Theresa Powell, PhD
Professor, Pediatrics-Neonatology

Publications

  • Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2018 Oct 22;:fj201801015R. [Epub ahead of print] PubMed PMID: 30346829
  • Michelsen TM, Holme AM, Holm MB, Roland MC, Haugen G, Powell TL, Jansson T, Henriksen T. Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies. J Clin Endocrinol Metab. 2018 Oct 18. [Epub ahead of print] PubMed PMID: 30339207
  • Michelsen TM, Henriksen T, Reinhold D, Powell TL, Jansson T. The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling. FASEB J. 2018 Oct 18;:fj201801193R. [Epub ahead of print] PubMed PMID: 30335547
  • Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab. 2018 Aug 16. [Epub ahead of print] PubMed PMID: 30124960
  • Chen YY, Gupta MB, Grattton R, Powell TL, Jansson T. Down-regulation of placental folate transporters in intrauterine growth restriction. J Nutr Biochem. 2018 Sep;59:136-141. PubMed PMID: 29986308
  • Capobianco E, Gomez Ribot D, Fornes D, Powell TL, Levieux C, Jansson T, Jawerbaum A. Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming. Mol Nutr Food Res. 2018 Oct;62(19):e1800263. PubMed PMID: 29939470
  • Grindler NM, Allshouse AA, Jungheim E, Powell TL, Jansson T, Polotsky AJ. OBGYN screening for environmental exposures: A call for action. PLoS One. 2018;13(5):e0195375. PubMed PMID: 29768418
  • Grindler NM, Vanderlinden L, Karthikraj R, Kannan K, Teal S, Polotsky AJ, Powell TL, Yang IV, Jansson T. Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women. Sci Rep. 2018 Apr 17;8(1):6086. PubMed PMID: 29666409
  • Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta. 2018 Apr;64:53-60. PubMed PMID: 29626981
  • Roberti SL, Higa R, White V, Powell TL, Jansson T, Jawerbaum A. Critical role of mTOR, PPAR? and PPARd signaling in regulating early pregnancy decidual function, embryo viability and feto-placental growth. Mol Hum Reprod. 2018 Jun 1;24(6):327-340. PubMed PMID: 29538677
  • Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction. Clin Sci (Lond). 2018 Mar 15;132(5):595-607. PubMed PMID: 29463583
  • Capobianco E, Fornes D, Roberti SL, Powell TL, Jansson T, Jawerbaum A. Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPAR? and mTOR signaling in female offspring developing gestational diabetes. J Nutr Biochem. 2017 Nov 27;53:39-47. [Epub ahead of print] PubMed PMID: 29190548
  • Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ, Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Oct 18. [Epub ahead of print] PubMed PMID: 29053802
  • Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell TL. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017 Sep;57:52-59. PubMed PMID: 28864019
  • Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:14-20. PubMed PMID: 28651693
  • Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 Jun 21;7(1):3982. PubMed PMID: 28638048
  • Silva E, Rosario FJ, Powell TL, Jansson T. Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function. J Nutr. 2017 Jul;147(7):1237-1242. PubMed PMID: 28592519
  • Foster BA, Escaname E, Powell TL, Larsen B, Siddiqui SK, Menchaca J, Aquino C, Ramamurthy R, Hale DE. Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes. Nutrients. 2017 Jun 2;9(6). PubMed PMID: 28574453
  • Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 Jul 1;595(13):4189-4206. PubMed PMID: 28374905
  • Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017;145:217-251. PubMed PMID: 28110752
  • Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D(3) stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2016 Dec 9;442:90-97. [Epub ahead of print] PubMed PMID: 27956114
  • Howell KR, Powell TL. Effects of maternal obesity on placental function and fetal development. Reproduction. 2017 Mar;153(3):R97-R108. PubMed PMID: 27864335
  • Castillo-Castrejon M, Powell TL. Placental Nutrient Transport in Gestational Diabetic Pregnancies. Front Endocrinol (Lausanne). 2017;8:306. PubMed PMID: 29163373
  • Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ, Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Oct 18. [Epub ahead of print] PubMed PMID: 29053802
  • Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 21;:ajpregu.00356.2015. [Epub ahead of print] PubMed PMID: 26491103
  • Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2. Clin Sci (Lond). 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26608079
  • Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol. 2016 Feb 15;422:221-32. PubMed PMID: 26747729
  • Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E261. PubMed PMID: 26755612
  • Dimasuay KG, Boeuf P, Powell TL, Jansson T. Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol. 2016 Jan 29;7:12. PubMed PMID: 26858656
  • Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women. Placenta. 2016 Apr;40:60-6. PubMed PMID: 27016784
  • Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 Aug 26;6:31705. PubMed PMID: 27562465
  • Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27605346
  • Cleaton MA, Dent CL, Howard M, Corish JA, Gutteridge I, Sovio U, Gaccioli F, Takahashi N, Bauer SR, Charnock-Jones DS, Powell TL, Smith GC, Ferguson-Smith AC, Charalambous M. Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction. Nat Genet. 2016 Dec;48(12):1473-1480. PubMed PMID: 27776119
  • Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 21;:ajpregu.00385.2015. [Epub ahead of print] PubMed PMID: 26491104
  • Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 21;:ajpregu.00356.2015. [Epub ahead of print] PubMed PMID: 26491103
  • Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. PubMed PMID: 26417088
  • Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec 1;129(12):1131-41. PubMed PMID: 26374858
  • Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R740-6. PubMed PMID: 26246504
  • Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug;23(8):1663-70. PubMed PMID: 26193061
  • Gaccioli F, Aye IL, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015 Jun 9;13:57. PubMed PMID: 26050671
  • Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015 Jul;36(7):709-15. PubMed PMID: 25972077
  • Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2014 Aug 14. [Epub ahead of print] PubMed PMID: 25132463
  • Lager S, Aye IL, Gaccioli F, Ramirez VI, Jansson T, Powell TL. Labor inhibits placental mechanistic target of rapamycin complex 1 signaling. Placenta. 2014 Dec;35(12):1007-12. PubMed PMID: 25454472
  • Ramirez VI, Miller E, Meireles CL, Gelfond J, Krummel DA, Powell TL. Adiponectin and IGFBP-1 in the development of gestational diabetes in obese mothers. BMJ Open Diabetes Res Care. 2014;2(1):e000010. PubMed PMID: 25452858
  • Lager S, Jansson T, Powell TL. Reply to "Letter to the editor: 'Fatty acids and placental transport: insight or in vitro artifact?'". Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C1069. PubMed PMID: 25452383
  • Lager S, Jansson T, Powell TL. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C738-44. PubMed PMID: 25143349
  • Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2014 Aug 14. [Epub ahead of print] PubMed PMID: 25132463
  • Díaz P, Powell TL, Jansson T. The role of placental nutrient sensing in maternal-fetal resource allocation. Biol Reprod. 2014 Oct;91(4):82. PubMed PMID: 25122064
  • Lager S, Ramirez VI, Gaccioli F, Jansson T, Powell TL. Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta. Placenta. 2014 Jul;35(7):523-5. PubMed PMID: 24844436
  • Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun;90(6):129. PubMed PMID: 24759787
  • Lager S, Samulesson AM, Taylor PD, Poston L, Powell TL, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014 Feb 1;2(2):e00242. PubMed PMID: 24744907
  • Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr;28(4):512-24. PubMed PMID: 24606127
  • Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J. 2014 Mar;28(3):1294-305. PubMed PMID: 24334703
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General Information

Department: Pediatrics-Neonatology
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