School:
  • MD, University of Colorado Denver Health Sciences Center (2007)
Graduate School :
  • PhD, University of Colorado Health Sciences Center (2005)
Undergraduate School:
  • BS, University of Kansas (KS) (1999)
Internship:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital (2008)
Residency:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Chief Resident, Internal Medicine (2011)
Fellowships:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Rheumatology (2013)
Languages: English
Department: Medicine-Rheumatology

Recognition & Awards

  • Outstanding Early Career Scholar, Department of Medicine, University of Colorado School of Medicine (2018)
  • Bruckel Early Career Investigator Award in AxSpA, Spondyloarthritis Association of America (2018)
  • Webb-Warring Early Career Investigator, Boettcher Foundation (2017)
  • Rising Star Award, Department of Medicine, University of Colorado School of Medicine (2017)
  • Distinguished Fellow Award, American College of Rheumatology (2013)
  • Distinguished Fellow Award, American College of Rheumatology (2013)

Teaching

  • Assistant Professor (2013)
    School of Medicine, Medicine

Publications

  • Okamato Y, Ghosh T, Okamoto T, Schuyler RP, Seifert J, Charry LL, Visser A, Feser M, Fleischer C, Pedrick C, August J, Moss L, Bemis EA, Norris JM, Kuhn KA, Demoruelle MK, Deane KD, Ghosh D, Holers VM, Hsieh EWY. Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14(hi) monocytes. J Autoimmun. 2020 Dec 9;117:102581. [Epub ahead of print] PubMed PMID: 33310262
  • Wilson TM, Trent B, Kuhn KA, Demoruelle MK. Microbial Influences of Mucosal Immunity in Rheumatoid Arthritis. Curr Rheumatol Rep. 2020 Oct 6;22(11):83. PubMed PMID: 33025188
  • Berlinberg A, Kuhn KA. Barrier lymphocytes in spondyloarthritis. Curr Opin Rheumatol. 2020 Jul;32(4):343-348. PubMed PMID: 32412993
  • Berlinberg A, Kuhn KA. Molecular Biology Approaches to Understanding Spondyloarthritis. Rheum Dis Clin North Am. 2020 May;46(2):203-211. PubMed PMID: 32340696
  • Kuhn KA, Morrison TE. Introduction: Evolution of inflammatory arthritis from innate to adaptive immune mechanisms. Immunol Rev. 2020 Mar;294(1):5-8. PubMed PMID: 32103544
  • Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 Mar;105(3):585-597. PubMed PMID: 31101752
  • Siebert JC, Neff CP, Schneider JM, Regner EH, Ohri N, Kuhn KA, Palmer BE, Lozupone CA, Görg C. VOLARE: visual analysis of disease-associated microbiome-immune system interplay. BMC Bioinformatics. 2019 Aug 20;20(1):432. PubMed PMID: 31429723
  • Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 1;10(1):2965. PubMed PMID: 31263097
  • Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Meyers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2019 May 17. [Epub ahead of print] PubMed PMID: 31101752
  • Li SX, Sen S, Schneider JM, Xiong KN, Nusbacher NM, Moreno-Huizar N, Shaffer M, Armstrong AJS, Severs E, Kuhn K, Neff CP, McCarter M, Campbell T, Lozupone CA, Palmer BE. Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection. PLoS Pathog. 2019 Apr;15(4):e1007611. PubMed PMID: 30947289
  • Chriswell ME, Kuhn KA. Microbiota-mediated mucosal inflammation in arthritis. Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101492. PubMed PMID: 32151461
  • Caplan L, Kuhn KA. Gastrointestinal and Hepatic Disease in Spondyloarthritis. Rheum Dis Clin North Am. 2018 Feb;44(1):153-164. PubMed PMID: 29149924
  • Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462. PubMed PMID: 30367045
  • Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nat Rev Rheumatol. 2018 Sep;14(9):542-557. PubMed PMID: 30111803
  • Regner EH, Ohri N, Stahly A, Gerich ME, Fennimore BP, Ir D, Jubair WK, Görg C, Siebert J, Robertson CE, Caplan L, Frank DN, Kuhn KA. Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota. Arthritis Res Ther. 2018 Jul 20;20(1):149. PubMed PMID: 30029674
  • Jubair WK, Hendrickson JD, Severs EL, Schulz HM, Adhikari S, Ir D, Pagan JD, Anthony RM, Robertson CE, Frank DN, Banda NK, Kuhn KA. Modulation of Inflammatory Arthritis in Mice by Gut Microbiota Through Mucosal Inflammation and Autoantibody Generation. Arthritis Rheumatol. 2018 Aug;70(8):1220-1233. PubMed PMID: 29534332
  • Caplan L, Kuhn KA. Gastrointestinal and Hepatic Disease in Spondyloarthritis. Rheum Dis Clin North Am. 2018 Feb;44(1):153-164. PubMed PMID: 29149924
  • Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2018 Mar;11(2):357-368. PubMed PMID: 28812548
  • Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017 Feb;31(1):3-18. PubMed PMID: 29221595
  • Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2017 Aug 16. [Epub ahead of print] PubMed PMID: 28812548
  • Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M, Malvin NP, Glowacki RW, Hansson GC, Allen PM, Martens EC, Stappenbeck TS. Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 2015 May 13;17(5):672-80. PubMed PMID: 25974305
  • Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell. 2015 Jun 15;26(12):2252-62. PubMed PMID: 25904334
  • Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015 May 13;17(5):662-71. PubMed PMID: 25865369
  • Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One. 2014;9(12):e114195. PubMed PMID: 25478789
  • Kuhn KA, Pedraza I, Demoruelle MK. Mucosal immune responses to microbiota in the development of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov;40(4):711-25. PubMed PMID: 25437287
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Professional Memberships

  • American College of Rheumatology, Member

Practice Locations

Rheumatology Clinic - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-7700

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2010)
  • Rheumatology, Board Certification (2013)
Conditions & Treatments
  • Bones, Joints and Muscles - Arthritis
  • Immune System - Autoimmune Disorders
  • Immune System - Rheumatoid Arthritis
  • Bones, Joints and Muscles
  • Immune System

General Information

Medical Schools:
  • MD, University of Colorado Denver Health Sciences Center (2007)
Graduate Schools:
  • PhD, University of Colorado Health Sciences Center (2005)
Undergraduate Schools:
  • BS, University of Kansas (KS) (1999)
Internships:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital (2008)
Residency Programs:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Chief Resident, Internal Medicine (2011)
Fellowships:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Rheumatology (2013)
Languages: English
Department: Medicine-Rheumatology
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