Kevin Messacar, MD
Assistant Professor, Pediatrics-Pediatric Hospital Medicine

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Medical School:
  • MD, University of Michigan Medical School (2008)
Undergraduate School:
  • BS, University of Michigan (MI) (2003)
Internship:
  • University of Colorado (Children's Hospital Colorado) Program (2009)
Residency:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2011)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Infectious Diseases (2014)
Languages: English, Spanish
Department: Pediatrics-Pediatric Hospital Medicine

Professional Titles

  • Assistant Professor, Pediatrics-Pediatric Hospital Medicine
  • Assistant Professor, Department of Pediatrics, Sections of Hospital Medicine and Infectious Diseases

Recognition & Awards

  • Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2019)
    Voted by licensed CO physicians
  • Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2018)
    Voted by licensed CO physicians
  • Century Award, Children's Hospital Colorado (2018)
    Recognizes a staff member with five or fewer years of training who has made major contributions through committee work, leadership and/or advocacy.
  • Acute Flaccid Myelitis Task Force, Centers for Disease Control and Prevention Board of Scientific Counselors (2018)
    https://www.cdc.gov/ddid/bsc/afm-task-force.html
  • Gary Way Award for Outstanding Teaching by a Faculty Member, University of Colorado Department of Pediatrics (2017)
    Elected by the University of Colorado pediatric residents
  • Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2017)
    Voted by licensed CO physicians
  • Research Scholars Award, Children's Hospital Colorado Research Institute (2015)
  • Astute Clinician Award, Colorado Department of Public Health and Environment (2014)
    For initial description of the association of Acute Flaccid Myelitis and Enterovirus D68 in CO in 2014
  • Fellow Teaching Award, University of Colorado School of Medicine, Department of Pediatrics (2013)
    Voted by University of Colorado pediatric residents
  • Outstanding Resident of the Year, University of Colorado NICU (2011)
  • Resident Teaching Award, University of Colorado School of Medicine, Department of Pediatrics (2011)
    Voted by University of Colorado medical students
  • Outstanding Intern of the Year, University of Colorado NICU (2009)
  • MCAS Academic Achievement Award, University of Michigan Medical School (2008)
    Highest Academic Standing in the Graduating Class of 2008
  • Alpha Omega Alpha Medical Honors Society, Alpha Omega Alpha, University of Michigan Chapter (2008)
  • Dean’s Commendation for Excellence in Clinical Skills and the Art of Medicine, University of Michigan Medical School (2008)
  • Distinction in Service, University of Michigan Medical School (2008)
  • Dean’s Merit Scholarship, University of Michigan Medical School (2003)
  • Highest Distinction and Highest Honors in Biochemistry, University of Michigan (2003)

Research Interests

My research interests include using new rapid tests to improve the care of children with infections. I am interested in learning more about what causes brain and spinal cord infections in children. I have been investigating the causes of acute flaccid myelitis, which causes paralysis in children, including enterovirus D68 and A71.

Teaching

  • Infectious Disease Rotation Coordinator (2016)
    School of Medicine, Pediatrics
  • Evidence Based Clinical Effectiveness Conference Faculty Co-Facilitator (2016)
    School of Medicine, Pediatrics

Publications

  • Schubert RD, Hawes IA, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O'Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa GA, Sample HA, Zorn KC, Banerji D, Khan LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner BL, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2019 Oct 21. [Epub ahead of print] PubMed PMID: 31636453
  • Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 2019 Sep 4;11(9). PubMed PMID: 31487952
  • Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY. Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. N Engl J Med. 2019 Jun 13;380(24):2327-2340. PubMed PMID: 31189036
  • Abedi GR, Messacar K, Luong W, Nix WA, Rogers S, Queen K, Tong S, Oberste MS, Watt J, Rothrock G, Dominguez S, Gerber SI, Watson JT. Picornavirus etiology of acute infections among hospitalized infants. J Clin Virol. 2019 Jul;116:39-43. PubMed PMID: 31100674
  • Miller S, Naccache SN, Samayoa E, Messacar K, Arevalo S, Federman S, Stryke D, Pham E, Fung B, Bolosky WJ, Ingebrigtsen D, Lorizio W, Paff SM, Leake JA, Pesano R, DeBiasi R, Dominguez S, Chiu CY. Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid. Genome Res. 2019 May;29(5):831-842. PubMed PMID: 30992304
  • Kane MS, Sonne C, Zhu S, Malhotra A, Van Haren K, Messacar K, Glaser CA. Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016. Pediatr Infect Dis J. 2019 Jul;38(7):667-672. PubMed PMID: 30985511
  • Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2019 Mar 1;76(3):301-309. PubMed PMID: 30575890
  • Elrick MJ, Gordon-Lipkin E, Crawford TO, Van Haren K, Messacar K, Thornton N, Dee E, Voskertchian A, Nance JR, Muñoz LS, Gorman MP, Benson LA, Thomas DL, Pardo CA, Milstone AM, Duggal P. Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. JAMA Pediatr. 2019 Feb 1;173(2):134-139. PubMed PMID: 30500056
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30;92(18):e2118-e2126. PubMed PMID: 30413631
  • Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):282-283. PubMed PMID: 30299497
  • Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2019 Jan;93(1):22-23. PubMed PMID: 30213466
  • Elrick MJ, Gordon-Lipkin E, Crawford TO, Van Haren K, Messacar K, Thornton N, Dee E, Voskertchian A, Nance JR, Muñoz LS, Gorman MP, Benson LA, Thomas DL, Pardo CA, Milstone AM, Duggal P. Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. JAMA Pediatr. 2018 Nov 30. [Epub ahead of print] PubMed PMID: 30500056
  • Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2018 Oct 9. [Epub ahead of print] PubMed PMID: 30299497
  • Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 Nov;13:1553-1554. PubMed PMID: 30421966
  • Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Dec;18(12):1299-1301. PubMed PMID: 30389483
  • Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14;67(36):1017-1018. PubMed PMID: 30212441
  • Messacar K. Narrow-spectrum, compared with broad-spectrum, antibiotics equally effective with less adverse events. J Pediatr. 2018 May;196:324-327. PubMed PMID: 29703366
  • Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
  • Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
  • Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
  • Phan TG, Messacar K, Dominguez SR, da Costa AC, Deng X, Delwart E. A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis. Arch Virol. 2016 Nov;161(11):3231-5. PubMed PMID: 27522586
  • Rao S, Messacar K, Torok MR, Rick AM, Holzberg J, Montano A, Bagdure D, Curtis DJ, Oberste MS, Nix WA, de Masellis G, Robinson CC, Dominguez SR. Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza. Pediatr Crit Care Med. 2016 Nov;17(11):1023-1031. PubMed PMID: 27505715
  • Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016 Aug;22(8):1387-94. PubMed PMID: 27434186
  • Bagdure D, Custer JW, Rao S, Messacar K, Dominguez S, Beam BW, Bhutta A. Hospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study. Pediatr Neurol. 2016 Aug;61:58-62. PubMed PMID: 27353693
  • Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI findings in children with acute flaccid paralysis and cranial nerve dysfunction occurring during the 2014 enterovirus D68 outbreak. AJNR Am J Neuroradiol. 2015 Feb;36(2):245-50. PubMed PMID: 25414005
  • Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun;15(6):671-82. PubMed PMID: 25837569
  • Gaensbauer JT, Lindsey NP, Messacar K, Staples JE, Fischer M. Neuroinvasive arboviral disease in the United States: 2003 to 2012. Pediatrics. 2014 Sep;134(3):e642-50. PubMed PMID: 25113294
  • Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak. AJNR Am J Neuroradiol. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414005
  • Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L, Centers for Disease Control and Prevention (CDC). Acute neurologic illness of unknown etiology in children - Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep. 2014 Oct 10;63(40):901-2. PubMed PMID: 25299607
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Professional Memberships

  • American Academy of Pediatrics (AAP), Member
  • Pediatric Infectious Disease Society, Member
  • Infectious Disease Society of America, Member
  • Society of Pediatric Research, Member
  • Colorado Chapter of the Infectious Disease Society of America, Board Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Infectious Diseases, Board Certification (2015)
  • Pediatrics, Board Certification (2011)
Conditions & Treatments
  • Infections - Viral Infections
  • Infections
  • Infections - Bacterial Infections
  • Brain and Nervous System - Meningitis
  • Brain and Nervous System
  • Child and Teen Health - Pediatric Diseases and Conditions
  • Child and Teen Health
Clinical Interests
Pediatric Infectious Diseases

Public Speaking
Yes

General Information

Medical Schools:
  • MD, University of Michigan Medical School (2008)
Undergraduate Schools:
  • BS, University of Michigan (MI) (2003)
Internships:
  • University of Colorado (Children's Hospital Colorado) Program (2009)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2011)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Infectious Diseases (2014)
Languages: English, Spanish
Department: Pediatrics-Pediatric Hospital Medicine
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