Brigitte Frohnert, MD, PhD
Associate Professor, Pediatrics-Barbara Davis Center

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Medical School:
  • MD, University of Minnesota Medical School (2002)
Graduate School :
  • PhD, University of Minnesota - Minneapolis (2000)
Undergraduate Schools:
  • BS, Michigan State University (MI) (1994)
  • BA, Michigan State University (MI) (1994)
Internship:
  • University of Minnesota Medical School Program (2004)
Residency:
  • University of Minnesota Medical School Program, Chief Resident, Pediatrics (2007)
Fellowships:
  • University of Minnesota Medical School Program, Pediatric Endocrinology (2010)
Languages: English, Spanish, German
Department: Pediatrics-Barbara Davis Center

Publications

  • Onengut-Gumuscu S, Paila U, Chen WM, Ratan A, Zhu Z, Steck AK, Frohnert BI, Waugh KC, Webb-Robertson BM, Norris JM, Lange LA, Rewers MJ, Rich SS. Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes. Sci Rep. 2020 Nov 5;10(1):19193. PubMed PMID: 33154504
  • Webb-Robertson BM, Bramer LM, Stanfill BA, Reehl SM, Nakayasu ES, Metz TO, Frohnert BI, Norris JM, Johnson RK, Rich SS, Rewers MJ. Prediction of the Development of Islet Autoantibodies through Integration of Environmental, Genetic, and Metabolic Markers. J Diabetes. 2020 Jul 22. [Epub ahead of print] PubMed PMID: 33124145
  • Stahl MG, Geno Rasmussen C, Dong F, Waugh K, Norris JM, Baxter J, Yu L, Steck AK, Frohnert BI, Liu E, Rewers MJ. Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study. Am J Gastroenterol. 2020 Jul 22. [Epub ahead of print] PubMed PMID: 32701732
  • Gardner JA, Johnson RK, Dong F, Hoffman M, Steck AK, Frohnert BI, Rewers M, Norris JM. Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY). Endocrine. 2020 Nov;70(2):331-337. PubMed PMID: 32651851
  • Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 Aug;68(6):1128-1134. PubMed PMID: 32641352
  • McQueen RB, Geno Rasmussen C, Waugh K, Frohnert BI, Steck AK, Yu L, Baxter J, Rewers M. Cost and Cost-effectiveness of Large-scale Screening for Type 1 Diabetes in Colorado. Diabetes Care. 2020 Jul;43(7):1496-1503. PubMed PMID: 32327420
  • Kwon BC, Anand V, Severson KA, Ghosh S, Sun Z, Frohnert BI, Lundgren M, Ng K. DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways. IEEE Trans Vis Comput Graph. 2020 Apr 7. [Epub ahead of print] PubMed PMID: 32275600
  • Johnson RK, Vanderlinden LA, Dong F, Carry PM, Seifert J, Waugh K, Shorrosh H, Fingerlin T, Frohnert BI, Yang IV, Kechris K, Rewers M, Norris JM. Longitudinal DNA methylation differences precede type 1 diabetes. Sci Rep. 2020 Feb 28;10(1):3721. PubMed PMID: 32111940
  • Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM. DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2020 Jun;21(4):597-605. PubMed PMID: 32061050
  • Berget C, Messer LH, Vigers T, Frohnert BI, Pyle L, Wadwa RP, Driscoll KA, Forlenza GP. Six months of hybrid closed loop in the real-world: An evaluation of children and young adults using the 670G system. Pediatr Diabetes. 2020 Mar;21(2):310-318. PubMed PMID: 31837064
  • Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M. Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources. Diabetes. 2020 Feb;69(2):238-248. PubMed PMID: 31740441
  • Halper-Stromberg E, Gallo T, Champakanath A, Taki I, Rewers M, Snell-Bergeon J, Frohnert BI, Shah VN. Bone Mineral Density across the Lifespan in Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2020 Mar 1;105(3). PubMed PMID: 31676897
  • Berget C, Messer LH, Vigers T, Frohnert BI, Pyle L, Wadwa RP, Driscoll KA, Forlenza GP. Six months of Hybrid Closed Loop in the Real-World: An Evaluation of Children and Young Adults using the 670G System. Pediatr Diabetes. 2019 Dec 13. [Epub ahead of print] PubMed PMID: 31837064
  • Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M. Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources. Diabetes. 2019 Nov 18. [Epub ahead of print] PubMed PMID: 31740441
  • Halper-Stromberg E, Gallo T, Champakanath A, Taki I, Rewers M, Snell-Bergeon J, Frohnert BI, Shah VN. Bone Mineral Density across the Life-Span in Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Nov 2. [Epub ahead of print] PubMed PMID: 31676897
  • Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ. Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. PubMed PMID: 30844073
  • Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2019 Sep;56(9):602-605. PubMed PMID: 30287597
  • Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2018 Oct 4. [Epub ahead of print] PubMed PMID: 30287597
  • Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. PLoS Med. 2018 Apr;15(4):e1002548. PubMed PMID: 29614081
  • Steck AK, Dong F, Frohnert BI, Waugh K, Hoffman M, Norris JM, Rewers MJ. Predicting progression to diabetes in islet autoantibody positive children. J Autoimmun. 2018 Jun;90:59-63. PubMed PMID: 29395739
  • Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, Onengut-Gumuscu S, Törn C, Steck AK, Frohnert BI, Rewers M, Ziegler AG, Lernmark Å, Toppari J, Krischer JP, Akolkar B, Rich SS, She JX. Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. J Autoimmun. 2018 May;89:90-100. PubMed PMID: 29310926
  • Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK. Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2018 Mar;19(2):277-283. PubMed PMID: 28695611
  • Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK. Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2017 Jul 11. [Epub ahead of print] PubMed PMID: 28695611
  • Alonso GT, Pyle L, Frohnert B. Change in hemoglobin A1c one year following the 2014 American Diabetes Association guideline update. Diabetes Res Clin Pract. 2017 Jul;129:169-172. PubMed PMID: 28528078
  • Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One. 2017;12(4):e0174840. PubMed PMID: 28380011
  • Frohnert BI, Ide L, Dong F, Barón AE, Steck AK, Norris JM, Rewers MJ. Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia. 2017 Jun;60(6):998-1006. PubMed PMID: 28314946
  • Liu E, Dong F, Barón AE, Taki I, Norris JM, Frohnert BI, Hoffenberg EJ, Rewers M. High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes. Gastroenterology. 2017 May;152(6):1329-1336.e1. PubMed PMID: 28188747
  • Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2016 Feb;169:44-8.e1. PubMed PMID: 26561381
  • Frohnert BI, Rewers MJ. Metabolomics in childhood diabetes. Pediatr Diabetes. 2016 Feb;17(1):3-14. PubMed PMID: 26420304
  • Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J. Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep. 2016 Jun 16;6:27887. PubMed PMID: 27306948
  • Lernmark B, Lynch K, Baxter J, Roth R, Simell T, Smith L, Swartling U, Johnson SB. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016:2720650. PubMed PMID: 26682228
  • Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM. Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr. 2016 Jan;170(1):20-8. PubMed PMID: 26552054
  • Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark Å, Norris JM, Agardh D. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016 Mar;14(3):403-409.e3. PubMed PMID: 26453955
  • Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2015 Nov 7. [Epub ahead of print] PubMed PMID: 26561381
  • Frohnert BI, Rewers MJ. Metabolomics in childhood diabetes. Pediatr Diabetes. 2015 Sep 30. [Epub ahead of print] PubMed PMID: 26420304
  • Frohnert BI, Alonso GT. Challenges in Delivering Smaller Doses of Insulin. Diabetes Technol Ther. 2015 Sep;17(9):597-9. PubMed PMID: 26317878
  • Chahla SE, Frohnert BI, Thomas W, Kelly AS, Nathan BM, Polgreen LE. Higher daily physical activity is associated with higher osteocalcin levels in adolescents. Prev Med Rep. 2015;2:568-571. PubMed PMID: 26236583
  • Jahansouz C, Serrot FJ, Frohnert BI, Foncea RE, Dorman RB, Slusarek B, Leslie DB, Bernlohr DA, Ikramuddin S. Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue. Obes Surg. 2015 May 15. [Epub ahead of print] PubMed PMID: 25975200
  • Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 2015 May;64(5):1818-29. PubMed PMID: 25422107
  • Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015 May;38(5):808-13. PubMed PMID: 25665818
  • Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015 Apr;135(4):627-34. PubMed PMID: 25733751
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Practice Locations

Barbara Davis Center for Childhood Diabetes - Specialty Clinic
1775 Aurora Ct
Aurora, CO 80045
303-724-2323

Children's Colorado Health Pavilion
860 N Potomac Cir
Aurora, CO 80111
720-777-1234

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatric Endocrinology, Board Certification
  • Pediatrics, Board Certification
Public Speaking
Yes

General Information

Medical Schools:
  • MD, University of Minnesota Medical School (2002)
Graduate Schools:
  • PhD, University of Minnesota - Minneapolis (2000)
Undergraduate Schools:
  • BS, Michigan State University (MI) (1994)
  • BA, Michigan State University (MI) (1994)
Internships:
  • University of Minnesota Medical School Program (2004)
Residency Programs:
  • University of Minnesota Medical School Program, Chief Resident, Pediatrics (2007)
Fellowships:
  • University of Minnesota Medical School Program, Pediatric Endocrinology (2010)
Languages: English, Spanish, German
Department: Pediatrics-Barbara Davis Center
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