Tyler Buckner, MD
Associate Professor, Medicine-Hematology

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Medical School:
  • MD, University of North Carolina at Chapel Hill School of Medicine (2005)
Graduate School :
  • MSc, University of North Carolina at Chapel Hill (2014)
Undergraduate School:
  • BS, Rhodes College (TN) (2000)
Internship:
  • University of North Carolina Hospitals Program (2006)
Residency:
  • University of North Carolina Hospitals Program, Chief Resident, Internal Medicine - Pediatrics (2009)
Fellowships:
  • University of North Carolina Hospitals Program, Hematology and Oncology (2013)
  • University of North Carolina Hospitals Program, Pediatric Hematology / Oncology (2013)
Languages: English
Department: Medicine-Hematology

Research Interests

Dr. Buckner is currently the principal investigator of a study of pain assessment tools in men with hemophilia, as well as a multicenter observational study, the Hemophilia Natural History Study (ATHN7). He is also involved in studies investigating how hip and knee replacement surgeries affect pain, physical function, and quality of life in persons with hemophilia; methods for assessing physical function in men with hemophilia; and multiple studies of new therapeutics for treatment of bleeding disorders.

Publications

  • Guasch S, Scott LC, Figueroa J, Buckner TW, Mattis S, Tran DQ Jr, Kempton CL. Cross-sectional study evaluating the association of haemophilia-related distress and clinically relevant outcomes. Haemophilia. 2023 Jan 14. [Epub ahead of print] PubMed PMID: 36639952
  • Schreiber AR, Santos J, McMahon B, Buckner TW, Olson C, Alberti MO, Guimarães-Young A, Knoeckel C, Broussard L, Aubrey M, Palmer BE, Weiss E, Connors GR, Brunner S, Wisell JA, Pacheco T, Aisner DL, Gutman JA. A Case of Fetal-Induced Graft-versus-Host Disease. N Engl J Med. 2023 Aug 17;389(7):668-670. PubMed PMID: 37585636
  • Astermark J, Buckner TW, Frenzel L, Hatswell AJ, You X, Liu H, Goodman E, Santos S, Hawes C, Hinds D, Klamroth R. Matching-adjusted indirect comparison of bleeding outcomes in severe haemophilia A: Comparing valoctocogene roxaparvovec gene therapy, emicizumab prophylaxis, and FVIII replacement prophylaxis. Haemophilia. 2023 Jul;29(4):1087-1094. PubMed PMID: 37347645
  • Fedewa SA, Buckner TW, Parks SG, Tran DQ, Cafuir L, Antun AG, Mattis S, Kempton CL. Racial and Ethnic Differences in Distress, Depression, and Quality of Life in people with hemophilia. J Racial Ethn Health Disparities. 2023 May 3. [Epub ahead of print] PubMed PMID: 37133726
  • Byams VR, Baker JR, Bailey C, Connell NT, Creary MS, Curtis RG, Dinno A, Guelcher CJ, Kim M, Kulkarni R, Lattimore S, Norris KL, Ramirez L, Skinner MW, Symington S, Tobase P, Vázquez E, Warren BB, Wheat E, Buckner TW. Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities in health services; diversity, equity, and inclusion; and implementation science. Expert Rev Hematol. 2023 Mar;16(sup1):87-106. PubMed PMID: 36920863
  • Guasch S, Scott LC, Figueroa J, Buckner TW, Mattis S, Tran DQ Jr, Kempton CL. Cross-sectional study evaluating the association of haemophilia-related distress and clinically relevant outcomes. Haemophilia. 2023 Mar;29(2):505-512. PubMed PMID: 36639952
  • Newman JR, Durben N, Baumann K, Lambing AY, Nichols CD, Witkop M, Santaella ME, Buckner TW. Physical therapy within US HTCs: A multicentre survey of utilization, practice patterns and pain management approaches. Haemophilia. 2022 Mar;28(2):343-350. PubMed PMID: 35152533
  • Kleiboer B, Layer MA, Cafuir LA, Cuker A, Escobar M, Eyster ME, Kraut E, Leavitt AD, Lentz SR, Quon D, Ragni MV, Thornhill D, Wang M, Key NS, Buckner TW. Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study. J Thromb Haemost. 2022 Apr;20(4):857-865. PubMed PMID: 35080347
  • Witkop M, Santaella M, Nichols CD, Lambing AY, Baumann K, Curtis RG, Humphrey C, Humphries TJ, Newman J, Durben N, Fritz R, Mauer K, Thibodeaux CB, Wheat E, Buckner T. Understanding the Pain Management Landscape Within the US Bleeding Disorder Community: A Multi-Center Survey. Pain Med. 2022 Feb 1;23(2):269-279. PubMed PMID: 34185087
  • Buckner, Tyler W., Daoud, Nabil, Miles, Moses, O'Neill, Carrie, Watson, Crystal and Recht, Michael. "Designing ATHN 7: Safety, effectiveness and practice of treatment of people with haemophilia in the United States through a natural history cohort study" The Journal of Haemophilia Practice, vol.9, no.1, 2022, pp.147-155. https://doi.org/10.2478/jhp-2022-0020
  • Manco-Johnson MJ, Warren BB, Buckner TW, Funk SM, Wang M. Outcome measures in Haemophilia: Beyond ABR (Annualized Bleeding Rate). Haemophilia. 2021 Jan 4. [Epub ahead of print] PubMed PMID: 33398908
  • Maher KN, Gibson E, Warren BB, Funk SM, Shearer R, Buckner TW, Wang M, Manco-Johnson MJ, Ng CJ. Prophylaxis for children with moderate hemophilia: Use of a guideline to increase early initiation. Pediatr Blood Cancer. 2021 Jan;68(1):e28577. PubMed PMID: 32881253
  • Maher KN, Gibson E, Warren BB, Funk SM, Shearer R, Buckner TW, Wang M, Manco-Johnson MJ, Ng CJ. Prophylaxis for children with moderate hemophilia: Use of a guideline to increase early initiation. Pediatr Blood Cancer. 2021 Jan;68(1):e28577. PubMed PMID: 32881253
  • Kempton CL, Michaels Stout M, Barry V, Figueroa J, Buckner TW, Gillespie S, Ellen Lynch M, Mattis S, Whitten S, McCracken C. Validation of a new instrument to measure disease-related distress among patients with haemophilia. Haemophilia. 2021 Jan;27(1):60-68. PubMed PMID: 33141984
  • Manco-Johnson MJ, Warren BB, Buckner TW, Funk SM, Wang M. Outcome measures in Haemophilia: Beyond ABR (Annualized Bleeding Rate). Haemophilia. 2021 Feb;27 Suppl 3:87-95. PubMed PMID: 33398908
  • O'Hara J, Martin AP, Nugent D, Witkop M, Buckner TW, Skinner MW, O'Mahony B, Mulhern B, Morgan G, Li N, Sawyer EK. Evidence of a disability paradox in patient-reported outcomes in haemophilia. Haemophilia. 2021 Mar;27(2):245-252. PubMed PMID: 33595148
  • Buckner TW, Bocharova I, Hagan K, Bensimon AG, Yang H, Wu EQ, Sawyer EK, Li N. Health care resource utilization and cost burden of hemophilia B in the United States. Blood Adv. 2021 Apr 13;5(7):1954-1962. PubMed PMID: 33830206
  • Barry V, Buckner TW, Lynch ME, Figueroa J, Mattis S, Stout ME, Kempton CL. An evaluation of PROMIS health domains in adults with haemophilia: A cross-sectional study. Haemophilia. 2021 May;27(3):375-382. PubMed PMID: 33866654
  • Ng CJ, Spomer N, Shearer R, LeBlanc A, Funk S, Manco-Johnson M, Branchford B, Warren B, Buckner TW, Cowell A, Moyer G, Wang M, Gibson E, Mashburn C. Improvements in Communication and Coordination of Care in a Hemophilia Treatment Center. Acta Haematol. 2021;144(6):672-677. PubMed PMID: 33915533
  • Witkop M, Santaella M, Nichols CD, Lambing AY, Baumann K, Curtis RG, Humphrey C, Humphries TJ, Newman J, Fritz R, Mauer K, Thibodeaux CB, Wheat E, Buckner T. Understanding the Pain Management Landscape within the US Bleeding Disorder Community: A Multi-Center Survey. Pain Med. 2021 Jun 29. [Epub ahead of print] PubMed PMID: 34185087
  • Witkop M, Morgan G, O'Hara J, Recht M, Buckner TW, Nugent D, Curtis R, O'Mahony B, Skinner MW, Mulhern B, Cawson M, Ali TM, Sawyer EK, Li N. Patient preferences and priorities for haemophilia gene therapy in the US: A discrete choice experiment. Haemophilia. 2021 Sep;27(5):769-782. PubMed PMID: 34310811
  • Warren BB, Chan A, Manco-Johnson M, Branchford BR, Buckner TW, Moyer G, Gibson E, Thornhill D, Wang M, Ng CJ. Emicizumab initiation and bleeding outcomes in people with hemophilia A with and without inhibitors: A single-center report. Res Pract Thromb Haemost. 2021 Jul;5(5):e12571. PubMed PMID: 34377887
  • Miller CH, Soucie JM, Byams VR, Payne AB, Sidonio RF Jr, Buckner TW, Bean CJ. Women and girls with haemophilia receiving care at specialized haemophilia treatment centres in the United States. Haemophilia. 2021 Nov;27(6):1037-1044. PubMed PMID: 34480812
  • Kuijlaars IAR, van der Net J, Buckner TW, Kempton CL, Schutgens REG, Fischer K. Shortening the Haemophilia Activities List (HAL) from 42 items to 18 items. Haemophilia. 2021 Nov;27(6):1062-1070. PubMed PMID: 34498348
  • Kempton CL, Michaels Stout M, Barry V, Figueroa J, Buckner TW, Gillespie S, Ellen Lynch M, Mattis S, Whitten S, McCracken C. Validation of a new instrument to measure disease-related distress among patients with haemophilia. Haemophilia. 2020 Nov 3. [Epub ahead of print] PubMed PMID: 33141984
  • Chiasakul T, Buckner TW, Li M, Vega R, Gimotty PA, Cuker A. In-Hospital Complications and Readmission in Patients with Hemophilia Undergoing Hip or Knee Arthroplasty. JB JS Open Access. 2020 Apr-Jun;5(2):e0085. PubMed PMID: 33123670
  • Lim MY, Buckner TW. Nonsevere hemophilia A: often overlooked, but not forgotten. Curr Opin Hematol. 2020 Sep;27(5):295-301. PubMed PMID: 32701616
  • Asher ZP, Buckner TW, McIntyre RC Jr. Postoperative hemorrhage secondary to acquired hemophilia A. JAAPA. 2020 Jun;33(6):24-26. PubMed PMID: 32452957
  • Soucie JM, Miller CH, Dupervil B, Le B, Buckner TW. Occurrence rates of haemophilia among males in the United States based on surveillance conducted in specialized haemophilia treatment centres. Haemophilia. 2020 May;26(3):487-493. PubMed PMID: 32329553
  • Buckner TW, Watson C, Recht M. Emicizumab in Hemophilia A. N Engl J Med. 2020 Feb 20;382(8):785-786. PubMed PMID: 32074441
  • Buckner TW, Sidonio R Jr, Witkop M, Guelcher C, Cutter S, Iyer NN, Cooper DL. Correlations between patient-reported outcomes and self-reported characteristics in adults with hemophilia B and caregivers of children with hemophilia B: analysis of the B-HERO-S study. Patient Relat Outcome Meas. 2019;10:299-314. PubMed PMID: 31572035
  • Buckner TW, Sidonio R Jr, Guelcher C, Kessler CM, Witkop M, Clark D, Owens W, Fridman M, Iyer NN, Cooper DL. Reliability and validity of patient-reported outcome instruments in US adults with hemophilia B and caregivers in the B-HERO-S study. Eur J Haematol. 2018 Dec;101(6):781-790. PubMed PMID: 30179272
  • Buckner TW, Witkop M, Guelcher C, Sidonio R, Kessler CM, Clark DB, Owens W, Frick N, Iyer NN, Cooper DL. Impact of hemophilia B on quality of life in affected men, women, and caregivers-Assessment of patient-reported outcomes in the B-HERO-S study. Eur J Haematol. 2018 Jun;100(6):592-602. PubMed PMID: 29505680
  • Buckner TW, Batt K, Cooper DL, Kempton CL. What can we learn from using formal patient-reported outcome instruments to assess pain, functional impairment, anxiety, and depression in US adults with hemophilia?. Eur J Haematol. 2018 Apr;100 Suppl 1:3-4. PubMed PMID: 29498785
  • Buckner TW, Batt K, Quon D, Witkop M, Recht M, Kessler C, Baumann K, Hernandez G, Wang M, Cooper DL, Kempton CL. Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient-reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. Eur J Haematol. 2018 Apr;100 Suppl 1:5-13. PubMed PMID: 29498784
  • Batt K, Boggio L, Neff A, Buckner TW, Wang M, Quon D, Witkop M, Recht M, Kessler C, Iyer NN, Cooper DL. Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. Eur J Haematol. 2018 Apr;100 Suppl 1:14-24. PubMed PMID: 29498783
  • Kempton CL, Buckner TW, Fridman M, Iyer NN, Cooper DL. Factors associated with pain severity, pain interference, and perception of functional abilities independent of joint status in US adults with hemophilia: Multivariable analysis of the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. Eur J Haematol. 2018 Apr;100 Suppl 1:25-33. PubMed PMID: 29498782
  • Kempton CL, Recht M, Neff A, Wang M, Buckner TW, Soni A, Quon D, Witkop M, Boggio L, Gut RZ, Cooper DL. Impact of pain and functional impairment in US adults with haemophilia: Patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study. Haemophilia. 2018 Mar;24(2):261-270. PubMed PMID: 29218759
  • Kempton CL, Recht M, Neff A, Wang M, Buckner TW, Soni A, Quon D, Witkop M, Boggio L, Gut RZ, Cooper DL. Impact of pain and functional impairment in US adults with haemophilia: Patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study. Haemophilia. 2017 Dec 8. [Epub ahead of print] PubMed PMID: 29218759
  • Buckner TW, Wang M, Cooper DL, Iyer NN, Kempton CL. Known-group validity of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study. Patient Prefer Adherence. 2017;11:1745-1753. PubMed PMID: 29066870
  • Kempton CL, Wang M, Recht M, Neff A, Shapiro AD, Soni A, Kulkarni R, Buckner TW, Batt K, Iyer NN, Cooper DL. Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ) study. Patient Prefer Adherence. 2017;11:1603-1612. PubMed PMID: 29033549
  • Witkop M, Neff A, Buckner TW, Wang M, Batt K, Kessler CM, Quon D, Boggio L, Recht M, Baumann K, Gut RZ, Cooper DL, Kempton CL. Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study. Haemophilia. 2017 Jul;23(4):556-565. PubMed PMID: 28419637
  • Buckner TW, Witkop M, Guelcher C, Frey MJ, Hunter S, Peltier S, Recht M, Walsh C, Kessler CM, Owens W, Clark DB, Frick N, Rice M, Iyer NN, Holot N, Cooper DL, Sidonio R Jr. Management of US men, women, and children with hemophilia and methods and demographics of the Bridging Hemophilia B Experiences, Results and Opportunities into Solutions (B-HERO-S) study. Eur J Haematol. 2017 Apr;98 Suppl 86:5-17. PubMed PMID: 28319338
  • Lim MY, Buckner TW, Kasthuri RS, Ma AD, Key NS. Management of adult non-severe haemophilia A patients with inhibitors: a practice-pattern survey. Haemophilia. 2015 Sep;21(5):e422-4. PubMed PMID: 26010777
  • Ishaku NG, Key NS, Miller CH, Nielsen B, Buckner T, Chen SL, Hooper WC, Soucie JM. Cluster of inhibitors among adult inpatients with haemophilia in a single institution. Haemophilia. 2015 Jul;21(4):e325-8. PubMed PMID: 25939561
  • Buckner TW, Nielsen BI, Key NS, Ma A. Factor VIII inhibitory antibody in a patient with combined factor V/factor VIII deficiency. Haemophilia. 2015 Jan;21(1):e77-80. PubMed PMID: 25472918
  • Itzler R, Buckner TW, Leebeek F, Miller J, Recht M, Drelich D, Monahan P, Pipe S. Effect of etranacogene dezaparvocec on quality of life for severe and moderately severe haemophilia B participants: Results from the phase III HOPE-B trial 2 years after gene therapy. Haemophilia.
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Professional Memberships

  • American Society of Hematology (ASH), Member
  • Hemostasis and Thrombosis Research Society (HTRS), Member
  • International Society on Thrombosis and Haemostasis (ISTH), Member

Practice Locations

Hemophilia & Thrombosis Center
13199 E. Montview Blvd
Suite 100
Aurora, CO 80045
303-724-0724

UCHealth Blood Disorders and Cell Therapies Center - Anschutz Medical Campus
1665 Aurora Court
3rd floor, Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-6400

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Hematology, Board Certification (2013)
  • Pediatric Hematology / Oncology, Board Certification (2015)
  • Internal Medicine, Board Certification (2009)
  • Pediatrics, Board Certification (2009)
Conditions & Treatments
  • Blood / Lymphatic System - Blood Disorders
  • Blood / Lymphatic System
Personal Interests
Dr. Buckner received his medical degree and completed Internal Medicine and Pediatrics residency and a combined fellowship in Hematology (adult) and Pediatric Hematology/Oncology at the University of North Carolina – Chapel Hill. He also completed a Masters degree in clinical research at the UNC School of Public Health and a post-doctoral fellowship at the UNC Cecil G Sheps Center for Health Services Research. In January 2015, Dr. Buckner joined the Hematology faculty at the University of Colorado. His research seeks to identify clinical management strategies that lead to improved patient outcomes for patients with bleeding and clotting disorders.

General Information

Medical Schools:
  • MD, University of North Carolina at Chapel Hill School of Medicine (2005)
Graduate Schools:
  • MSc, University of North Carolina at Chapel Hill (2014)
Undergraduate Schools:
  • BS, Rhodes College (TN) (2000)
Internships:
  • University of North Carolina Hospitals Program (2006)
Residency Programs:
  • University of North Carolina Hospitals Program, Chief Resident, Internal Medicine - Pediatrics (2009)
Fellowships:
  • University of North Carolina Hospitals Program, Hematology and Oncology (2013)
  • University of North Carolina Hospitals Program, Pediatric Hematology / Oncology (2013)
Languages: English
Department: Medicine-Hematology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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