Eric Poeschla, MD
Professor, Medicine-Infectious Disease

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Medical School:
  • MD, Yale University School of Medicine (0001)
Internship:
  • University of California (San Francisco) School of Medicine Program (0001)
Residency:
  • University of California (San Francisco) School of Medicine Program, Internal Medicine (0001)
Fellowships:
  • University of California (San Diego) Program, Infectious Disease (0001)
Languages: English
Department: Medicine-Infectious Disease

Professional Titles

  • Professor, Medicine-Infectious Disease
  • Tim Gill Professor of Medicine, Division of Infectious Diseases

Recognition & Awards

  • Elected to American Association of Physicians, AAP (2016)
  • Pfizer Scholars Award for New Faculty, Pfizer Scholars Program (1998)
  • Peter F. Curran Research Prize, Yale Medical School (1988)

Research Interests

Eric M. Poeschla, M.D., is Professor of Medicine and Chief of Infectious Diseases at the University of Colorado School of Medicine, where he holds the Tim Gill Chair in HIV Research. He graduated from Yale Medical School and completed his clinical residency in internal medicine at UC San Francisco, followed by a fellowship in infectious diseases and molecular virology at UC San Diego. Before joining the University of Colorado, he was on the faculty of the Department of Molecular Medicine at the Mayo Clinic College of Medicine. His research group investigates the roles that cellular proteins play in viral replication cycles, including HIV-exploited factors and innate immune system factors that mediate frontline antiviral defenses and prevent cross-species virus transmission. They are interested in cellular systems that sense and respond defensively to viral RNA and DNA and also prevent autoimmunity to self nucleic acids. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Poeschla+E

Publications

  • Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease. J Virol. 2020 Feb 12. [Epub ahead of print] PubMed PMID: 32051266
  • Poeschla M, Valenzano DR. The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1). PubMed PMID: 32034047
  • Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 Feb;26(2):383-385. PubMed PMID: 31961310
  • Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 Jan 16;5(1). PubMed PMID: 31805010
  • Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Jan 7. [Epub ahead of print] PubMed PMID: 30628571
  • Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 Oct 14;11(10). PubMed PMID: 31615058
  • Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Mar;100(3):588-590. PubMed PMID: 30628571
  • Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. PubMed PMID: 30173955
  • Kumar S, Morrison JH, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018 Aug 15;92(16). PubMed PMID: 29769349
  • Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
  • Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
  • Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
  • Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 1;29(21):2287-97. PubMed PMID: 26545813
  • Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 Mar 12;12:24. PubMed PMID: 25808736
  • Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
  • Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of N ¿ -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25;11(1):100. [Epub ahead of print] PubMed PMID: 25421939
  • Abidi MZ, Sohail MR, Cummins N, Wilhelm M, Wengenack N, Brumble L, Shah H, Jane Hata D, McCullough A, Wendel A, Vikram HR, Kusne S, Litzow M, Letendre L, Lahr BD, Poeschla E, Walker RC. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies. Mycoses. 2014 Nov;57(11):687-98. PubMed PMID: 25040241
  • Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 1;88(17):9704-17. PubMed PMID: 24942577
  • Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May;10(5):e1004171. PubMed PMID: 24874515
  • Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb;10(2):e1003969. PubMed PMID: 24586169
  • Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014 Mar;88(6):3255-72. PubMed PMID: 24390322
  • Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr;53(4):300-13. PubMed PMID: 23138933
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Professional Memberships

  • Association of American Physicians (AAP), Elected 2016
  • Editorial Boards, Journal of Virology, Viruses, Member
  • American Society of Virology (ASV), Member
  • Association of American Immunologists (AAI), Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Infectious Disease, Board Certification
  • Internal Medicine, Board Certification
  • ABIM, Board Certification (0001)
Clinical Interests
Infectious Diseases, Emerging Infectious Diseases, Viral infections, Antiviral immunity, HIV, Interferonopathies, Coccidioidomycosis, COVID-19

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Yale University School of Medicine (0001)
Internships:
  • University of California (San Francisco) School of Medicine Program (0001)
Residency Programs:
  • University of California (San Francisco) School of Medicine Program, Internal Medicine (0001)
Fellowships:
  • University of California (San Diego) Program, Infectious Disease (0001)
Languages: English
Department: Medicine-Infectious Disease
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