Connie Hess, MD
Associate Professor, Medicine-Cardiology

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Medical School:
  • MD, Harvard Medical School (2005)
Graduate School :
  • MHS, Duke University (2013)
Undergraduate School:
  • BA, Harvard University (MA) (2000)
Internship:
  • Massachusetts General Hospital Program (2006)
Residency:
  • Massachusetts General Hospital Program, Internal Medicine (2008)
Fellowships:
  • Duke University Hospital Program, Cardiology (2013)
  • Duke University Hospital Program, Interventional Cardiology (2014)
Department: Medicine-Cardiology

Research Interests

My research is focused on modification of ischemic cardiac and limb-related risk in patients with atherosclerotic vascular disease through medical therapies, including antithrombotic and lipid-lowering strategies. I am also interested in device-based therapies and optimization of peri-procedural care for patients undergoing percutaneous coronary and peripheral vascular interventions. My research is conducted through a combination of clinical trials, observational studies, and implementation science.

Publications

  • Rao SV, Vidovich MI, Gilchrist IC, Gulati R, Gutierrez JA, Hess CN, Kaul P, Martinez SC, Rymer J. 2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2021 Feb 16;77(6):811-825. PubMed PMID: 33423859
  • Hess CN, Wang TY, Weleski Fu J, Gundrum J, Allen LaPointe NM, Rogers RK, Hiatt WR. Long-Term Outcomes and Associations With Major Adverse Limb Events After Peripheral Artery Revascularization. J Am Coll Cardiol. 2020 Feb 11;75(5):498-508. PubMed PMID: 32029132
  • Hess CN, Hiatt WR. Progress in the prevention and treatment of atherosclerotic cardiovascular disease: two steps forward, one step back. Eur Heart J. 2020 Jan 31. [Epub ahead of print] PubMed PMID: 32003776
  • Secemsky EA, Barrette E, Bockstedt L, Bonaca MP, Hess CN, Hanson T, Monteiro J, Manda B, Yeh RW. Long-Term Safety of Drug-Coated Devices for Peripheral Revascularisation. EuroIntervention. 2020 Dec 22. [Epub ahead of print] PubMed PMID: 33342764
  • Hiatt WR, Bonaca MP, Patel MR, Nehler MR, Debus ES, Anand SS, Capell WH, Brackin T, Jaeger N, Hess CN, Pap AF, Berkowitz SD, Muehlhofer E, Haskell L, Brasil D, Madaric J, Sillesen H, Szalay D, Bauersachs R. Rivaroxaban and Aspirin in Peripheral Artery Disease Lower Extremity Revascularization: Impact of Concomitant Clopidogrel on Efficacy and Safety. Circulation. 2020 Dec 8;142(23):2219-2230. PubMed PMID: 33138628
  • Hess CN, Bonaca MP. Contemporary Review of Antithrombotic Therapy in Peripheral Artery Disease. Circ Cardiovasc Interv. 2020 Oct;13(10):e009584. PubMed PMID: 33023325
  • Bonaca MP, Hess CN. ASCVD Risk and Statin Use in PAD: Implementing a New Approach to an Old Problem. J Am Coll Cardiol. 2020 Jul 21;76(3):265-267. PubMed PMID: 32674790
  • Bonaca MP, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Patel MR, Fanelli F, Capell WH, Diao L, Jaeger N, Hess CN, Pap AF, Kittelson JM, Gudz I, Mátyás L, Krievins DK, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Berkowitz SD, Hiatt WR. Rivaroxaban in Peripheral Artery Disease after Revascularization. N Engl J Med. 2020 May 21;382(21):1994-2004. PubMed PMID: 32222135
  • Bonaca MP, Hess CN, Hiatt WR. The Pathobiology of Acute Limb Ischemic Events and Stent Failure in Peripheral Artery Disease: A Step in the Right Direction. JACC Cardiovasc Interv. 2020 Feb 24;13(4):428-430. PubMed PMID: 32081235
  • Haine A, Kavanagh S, Berger JS, Hess CN, Norgren L, Fowkes FGR, Katona BG, Mahaffey KW, Blomster JI, Patel MR, Jones WS, Rockhold FW, Hiatt WR, Baumgartner I. Sex-Specific Risks of Major Cardiovascular and Limb Events in Patients With Symptomatic Peripheral Artery Disease. J Am Coll Cardiol. 2020 Feb 18;75(6):608-617. PubMed PMID: 32057375
  • Hess CN, Hiatt WR. Progress in the prevention and treatment of atherosclerotic cardiovascular disease: two steps forward, one step back. Eur Heart J. 2020 May 1;41(17):1650-1652. PubMed PMID: 32003776
  • Hess CN, Wang TY, Weleski Fu J, Gundrum J, Allen LaPointe NM, Rogers RK, Hiatt WR. Long-Term Outcomes and Associations With Major Adverse Limb Events After Peripheral Artery Revascularization. J Am Coll Cardiol. 2020 Feb 11;75(5):498-508. PubMed PMID: 32029132
  • Hiatt WR, Hess CN, Bonaca MP. Heterogeneity of Risk and Benefit in Subgroups of COMPASS: Relatively Similar But Absolutely Different. J Am Coll Cardiol. 2019 Jul 2;73(25):3292-3294. PubMed PMID: 31248550
  • Hess CN, Huang Z, Patel MR, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Held P, Jones WS, Katona B, Mahaffey KW, Norgren L, Rockhold FW, Hiatt WR. Acute Limb Ischemia in Peripheral Artery Disease. Circulation. 2019 Aug 13;140(7):556-565. PubMed PMID: 31238713
  • Hess CN, Hiatt WR. Lost in translation: Why 'lost to follow-up' matters. Vasc Med. 2019 Aug;24(4):339-340. PubMed PMID: 31195921
  • Rymer JA, Kaltenbach LA, Kochar A, Hess CN, Gilchrist IC, Messenger JC, Harrington RA, Jolly SS, Jacobs AK, Abbott JD, Wojdyla DM, Krucoff MW, Rao SV. Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women. Circ Cardiovasc Interv. 2019 May;12(5):e007086. PubMed PMID: 31014090
  • Ibrahim H, Kaltenbach LA, Hess CN, Recchia T, Effron MB, Stone GW, Wang TY. Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study. Catheter Cardiovasc Interv. 2019 Mar 1;93(4):E204-E210. PubMed PMID: 30244509
  • Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2018 Jan 29;69:133-145. PubMed PMID: 29095667
  • Koshy LM, Aberle LH, Krucoff MW, Hess CN, Mazzaferri E Jr, Jolly SS, Jacobs A, Gibson CM, Mehran R, Gilchrist IC, Rao SV. Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention. J Invasive Cardiol. 2018 Jan;30(1):18-22. PubMed PMID: 29035844
  • Pagidipati NJ, Clare RM, Keenan RT, Chiswell K, Roe MT, Hess CN. Association of Gout With Long-Term Cardiovascular Outcomes Among Patients With Obstructive Coronary Artery Disease. J Am Heart Assoc. 2018 Aug 21;7(16):e009328. PubMed PMID: 30369327
  • Ibrahim H, Kaltenbach LA, Hess CN, Recchia T, Effron MB, Stone GW, Wang TY. Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study. Catheter Cardiovasc Interv. 2018 Sep 23. [Epub ahead of print] PubMed PMID: 30244509
  • Hess CN, Rogers RK, Wang TY, Fu R, Gundrum J, Allen LaPointe NM, Hiatt WR. Major Adverse Limb Events and 1-Year Outcomes After Peripheral Artery Revascularization. J Am Coll Cardiol. 2018 Aug 28;72(9):999-1011. PubMed PMID: 30139446
  • Hess CN, Hiatt WR. Antithrombotic Therapy for Peripheral Artery Disease in 2018. JAMA. 2018 Jun 12;319(22):2329-2330. PubMed PMID: 29860284
  • Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2018 Jan 29;69:133-145. PubMed PMID: 29095667
  • Koshy LM, Aberle LH, Krucoff MW, Hess CN, Mazzaferri E Jr, Jolly SS, Jacobs A, Gibson CM, Mehran R, Gilchrist IC, Rao SV. Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention. J Invasive Cardiol. 2018 Jan;30(1):18-22. PubMed PMID: 29035844
  • Goldberg RJ, Gore JM, McManus DD, McManus R, Tisminetzky M, Lessard D, Gurwitz JH, Parish DC, Allison J, Hess CN, Wang T, Kiefe C. Race and place differences in patients hospitalized with an acute coronary syndrome: Is there double jeopardy? Findings from TRACE-CORE. Prev Med Rep. 2017 Jan 24;6:1-8. PubMed PMID: 28210536
  • Hess CN, Kaltenbach LA, Doll JA, Cohen DJ, Peterson ED, Wang TY. Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization. Circulation. 2017 Feb 7;135(6):532-543. PubMed PMID: 28153990
  • Hess CN, Roe MT. Treatment of coronary artery disease in cancer survivors: an emerging challenge. Coron Artery Dis. 2017 Jan;28(1):1-2. PubMed PMID: 27776090
  • Hess CN, Hiatt WR. Response by Hess and Hiatt to Letter Regarding Article, "A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization: A TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) Initiative". Circulation. 2017 Dec 19;136(25):2524-2525. PubMed PMID: 29255130
  • Fanaroff AC, Kaltenbach LA, Peterson ED, Hess CN, Cohen DJ, Fonarow GC, Wang TY. Management of Persistent Angina After Myocardial Infarction Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study. J Am Heart Assoc. 2017 Oct 19;6(10). PubMed PMID: 29051217
  • Hess CN, Norgren L, Ansel GM, Capell WH, Fletcher JP, Fowkes FGR, Gottsäter A, Hitos K, Jaff MR, Nordanstig J, Hiatt WR. A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization: A TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) Initiative. Circulation. 2017 Jun 20;135(25):2534-2555. PubMed PMID: 28630267
  • Pagidipati NJ, Hess CN, Clare RM, Akerblom A, Tricoci P, Wojdyla D, Keenan RT, James S, Held C, Mahaffey KW, Klein AB, Wallentin L, Roe MT. An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome. Am Heart J. 2017 May;187:53-61. PubMed PMID: 28454808
  • Hess CN, Clare RM, Neely ML, Tricoci P, Mahaffey KW, James SK, Alexander JH, Held C, Lopes RD, Fox KAA, White HD, Wallentin L, Armstrong PW, Harrington RA, Ohman EM, Roe MT. Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome. Am Heart J. 2017 May;187:194-203. PubMed PMID: 28454804
  • Goldberg RJ, Gore JM, McManus DD, McManus R, Tisminetzky M, Lessard D, Gurwitz JH, Parish DC, Allison J, Hess CN, Wang T, Kiefe C. Race and place differences in patients hospitalized with an acute coronary syndrome: Is there double jeopardy? Findings from TRACE-CORE. Prev Med Rep. 2017 Jun;6:1-8. PubMed PMID: 28210536
  • Hess CN, Kaltenbach LA, Doll JA, Cohen DJ, Peterson ED, Wang TY. Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization. Circulation. 2017 Feb 7;135(6):532-543. PubMed PMID: 28153990
  • Hess CN, Roe MT. Treatment of coronary artery disease in cancer survivors: an emerging challenge. Coron Artery Dis. 2017 Jan;28(1):1-2. PubMed PMID: 27776090
  • Hess CN, Wang TY, McCoy LA, Messenger JC, Effron MB, Zettler ME, Henry TD, Peterson ED, Fonarow GC. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2016 Feb 2;133(5):493-501. PubMed PMID: 26680241
  • Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation. 2016 Jun 14;133(24):2459-502. PubMed PMID: 27297342
  • Hess CN, Hellkamp AS, Roe MT, Thomas L, Scirica BM, Peng SA, Peterson ED, Wang TY. Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization. J Am Heart Assoc. 2016 Mar 14;5(3):e002784. PubMed PMID: 26976877
  • Hess CN, Wang TY, McCoy LA, Messenger JC, Effron MB, Zettler ME, Henry TD, Peterson ED, Fonarow GC. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2016 Feb 2;133(5):493-501. PubMed PMID: 26680241
  • Hess CN, Krucoff MW, Sheng S, Anstrom KJ, Barham WB, Gilchrist IC, Harrington RA, Jacobs AK, Mehran R, Messenger JC, Mark DB, Rao SV. Comparison of quality-of-life measures after radial versus femoral artery access for cardiac catheterization in women: Results of the Study of Access Site for Enhancement of Percutaneous Coronary Intervention for Women quality-of-life substudy. Am Heart J. 2015 Aug;170(2):371-9. PubMed PMID: 26299236
  • Hess CN, James S, Lopes RD, Wojdyla DM, Neely ML, Liaw D, Hagstrom E, Bhatt DL, Husted S, Goodman SG, Lewis BS, Verheugt FW, De Caterina R, Ogawa H, Wallentin L, Alexander JH. Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial. J Am Coll Cardiol. 2015 Aug 18;66(7):777-87. PubMed PMID: 26271059
  • Hess CN, Peterson ED, Peng SA, de Lemos JA, Fosbol EL, Thomas L, Bhatt DL, Saucedo JF, Wang TY. Use and Outcomes of Triple Therapy Among Older Patients With Acute Myocardial Infarction and Atrial Fibrillation. J Am Coll Cardiol. 2015 Aug 11;66(6):616-27. PubMed PMID: 26248987
  • Hess CN, Lopes RD, Gibson CM, Hager R, Wojdyla DM, Englum BR, Mack MJ, Kouchoukos NT, Peterson ED, Alexander JH. Response to Letters Regarding Article, "Saphenous Vein Graft Failure After Coronary Artery Bypass Surgery: Insights From PREVENT IV". Circulation. 2015 Jul 28;132(4):e29. PubMed PMID: 26216091
  • Hess CN, Roe MT, Clare RM, Chiswell K, Kelly J, Tcheng JE, Hagstrom E, James SK, Khouri MG, Hirsch BR, Kong DF, Abernethy AP, Krucoff MW. Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention. J Am Heart Assoc. 2015 Jul 6;4(7). PubMed PMID: 26150477
  • Wang TY, Henry TD, Effron MB, Honeycutt E, Hess CN, Zettler ME, Cohen DJ, Baker BA, Berger PB, Anstrom KJ, Angiolillo DJ, Peterson ED. Cluster-randomized clinical trial examining the impact of platelet function testing on practice: the treatment with adenosine diphosphate receptor inhibitors: longitudinal assessment of treatment patterns and events after acute coronary syndrome prospective open label antiplatelet therapy study. Circ Cardiovasc Interv. 2015 Jun;8(6):e001712. PubMed PMID: 26025216
  • Hess CN, Krucoff MW, Rao SV. Reply: Transradial PCI in Women: Zeroing in on Crossovers. JACC Cardiovasc Interv. 2015 Apr 20;8(4):639. PubMed PMID: 25907092
  • Hess CN, Peterson ED, Neely ML, Dai D, Hillegass WB, Krucoff MW, Kutcher MA, Messenger JC, Pancholy S, Piana RN, Rao SV. Response to letter regarding article, "The learning curve for transradial percutaneous coronary intervention among operators in the United States: a study from the National Cardiovascular Data Registry". Circulation. 2015 Feb 24;131(8):e358. PubMed PMID: 25712065
  • Hess CN, Rao SV, McCoy LA, Neely ML, Singh M, Spertus JA, Krone RJ, Weaver WD, Peterson ED. Identification of hospital outliers in bleeding complications after percutaneous coronary intervention. Circ Cardiovasc Qual Outcomes. 2015 Jan;8(1):15-22. PubMed PMID: 25424242
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Practice Locations

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Cardiology, Board Certification
  • Interventional Cardiology, Board Certification
Conditions & Treatments
  • Heart and Circulation

General Information

Medical Schools:
  • MD, Harvard Medical School (2005)
Graduate Schools:
  • MHS, Duke University (2013)
Undergraduate Schools:
  • BA, Harvard University (MA) (2000)
Internships:
  • Massachusetts General Hospital Program (2006)
Residency Programs:
  • Massachusetts General Hospital Program, Internal Medicine (2008)
Fellowships:
  • Duke University Hospital Program, Cardiology (2013)
  • Duke University Hospital Program, Interventional Cardiology (2014)
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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