Theresa Powell, PhD
Professor, Pediatrics-Neonatology

Publications

• Rosario FJ, Urschitz J, Powell TL, Brown TL, Jansson T. Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling. Clin Sci (Lond). 2023 Oct 20. [Epub ahead of print] PubMed PMID: 37861075
• Kramer AC, Jansson T, Bale TL, Powell TL. Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism. Development. 2023 Oct 15;150(20). PubMed PMID: 37831056
• Powell TL, Uhlson C, Madi L, Berry KZ, Chassen SS, Jansson T, Ferchaud-Roucher V. Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity. Biol Sex Differ. 2023 Sep 28;14(1):66. PubMed PMID: 37770949
• Kelly A, Chan J, Powell TL, Cox LA, Jansson T, Rosario FJ. Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner. Front Cell Dev Biol. 2023;11:1178533. PubMed PMID: 37397247
• Rosario FJ, Chopra A, Biggar K, Powell TL, Gupta MB, Jansson T. Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability. Int J Mol Sci. 2023 Apr 14;24(8). PubMed PMID: 37108437
• Dumolt JH, Rosario FJ, Kramer AC, Horwitz S, Powell TL, Jansson T. Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity. Clin Sci (Lond). 2023 Apr 26;137(8):663-678. PubMed PMID: 37014924
• Joshi, Nikita; Sahay, Akriti; Mane, Aditi; Sundrani, Deepali; Randhir, Karuna; Wagh, Girija; Thornburg, Kent; Powell, Theresa; Yajnik, Chittaranjan; Joshi, Sadhana. Altered expression of nutrient transporters in syncytiotrophoblast membranes in preeclampsia placentae. 2023. Placenta 139:181-189. 
• Theresa Powell, Elena Silva, Veronique Ferchaud-Roucher, Anita Kramer, Lana Madi, Priya Pantham, Stephanie Chassen, and Thomas Jansson. Oleic acid stimulation of amino acid uptake in primary human trophoblast cells is mediated by phosphatidic acid and mTOR signaling. 2023. FASEB Bioadvances accepted.
• James-Allan LB, Rosario FJ, Madi L, Barner K, Nair S, Lai A, Carrion F, Powell TL, Salomon C, Jansson T. A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice. Clin Sci (Lond). 2022 Nov 11;136(21):1535-1549. PubMed PMID: 36239315
• Chassen SS, Zemski-Berry K, Raymond-Whish S, Driver C, Hobbins JC, Powell TL. Altered Cord Blood Lipid Concentrations Correlate with Birth Weight and Doppler Velocimetry of Fetal Vessels in Human Fetal Growth Restriction Pregnancies. Cells. 2022 Oct 2;11(19). PubMed PMID: 36231072
• Bidne KL, Uhlson C, Palmer C, Zemski-Berry K, Powell TL. Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation. Clin Sci (Lond). 2022 Oct 14;136(19):1389-1404. PubMed PMID: 36103262
• Kelly AC, J Rosario F, Chan J, Cox LA, Powell TL, Jansson T. Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese mice. Am J Physiol Endocrinol Metab. 2022 Oct 1;323(4):E336-E353. PubMed PMID: 35858246
• Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM. Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?. BMC Med. 2022 Jul 1;20(1):227. PubMed PMID: 35773701
• Dumolt J, Powell TL, Jansson T, Rosario FJ. Normalization of maternal adiponectin in obese pregnant mice prevents programming of impaired glucose metabolism in adult offspring. FASEB J. 2022 Jul;36(7):e22383. PubMed PMID: 35670755
• Schreiner C, Powell TL, Palmer C, Jansson T. Placental proteins with predicted roles in fetal development decrease in premature infants. Pediatr Res. 2022 Feb 7. [Epub ahead of print] PubMed PMID: 35132128
• Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity. J Clin Endocrinol Metab. 2022 Jan 1;107(1):53-66. PubMed PMID: 34519830
• Chassen, SS; Zemski-Berry, K; Raymond-Whish, S; Driver-Rigdon, C; Hobbins, J; Powell, T; ELEVATED TRIGLYCERIDE CONCENTRATIONS IN UMBILICAL CORD PLASMA FROM HUMAN INTRAUTERINE GROWTH RESTRICTED PREGNANCIES CORRELATE WITH ULTRASOUND MARKERS OF POOR FETAL WELLBEING JOURNAL OF INVESTIGATIVE MEDICINE 70 1 246-246 2022
• Vaughan, Owen R; Rosario, Fredrick J; Chan, Jeannie; Cox, Laura A; Ferchaud-Roucher, Veronique; Zemski-Berry, Karin A; Reusch, Jane EB; Keller, Amy C; Powell, Theresa L; Jansson, Thomas; Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice The Journal of Physiology 2022
• Rosario FJ, Pardo S, Michelsen TM, Erickson K, Moore L, Powell TL, Weintraub ST, Jansson T. Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture. Front Cell Dev Biol. 2021;9:704781. PubMed PMID: 34595166
• Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity. J Clin Endocrinol Metab. 2021 Sep 14. [Epub ahead of print] PubMed PMID: 34519830
• Rosario FJ, Kramer A, Li C, Galan HL, Powell TL, Nathanielsz PW, Jansson T. Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate. Nutrients. 2021 Aug 23;13(8). PubMed PMID: 34445051
• Vaughan OR, Maksym K, Silva E, Barentsen K, Anthony RV, Brown TL, Hillman SL, Spencer R, David AL, Rosario FJ, Powell TL, Jansson T. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice. Clin Sci (Lond). 2021 Sep 17;135(17):2049-2066. PubMed PMID: 34406367
• Castillo-Castrejon M, Yamaguchi K, Rodel RL, Erickson K, Kramer A, Hirsch NM, Rolloff K, Jansson T, Barbour LA, Powell TL. Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity. Mol Cell Endocrinol. 2021 Jul 15;532:111319. PubMed PMID: 33989714
• Dumolt JH, Powell TL, Jansson T. Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction. Obstet Gynecol Clin North Am. 2021 Jun;48(2):247-266. PubMed PMID: 33972064
• Kristiansen O, Zucknick M, Reine TM, Kolset SO, Jansson T, Powell TL, Haugen G, Henriksen T, Michelsen TM. Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies. J Clin Endocrinol Metab. 2021 Jun 16;106(7):1977-1993. PubMed PMID: 33713406
• Higa R, Rosario FJ, Powell TL, Jansson T, Jawerbaum A. Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability. Reproduction. 2021 Apr;161(4):365-373. PubMed PMID: 33528379
• Castillo-Castrejon M, Yang IV, Davidson EJ, Borengasser SJ, Jambal P, Westcott J, Kemp JF, Garces A, Ali SA, Saleem S, Goldenberg RL, Figueroa L, Hambidge KM, Krebs NF, Powell TL. Preconceptional Lipid-Based Nutrient Supplementation in 2 Low-Resource Countries Results in Distinctly Different IGF-1/mTOR Placental Responses. J Nutr. 2021 Mar 11;151(3):556-569. PubMed PMID: 33382407
• Powell TL, Barner K, Madi L, Armstrong M, Manke J, Uhlson C, Jansson T, Ferchaud-Roucher V. Sex-specific responses in placental fatty acid oxidation, esterification and transfer capacity to maternal obesity. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Mar;1866(3):158861. PubMed PMID: 33321178
• Hoffman DJ, Powell TL, Barrett ES, Hardy DB. Developmental origins of metabolic diseases. Physiol Rev. 2021 Jul 1;101(3):739-795. PubMed PMID: 33270534
• Roeca C, Silva E, Barentsen C, Powell TL, Jansson T. Effects of vitrification and the superovulated environment on placental function and fetal growth in an IVF mouse model. Mol Hum Reprod. 2020 Aug 1;26(8):624-635. PubMed PMID: 32618997
• Chassen SS, Ferchaud-Roucher V, Palmer C, Li C, Jansson T, Nathanielsz PW, Powell TL. Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction. J Physiol. 2020 Jun;598(12):2469-2489. PubMed PMID: 32338384
• Kelly AC, Powell TL, Jansson T. Placental function in maternal obesity. Clin Sci (Lond). 2020 Apr 30;134(8):961-984. PubMed PMID: 32313958
• James-Allan LB, Rosario FJ, Barner K, Lai A, Guanzon D, McIntyre HD, Lappas M, Powell TL, Salomon C, Jansson T. Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB J. 2020 Apr;34(4):5724-5739. PubMed PMID: 32154621
• James-Allan LB, Teal S, Powell TL, Jansson T. Changes in Placental Nutrient Transporter Protein Expression and Activity Across Gestation in Normal and Obese Women. Reprod Sci. 2020 Sep;27(9):1758-1769. PubMed PMID: 32072607
• Jessel RH, Rosario FJ, Chen YY, Erickson K, Teal SB, Kramer A, Cotton E, Ryan S, Jansson T, Powell TL. Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. J Nutr Biochem. 2020 Mar;77:108305. PubMed PMID: 31926453
• Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
• Jansson T, Castillo-Castrejon M, Gupta MB, Powell TL, Rosario FJ. Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. Clin Sci (Lond). 2020 Jan 17;134(1):53-70. PubMed PMID: 31825077
• Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891
• Rosario FJ, Powell TL, Gupta MB, Cox L, Jansson T. mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells. Front Cell Dev Biol. 2020;8:583801. PubMed PMID: 33324640
• Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2020 Feb;44(2):488-499. PubMed PMID: 31076636
• Kelly AC, Kramer A, Rosario FJ, Powell TL, Jansson T. Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta. Clin Sci (Lond). 2020 Dec 11;134(23):3123-3136. PubMed PMID: 33215629
• Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2019 May 10. [Epub ahead of print] PubMed PMID: 31076636
• Castillo-Castrejon M, Jansson T, Powell TL. No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in obesity and gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2019 Oct 1. [Epub ahead of print] PubMed PMID: 31573844
• James-Allan LB, Arbet J, Teal SB, Powell TL, Jansson T. Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta. J Clin Endocrinol Metab. 2019 May 21. [Epub ahead of print] PubMed PMID: 31112275
• Vaughan OR, Powell TL, Jansson T. Apelin is a novel regulator of human trophoblast amino acid transport. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E810-E816. PubMed PMID: 30835509
• Ferchaud-Roucher V, Barner K, Jansson T, Powell TL. Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties. FASEB J. 2019 May;33(5):6643-6654. PubMed PMID: 30811959
• Rosario FJ, Gupta MB, Myatt L, Powell TL, Glenn JP, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis. Sci Rep. 2019 Jan 22;9(1):246. PubMed PMID: 30670706
• Ferchaud-Roucher V, Kramer A, Silva E, Pantham P, Weintraub ST, Jansson T, Powell TL. A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):394-402. PubMed PMID: 30572119
• Vyas V, Guerra DD, Bok R, Powell T, Jansson T, Hurt KJ. Adiponectin links maternal metabolism to uterine contractility. FASEB J. 2019 Oct 30;:fj201901646R. [Epub ahead of print] PubMed PMID: 31665924
• Ramzan AA, Bitler BG, Hicks D, Barner K, Qamar L, Behbakht K, Powell T, Jansson T, Wilson H. Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells. Mol Cell Biochem. 2019 Nov;461(1-2):37-46. PubMed PMID: 31292831
• Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2018 Oct 22;:fj201801015R. [Epub ahead of print] PubMed PMID: 30346829
• Michelsen TM, Holme AM, Holm MB, Roland MC, Haugen G, Powell TL, Jansson T, Henriksen T. Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies. J Clin Endocrinol Metab. 2018 Oct 18. [Epub ahead of print] PubMed PMID: 30339207
• Michelsen TM, Henriksen T, Reinhold D, Powell TL, Jansson T. The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling. FASEB J. 2018 Oct 18;:fj201801193R. [Epub ahead of print] PubMed PMID: 30335547
• Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab. 2018 Aug 16. [Epub ahead of print] PubMed PMID: 30124960
• Chen YY, Gupta MB, Grattton R, Powell TL, Jansson T. Down-regulation of placental folate transporters in intrauterine growth restriction. J Nutr Biochem. 2018 Sep;59:136-141. PubMed PMID: 29986308
• Capobianco E, Gomez Ribot D, Fornes D, Powell TL, Levieux C, Jansson T, Jawerbaum A. Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming. Mol Nutr Food Res. 2018 Oct;62(19):e1800263. PubMed PMID: 29939470
• Grindler NM, Allshouse AA, Jungheim E, Powell TL, Jansson T, Polotsky AJ. OBGYN screening for environmental exposures: A call for action. PLoS One. 2018;13(5):e0195375. PubMed PMID: 29768418
• Grindler NM, Vanderlinden L, Karthikraj R, Kannan K, Teal S, Polotsky AJ, Powell TL, Yang IV, Jansson T. Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women. Sci Rep. 2018 Apr 17;8(1):6086. PubMed PMID: 29666409
• Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta. 2018 Apr;64:53-60. PubMed PMID: 29626981
• Roberti SL, Higa R, White V, Powell TL, Jansson T, Jawerbaum A. Critical role of mTOR, PPAR? and PPARd signaling in regulating early pregnancy decidual function, embryo viability and feto-placental growth. Mol Hum Reprod. 2018 Jun 1;24(6):327-340. PubMed PMID: 29538677
• Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction. Clin Sci (Lond). 2018 Mar 15;132(5):595-607. PubMed PMID: 29463583
• Capobianco E, Fornes D, Roberti SL, Powell TL, Jansson T, Jawerbaum A. Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPAR? and mTOR signaling in female offspring developing gestational diabetes. J Nutr Biochem. 2018 Mar;53:39-47. PubMed PMID: 29190548
• Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ, Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Oct 18. [Epub ahead of print] PubMed PMID: 29053802
• Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell TL. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017 Sep;57:52-59. PubMed PMID: 28864019
• Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:14-20. PubMed PMID: 28651693
• Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 Jun 21;7(1):3982. PubMed PMID: 28638048
• Silva E, Rosario FJ, Powell TL, Jansson T. Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function. J Nutr. 2017 Jul;147(7):1237-1242. PubMed PMID: 28592519
• Foster BA, Escaname E, Powell TL, Larsen B, Siddiqui SK, Menchaca J, Aquino C, Ramamurthy R, Hale DE. Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes. Nutrients. 2017 Jun 2;9(6). PubMed PMID: 28574453
• Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 Jul 1;595(13):4189-4206. PubMed PMID: 28374905
• Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017;145:217-251. PubMed PMID: 28110752
• Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D(3) stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2017 Feb 15;442:90-97. PubMed PMID: 27956114
• Howell KR, Powell TL. Effects of maternal obesity on placental function and fetal development. Reproduction. 2017 Mar;153(3):R97-R108. PubMed PMID: 27864335
• Castillo-Castrejon M, Powell TL. Placental Nutrient Transport in Gestational Diabetic Pregnancies. Front Endocrinol (Lausanne). 2017;8:306. PubMed PMID: 29163373
• Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ, Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Dec 1;102(12):4557-4567. PubMed PMID: 29053802
• Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. PubMed PMID: 26491103
• Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016 Apr 1;130(7):499-512. PubMed PMID: 26608079
• Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol. 2016 Feb 15;422:221-32. PubMed PMID: 26747729
• Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E261. PubMed PMID: 26755612
• Dimasuay KG, Boeuf P, Powell TL, Jansson T. Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol. 2016 Jan 29;7:12. PubMed PMID: 26858656
• Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women. Placenta. 2016 Apr;40:60-6. PubMed PMID: 27016784
• Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 Aug 26;6:31705. PubMed PMID: 27562465
• Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27605346
• Cleaton MA, Dent CL, Howard M, Corish JA, Gutteridge I, Sovio U, Gaccioli F, Takahashi N, Bauer SR, Charnock-Jones DS, Powell TL, Smith GC, Ferguson-Smith AC, Charalambous M. Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction. Nat Genet. 2016 Dec;48(12):1473-1480. PubMed PMID: 27776119
• Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 21;:ajpregu.00385.2015. [Epub ahead of print] PubMed PMID: 26491104
• Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 21;:ajpregu.00356.2015. [Epub ahead of print] PubMed PMID: 26491103
• Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. PubMed PMID: 26417088
• Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec 1;129(12):1131-41. PubMed PMID: 26374858
• Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R740-6. PubMed PMID: 26246504
• Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug;23(8):1663-70. PubMed PMID: 26193061
• Gaccioli F, Aye IL, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015 Jun 9;13:57. PubMed PMID: 26050671
• Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015 Jul;36(7):709-15. PubMed PMID: 25972077
• Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015 Feb;212(2):227.e1-7. PubMed PMID: 25132463
• Lager S, Aye IL, Gaccioli F, Ramirez VI, Jansson T, Powell TL. Labor inhibits placental mechanistic target of rapamycin complex 1 signaling. Placenta. 2014 Dec;35(12):1007-12. PubMed PMID: 25454472
• Ramirez VI, Miller E, Meireles CL, Gelfond J, Krummel DA, Powell TL. Adiponectin and IGFBP-1 in the development of gestational diabetes in obese mothers. BMJ Open Diabetes Res Care. 2014;2(1):e000010. PubMed PMID: 25452858
• Lager S, Jansson T, Powell TL. Reply to "Letter to the editor: 'Fatty acids and placental transport: insight or in vitro artifact?'". Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C1069. PubMed PMID: 25452383
• Lager S, Jansson T, Powell TL. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C738-44. PubMed PMID: 25143349
• Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2014 Aug 14. [Epub ahead of print] PubMed PMID: 25132463
• Díaz P, Powell TL, Jansson T. The role of placental nutrient sensing in maternal-fetal resource allocation. Biol Reprod. 2014 Oct;91(4):82. PubMed PMID: 25122064
• Lager S, Ramirez VI, Gaccioli F, Jansson T, Powell TL. Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta. Placenta. 2014 Jul;35(7):523-5. PubMed PMID: 24844436
• Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun;90(6):129. PubMed PMID: 24759787
• Lager S, Samulesson AM, Taylor PD, Poston L, Powell TL, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014 Feb 1;2(2):e00242. PubMed PMID: 24744907
• Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr;28(4):512-24. PubMed PMID: 24606127
• Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J. 2014 Mar;28(3):1294-305. PubMed PMID: 24334703