Shanlee Davis, MD, MSCS
Assistant Professor, Pediatrics-Endocrinology

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Medical School:
  • MD, Mayo Medical School (2010)
Graduate Schools :
  • MSCS, University of Colorado Denver (2016)
  • PhD, University of Colorado Health Sciences Center (2020)
Undergraduate School:
  • BA/BS, University of California–Davis (CA) (2006)
Internship:
  • University of Colorado (Children's Hospital Colorado) Program (2011)
Residency:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2013)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Endocrinology (2016)
  • University of Colorado (Children's Hospital Colorado) Program, Clinical Research in X & Y Chromosome Variations (2017)
Languages: English
Department: Pediatrics-Endocrinology

Professional Titles

  • Assistant Professor of Pediatrics

Research Interests

My research interests include cardiometabolic health and gonadal function in infants, children and adolescents with X and Y chromosome variations, including Klinefelter and Turner syndromes.

Publications

  • Howell S, Buchanan C, Davis SM, Miyazawa H, Furuta GT, Tartaglia NR, Nguyen N. Eosinophilic esophagitis in individuals with sex chromosome aneuploidies: Clinical presentations and management implications. Mol Genet Genomic Med. 2021 Nov 5;:e1833. [Epub ahead of print] PubMed PMID: 34738344
  • Auchus RJ, Sarafoglou K, Fechner PY, Vogiatzi MG, Imel EA, Davis SM, Giri N, Sturgeon J, Roberts E, Chan JL, Farber RH. Crinecerfont Lowers Elevated Hormone Markers in Adults with 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2021 Oct 15. [Epub ahead of print] PubMed PMID: 34653252
  • Nunes-Moreno M, Buchanan C, Cole FS, Davis S, Dempsey A, Dowshen N, Furniss A, Kazak AE, Kerlek AJ, Margolis P, Pyle L, Razzaghi H, Reirden DH, Schwartz B, Sequeira GM, Nokoff NJ. Behavioral Health Diagnoses in Youth with Gender Dysphoria Compared with Controls: A PEDSnet Study. J Pediatr. 2021 Sep 24. [Epub ahead of print] PubMed PMID: 34571022
  • Patel N, Klamer B, Davis S, Nahata L. Patient-parent perceptions of transition readiness in Turner syndrome and associated factors. Clin Endocrinol (Oxf). 2021 Sep 23. [Epub ahead of print] PubMed PMID: 34553783
  • Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2021 Sep 7. [Epub ahead of print] PubMed PMID: 34493629
  • Sewell R, Buchanan CL, Davis S, Christakis DA, Dempsey A, Furniss A, Kazak AE, Kerlek AJ, Magnusen B, Pajor NM, Pyle L, Pyle LC, Razzaghi H, Schwartz BI, Vogiatzi MG, Nokoff NJ. Behavioral Health Diagnoses in Youth with Differences of Sex Development or Congenital Adrenal Hyperplasia Compared with Controls: A PEDSnet Study. J Pediatr. 2021 Aug 27. [Epub ahead of print] PubMed PMID: 34461062
  • Vogiatzi MG, Davis SM, Ross JL. Cortical Bone Mass is Low in Boys with Klinefelter Syndrome and Improves with Oxandrolone. J Endocr Soc. 2021 Apr 1;5(4):bvab016. PubMed PMID: 33733020
  • Guzewicz L, Howell S, Crerand CE, Umbaugh H, Nokoff NJ, Barker J, Davis SM. Clinical phenotype and management of individuals with mosaic monosomy X with Y chromosome material stratified by genital phenotype. Am J Med Genet A. 2021 May;185(5):1437-1447. PubMed PMID: 33616298
  • Patel N, Davis S, Nahata L. TRANSITION-RELATED DISCUSSIONS AMONG ADOLESCENT FEMALES WITH TURNER SYNDROME: CURRENT PRACTICES AND ASSOCIATED FACTORS. Endocr Pract. 2021 Jan;27(1):56-62. PubMed PMID: 33475502
  • Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 Aug;68(6):1128-1134. PubMed PMID: 32641352
  • Davis SM, Soares K, Howell S, Cree-Green M, Buyers E, Johnson J, Tartaglia NR. Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome. Reprod Sci. 2020 Nov;27(11):1985-1991. PubMed PMID: 32578162
  • Davis SM, Bloy L, Roberts TPL, Kowal K, Alston A, Tahsin A, Truxon A, Ross JL. Testicular function in boys with 47,XYY and relationship to phenotype. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):371-385. PubMed PMID: 32544298
  • Davis SM, DeKlotz S, Nadeau KJ, Kelsey MM, Zeitler PS, Tartaglia NR. High prevalence of cardiometabolic risk features in adolescents with 47,XXY/Klinefelter syndrome. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):327-333. PubMed PMID: 32542985
  • Tartaglia N, Howell S, Davis S, Kowal K, Tanda T, Brown M, Boada C, Alston A, Crawford L, Thompson T, van Rijn S, Wilson R, Janusz J, Ross J. Early neurodevelopmental and medical profile in children with sex chromosome trisomies: Background for the prospective eXtraordinarY babies study to identify early risk factors and targets for intervention. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):428-443. PubMed PMID: 32506668
  • Chang S, Skakkebaek A, Davis SM, Gravholt CH. Morbidity in Klinefelter syndrome and the effect of testosterone treatment. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):344-355. PubMed PMID: 32496001
  • Aksglaede L, Davis SM, Ross JL, Juul A. Minipuberty in Klinefelter syndrome: Current status and future directions. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):320-326. PubMed PMID: 32476267
  • Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD. Automated syndrome diagnosis by three-dimensional facial imaging. Genet Med. 2020 Oct;22(10):1682-1693. PubMed PMID: 32475986
  • Thompson T, Howell S, Davis S, Wilson R, Janusz J, Boada R, Pyle L, Tartaglia N. Current survey of early childhood intervention services in infants and young children with sex chromosome aneuploidies. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):414-427. PubMed PMID: 32449585
  • Thompson T, Zieba B, Howell S, Karakash W, Davis S. A mixed methods study of physical activity and quality of life in adolescents with Turner syndrome. Am J Med Genet A. 2020 Feb;182(2):386-396. PubMed PMID: 31814298
  • Davis S, Ware MA, Zeiger J, Deardorff MA, Grand K, Grimberg A, Hsu S, Kelsey M, Majidi S, Matthew RP, Napier M, Nokoff N, Prasad C, Riggs AC, McKinnon ML, Mirzaa G. Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA. Am J Med Genet A. 2020 Jan;182(1):162-168. PubMed PMID: 31729162
  • Davis S, Crerand C, Hutaff-Lee C, Thompson T, Tishelman A, Samara O, Umbaugh H, Nahata L, Kremen J. Neurodevelopmental and Mental Health Screening for Patients with Turner Syndrome in Pediatric Endocrine Clinics: Results of a Pediatric Endocrine Society Survey. Horm Res Paediatr. 2020;93(11-12):643-650. PubMed PMID: 33915553
  • Prakash SK, Lugo-Ruiz S, Rivera-Dávila M, Rubio N Jr, Shah AN, Knickmeyer RC, Scurlock C, Crenshaw M, Davis SM, Lorigan GA, Dorfman AT, Rubin K, Maslen C, Bamba V, Kruszka P, Silberbach M. The Turner syndrome research registry: Creating equipoise between investigators and participants. Am J Med Genet C Semin Med Genet. 2019 Mar;181(1):135-140. PubMed PMID: 30758128
  • Dabrowski E, Johnson EK, Patel V, Hsu Y, Davis S, Goetsch AL, Habiby R, Brickman WJ, Finlayson C. Turner Syndrome with Y Chromosome: Spontaneous Thelarche, Menarche, and Risk of Malignancy. J Pediatr Adolesc Gynecol. 2019 Aug 26. [Epub ahead of print] PubMed PMID: 31465855
  • Hsu SC, Bartz S, Pyle L, Fete M, Davis S, Ohman-Hanson R, Fete TJ, Motil KJ. Growth failure in focal dermal hypoplasia. Am J Med Genet A. 2019 Apr;179(4):628-633. PubMed PMID: 30693654
  • Martin S, Cordeiro L, Richardson P, Davis S, Tartaglia N. The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes. Phys Occup Ther Pediatr. 2019;39(4):446-459. PubMed PMID: 30592247
  • Tartaglia NR, Wilson R, Miller JS, Rafalko J, Cordeiro L, Davis S, Hessl D, Ross J. Autism Spectrum Disorder in Males with Sex Chromosome Aneuploidy: XXY/Klinefelter Syndrome, XYY, and XXYY. J Dev Behav Pediatr. 2017 Apr;38(3):197-207. PubMed PMID: 28333849
  • Ross JL, Kushner H, Kowal K, Bardsley M, Davis S, Reiss AL, Tartaglia N, Roeltgen D. Androgen Treatment Effects on Motor Function, Cognition, and Behavior in Boys with Klinefelter Syndrome. J Pediatr. 2017 Jun;185:193-199.e4. PubMed PMID: 28285751
  • Davis SM, Cox-Martin MG, Bardsley MZ, Kowal K, Zeitler PS, Ross JL. Effects of Oxandrolone on Cardiometabolic Health in Boys With Klinefelter Syndrome: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2017 Jan 1;102(1):176-184. PubMed PMID: 27802097
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Emergency Medicine
  • Pediatric Endocrinology
Conditions & Treatments
  • Endocrine System (Hormones)
  • Genetic Conditions and Testing
Clinical Interests
My clinical and research interests include caring for infants, children and adolescents with X & Y chromosome variations, including XXY / Klinefelter syndrome and Turner syndrome, and other genetic syndromes that are associated with endocrine conditions.

Care Philosophy
I value working on interdisciplinary teams to provide comprehensive care for children and families with complex medical conditions.

Public Speaking
Yes
Puberty and X & Y chromosome variations

General Information

Medical Schools:
  • MD, Mayo Medical School (2010)
Graduate Schools:
  • MSCS, University of Colorado Denver (2016)
  • PhD, University of Colorado Health Sciences Center (2020)
Undergraduate Schools:
  • BA/BS, University of California–Davis (CA) (2006)
Internships:
  • University of Colorado (Children's Hospital Colorado) Program (2011)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2013)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Endocrinology (2016)
  • University of Colorado (Children's Hospital Colorado) Program, Clinical Research in X & Y Chromosome Variations (2017)
Languages: English
Department: Pediatrics-Endocrinology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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