Samantha Holden, MD
Assistant Professor, Neurology

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Medical School:
  • MD, The School of Medicine at Stony Brook University Medical Center (2010)
Graduate School :
  • MSCS, University of Colorado Denver (2018)
Undergraduate School:
  • BS, New York University (NY) (2006)
Internship:
  • Rush University Medical Center Program (2011)
Residency:
  • Rush University Medical Center Program, Chief Resident, Neurology (2014)
Fellowships:
  • University of Colorado, Movement Disorders; Behavioral Neurology & Neuropsychiatry (2017)
Languages: English
Department: Neurology

Professional Titles

  • Assistant Professor of Neurology
  • Medical Director, Memory Disorders Clinic
  • Co-Director, Lewy Body Dementia Association Research Center of Excellence at the University of Colorado
  • Clinical Director of Outpatient Neurology

Recognition & Awards

  • National Institute of Health Clinical Loan Repayment Program, National Institute of Neurological Disorders and Stroke (2017)
    Educational debt repayment program meant to allow clinician-scientists to maintain their commitment to research

Research Interests

My research is focused on how to best evaluate cognition as it relates to daily functioning. Paper and pencil tests done in clinic do not always fully evaluate how thinking and memory problems can affect someone's day-to-day function. I hope to validate a new type of assessment that directly evaluates daily activities that require higher levels of cognitive function. In the future, I hope to work on developing non-pharmacologic treatments for cognitive impairment that focus on improving independence and functionality, such as an exercise program that also involves cognitive training.

Teaching

  • Associate Program Director, Behavior Neurology & Neuropsychiatry Fellowship (2018)
    School of Medicine, Neurology

Publications

  • Medina LD, Heffernan K, Holden S, Simpson A, Bettcher BM. Neural correlates of daily function: A pilot study of the white matter retrogenesis hypothesis and three separate performance-based functional assessments. Neuropsychology. 2021 Jan;35(1):103-110. PubMed PMID: 33393804
  • Macchi ZA, Kletenik I, Olvera C, Holden SK. Psychiatric comorbidities in functional movement disorders: A retrospective cohort study. 2021 Mov Disord Clin Pract. ePub ahead of print. doi: 10.1002/mdc3.13226.
  • Buard I, Lattanzio L, Stewart R, Thompson S, Sjoberg K, Hookstadt K, Morrow M, Holden SK, Sillau S, Thaut M, Kluger B. Randomized controlled trial of neurologic music therapy in Parkinson's disease: research rehabilitation protocols for mechanistic and clinical investigations. Trials. 2021 Aug 28;22(1):577. PubMed PMID: 34454592
  • Macchi ZA, Kletenik I, Olvera C, Holden SK. Psychiatric Comorbidities in Functional Movement Disorders: A Retrospective Cohort Study. Mov Disord Clin Pract. 2021 Jul;8(5):725-732. PubMed PMID: 34307745
  • Lattanzio L, Seames A, Holden SK, Buard I. The emergent relationship between temporoparietal junction and anosognosia in Alzheimer's disease. J Neurosci Res. 2021 Sep;99(9):2091-2096. PubMed PMID: 34131953
  • Medina LD, Heffernan K, Holden S, Simpson A, Bettcher BM. Neural correlates of daily function: A pilot study of the white matter retrogenesis hypothesis and three separate performance-based functional assessments. Neuropsychology. 2021 Jan;35(1):103-110. PubMed PMID: 33393804
  • Holden SK, Bettcher BM, Pelak VS. Update on posterior cortical atrophy. Curr Opin Neurol. 2020 Feb;33(1):68-73. PubMed PMID: 31688098
  • Holden SK, Van Dok E, Pelak VS. Co-occurrence of Convergence Insufficiency and Cognitive Impairment in Parkinsonian Disorders: A Pilot Study. Front Neurol. 2019;10:864. PubMed PMID: 31447772
  • Holden SK, Sheffler J, Stewart R, Thompson S, Persson J, Finseth T, Sillau S, Kluger BM. Feasibility of Home-Based Neurologic Music Therapy for Behavioral and Psychological Symptoms of Dementia: A Pilot Study. J Music Ther. 2019 Aug 13;56(3):265-286. PubMed PMID: 31346625
  • Holden SK, Koljack CE, Prizer LP, Sillau SH, Miyasaki JM, Kluger BM. Measuring quality of life in palliative care for Parkinson's disease: A clinimetric comparison. Parkinsonism Relat Disord. 2019 Aug;65:172-177. PubMed PMID: 31253494
  • Peterson B, Armstrong M, Galasko D, Galvin JE, Goldman J, Irwin D, Paulson H, Kaufer D, Leverenz J, Lunde A, McKeith IG, Siderowf A, Taylor A, Amodeo K, Barrett M, Domoto-Reilly K, Duda J, Gomperts S, Graff-Radford N, Holden S, Honig L, Huddleston D, Lippa C, Litvan I, Manning C, Marder K, Moussa C, Onyike C, Pagan F, Pantelyat A, Pelak V, Poston K, Quinn J, Richard I, Rosenthal LS, Sabbagh M, Scharre D, Sha S, Shill H, Torres-Yaghi Y, Christie T, Graham T, Richards I, Koehler M, Boeve B. Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings. Alzheimers Res Ther. 2019 Mar 13;11(1):23. PubMed PMID: 30867052
  • Holden SK, Finseth T, Sillau SH, Berman BD. Progression of MDS-UPDRS Scores Over Five Years in De Novo Parkinson Disease from the Parkinson's Progression Markers Initiative Cohort. Mov Disord Clin Pract. 2018 Jan-Feb;5(1):47-53. PubMed PMID: 29662921
  • Goldman JG, Holden SK, Litvan I, McKeith I, Stebbins GT, Taylor JP. Evolution of diagnostic criteria and assessments for Parkinson's disease mild cognitive impairment. Mov Disord. 2018 Apr;33(4):503-510. PubMed PMID: 29488270
  • Kluger BM, Persenaire MJ, Holden SK, Palmer LT, Redwine H, Berk J, Anderson CA, Filley CM, Kutner J, Miyasaki J, Carter J. Implementation issues relevant to outpatient neurology palliative care. Ann Palliat Med. 2018 Jul;7(3):339-348. PubMed PMID: 29307208
  • Holden SK, Medina LD, Hoyt B, Sillau SH, Berman BD, Goldman JG, Weintraub D, Kluger BM. Validation of a performance-based assessment of cognitive functional ability in Parkinson's disease. Mov Disord. 2018 Nov;33(11):1760-1768. PubMed PMID: 30306618
  • Holden SK, Jones WE, Baker KA, Boersma IM, Kluger BM. Outcome measures for Parkinson's disease dementia: a systematic review. Mov Disord Clin Pract. 2016 Jan-Feb;3(1):9-18. PubMed PMID: 26998505
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Professional Memberships

  • American Academy of Neurology, Member
  • International Parkinson and Movement Disorder Society, Member
  • Colorado Society of Clinical Neurologists, Member
  • American Neuropsychiatric Association, Member
  • American Neurological Association, Member
  • Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment, Member

Practice Locations

CU Memory Disorders Clinic - Central Park
3055 Roslyn Street
Suite 120
Denver, CO 80238
720-848-2080

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Neurology, Board Certification (2014)
  • Behavioral Neurology and Neuropsychiatry, Board Certification (2016)
Conditions & Treatments
  • Brain and Nervous System - Alzheimer's Disease
  • Brain and Nervous System
  • Brain and Nervous System - Movement Disorders
  • Brain and Nervous System - Parkinson's Disease
Clinical Interests
I am interested in conditions that present with symptoms affecting both cognition and movement, such as Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease with parkinsonism. I have fellowship training in both Movement Disorders and Behavioral Neurology, which has laid the foundation for these interests.

Care Philosophy
I hope to ensure that my patients are living their best life possible, even in the face of a chronic neurologic disease. I emphasize the importance of physical exercise, diet, social activities, and cognitively stimulating activity to not only improve quality of life, but to help delay the progression of the neurodegenerative diseases I treat.

Personal Interests
I enjoy reading historical fiction, especially anything that focuses on Eleanor of Aquitaine.

Public Speaking
Yes
I enjoy speaking to support groups, especially about cognitive and other non-motor symptoms of Parkinson's disease. I have given several lectures for the Parkinson Association of the Rockies.

General Information

Medical Schools:
  • MD, The School of Medicine at Stony Brook University Medical Center (2010)
Graduate Schools:
  • MSCS, University of Colorado Denver (2018)
Undergraduate Schools:
  • BS, New York University (NY) (2006)
Internships:
  • Rush University Medical Center Program (2011)
Residency Programs:
  • Rush University Medical Center Program, Chief Resident, Neurology (2014)
Fellowships:
  • University of Colorado, Movement Disorders; Behavioral Neurology & Neuropsychiatry (2017)
Download CV
Languages: English
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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